How Chromosomal Aberrations Are Induced by Telomere Dysfunction

• Project/Area Number: 17013043
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: ISHIKAWA Fuyuki Kyoto University, 大学院・生命科学研究科, 教授 (30184493)
• Co-Investigator(Kenkyū-buntansha): URANO Takeshi 島根大学, 医学部, 教授 (70293701) ; NABETANI Akira 京都大学, 大学院・生命科学研究科, 助教 (40334495)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥360,400,000 (Direct Cost: ¥360,400,000); Fiscal Year 2009: ¥72,500,000 (Direct Cost: ¥72,500,000); Fiscal Year 2008: ¥72,500,000 (Direct Cost: ¥72,500,000); Fiscal Year 2007: ¥72,500,000 (Direct Cost: ¥72,500,000); Fiscal Year 2006: ¥72,500,000 (Direct Cost: ¥72,500,000); Fiscal Year 2005: ¥70,400,000 (Direct Cost: ¥70,400,000)
• Keywords: 染色体 / テロメア / クロマチン / テロメレース / 癌 / シグナル伝達 / Pot1 / ALT / 細胞老化 / ヒストンH1 / HMGA2 / がん抑制機構 / SAHF / ヘテロクロマチン / S期 / M期 / アフリカツメガエル / 卵抽出液 / TRF1

Research Abstract

It is now well established that chromosomal aberrations play a major role in carcinogenesis. Yet, the precise mechanisms how aberrant chromosomes are formed remain unknown. In this study, we focused on the telomere, the terminal domain of linear chromosomes. First, we identified novel chromatin structures at telomeres, and next we examined how chromosomes would become unstable in dysfunctional telomeres.

Research Products

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  • Journal Title: J Biochem 149 Pages: 5-14
  • NAID: 10030582554
• [Journal Article] ヘテロクロマチンとしてのテロメア (2010)
  • Author(s): 石川冬木
  • Journal Title: 化学と生物 48 Pages: 550-554
  • NAID: 10026547199
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• [Journal Article] テロメアの機能と構造 (2010)
  • Author(s): 石川冬木
  • Journal Title: 化学と生物 48 Pages: 493-497
  • NAID: 10026875624
• [Journal Article] テロメアと老化 (2010)
  • Author(s): 三河拓己、石川冬木
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• [Journal Article] Fission yeast Vps1 and Atg8 contribute to oxidative stress resistance. (2010)
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  • Journal Title: Genes to Cells Volume: 15 Pages: 229-242
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• [Journal Article] RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. (2009)
  • Author(s): Miyake, Y., Nakamura, M., Nabetani, A., Shimamura, S., Tamura, M., Yonehara, S., Saito, M., Ishikawa, F.
  • Journal Title: Mol Cell 36 Pages: 193-206
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• [Journal Article] A crucial role for adipose tissue p53 in the regulation of insulin resistance. (2009)
  • Author(s): Minamino, T., Orimo, M., Shimizu, I., Kunieda, T., Yokoyama, M., Ito, T., Nojima, A., Nabetani, A., Oike, Y., Matsubara, H., Ishikawa,F., Komurao, I.
  • Journal Title: Nat Med 15 Pages: 1082-1087
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• [Journal Article] Fission yeast Ku protein is required for recovery from DNA replication stress. (2009)
  • Author(s): Miyoshi, T., Kanoh, J., Ishikawa, F.
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• [Journal Article] 加齢のメカニズム:老化は遺伝子に刷り込まれているのか (2009)
  • Author(s): 石川冬木
  • Journal Title: 画像診断 29 Pages: 120-123
• [Journal Article] テロメアとゲノム安定性 (2009)
  • Author(s): 齊藤基輝、石川冬木
  • Journal Title: 日本臨牀(増刊) 67 Pages: 107-112
• [Journal Article] Unusual telomeric DNAs in human telomerase-negative immortalized cells. (2009)
  • Author(s): Nabetani, A., Ishikawa, F.
  • Journal Title: Mol Cell Biol 29 Pages: 703-713
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• [Journal Article] RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. (2009)
  • Author(s): Miyake, Y.
  • Journal Title: Molecular Cell Volume: 36 Pages: 193-206
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• [Journal Article] A crucial role for adipose tissue p53 in the regulation of insulin resistance. (2009)
  • Author(s): Minamino, T.
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• [Journal Article] Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase. (2009)
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• [Journal Article] Fission yeast Ku protein is required for recovery from DNA replication stress (2009)
  • Author(s): Miyoshi, T.
  • Journal Title: Genes Cells Volume: 14 Pages: 1091-1103
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• [Journal Article] テロメア分子生物学のはじまり (2009)
  • Author(s): 石川冬木
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• [Journal Article] Unusual telomeric DNAs in human telomerase-negative immortalized cells (2009)
  • Author(s): Nabetani, A.
  • Journal Title: Molecular and cellular biology 29 Pages: 703-713
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• [Journal Article] テロメアとゲノム安定性 (2009)
  • Author(s): 齊藤基輝
  • Journal Title: 日本臨牀(増刊) 67 Pages: 107-112
  • Peer Reviewed
• [Journal Article] 加齢のメカニズム : 老化は遺伝子に刷り込まれているのか (2009)
  • Author(s): 石川冬木
  • Journal Title: 画像診断 29 Pages: 120-123
• [Journal Article] Interaction between DNMT1 and DNA replication reactions in the SV40 in vitro replication system. (2008)
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  • Journal Title: Cancer Sci 99 Pages: 1960-1966
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• [Journal Article] ヒトと分裂酵母で保存されたテロメアの最末端構造 (2008)
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• [Journal Article] 分裂酵母Pot1-Tpp1による染色体末端保護とテロメア長制御 (2008)
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• [Journal Article] Fission yeastPot1-Tpp1 protects telomeres and regulates telomere length. (2008)
  • Author(s): Miyoshi, T., Kanoh, J., Saito, M., Ishikawa, F.
  • Journal Title: Science 320 Pages: 1341-1344
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• [Journal Article] Heterochromatin and RNAi are required to establish CENP-A chromatin at centromeres. (2008)
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  • Journal Title: Science 319 Pages: 94-97
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• [Journal Article] TERT promotes cellular and organismal survival independently of telomerase activity (2008)
  • Author(s): Lee, J.
  • Journal Title: Oncogene 27 Pages: 3754-3760
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• [Journal Article] Fission yeast Potl-Tppl protects telomeres and regulatestelomere length (2008)
  • Author(s): Miyoshi, T.
  • Journal Title: Science 320 Pages: 1341-1344
  • Peer Reviewed
• [Journal Article] Spatial control of branching within dendritic arbors by dynein-dependent transport of Rab5-endosomes (2008)
  • Author(s): Sato, D.
  • Journal Title: Nature cell biology 10 Pages: 1164-1171
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• [Journal Article] Interaction between DNMT1 and DNA replication reactions in the SV40 in vitro replication system (2008)
  • Author(s): Shimamura, S.
  • Journal Title: Cancer science 99 Pages: 1960-1966
  • Peer Reviewed
• [Journal Article] 分裂酵母Pot1-Tpp1による染色体末端保護とテロメア長制御 (2008)
  • Author(s): 三好知一郎
  • Journal Title: 実験医学 26 Pages: 2601-2605
• [Journal Article] ヒトと分裂酵母で保存されたテロメアの最末端構造 (2008)
  • Author(s): 三好知一郎
  • Journal Title: 蛋白質・核酸・酵素 53 Pages: 1850-1857
• [Journal Article] Heterochromatin and RNAi Are Required to Establish CENP-A Chromatin at Centromeres. (2008)
  • Author(s): Folco, H. D.
  • Journal Title: Science 319 Pages: 94-97
  • Peer Reviewed
• [Journal Article] Cdc2p controls the forkhead transcription factor Fkh2p by phosphorylation during sexualdifferentiation in fission yeast. (2008)
  • Author(s): Shimada, M.
  • Journal Title: The EMBO journal 27 Pages: 132-142
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• [Journal Article] Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells. (2008)
  • Author(s): Hamamura, K.
  • Journal Title: Biochimica et biophysica acts 1780 Pages: 513-519
  • Peer Reviewed
• [Journal Article] 細胞老化におけるヒストンH1の消失:細胞老化、アポトーシス、がんの抑制をつなぐ現象として注目 (2007)
  • Author(s): 舟山亮、石川冬木
  • Journal Title: 化学と生物 45 Pages: 740-742
  • NAID: 10019767696
• [Journal Article] ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence. (2007)
  • Author(s): Fujikawa, M., Katagiri, T., Tugores, A., Nakamura, Y., Ishikawa, F.
  • Journal Title: Cancer Sci 98 Pages: 1468-1475
  • NAID: 10019999020
  • Peer Reviewed
• [Journal Article] がん抑制機構としての細胞老化の役割とクロマチンの構造変化 (2007)
  • Author(s): 舟山亮、石川冬木
  • Journal Title: 日本老年医学会雑誌 44 Pages: 546-550
  • NAID: 10021237720
• [Journal Article] Cellular senescence and chromatin structure. (2007)
  • Author(s): Funayama, R., Ishikawa, F.
  • Journal Title: Chromosoma 116 Pages: 431-440
• [Journal Article] Tel2 is required for activation of the Mrc1-mediated replication checkpoint. (2007)
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  • Peer Reviewed
• [Journal Article] ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence. (2007)
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  • Journal Title: Cancer science 98 Pages: 1468-1475
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• [Journal Article] RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation. (2007)
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  • Journal Title: Genes to Cells 12 Pages: 811-826
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• [Journal Article] Telomerase activity is required for bleomycin-induced pulmonaryfibrosis in mice. (2007)
  • Author(s): Liu, T.
  • Journal Title: The Journal of Clinical Investigation 117 Pages: 3800-3809
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• [Journal Article] Large defects of type I allergic response in telomerase reversetranscriptase knockout mice. (2007)
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  • Journal Title: Journal of leukocyte biology 82 Pages: 429-435
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• [Journal Article] Cellular senescence and chromatin structure. (2007)
  • Author(s): Funayama, R.
  • Journal Title: Chromosoma 116 Pages: 431-440
  • Peer Reviewed
• [Journal Article] がん抑制機構としての細胞老化の役割とクロマチンの構造変化 (2007)
  • Author(s): 舟山 亮
  • Journal Title: 日本老年医学会雑誌 44 Pages: 546-550
• [Journal Article] 細胞老化におけるヒストンH1の消失:細胞老化、アポトーシス、がんの抑制をつなぐ現象として注目 (2007)
  • Author(s): 舟山 亮
  • Journal Title: 化学と生物 45 Pages: 740-742
• [Journal Article] The JmjC domain protein Epel prevents unregulated assembly and disassembly of heterochromatin. (2007)
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• [Journal Article] Gene amplification and overexpression of PRDM14 in breastcancers. (2007)
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  • Journal Title: Cancer research 67 Pages: 9649-9657
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• [Journal Article] Analysis of the role of Aurora B on the chromosomal targeting of condensin I. (2007)
  • Author(s): Takemoto, A.
  • Journal Title: Nucleic Acids Research 35 Pages: 2403-2412
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• [Journal Article] Role of DNA methylation and histone H3 Lysine 27 methylation in tissue-specific imprinting of mouse Grb10. (2007)
  • Author(s): Yamasaki-Ishizaki, Y,
  • Journal Title: Molecular and cellular biology 27 Pages: 732-742
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• [Journal Article] Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: down-regulation of ST6GalNAc. VI in renalcancers. (2007)
  • Author(s): Senda, M.
  • Journal Title: The Biochemical Journal 402 Pages: 459-470
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• [Journal Article] Overexpression of caveolin-1 in a human melanoma cell line results in dispersion of ganglioside GD3 from lipid rafts and alteration of leading edges, leading to attenuation of malignant properties. (2007)
  • Author(s): Nakashima, H.
  • Journal Title: Cancer science 98 Pages: 512-520
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• [Journal Article] Tel2 is required for activation of the Mrc1-mediated replication checkpoint. (2007)
  • Author(s): Shikata, M.
  • Journal Title: J.Biol.Chem. 282・8 Pages: 5346-5355
• [Journal Article] Loss of linker histone H1 in cellular senescence. (2006)
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  • Journal Title: J Cell Biol 175 Pages: 869-880
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• [Journal Article] Cellular senescence as a stress response. (2006)
  • Author(s): Ishikawa, F.
  • Journal Title: Cornea 25
• [Journal Article] 複製ストレスとテロメア (2006)
  • Author(s): 中村未来、西山敦哉、石川冬木
  • Journal Title: 蛋白質・核酸・酵素 51 Pages: 2245-2249
• [Journal Article] Nucleophosmin: a versatile molecule associated with hematological malignancies. (2006)
  • Author(s): Naoe, T., Suzuki, T., Kiyoi, H., Urano, T.
  • Journal Title: Cancer Sci 97 Pages: 963-969
  • NAID: 10019377506
  • Peer Reviewed
• [Journal Article] Cell-cycle-dependent regulation of telomere binding proteins : roles of Polo-like kinase. (2006)
  • Author(s): Nishiyama, A., Ishikawa, F.
  • Journal Title: Cell Cycle 5 Pages: 1403-1406
• [Journal Article] Cell-cycle-dependent Xenopus TRF1 recruitment to telomere chromatin regulated by Polo-like kinase. (2006)
  • Author(s): Nishiyama, A., Muraki, K., Saito, M., Ohsumi, K., Kishimoto, T., Ishikawa, F.
  • Journal Title: EMBO J 25 Pages: 575-584
  • Peer Reviewed
• [Journal Article] Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmtl, Dnmt3a and Dnmt3b. (2006)
  • Author(s): Tsumura, A.
  • Journal Title: Genes to Cells 11・7 Pages: 805-814
• [Journal Article] Loss of Linker Histone H1 in Cellular Senescence. (2006)
  • Author(s): Funayama, R.
  • Journal Title: J.Cell Biol. 175・6 Pages: 869-880
• [Journal Article] Phospho-regulation of human Protein Kinase Aurora-A : Analysis using anti-phospho-Thr288 monoclonal antibodies. (2006)
  • Author(s): Ohashi, S.
  • Journal Title: Oncogene 14・25 Pages: 7691-7702
• [Journal Article] Nucleophosmin (NPM) : a versatile molecule associated with hematological malignancies. (2006)
  • Author(s): Naoe, T.
  • Journal Title: Cancer Sci. 97・10 Pages: 963-969
• [Journal Article] Complex formation of Plk1 and INCENP required for metaphase-anaphase transition. (2006)
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• [Journal Article] Cell-cycle-dependent Xenopus TRF1 recruitment to telomere chromatin regulated by Polo-like kinase. (2006)
  • Author(s): Nishiyama, A., Muraki, K., Saito, M., Ohsumi, K., Kishimoto, T., Ishikawa, F.
  • Journal Title: EMBO J. 25 Pages: 575-584
• [Journal Article] Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase alpha. (2005)
  • Author(s): Nakamura, M., Nabetani, A., Mizuno, T., Hanaoka, F. Ishikawa, F.
  • Journal Title: Mol Cell Biol 25 Pages: 11073-11088
  • Peer Reviewed
• [Journal Article] なぜ老化因子は保存されているのか? (2005)
  • Author(s): 石川冬木
  • Journal Title: 実験医学 23 Pages: 2876-2879
• [Journal Article] Telomere binding protein Taz1 establishes Swi6 heterochromatin independently of RNAi at telomeres. (2005)
  • Author(s): Kanoh, J., Sadaie, M., Urano, T., Ishikawa, F.
  • Journal Title: Curr Biol 15 Pages: 1808-1819
  • Peer Reviewed
• [Journal Article] 進化における体細胞突然変異の意義 (2005)
  • Author(s): 石川冬木
  • Journal Title: 化学と生物 43 Pages: 531-537
  • NAID: 10019044388
• [Journal Article] RNA polymerase II is required for RNAi-dependent heterochromatin assembly. (2005)
  • Author(s): Kato, H., Goto, D.B., Martienssen, R.A., Urano, T., Furukawa, K., Murakami, Y.
  • Journal Title: Science 309 Pages: 467-469
  • Peer Reviewed
• [Journal Article] Structure of hnRNP D complexed with single-strande telomere DNA and unfolding of the quadruplex by heterogeneous nuclear ribonucleoprotein D. (2005)
  • Author(s): Knokizono, Y., Konishi, Y., Nagata, K., Ouhashi, K., Uesugi, S., Ishikawa, F., Katahira, M.
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• [Journal Article] Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes : identification of an aneuploidy-promoting property. (2005)
  • Author(s): Nguyen, HG., Chinnappan, D., Urano, T., Ravid, K.
  • Journal Title: Mol.Cell Biol. 25 Pages: 4977-4992
• [Journal Article] RNA polymerase II is required for RNAi-dependent heterochromatin assembly. (2005)
  • Author(s): Kato, H., Goto, DB., Martienssen, RA., Urano, T., Furukawa, K., Murakami, Y.
  • Journal Title: Science 309 Pages: 467-469
• [Journal Article] Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells. (2005)
  • Author(s): Hamamura, K., Furukawa, K., Hayashi, T., Hattori, T., Nakano, J., Nakashima, H., Okuda, T., Mizutani, H., Hattori, H., Ueda, M., Urano, T., Lloyd, KO., Furukawa, K
  • Journal Title: Proc.Natl.Acad.Sci. U S A. 102 Pages: 11041-11046
• [Journal Article] Neuron-specific relaxation of Igf2r imprinting is associated with neuron-specific histone modifications and lack of its antisense transcript Air. (2005)
  • Author(s): Yamasaki, Y., Kakashima, T., Soejima, H., Kinoshi ta, A., Yoshiura, K., Matsumoto, N., Ohta, T., Urano, T., Masuzaki, H., Ishimaru, T., Mukai, T., Niikawa, N., Kishino, T.
  • Journal Title: Hum.Mol.Genet. 14 Pages: 2511-2520
• [Journal Article] Telomere-Binding Protein Taz1 Establishes Swi6 Heterochromatin Independently of RNAi at Telomeres. (2005)
  • Author(s): Kanoh, J., Sadaie, M., Urano, T., Ishikawa F.
  • Journal Title: Curr.Biol. 15 Pages: 1808-1819
• [Journal Article] Alterations of DNA and Chromatin Structures at Telomeres, and Genetic Instability in Mouse Cells Defective in DNA Polymerase α. (2005)
  • Author(s): Nakamura, M., Nabetani, A., Mizuno, T., Hanaoka, F., Ishikawa, F.
  • Journal Title: Mol.Cell.Biol. 25 Pages: 11073-11088
• [Presentation] Regulation of telomerase through Tel1ATM and/or Rad3ATR-mediated phosphorylation of the shelterin component Ccq1 in fission yeast. (2010)
  • Author(s): Fuyuki Ishikawa
  • Organizer: EMBO Conference Series 'Telomeres and the DNA Damage Response'.
  • Place of Presentation: The Hotel Pullman, Marseille, France
  • Year and Date: 2010-09-17
• [Presentation] Telomere metabolism during the cell cycle revealed by analyzing single telomeres in human cells. (2010)
  • Author(s): Fuyuki Ishikawa
  • Organizer: AACR Special Conference-The Role of Telomeres an Telomerase in Cancer Research.
  • Place of Presentation: The Worthington Renaissance Fort Worth Hotel, Fort Worth, Texas, U.S.A
  • Year and Date: 2010-03-01
• [Presentation] Telomere metabolism during the cell cycle revealed by analyzing single telomeres in human cells. (2010)
  • Author(s): Fuyuki Ishikawa
  • Organizer: AACR Special Conference "The Role of Telomeres an Telomerase in Cancer Research"
  • Place of Presentation: The Worthington Renaissance Fort Worth Hotel, Fort Worth, Texas, U.S.A
  • Year and Date: 2010-03-01
• [Presentation] 低容量ストレス反応 (2010)
  • Author(s): 石川冬木
  • Organizer: 島根大学医学部セミナー
  • Place of Presentation: 出雲市、島根大学医学部
  • Year and Date: 2010-01-29
• [Presentation] がん細胞悪性化の原動力としてのテロメア機能異常 (2010)
  • Author(s): 石川冬木
  • Organizer: 科学研究費補助金「特定領域研究」がん研究に係わる特定領域研究平成21年度5領域合同シンポジウム
  • Place of Presentation: 東京都、学術総合センター
  • Year and Date: 2010-01-15
• [Presentation] がん細胞悪性化の原動力としてのテロメア機能異常 (2010)
  • Author(s): 石川冬木
  • Organizer: がん研究に係わる特定領域研究 成21年度5領域合同シンポジウム
  • Place of Presentation: 東京都、学術総合センター
  • Year and Date: 2010-01-15
• [Presentation] 分子生物学の過去、現在、未来 (2009)
  • Author(s): 石川冬木
  • Organizer: モノクローナル抗体研究所創立5周年記念講演会
  • Place of Presentation: 横浜市、神奈川歯科大学付属横浜研修センター
  • Year and Date: 2009-12-12
• [Presentation] xTRF2 is required for telomere replication in Xenopus egg extracts. (2009)
  • Author(s): Fuyuki Ishikawa
  • Organizer: 25th Radiation Biology Center International Symposium
  • Place of Presentation: Co-op Inn Kyoto, Kyoto
  • Year and Date: 2009-11-30
• [Presentation] A Novel Rpa-Like Mammalian Stc1-Stn1-Ten1 Complex. (2009)
  • Author(s): Fuyuki Ishikawa
  • Organizer: International symposium 'Next-Generation Cancer and Genomic Biology-Telomere, Kinetochore and Genome-'
  • Place of Presentation: Shirankaikan Inamori Hall, Kyoto University, Kyoto
  • Year and Date: 2009-11-02
• [Presentation] Low-Dose Stress Responses. (2009)
  • Author(s): Fuyuki Ishikawa
  • Organizer: The 5th International Fission Yeast meeting 'Pombe 2009'
  • Place of Presentation: National Olympics Memorial Youth Center, Tokyo
  • Year and Date: 2009-10-29
• [Presentation] Low-Dose Stress Responses (2009)
  • Author(s): Fuyuki Ishikawa
  • Organizer: The 5th International Fission Yeast meeting 'Pombe 2009'
  • Place of Presentation: National Olympics Memorial Youth Center, Tokyo
  • Year and Date: 2009-10-29
• [Presentation] ヒトALT細胞のテロメア代謝に特徴的な単鎖構造 (2009)
  • Author(s): 鍋谷彰
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸市、神戸国際会議場
  • Year and Date: 2009-10-23
• [Presentation] RPA-like Mammalian Ctc1-Stn1-Ten1 Complex Binds to Single-Stranded DNA and Protects Telomeres Independently of the Pot1 Pathway. (2009)
  • Author(s): Yasuyuki Miyake, Mirai Nakamura, Akira Nabetani, Shoko Fujita, Shintaro Shimamura, Miki Tamura, Motoki Saito, Fuyuki Ishikawa
  • Organizer: Keystone Symposia on Molecular and Cellular Biology 'Telomere Biology and DNA Repair'.
  • Place of Presentation: RACV Royal Pines Resort, Queensland, Australia
  • Year and Date: 2009-10-10
• [Presentation] RPA-like Mammalian Ctc1-Stn1-Ten1 Complex Binds to Single-Stranded DNA and Protects Telomeres Independently of the Pot1 Pathway. (2009)
  • Author(s): Fuyuki Ishikawa
  • Organizer: Keystone Symposia on Molecular and Cellular Biology 'Telomere Biology and DNA Repair'
  • Place of Presentation: RACV Royal Pines Resort, Queensland, Australia
  • Year and Date: 2009-10-10
• [Presentation] Unusual single-stranded telomeric DNA structures for telomere metabolism in human ALT cells. (2009)
  • Author(s): Akira Nabetani, Fuyuki Ishikawa
  • Organizer: 68th Annual Meeting of the Japanese Cancer Association.
  • Place of Presentation: Pasifico Yokohama Convention Center, Yokohama
  • Year and Date: 2009-10-03
• [Presentation] Unusual single-stranded telomeric DNA structures for telomere metabolism in human ALT cells. (2009)
  • Author(s): Akira Nabetani
  • Organizer: 68th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Pacifico Yokohama, Yokohama
  • Year and Date: 2009-10-03
• [Presentation] A novel mammalian RPA-like complex, Ctc1-Stn1-Ten1, protects telomeres. (2009)
  • Author(s): Fuyuki Ishikawa
  • Organizer: 68th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Pasifico Yokohama Convention Center, Yokohama
  • Year and Date: 2009-10-02
• [Presentation] A novel RPA-like mammalian complex CST. (2009)
  • Author(s): Fuyuki Ishikawa
  • Organizer: French-Japanese Workshop in Life Sciences.
  • Place of Presentation: CNRS, Campus Gerard-Megie, Paris
  • Year and Date: 2009-09-22
• [Presentation] A novel RPA-like mammalian complex CST. (2009)
  • Author(s): Fuyuki Ishikawa
  • Organizer: French-Japanese Workshop in Life Sciences
  • Place of Presentation: CNRS, Campus Gerard-Megie, Paris(フランス)
  • Year and Date: 2009-09-22
• [Presentation] A novel RPA-like mammalian complex CST. (2009)
  • Author(s): Fuyuki Ishikawa
  • Organizer: Japanese-German Cancer Workshop
  • Place of Presentation: Elsa-Braendstroem-Haus, Hamburg, Germany
  • Year and Date: 2009-09-17
• [Presentation] 「がん」はどのようにして起こるのか? (2009)
  • Author(s): 石川冬木
  • Organizer: 第11回生命科学研究科シンポジウム
  • Place of Presentation: 京都市、京都大学芝蘭会館
  • Year and Date: 2009-07-03
• [Presentation] 「がん」はどのようにして起こるのか? (2009)
  • Author(s): 石川冬木
  • Organizer: 第5回文部科学省科学研究費補助金特定領域研究「がん特定」青少年・市民公開講座
  • Place of Presentation: 島根県出雲市、出雲市民会館
  • Year and Date: 2009-06-20
• [Presentation] 新規ほ乳類RPA様複合体Ctc1-Stn1-Ten1 (2009)
  • Author(s): 石川冬木
  • Organizer: 第5回文部科学省科学研究費補助金特定領域研究「がん特定」青少年・市民公開講座
  • Place of Presentation: 出雲市、出雲市民会館
  • Year and Date: 2009-06-20
• [Presentation] Ctc1-Stn1-Ten1 complex. (2009)
  • Author(s): Fuyuki Ishikawa
  • Organizer: CSHL meeting 'Telomere and Telomerase'.
  • Place of Presentation: Cold Spring Harbor Laboratory, NY, U.S.A
  • Year and Date: 2009-04-29
• [Presentation] Ctc1-Stn1-Ten1 complex. (2009)
  • Author(s): Fuyuki Ishikawa
  • Organizer: CSHL meeting 'Telomere and Telomerase'
  • Place of Presentation: Cold Spring Harbor Laboratory, NY, U.S.A
  • Year and Date: 2009-04-29
• [Presentation] 生物学的時間とスケール変換(生物) (2009)
  • Author(s): Ishikawa, F.
  • Organizer: 数理研短期共同研究集会 : RIMS共同研究 : 離散力学系の分子細胞生物学への応用数理
  • Place of Presentation: 京都大学理学部
  • Year and Date: 2009-01-06
• [Presentation] Roles of shelterin complex in telomere maintenance (2008)
  • Author(s): Ishikawa, F.
  • Organizer: BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-10
• [Presentation] Sheltrin telomere complex. (2008)
  • Author(s): Fuyuki Ishikawa
  • Organizer: 67th Annual Meeting of the Japanese Cancer Association.
  • Place of Presentation: Nagoya Congress Center, Nagoya
  • Year and Date: 2008-10-28
• [Presentation] Sheltrin telomere complex (2008)
  • Author(s): Ishikawa, F.
  • Organizer: 67th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-28
• [Presentation] Human ALT cells contain unusual single-stranded telomeric DNAs (2008)
  • Author(s): Nabetani, A.
  • Organizer: EMBO conference "Telomeres and the DNA damageresponse"
  • Place of Presentation: Eurotel Victoria Villars, Villars-sur-Ollon, Switzerland
  • Year and Date: 2008-09-19
• [Presentation] Shelterin complex in fission yeast. (2008)
  • Author(s): Fuyuki Ishikawa
  • Organizer: EMBO Conference 2008 "Telomeres and the DNA damage response"
  • Place of Presentation: Eurotel Victoria Villars, Villars- sur-Ollon, Switzerland
  • Year and Date: 2008-09-18
• [Presentation] Shelterin complex in fission yeast (2008)
  • Author(s): Ishikawa, F.
  • Organizer: EMBO Conference 2008 "Telomeres and the DNA damageresponse"
  • Place of Presentation: Eurotel Victoria Villars, Villars-sur-Ollon, Switzerland
  • Year and Date: 2008-09-18
• [Presentation] Shelterin complex in fission yeast. (2008)
  • Author(s): Fuyuki Ishikawa
  • Organizer: Internal seminar of Institut de Genetique Humaine, CNRS (Host : Marcel Mechali)
  • Place of Presentation: CNRS, Montpellier, France
  • Year and Date: 2008-09-10
• [Presentation] Shelterin complex in fission yeast. (2008)
  • Author(s): Fuyuki Ishikawa
  • Organizer: Internal seminar of Institut de Biologie Structurale et Microbiologie, CNRS (Host : Vincent Geli)
  • Place of Presentation: CNRS, Marseille, France
  • Year and Date: 2008-09-08
• [Presentation] 老化のメカニズム : 分子生物学の立場から (2008)
  • Author(s): 石川冬木
  • Organizer: 第27回東京MRI研究会
  • Place of Presentation: 東京コンファレンスセンター・品川
  • Year and Date: 2008-07-05
• [Presentation] テロメアの複製機構 (2008)
  • Author(s): 石川冬木
  • Organizer: 第10回生命科学研究科シンポジウム
  • Place of Presentation: 京大会館
  • Year and Date: 2008-06-27
• [Presentation] Unusual DNAs as intermediates of telomere metabolism in humantelomerase-negative immortalized cells (2008)
  • Author(s): Nabetani, A.
  • Organizer: International Symposium on Chromosome Dynamics in Ise
  • Place of Presentation: アクアヴィラ伊勢志摩
  • Year and Date: 2008-05-30
• [Presentation] 低容量ストレス反応 (2008)
  • Author(s): 石川冬木
  • Organizer: 日本生化学会東北支部第74回例会
  • Place of Presentation: アイーナいわて県民交流センター
  • Year and Date: 2008-05-17
• [Presentation] 低容量ストレス (2008)
  • Author(s): 石川冬木
  • Organizer: 東京大学先端科学技術センターセミナー
  • Place of Presentation: 東京都、東京大学先端科学技術センター
  • Year and Date: 2008-04-25
• [Presentation] 低容量とストレス (2008)
  • Author(s): 石川 冬木
  • Organizer: 慶應義塾大学医学部眼科教室・腎臓代謝内分泌内科主催・アンチエイジングセミナー
  • Place of Presentation: 慶應義塾大学医学部
  • Year and Date: 2008-03-06
• [Presentation] 低容量とストレス (2008)
  • Author(s): 石川 冬木
  • Organizer: 京都大学[医学領域」産学連携推進機構/(社)芝蘭会平成19年度 第3回 産学情報交流会
  • Place of Presentation: 京都大学
  • Year and Date: 2008-02-15
• [Presentation] 染色体の最末端構造と制御 (2007)
  • Author(s): 石川冬木
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会BMB2007
  • Place of Presentation: 横浜市、パシフィコ横浜
  • Year and Date: 2007-12-14
• [Presentation] 癌転移に関与する糖転移酵素の同定:複合糖鎖の変化における作用機構の解析 (2007)
  • Author(s): 松本康之
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会BMB2007
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-14
• [Presentation] 染色体の最末端構造と制御 (2007)
  • Author(s): 石川 冬木
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会BMB2007
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-14
• [Presentation] 分裂酵母におけるヘテロクロマチンタンパク質のリン酸化制御 (2007)
  • Author(s): 島田 篤
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会BMB2007
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-12
• [Presentation] 微小管プラス端集積因子EB3のタンパク質分解機構 (2007)
  • Author(s): 伴 玲子
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会BMB2007
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-11
• [Presentation] Molecular characterization of Art7, glycosylphosphatodylinositol-anchored arginine-specific ADP-ribosyltransferase 7 - insights into catalytic domains (2007)
  • Author(s): 寺嶋 正治
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会BMB2007
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-11
• [Presentation] TGF-β1 suppresses cAMP-induced nitric oxide synthase expression by impeding the nucleocytoplasmic shuttling of protein kinase A (2007)
  • Author(s): 成相裕子
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会BMB2007
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-11
• [Presentation] テロメアはどのようにして自分の長さを測定しているのか (2007)
  • Author(s): 石川 冬木
  • Organizer: 東京呼吸器リサーチフォーラム
  • Place of Presentation: 東京ステーションコンファレンス
  • Year and Date: 2007-11-17
• [Presentation] 癌転移に関与する糖転移酵素の固定と作用機構の解析 (2007)
  • Author(s): 松本 康之
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-10-04
• [Presentation] How cells sense their telomere lengths? (2007)
  • Author(s): Fuyuki Ishikawa
  • Organizer: The 66th Annual Meeting of the Japanese Cancer Association.
  • Place of Presentation: Pasifico Yokohama Convention Center, Yokohama
  • Year and Date: 2007-10-03
• [Presentation] How cells sense their telomere lengths? (2007)
  • Author(s): 石川 冬木
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-10-03
• [Presentation] Involvement of integrins in the malignant phenotypes of humanmelanomas enhanced by ganglioside GD3 (2007)
  • Author(s): 大川 裕樹
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-10-03
• [Presentation] The Extreme Terminus of Chromosomes. (2007)
  • Author(s): Tomoichiro Miyoshi, Motoki Saito, Junko Kanoh, Fuyuki Ishikawa
  • Organizer: The 79th Annual Meeting of the Genetics Society of Japan.
  • Place of Presentation: Okayama University, Okayama
  • Year and Date: 2007-09-21
• [Presentation] The extreme terminus of chromosomes. (2007)
  • Author(s): 三好 知一郎
  • Organizer: The 79th Annual Meeting of the Genetics Society of Japan
  • Place of Presentation: 岡山大学
  • Year and Date: 2007-09-21
• [Presentation] 生命はどのようにして進化したのか (2007)
  • Author(s): 石川冬木
  • Organizer: 第28回宇宙ステーション利用計画ワークショップ:きぼうから始まる未来
  • Place of Presentation: 東京都、学術総合センター
  • Year and Date: 2007-08-07
• [Presentation] 生命はどのようにして進化したのか (2007)
  • Author(s): 石川 冬木
  • Organizer: 第28回宇宙ステーション利用計画ワークショップ:きぼうから始まる未来
  • Place of Presentation: 学術総合センター
  • Year and Date: 2007-08-07
• [Presentation] 細胞周期を制御する分裂期キナーゼAurora (2007)
  • Author(s): 浦野 健
  • Organizer: 第16回日本アポトーシス研究会
  • Place of Presentation: 千葉 東邦大学
  • Year and Date: 2007-08-04
• [Presentation] 細胞のストレス反応 (2007)
  • Author(s): 石川 冬木
  • Organizer: 生命科学研究科シンポジウム
  • Place of Presentation: 京大会館
  • Year and Date: 2007-06-22
• [Presentation] The Extreme Terminus of Chromosomes. (2007)
  • Author(s): Fuyuki Ishikawa
  • Organizer: Fourth International Fission Yeast Meeting, Pombe2007.
  • Place of Presentation: Copenhagen University, Copenhagen, Denmark
  • Year and Date: 2007-06-13
• [Presentation] The Extreme Terminus of Chromosomes. (2007)
  • Author(s): 石川 冬木
  • Organizer: Fourth International Fission Yeast Meeting, Pombe2007
  • Place of Presentation: Copenhagen University, Copenhagen, Denmark
  • Year and Date: 2007-06-13
• [Presentation] ゲノムと環境 (2007)
  • Author(s): 石川 冬木
  • Organizer: 岡山大学特別講義
  • Place of Presentation: 岡山大学
  • Year and Date: 2007-05-25
• [Presentation] The Pot1 complex maintains telomere integrity in fission yeast. (2007)
  • Author(s): Fuyuki Ishikawa
  • Organizer: CSHL meeting 'Telomere and Telomerase'
  • Place of Presentation: Cold Spring Harbor Laboratory, NY, U.S.A
  • Year and Date: 2007-05-04
• [Presentation] The Pot1 complex maintains telomere integrity in fission yeast. (2007)
  • Author(s): 石川 冬木
  • Organizer: CSHL meeting' Telomere and Telomerase'
  • Place of Presentation: Cold Spring Harbor Laboratory, NY, U.S.A
  • Year and Date: 2007-05-04
• [Presentation] 細胞老化:ストレス反応としてのがん抑制機構 (2007)
  • Author(s): 石川冬木
  • Organizer: 第27回日本医学会総会
  • Place of Presentation: 大阪市、大阪国際会議場
  • Year and Date: 2007-04-06
• [Presentation] 細胞老化:ストレス反応としてのがん抑制機構 (2007)
  • Author(s): 石川 冬木
  • Organizer: 第27回日本医学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2007-04-06
• [Presentation] 染色体末端構造 (2006)
  • Author(s): 石川冬木
  • Organizer: がん特定領域研究発がん分野A01/A02合同研究発表会
  • Place of Presentation: 倉敷市、せとうち児島ホテル
  • Year and Date: 2006-12-02
• [Presentation] がん細胞とは何か? (2006)
  • Author(s): 石川冬木
  • Organizer: がん特定領域研究高等学校対象出前講義
  • Place of Presentation: 徳島市、徳島市立高等学校
  • Year and Date: 2006-11-20
• [Presentation] Altered Balance of Linker-DNA Binding Proteins in Cellular Senescence. (2006)
  • Author(s): Fuyuki Ishikawa
  • Organizer: Josef Steiner-CNIO Cancer Conference : Telomeres & Telomerase.
  • Place of Presentation: Spanish National Cancer Research Centre, Madrid, Spain
  • Year and Date: 2006-11-13
• [Presentation] 細胞老化におけるクロマチン構造の変化 (2006)
  • Author(s): 石川冬木
  • Organizer: 情報伝達系北海道研究会
  • Place of Presentation: 札幌市、札幌アスペンホテル
  • Year and Date: 2006-11-03
• [Presentation] 染色体テロメアの構造と機能 (2006)
  • Author(s): 石川冬木
  • Organizer: 第51回日本人類遺伝学会大会
  • Place of Presentation: 米子市、米子コンベンションセンター
  • Year and Date: 2006-10-19
• [Presentation] ヒトはどうして老化するのか (2006)
  • Author(s): 石川冬木
  • Organizer: 西宮市ライフサイエンスセミナー
  • Place of Presentation: 西宮市、夙川公民館
  • Year and Date: 2006-10-13
• [Presentation] 非致死的ストレスによる染色体不安定化 (2006)
  • Author(s): 石川冬木
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜市、パシフィコ横浜国際会議場
  • Year and Date: 2006-09-29
• [Presentation] Histone H1 loss in cellular senescence. (2006)
  • Author(s): Fuyuki Ishikawa
  • Organizer: Internal seminar of University of Geneva.
  • Place of Presentation: University of Geneva, Geneva, Switzerland
  • Year and Date: 2006-09-04
• [Presentation] The Pot1 complex maintains telomere integrity in fission yeast. (2006)
  • Author(s): Fuyuki Ishikawa
  • Organizer: International Symposium 'Telomeres and Genome Stability'.
  • Place of Presentation: Eurotel Victoria, Villars-sur-Ollon, Switzerland
  • Year and Date: 2006-08-31
• [Presentation] Histone H1 loss in cellular senescence. (2006)
  • Author(s): Fuyuki Ishikawa
  • Organizer: Internal seminar of Friedrich Miescher Institute.
  • Place of Presentation: Friedrich Miescher Institute, Basel, Switzerland
  • Year and Date: 2006-08-29
• [Presentation] Ageing, Cancer and Sex. (2006)
  • Author(s): Fuyuki Ishikawa
  • Organizer: JSPS 11th Japanese-German Symposium `Frontiers of Cancer Research'.
  • Place of Presentation: Ringhotel Munte am Stadtwald, Bremen, Germany
  • Year and Date: 2006-04-21
• [Presentation] Reproduction Strategies And Configurations Of Genetic Materials. (2006)
  • Author(s): Fuyuki Ishikawa
  • Organizer: The 52nd NIBB Conference : Reproductive Strategies.
  • Place of Presentation: National Institute for Basic Biology, Okazaki, Aichi
  • Year and Date: 2006-01-21
• [Presentation] Telomere Functions in DNA Replication and End Protection. (2005)
  • Author(s): Fuyuki Ishikawa
  • Organizer: Cancer Research in Korea and Japan .the Past and Coming Decade.
  • Place of Presentation: Tokyo Uniberisty, Tokyo
  • Year and Date: 2005-12-17
• [Presentation] ストレスと老化 (2005)
  • Author(s): 石川冬木
  • Organizer: 第28回分子生物学会年会市民公開講座「生命のからくりを分子でみる-遺伝子・病気・老化をテーマに-」
  • Place of Presentation: 福岡市、福岡エルガーラホール
  • Year and Date: 2005-12-11
• [Presentation] Cellular Senescence as a Stress Response. (2005)
  • Author(s): Fuyuki Ishikawa
  • Organizer: Kyoto Cornea Club.
  • Place of Presentation: Westin Miyako Kyoto Hotel, Kyoto
  • Year and Date: 2005-12-02
• [Presentation] ストレスに対するクロマチン反応としての老化 (2005)
  • Author(s): 石川冬木
  • Organizer: 千里ライフサイエンスセミナー「老化」
  • Place of Presentation: 豊中市、千里ライフサイエンスセンタービル
  • Year and Date: 2005-11-22
• [Presentation] Stress Responses at Telomeres. (2005)
  • Author(s): Fuyuki Ishikawa
  • Organizer: International Symposium on Ran and Cell Cycle.
  • Place of Presentation: Awaji Yumebutai International Conference Center, Awaji, Hyogo
  • Year and Date: 2005-10-02
• [Presentation] Stress Responses of Chromatin. (2005)
  • Author(s): Fuyuki Ishikawa
  • Organizer: 10th Japanese-German Workshop on Molecukar and Cellular Aspects of Carnigo Genesis.
  • Place of Presentation: Weisser Saal, Essen, Germany
  • Year and Date: 2005-09-29
• [Presentation] クロマチンの安定性と発がん過程 (2005)
  • Author(s): 石川冬木
  • Organizer: 第64回日本癌学会学術総会教育講演:モーニングレクチャー
  • Place of Presentation: 札幌市・ロイトン札幌ホテル
  • Year and Date: 2005-09-16
• [Book] がん化学療法・分子標的治療update(テロメアとテロメラーゼ)(西條長宏、西尾和人(編集)) (2009)
  • Author(s): 山崎晴丈、石川冬木
  • Publisher: 中外医学社
• [Book] がんの分子標的治療(テロメア長制御と末端保護機能:shelterin複合体)(鶴尾隆(編集)) (2008)
  • Author(s): 石川冬木
  • Publisher: 南山堂
• [Book] がんの分子標的医療 (2008)
  • Author(s): 鶴尾隆
  • Publisher: 南山堂
• [Remarks]
  • URL: http://www.med.shimane-u.ac.jp/biochem2/index.html