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Molecular mechanisms of translesion DNA synthesis and its involvement in carcinogenesis

Research Project

Project/Area Number 17013053
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionGakushuin University (2008-2009)
Osaka University (2005-2007)

Principal Investigator

HANAOKA Fumio  Gakushuin University, 理学部, 教授 (50012670)

Co-Investigator(Kenkyū-buntansha) YOKOI Masayuki  大阪大学, 生命機能研究科, 助教 (00322701)
IWAI Shigenori  大阪大学, 基礎工学研究科, 教授 (10168544)
Co-Investigator(Renkei-kenkyūsha) YOKOI Masayuki  学習院大学, 理学部, 助教 (00322701)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥180,600,000 (Direct Cost: ¥180,600,000)
Fiscal Year 2009: ¥36,400,000 (Direct Cost: ¥36,400,000)
Fiscal Year 2008: ¥36,400,000 (Direct Cost: ¥36,400,000)
Fiscal Year 2007: ¥36,400,000 (Direct Cost: ¥36,400,000)
Fiscal Year 2006: ¥36,400,000 (Direct Cost: ¥36,400,000)
Fiscal Year 2005: ¥35,000,000 (Direct Cost: ¥35,000,000)
Keywordsがん / 遺伝子 / ゲノム安定性 / DNAポリメラーゼ / DNA修復 / 損傷乗り越え複製 / ノックアウトマウス / 紫外線 / ミスマッチ修復 / タンパク質構造 / 癌 / ゲノム / 分裂酵母 / ユビキチン / DNAポリメラーゼ・イータ / REV1 / 色素性乾皮症 / DNAポリメラーゼ・イオタ / 複製フォーク停止 / 色素性乾皮症バリアント
Research Abstract

We have clarified the mechanism in which human DNA polymerase η (Polη) interacts with other proteins for switching between Polη and the replicative polymerase at stalled replication forks. We have solved high-resolution crystal structures of human Polη at four consecutive steps during DNA synthesis through cis-syn cyclobutane thymine dimers. In addition, we have generated Polηknockout mice and observed high incidence of skin tumors upon UV-B irradiation in these mice.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (79 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (47 results) (of which Peer Reviewed: 35 results) Presentation (28 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions.2010

    • Author(s)
      Hirota, K., Sonoda, E., Kawamoto, T., Motegi, A., Masutani, C., Hanaoka, F., Szuts, D., Iwai, S., Sale, J.E., Lehmann, A., Takeda, S.
    • Journal Title

      PLoS.Genet. 6

    • NAID

      120002661519

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure and mechanism of human DNA polymeraseη.2010

    • Author(s)
      Biertampfel, C., Zhao, Y., Kondo, Y., Ramon-Maiques, S., Gregory, M., Lee, J.Y., Masutani, C., Lehmann, A.R., Hanaoka, F., Yang, W.
    • Journal Title

      Nature 465

      Pages: 1044-1049

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The molecular chaperone Hsp90 regulates accumulation of DNA polymerase eta at replication stalling sites in UV-irradiated cells.2010

    • Author(s)
      Sekimoto, T., Oda, T., Pozo, F.M., Murakumo, Y., Masutani, C., Hanaoka, F., Yamaashita, T.
    • Journal Title

      Hal.Cell 37

      Pages: 79-89

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure and mechanism of human DNA polymerase eta.2010

    • Author(s)
      Biertumpfel, C., et al.
    • Journal Title

      Nature

      Volume: 465 Pages: 1044-1048

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The chromosomal association of condensin II is required by a noncatalytic function of PP2A.2009

    • Author(s)
      Takemoto, A., Maeshima, K., Ikehara, T., Yamaguchi, K., Murayama, A., Imamura, S., lamamoto, N., Yokoyama, S., Hirano, T., Watanabe, Y., Hanaoka, F., Yanagisawa, J., Kimura, K.
    • Journal Title

      Nat.Struct.Aiol.Biol. 16

      Pages: 1302-1308

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two-step recognition of DNA damage for mammalian nucleotide excision repair : Directional binding of the XPC complex and DNA strand scanning.2009

    • Author(s)
      Sugasawa, K., Akagi, J., Nishi, R., Iwai, S., Hanaoka, F.
    • Journal Title

      Alai.Cell 36

      Pages: 642-653

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant DNA polymerase alpha is excluded from the nucleus by defective import and degradation in the nucleus.2009

    • Author(s)
      Eichinger, C.S., Mizuno, T., Mizuno, K., Miyake, Y., Yanagi, K., Imamoto, N., Hanaoka, F.
    • Journal Title

      J.Biol.Chem. 284

      Pages: 30604-30614

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells.2009

    • Author(s)
      Akagi, J., Masutani, C., Kataoka, Y., Kan, T., Ohashi, E., Mori, T., Ohmori, H., Hanaoka, F.
    • Journal Title

      DM Repair 8

      Pages: 585-599

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclin A-Cdkl regulates the origin firing program in mammalian cells.2009

    • Author(s)
      Katsuno, Y., Suzuki, A., Sugimura, K., Okumura, K., Zineldeen, D.H., Shimada, M., Niida, H., Mizuno, T., Hanaoka, F., Nakanishi, M.
    • Journal Title

      Proc.Natl.Acad Sci.USA 106

      Pages: 3184-3189

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two-step recognition of DNA damage for mammalian nucleotide excision repair : Directional binding of the XPC complex and DNA strand scanning.2009

    • Author(s)
      Sugasawa, K., et al.
    • Journal Title

      Mol.Cell

      Volume: 36 Pages: 642-653

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A.2009

    • Author(s)
      Takemoto, A., et al.
    • Journal Title

      Nat.Struct.Mol.Biol.

      Volume: 16 Pages: 1302-1308

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Schizosaccharomyees pombe Ddbl recruits substrate-specific adaptor proteins through a novel protein motif, the DDB-box.2008

    • Author(s)
      Fukumoto, Y., Dohmae, N., Hanaoka, F.
    • Journal Title

      Mol.Cell.Biol. 28

      Pages: 6746-6756

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analysis reveals an intrinsic property of the germinal center B cells to generate A : T mutations2008

    • Author(s)
      Ouchida, R., et.al.
    • Journal Title

      DNA Repair 7

      Pages: 1392-1398

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T mutations in Ig genes and contributes to antibody affinity maturation2008

    • Author(s)
      Masuda, K., et.al.
    • Journal Title

      Eur. J. Immunol 38

      Pages: 2796-2805

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Miscoding propertes of 2'-deoxyinogine, a nitric oxide-derived DNA adduct, during translegion synthesis catalyzed by human DNA polymerases.2008

    • Author(s)
      Hidaka, K., et. al.
    • Journal Title

      DNA Repair 7

      Pages: 497-506

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo destabilization and functional defects of the xeroderma pigmentosum C protein caused by a pathogenic missense mutation.2007

    • Author(s)
      Yasuda, G., Nishi, R., Watanabe, E., Mori, T., Iwai, S., Orioli, D., Stefanini, M., Hanaoka, F., Sugasawa, K.
    • Journal Title

      Mol.Cell.Biol. 27

      Pages: 6606-6614

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A genome-wide survey and systematic RNAi-based characterization of helicase-like genes in Caenorhabditis elegans.2007

    • Author(s)
      Eki, T., Ishihara, T., Katsura, I., Hanaoka, F.
    • Journal Title

      DNA Res. 14

      Pages: 183-199

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rad54 dissociates homologous recombination intermediates by branch migration.2007

    • Author(s)
      Bugreev, D.V., Hanaoka, F., Mazin, A.V.
    • Journal Title

      Nat.Struct.Mol.Biol. 14

      Pages: 746-753

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure of the human GINS complex and its assembly and functional interface in replication initiation.2007

    • Author(s)
      Kamada, K., Kubota, Y., Arata, T., Shindo, Y., Hanaoka, F.
    • Journal Title

      Nature Struct.Mot.Biol. 14

      Pages: 388-396

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rad54 dissociates homologous recombination intermediates by branch migration.2007

    • Author(s)
      Bugreev, D.V., et. al.
    • Journal Title

      Nat. Struct. Mol. Biol. 14

      Pages: 746-753

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA polymerase eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes.2007

    • Author(s)
      Masuda, K., et. al.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 17387-17394

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation.2007

    • Author(s)
      Furumoto, T. et al.
    • Journal Title

      Genes Cells 12(1)

      Pages: 119-132

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Negative regulation of condensin I by CK2-mediated phosphorylation.2006

    • Author(s)
      Takemoto, A., Kimura, K., Yanagisawa, J., Yokoyama, S., Hanaoka, F.
    • Journal Title

      EMBO J. 25

      Pages: 5339-5348

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ultraviolet B radiation induces epithelial tumors in mice lacking pol η and mesenchymal tumors in mice deficient for pol2006

    • Author(s)
      Ohkumo, T., Kondo, Y., Yokoi, M., Tsukamoto, T., Yamada, A., Sugimoto, T., Kanao, R., Higashi, Y., Kondoh, H., Tatematsu, M., Masutani, C., Hanaoka, F.
    • Journal Title

      ι.Mal.Cell.Biol. 26

      Pages: 7696-7706

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A human DNA polymerase eta complex containing Rad18, Rad6 and Revl ; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest.2006

    • Author(s)
      Yuasa, M.S., Masutani, C., Hirano, A., Cohn, M.A., Yamaizumi, M., Nakatani, Y., Hanaoka, F.
    • Journal Title

      Genes Cells 11

      Pages: 731-744

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair.2006

    • Author(s)
      Fan, L., Arvai, A.S., Cooper, P.K., Iwai, S., Hanaoka, F., Tainer, J.A.
    • Journal Title

      Mot.Cell 22

      Pages: 27-37

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of the Caenorhabditis elegans DNA polymerase eta homologue increases sensitivity to UV radiation during germ-line development.2006

    • Author(s)
      Ohkumo, T., Masutani, C., Eki, T., Hanaoka, F.
    • Journal Title

      Cell Struct.Funct. 31

      Pages: 29-37

    • NAID

      130004137504

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Negative regulation of condensin I by CK2-mediated phosphorylation.2006

    • Author(s)
      Takemoto, A. et al.
    • Journal Title

      EMBO J. 25(22)

      Pages: 5339-5348

    • Related Report
      2006 Annual Research Report
  • [Journal Article] UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota.2006

    • Author(s)
      Ohkumo, T. et al.
    • Journal Title

      Mol. Cell. Biol. 26(20)

      Pages: 7696-7706

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A human DNA polymerase eta complex containing Rad18 Rad6 and Rev1 : proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest.2006

    • Author(s)
      Yuasa, M. et al.
    • Journal Title

      Genes Cells 11(7)

      Pages: 731-744

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A novel role of DNA polymerase eta in modulating cellular sensitivity to chemotherapeutic agents.2006

    • Author(s)
      Chen, Y.W.et al.
    • Journal Title

      Mol. Cancer Res. 4(4)

      Pages: 257-265

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Conserved XPB core structure and motifs for DNA unwinding : implications for pathway selection of transcription or excision repair.2006

    • Author(s)
      Fan, L.et al.
    • Journal Title

      Mol. Cell 22(1)

      Pages: 27-37

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Deficiency of the Caenorhabditis elegans DNA polymerase eta homologue increases sensitivity to UV radiation during germ-line development.2006

    • Author(s)
      Ohkumo, T. et al.
    • Journal Title

      Cell Struct.Funct. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase α.2005

    • Author(s)
      Nakamura, M., Nabetani, A., Mizuno, T., Hanaoka, F., Ishikawa, F.
    • Journal Title

      Mal.Cell.Biol. 25

      Pages: 11073-11088

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Azathioprine and UVA light generate mutagenic oxidative DNA damage.2005

    • Author(s)
      O'Donovan, P., Perrett, C.M., Zhang, X., Montaner, B., Xu, Y.Z., Harwood, C.A., McGregor, J.M., Walker, S.L., Hanaoka, F., Karran, P.
    • Journal Title

      Science 309

      Pages: 1871-1874

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conformational change in the catalytic site of the ribonuclease YoeB toxin by YefM antitoxin.2005

    • Author(s)
      Kamada, K., Hanaoka, F.
    • Journal Title

      Mal.Cell 19

      Pages: 497-509

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein.2005

    • Author(s)
      Nishi, R., Okuda, Y., Watanabe, E., Mori, T., Iwai, S., Masutani, C., Sugasawa, K., Hanaoka, F.
    • Journal Title

      Cell.Biol. 25

      Pages: 5664-5674

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of SUMO1-conjugated thymine DNA glycosylase.2005

    • Author(s)
      Baba, D., Maita, N., Jee, J.-G., Uchimura, Y., Saitoh, H., Sugasawa, K., Hanaoka, F., Tochio, H., Hiroaki, H., Shirakawa, M.
    • Journal Title

      Nature 435

      Pages: 979-982

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Different mutation signatures in DNA polymerase η- and MSH6-deficient mice suggest separate roles in antibody diversification.2005

    • Author(s)
      Martomo, S.A., Yang, W.W., Wersto, R.P., Ohkumo, T., Kondo, Y., Yokoi, M., Masutani, C., Hanaoka, F., Gearhart, P.J.
    • Journal Title

      Proc.Natl.Acad Sci.USA 102

      Pages: 8656-8661

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquit in ligase complex.2005

    • Author(s)
      Sugasawa, K., Okuda, Y., Sai jo, M., Nishi, R., Matsuda, N., Chu, G., Mori, T., Iwai, S., Tanaka, K., Tanaka, K., Hanaoka, F.
    • Journal Title

      Cell 121

      Pages: 387-400

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nucleosomal structure of undamaged DNA regions suppresses the non-specific DNA binding of the XPC complex.2005

    • Author(s)
      Yasuda, T., Sugasawa, K., Shimizu, Y., Iwai, S., Shiomi, T., Hanaoka, F.
    • Journal Title

      DNA Repair 4

      Pages: 389-395

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesis.2005

    • Author(s)
      Kawamoto, T. et al.
    • Journal Title

      Mol.Cell 20

      Pages: 793-799

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Azathioprine and UVA light generate mutagenic oxidative DNA damage.2005

    • Author(s)
      O'Donovan, P. et al.
    • Journal Title

      Science 309

      Pages: 1871-1874

    • Related Report
      2005 Annual Research Report
  • [Journal Article] DNA polymerases eta and Kappa are responsible for error-free translesion DNA synthesis activity over a cis-syn thymine dimmer in Xenopus laevis oocyte extracts.2005

    • Author(s)
      Yagi, Y. et al.
    • Journal Title

      DNA Repair 4

      Pages: 1252-1269

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Binding of MutS mismatch repair protein to DNA containing UV photoproducts, "mismatched" opposite Watson--Crick and novel nucleotides, in different DNA sequence contexts.2005

    • Author(s)
      Hoffman, P.D.
    • Journal Title

      DNA Repair 4

      Pages: 983-993

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Different mutation signatures in DNA polymerase η- and MSH6-deficient mice suggest separate roles in antibody diversification.2005

    • Author(s)
      Martomo, S.A. et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 102

      Pages: 8656-8661

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells

    • Author(s)
      Akagi, J., et.al.
    • Journal Title

      DNA Repair (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Regulation of translesion DNA synthesis with special emphasis on DNA polymerase η and PCNA ubiquitylation.2010

    • Author(s)
      Hanaoka, F., Deguchi, S., Kanao, R., Masutani, C.
    • Organizer
      EMBO Workshop, The Interface between the Ubiquitin Family and the DNA Damage Response
    • Place of Presentation
      Rovinj, Croatia
    • Related Report
      2009 Final Research Report
  • [Presentation] Tumorigenesis induced by chronic treatment with UV-B in Pol η- and Xpc-deficient mice.2010

    • Author(s)
      Hanaoka, F.
    • Organizer
      Gordon Research Conference, Mutagenesis
    • Place of Presentation
      Waterville, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] 損傷を乗り越えるポリメラーゼの機能と発癌の制御東北大学・加齢医学研究所・シンポジウム2009

    • Author(s)
      花岡文雄
    • Organizer
      平成20年度・ゲノムリサーチセンター・ワークショップ「癌と老化を乗り越えるDNA修復の科学」
    • Place of Presentation
      仙台
    • Year and Date
      2009-03-13
    • Related Report
      2009 Final Research Report
  • [Presentation] UV-induced mutations in the epidermal genome of TLS polymerase-deficient mice.2009

    • Author(s)
      Hanaoka, F.
    • Organizer
      The 40^<th> International Symposium of the Princess Takamatsu Cancer Research Fund
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] UV-induced mutations in the epidermal genome of DNA polymerase η- and ι-deficient mice occurring in vivo.2009

    • Author(s)
      Hanaoka, F.
    • Organizer
      Second Erling Seeberg Symposium on DNA Repair, Keynote Address
    • Place of Presentation
      Alesund and Geiranger, Nnrwav
    • Related Report
      2009 Final Research Report
  • [Presentation] ゲノム情報維持の分子機構に関する研究2009

    • Author(s)
      花岡文雄
    • Organizer
      日本薬学会第129年会日本薬学会賞受賞講演
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] 損傷乗り越え複製研究の最前線2008

    • Author(s)
      花岡文雄
    • Organizer
      東京都臨床医学総合研究所
    • Place of Presentation
      東京
    • Year and Date
      2008-12-19
    • Related Report
      2009 Final Research Report
  • [Presentation] 損傷乗り越え型DNAポリメラーゼ・イータおよびイオタ欠損マウスの皮膚における紫外線誘発発がんと突然変異2008

    • Author(s)
      花岡文雄
    • Organizer
      日本放射線影響学会第51回大会
    • Place of Presentation
      北九州
    • Year and Date
      2008-11-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 損傷乗り越え複製とがん2008

    • Author(s)
      花岡文雄
    • Organizer
      第67回日本癌学会学術総会、モーニング・レクチャー
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2009 Final Research Report
  • [Presentation] Translesion synthesis and cancer.2008

    • Author(s)
      Hanaoka, F.
    • Organizer
      Clare Hall Laboratories, Cancer Research UK
    • Place of Presentation
      South Mimms, UK
    • Year and Date
      2008-07-25
    • Related Report
      2009 Final Research Report
  • [Presentation] 損傷乗り越え型DNAポリメラーゼ・イータおよびイオタ欠損マウスの皮膚における紫外線誘発発がんと突然変異2008

    • Author(s)
      花岡文雄
    • Organizer
      日本放射線影響学会第51回大会、シンポジウム「放射線発がんの基盤を形成する遺伝子・細胞・組織の応答」
    • Place of Presentation
      北九州
    • Related Report
      2009 Final Research Report
  • [Presentation] Schizosaccharomyces pombe Ddbl recruits substrate-specific adaptor proteins through a novel protein motif, the DDB-box.2008

    • Author(s)
      Fukumoto, Y., Dohmae, N., Hanaoka, F.
    • Organizer
      The 6th 3R Symposium (3R Symposium 2008)
    • Place of Presentation
      掛川
    • Related Report
      2009 Final Research Report
  • [Presentation] In vivo and in vitro studies on DNA polymerase eta.2008

    • Author(s)
      Hanaoka, F.
    • Organizer
      Gordon Research Conference on Mutagenesis
    • Place of Presentation
      Oxford, UK
    • Related Report
      2009 Final Research Report
  • [Presentation] 損傷乗り越え複製の分子機構-DNAポリメラーゼ・イータを中心に-2007

    • Author(s)
      花岡文雄, ほか
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学大会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] Recent studies on mammalian DNA polymerase eta2007

    • Author(s)
      Hanaoka, F.
    • Organizer
      the product of XP variant responsible gene. Mayo Clinic
    • Place of Presentation
      Rochester, Minnesota, USA
    • Year and Date
      2007-05-21
    • Related Report
      2009 Final Research Report
  • [Presentation] Defective translesion DNA synthesis and links to human disease.2007

    • Author(s)
      Hanaoka, F.
    • Organizer
      9th Annual Midwest DNA Repair Symposium, Keynote Lecture
    • Place of Presentation
      Columbus, Ohio
    • Year and Date
      2007-05-20
    • Related Report
      2009 Final Research Report
  • [Presentation] DNA repair and ubiquitin.2007

    • Author(s)
      Hanaoka, F.
    • Organizer
      Ohio State University Medical Center
    • Place of Presentation
      Columbus, Ohio, USA
    • Year and Date
      2007-05-18
    • Related Report
      2009 Final Research Report
  • [Presentation] DNA損傷乗り越え複製と発がん2007

    • Author(s)
      花岡文雄
    • Organizer
      がん特定研究否同シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-02-23
    • Related Report
      2009 Final Research Report
  • [Presentation] 損傷乗り越え複製の分子機構-DNAポリメラーゼ・イータを中心に-2007

    • Author(s)
      花岡文雄、横井雅幸、大雲剛志、金尾梨絵、赤木純一、益谷央豪
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会(BMB2007)、シンポジウム「DNA修復研究の最前線」
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 損傷轍複製とがん2007

    • Author(s)
      花岡文雄、益谷央豪、塚本徹哉、立松正衛
    • Organizer
      第66回日本癌学会学術総会、シンポジウム「ゲノム不安定性」
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] TLS polymerase deficiencies and cancer.2007

    • Author(s)
      Hanaoka, F.
    • Organizer
      The 3rd Japan-US DNA Repair Meeting
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report
  • [Presentation] Translesion synthesis and cancer.2007

    • Author(s)
      Hanaoka, F.
    • Organizer
      7th Joint Conference of the American Association for Cancer Research and the Jananese Cancer Association.
    • Place of Presentation
      Waikoloa, Hawaii, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] 遺伝盾報を保持するしくみ2006

    • Author(s)
      花岡文雄
    • Organizer
      第16回遺伝医学セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2006-09-02
    • Related Report
      2009 Final Research Report
  • [Presentation] 色素性乾皮症バリアント群の解析から明らかにった新規DNA損傷応答について2006

    • Author(s)
      花岡文雄
    • Organizer
      山泉克教授追悼講演会「DNA傷害と修復応答」
    • Place of Presentation
      熊本
    • Year and Date
      2006-07-21
    • Related Report
      2009 Final Research Report
  • [Presentation] 紫外線障害修復機構-その概要とXPV遺伝子欠損ラウスを用いた皮膚発がん実験について-2006

    • Author(s)
      花岡文雄
    • Organizer
      第28回日本光医学・光生物学会
    • Place of Presentation
      徳島
    • Year and Date
      2006-07-07
    • Related Report
      2009 Final Research Report
  • [Presentation] DNA修復におけるユビキチン化の役割2006

    • Author(s)
      花岡文雄
    • Organizer
      千里ライフサイエンスセミナー「蛋白質の修飾と機能制御」
    • Place of Presentation
      大阪
    • Year and Date
      2006-07-05
    • Related Report
      2009 Final Research Report
  • [Presentation] In vivo and in vitro studies on DNA polymerase eta, the product of XP variant gene.2006

    • Author(s)
      Hanaoka, F.
    • Organizer
      The First International Symposium on the MEXT Priority Research Project.-The Chromosome Cycle-.
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] In vivo and in vitro studies on mammalian DNA polymerase eta, the product of XP-V responsible gene.2006

    • Author(s)
      Hanaoka, F.
    • Organizer
      Erling Seeberg Symposium on DNA Repair.
    • Place of Presentation
      Bodo and Henningsver, Lofoten, Norway
    • Related Report
      2009 Final Research Report
  • [Book] がん研究のいま (1)発がんの分子機構と防御2006

    • Author(s)
      笹月 健彦ら
    • Total Pages
      197
    • Publisher
      東京大学出版会
    • Related Report
      2005 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.gakushuin.ac.jp/univ/sci/bio/laboratory/detail_hanaoka/theme.html

    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] DNA損傷修復剤とスクリーニング方法2009

    • Inventor(s)
      菅澤薫、花岡文雄、清水祐一郎
    • Industrial Property Rights Holder
      科学技術振興機構、(独)理化学研究所
    • Acquisition Date
      2009-11-06
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 新規ヒトトポイソメラーゼ2α阻害蛋白質及びその利用2005

    • Inventor(s)
      中西啓、花岡文雄、大海忍
    • Industrial Property Rights Holder
      (独)理化学研究所
    • Acquisition Date
      2005-04-08
    • Related Report
      2009 Final Research Report

URL: 

Published: 2005-04-01   Modified: 2018-03-28  

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