Molecular mechanisms controlling spontaneous mutations

• Project/Area Number: 17013060
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: MAKI Hisaji Nara Institute of Science and Technology, バイオサイエンス研究科, 教授 (20199649)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥48,500,000 (Direct Cost: ¥48,500,000); Fiscal Year 2009: ¥9,700,000 (Direct Cost: ¥9,700,000); Fiscal Year 2008: ¥9,700,000 (Direct Cost: ¥9,700,000); Fiscal Year 2007: ¥9,700,000 (Direct Cost: ¥9,700,000); Fiscal Year 2006: ¥9,700,000 (Direct Cost: ¥9,700,000); Fiscal Year 2005: ¥9,700,000 (Direct Cost: ¥9,700,000)
• Keywords: 突然変異 / 酸素ラジカル / 活性酸素 / DNA複製 / DNA修復

Research Abstract

Studies of spontaneous mutations occurring in E. coli cells grown under a strict anaerobic condition revealed that oxygen radicals are a major cause of spontaneous mutations occurring in aerobically growing cells. In particular, hotspot-type of base substitutions appeared to be caused by oxygen radicals. We also found a mutagenic pathway caused by superoxide and one caused by nucleotide excision repair.

Research Products

• [Journal Article] Abundance of ribosomal RNA gene copies maintains genome integrity. (2010)
  • Author(s): Ide S., Miyazaki T., Maki H., Kobayashi T.
  • Journal Title: Science誌 327巻 Pages: 693-696
  • Peer Reviewed
• [Journal Article] Near-full-length REV3L appears to be a scarce maternal factor in Xenopus laevis eggs that changes qualitatively in early embryonic development. (2010)
  • Author(s): Ogawara D., Muroya T., Yamauchi K., Iwamoto TA., Yagi Y., Yamashita Y., Waga S., Akiyama M., Maki H.
  • Journal Title: DNA Repair(Amst)誌 9巻1号 Pages: 90-95
  • Peer Reviewed
• [Journal Article] Near-full-length REV3L appears to be a scarce maternal factor in Xenopus laevis eggs that changes qualitatively in early embryonic development. (2010)
  • Author(s): Ogawara D
  • Journal Title: DNA Repair 9(1) Pages: 90-95
  • Peer Reviewed
• [Journal Article] Abundance of ribosomal RNA gene copies maintains genome integrity. (2010)
  • Author(s): Ide S
  • Journal Title: Science 327 Pages: 693-696
  • Peer Reviewed
• [Journal Article] Overproduction of Escherichia coli DNA polymerase DinB (Pol IV) inhibits replication fork progression and is lethal. (2008)
  • Author(s): Uchida K., Furukohri A., Shinozaki Y., Mori T., Ogawara D., Kanaya S., Nohmi T., Maki H., Akiyama M.
  • Journal Title: Molecular Microbiology誌 70巻3号 Pages: 608-622
  • Peer Reviewed
• [Journal Article] A dynamic polymerase exchange with Escherichia coli pol IV replacing pol III on the sliding clamp. (2008)
  • Author(s): Furukohri A., Goodman M.F., Maki H.
  • Journal Title: J Biol Chem誌 283巻17号 Pages: 11260-11269
  • Peer Reviewed
• [Journal Article] Spontaneous Mutagenesis Associated with Nucleotide Excision Repair in Escherichia coli. (2008)
  • Author(s): Hasegawa K., Yoshiyama K., Maki H.
  • Journal Title: Genes to Cells誌 13巻 Pages: 459-469
  • Peer Reviewed
• [Journal Article] Spontaneous Mutagenesis Associated with Nucleotide Excision Repair in Escherichia coli (2008)
  • Author(s): Hasegawa, K.
  • Journal Title: Genes to Cells 13 Pages: 459-469
  • Peer Reviewed
• [Journal Article] A dynamic polymerase exchange with Escherichia coli pol IV replacing pol III on the sliding clamp (2008)
  • Author(s): Furukohri, A.
  • Journal Title: J Biol Chem 283(17) Pages: 11260-11269
  • Peer Reviewed
• [Journal Article] OverprocluCtion of Escherichia coli DNA polymerase DinB (Pol IV) inhibits replication fork progression-and is lethal (2008)
  • Author(s): Uchida, K.
  • Journal Title: Mol Microbiol 70(3) Pages: 608-622
  • Peer Reviewed
• [Journal Article] A dynamic polymerase exchange with Escherichia coli pol IV replacing pol III on the sliding clamp (2008)
  • Author(s): A. Furukohri
  • Journal Title: J Biol Chem (電子出版)
  • Peer Reviewed
• [Journal Article] Spontaneous Mutagenesis Associated with Nucleotide Excision Repair in Escherichia coli (2008)
  • Author(s): K. Hasegawa
  • Journal Title: Genes CeUs (in press)
  • Peer Reviewed
• [Journal Article] The dnaE173 mutator mutation confers on the a subunit of Escherichia coli DNA polymerase III a capacity for highly processive DNA synthesis and stable binding to primer-template DNA. (2007)
  • Author(s): Yanagihara F., Yoshida S., Sugaya Y., Maki H.
  • Journal Title: Genes Genet Systems誌 82巻4号 Pages: 273-280
  • Peer Reviewed
• [Journal Article] MUTYH-null mice are susceptible to spontaneous and oxidative-stress-induced intestinal tumorigenesis. (2007)
  • Author(s): Sakamoto K., Tominaga Y., Yamauchi K., Nakatsu Y., Sakumi K., Yoshiyama K., Egashira A., Kura S., Yao T., Tsuneyoshi M., Maki H., Nakabeppu Y., Tsuzuki, T.
  • Journal Title: Cancer Research誌 67巻14号 Pages: 6599-6604
  • Peer Reviewed
• [Journal Article] Roles of RecA protein in spontaneous mutagenesis in Escherichia coli. (2007)
  • Author(s): Kanie, S., Horibata, K., Kawano, M., Isogawa, A., Sakai, A., Matsuo, N., Nakanishi, M., Hasegawa, K., Yoshiyama, K., Maki, H.
  • Journal Title: Genes Genet Systems誌 82巻2号 Pages: 99-108
  • NAID: 10024393945
  • Peer Reviewed
• [Journal Article] Abnormality in initiation program of DNA replication is monitored by the highly repetitive rDNA array on chromosome XII in budding yeast. (2007)
  • Author(s): Ide, S., Watanabe, K., Watanabe, H., Shirahige, K., Kobayashi, T., Maki, H.
  • Journal Title: Mol Cell Biol誌 27巻 Pages: 568-578
  • Peer Reviewed
• [Journal Article] MUTYH-null mice are susceptible to spontaneous and oxidative-stress-induced intestinal tumorigenesis. (2007)
  • Author(s): K. Sakamoto
  • Journal Title: Cancer Research 67(14) Pages: 6599-6604
  • Peer Reviewed
• [Journal Article] The dnaE173 mutator mutation confers on the a subunit of Escherichia coli DNA polymerase III a capacity for highly processive DNA synthesis and stable binding to primer-template DNA (2007)
  • Author(s): F. Yanagihara
  • Journal Title: Genes Genet Systems 82(4) Pages: 273-280
  • Peer Reviewed
• [Journal Article] Abnormality in initiation program of DNA replication is monitored by the highly repetitive rDNA array on chromosome XII in budding yeast. (2007)
  • Author(s): S.Ide
  • Journal Title: Mol Cell Bio 27 Pages: 568-578
• [Journal Article] Double-stranded DNA binding, an unusual property of DNA polymerase epsilon, promotes epigenetic silencing in Saccharomyces cerevisiae. (2006)
  • Author(s): Tsubota, T., Tajima, R., Ode, K., Kubota, H., Fukuhara, N., Kawabata, T., Maki, S., Maki, H.
  • Journal Title: J Biol Chem誌 281巻 Pages: 32898-32908
  • Peer Reviewed
• [Journal Article] Impact of reactive oxygen species on spontaneous mutagenesis in Escherichia coli. (2006)
  • Author(s): Sakai, A., Nakanishi, M., Yoshiyama, K., Maki, H.
  • Journal Title: Genes Cells誌 11巻 Pages: 767-778
  • Peer Reviewed
• [Journal Article] Double-stranded DNA binding, an unusual property of DNA polymerase epsilon, promotes epigenetic silencing in Saccharomyces cerevisiae. (2006)
  • Author(s): T.Tsubota
  • Journal Title: J Biol Chem 281 Pages: 32898-32908
• [Journal Article] Impact of reactive oxygen species on spontaneous mutagenesis in Escherichia coli. (2006)
  • Author(s): A.Sakai
  • Journal Title: Genes Cells 11 Pages: 767-778
• [Journal Article] DNA polymerasesηandκare responsible for error-free translesion DNA synthesis activity over a cis-syn thymine dimer in Xenopus laevis oocyte extracts. (2005)
  • Author(s): Yagi, Y., Ogawara, D., Iwai, S., Hanaoka, F., Akiyama, M., Maki, H.
  • Journal Title: DNA Repair (Amst)誌 4巻 Pages: 1252-1269
  • Peer Reviewed
• [Journal Article] RNAi-mediated silencing of OsGEN-L (OsGEN-like), a new member of the RAD2/XPG nuclease family, causes male sterility by defect of microspore development in rice. (2005)
  • Author(s): Moritoh, S., Miki, D., Akiyama, M., Kawahara, M., Izawa, T., Maki, H., Shimamoto, K.
  • Journal Title: Plant Cell Physiol誌 46巻 Pages: 699-715
  • NAID: 10015661666
  • Peer Reviewed
• [Journal Article] RNAi-mediated silencing of OsGEN-L (OsGEN-like), a new member of the RAD2/XPG nuclease family, causes male sterility by defect of microspore development in rice. (2005)
  • Author(s): S.Moritoh
  • Journal Title: Plant Cell Physiol. 46 Pages: 699-715
• [Journal Article] DNA polymerases η and κ are responsible for error-free, translesion DNA synthesis activity over a cis-syn thymine dimmer in Xenopus laevis oocyte extracts. (2005)
  • Author(s): Y.Yagi
  • Journal Title: DNA Repair 4 Pages: 1252-1269
• [Presentation] 大腸菌dinBの過剰発現による染色体の断裂 (2009)
  • Author(s): 池田美央
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-12
• [Presentation] 大腸菌dinBの過剰発現による染色体の断裂 (2009)
  • Author(s): 池田美央
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-12
• [Presentation] DinB DNAポリメラーゼによるゲノム複製の調節 (2009)
  • Author(s): 秋山昌広
  • Organizer: 日本遺伝学会第81回大会
  • Place of Presentation: 信州大学理学部A棟および講義棟
  • Year and Date: 2009-09-18
• [Presentation] DinB DNAポリメラーゼによるゲノム複製の調節 (2009)
  • Author(s): 秋山昌広
  • Organizer: 日本遺伝学会第81回大会
  • Place of Presentation: 信州大学理学部(長野県)
  • Year and Date: 2009-09-18
• [Presentation] 大腸菌DNAポリメラーゼIの配列置換変異抑制機能 (2009)
  • Author(s): 真木寿治
  • Organizer: 日本遺伝学会第81回大会
  • Place of Presentation: 信州大学理学部A棟および講義棟
  • Year and Date: 2009-09-16
• [Presentation] 大腸菌dinBの過剰発現による染色体の分割 (2009)
  • Author(s): 池田美央
  • Organizer: 日本遺伝学会第81回大会
  • Place of Presentation: 信州大学理学部A棟および講義棟
  • Year and Date: 2009-09-16
• [Presentation] 大腸菌dinBの過剰発現による染色体の分割 (2009)
  • Author(s): 池田美央
  • Organizer: 日本遺伝学会第81回大会
  • Place of Presentation: 信州大学理学部(長野県)
  • Year and Date: 2009-09-16
• [Presentation] 大腸菌DNAポリメラーゼIの配列置換変異抑制機能 (2009)
  • Author(s): 真木寿治
  • Organizer: 日本遺伝学会第81回大会
  • Place of Presentation: 信州大学理学部(長野県)
  • Year and Date: 2009-09-16
• [Presentation] DNAポリメラーゼIV(DinB)の過剰発現によるゲノムの断裂 (2009)
  • Author(s): 池田美央
  • Organizer: 第6回21世紀大腸菌研究会
  • Place of Presentation: kkrホテル熱海
  • Year and Date: 2009-06-12
• [Presentation] DNAポリメラーゼIV(DinB)の過剰発現によるゲノムの断裂 (2009)
  • Author(s): 池田美央
  • Organizer: 第6回21世紀大腸菌研究会
  • Place of Presentation: KRホテル熱海(神奈川県)
  • Year and Date: 2009-06-12
• [Presentation] (標題)大腸菌DNAポリメラーゼIV (DinB)の活性制御機構の解析 (2008)
  • Author(s): 西川義人
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド神戸国際展示場1号館2階
  • Year and Date: 2008-12-12
• [Presentation] 大腸菌のSOS応答を誘導しない複製フォークの停止 (2008)
  • Author(s): 森哲也
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド神戸国際展示場1号館2階
  • Year and Date: 2008-12-12
• [Presentation] 大腸菌のSOS応答を誘導しない複製フォークの停止 (2008)
  • Author(s): 森哲也
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-12-12
• [Presentation] 大腸菌DNAポリメラーゼIV(DinB)の活性制御機構の解析 (2008)
  • Author(s): 西川義人
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-12-12
• [Presentation] Spontaneous mutagenesis associated with nucleotide excision repair in Escherichia coli (2008)
  • Author(s): Maki, H
  • Organizer: The 6th International 3R (DNA Replication, Recombination and Repair) Symposium
  • Place of Presentation: TSUMAGOI RESORT, Kakegawa, Shizuoka, Japan
  • Year and Date: 2008-10-28
• [Presentation] 大腸菌DinB DNAポリメラーゼのSOS応答レベルでの過剰発現によるDNA複製と細胞増殖の遅延 (2008)
  • Author(s): 秋山昌広
  • Organizer: 日本遺伝学会第80回大会
  • Place of Presentation: 名古屋大学工学部IB電子情報館
  • Year and Date: 2008-09-03
• [Presentation] 大腸菌ヌクレオチド除去修復による自然突然変異の誘発経路 (2008)
  • Author(s): 沙魚川公子
  • Organizer: 日本遺伝学会第80回大
  • Place of Presentation: 名古屋大学工学部IB電子情報館
  • Year and Date: 2008-09-03
• [Presentation] 大腸菌DinB DNAポリメラーゼの過剰発現による自殺的細胞分裂 (2008)
  • Author(s): 池田美央
  • Organizer: 日本遺伝学会第80回大会
  • Place of Presentation: 名古屋大学工学部IB電子情報館
  • Year and Date: 2008-09-03
• [Presentation] 大腸菌DinB DNAポリメラーゼの過剰発現による自殺的細胞分裂 (2008)
  • Author(s): 池田美央
  • Organizer: 日本遺伝学会第80回大会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-09-03
• [Presentation] 大腸菌ヌクレオチド除去修復による自然突然変異の誘発経路 (2008)
  • Author(s): 沙魚川公子
  • Organizer: 日本遺伝学会第80回大会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-09-03
• [Presentation] 大腸菌DinB DNAポリメラーゼのSOS応答レベルでの過剰発現によるDNA複製と細胞増殖の遅延 (2008)
  • Author(s): 秋山昌広
  • Organizer: 日本遺伝学会第80回大会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-09-03
• [Presentation] 大腸菌DinB(DNAポリメラーゼIV)の過剰発現による複製フォーク停止と自殺的細胞分裂 (2008)
  • Author(s): 池田美央
  • Organizer: 第5回21世紀大腸菌研究会
  • Place of Presentation: 静岡国民年金健康センター藤枝エミナース
  • Year and Date: 2008-07-29
• [Presentation] 大腸菌DinB(DNAポリメラーゼIV)の過剰発現による複製フオーク停止と自殺的細胞分裂 (2008)
  • Author(s): 池田美央
  • Organizer: 第5回21世紀大腸菌研究会
  • Place of Presentation: 藤枝市
  • Year and Date: 2008-07-29
• [Presentation] Upregulation of Escherichia coli DNA Polymerase Dinb(Pol IV) Arrests Replication Fork Progression and is Lethal. (2008)
  • Author(s): 秋山昌広
  • Organizer: XX International Congress of Genetics(第20回国際遺伝学会)
  • Place of Presentation: The congress center(ドイツ)
  • Year and Date: 2008-07-17
• [Presentation] Upregulation of Escherichia coli DNA Polymerase Dinh (Pol IV) Arrests Replication Fork Progression and is Lethal (2008)
  • Author(s): Akiyama, M.
  • Organizer: XX International Congress of Genetics(第20回国際遺伝学会)
  • Place of Presentation: Berlin, GerMany
  • Year and Date: 2008-07-17
• [Presentation] 大腸菌in vitro DNA複製系におけるDNA polymerase switchの解析:Pol IVによるPOL III制御機構, 組換え・染色体再編ワークショップ (2008)
  • Author(s): 古郡麻子
  • Organizer: 第19回DNA複製・分配ワークショップ(合同開催)
  • Place of Presentation: ラフォーレ修繕寺
  • Year and Date: 2008-03-05
• [Presentation] 大腸菌in vitro DNA複製糸におけるDNA polymerase switchの解析:Pol IVによるPOL III制御機構 (2008)
  • Author(s): 古郡麻子
  • Organizer: 組換え・染色体再編ワークショップ、第19回DNA複製・分配ワークショップ(合同開催)
  • Place of Presentation: フォーレ修繕寺(伊豆市)
  • Year and Date: 2008-03-05
• [Presentation] A new role of RDH54 in genome maintenance., The 6th International 3R (DNA Replication (2008)
  • Author(s): 山口和勇
  • Organizer: Recombination and Repair) Symposium
  • Place of Presentation: ヤマハリゾートつま恋
• [Presentation] Overproduction of Escherichia coli DNA polymerase DinB(Pol IV) inhibits replication fork progression and is lethal. (2008)
  • Author(s): 秋山昌広
  • Organizer: The 6th International 3R (DNA Replication, Recombination and Repair) Symposium
  • Place of Presentation: ヤマハリゾートつま恋
• [Presentation] A dynamic polymerase exchange with Escherichia coli Pol IV replacing Pol III on the sliding clamp. (2008)
  • Author(s): 古郡麻子
  • Organizer: The 6th International 3R (DNA Replication, Recombination and Repair) Symposium
  • Place of Presentation: ヤマハリゾートつま恋
• [Presentation] Spontaneous mutagenesis associated with nucleotide excision repair in Escherichia coli. (2008)
  • Author(s): 沙魚川公子
  • Organizer: The 6th International 3R (DNA Replication, Recombination and Repair) Symposium
  • Place of Presentation: ヤマハリゾートつま恋
• [Presentation] A dynamic polymerase exchange with Escherichia coli pol IV replacing pol III on the sliding clamp. (2008)
  • Author(s): 古郡麻子
  • Organizer: XX International Congress of Genetics(第20回国際遺伝学会)
  • Place of Presentation: The congress center(ドイツ)
• [Presentation] Spontaneous Mutagenesis Associated with Nucleotide Excision Repair in Escherichia coliSpontaneous Mutagenesis Associated with Nucleotide Excision Repair in Escherichia coli. (2008)
  • Author(s): 沙魚川公子
  • Organizer: XX International Congress of Genetics(第20回国際遺伝学会)
  • Place of Presentation: The congress center(ドイツ)
• [Presentation] Spontaneous Mutagenes-is Associated with NuCleotide Eicision Repair in Escherichia coli (2008)
  • Author(s): Hasegawa, K.
  • Organizer: XX International Comgress of Genetics(第20回国際遺伝学会)
  • Place of Presentation: Berlin, Germany
• [Presentation] A dynamic polymerase exchange with Escherichia coli pdl IV replacing pol III on the sliding clamp (2008)
  • Author(s): Furukohri, A.
  • Organizer: XX International Congress of Genetics(第20回国際遺伝学会)
  • Place of Presentation: Berlin, Germany
• [Presentation] Spontaneous Mutagenesis Associated with Nucleotide Excision Repair in Escherichia coli (2008)
  • Author(s): Hasegawa, K.
  • Organizer: The 6th International 3R (DNA Replication, Recombination and Repaif) Symposium
  • Place of Presentation: TSUMAGOI RESORT, Kakegawa, Shizuoka, Japan
• [Presentation] A dynamic polymerase exchange with Escherichia coli Pol IV replacing Pol III on the sliding clamp (2008)
  • Author(s): Furukohri, A.
  • Organizer: The 6th International 3R(DNA Replication, Recombination and Repair) Symposium
  • Place of Presentation: TSUMAGOI RESORT, Kakegawa, Shizuoka, Japan
• [Presentation] Overproduction of Escherichia coli DNA polymerase DinB(Pol IV) inhibits replication fork progression and is lethal (2008)
  • Author(s): Akiyama, M.
  • Organizer: The 6th International 3R (DNA Replication, Recombination and Repair) Symposium
  • Place of Presentation: TSUMAGOI RESORT, Kakegawa, Shizuoka, Japan
• [Presentation] 大腸菌in vitro DNA復製糸を用いたDNAポリメラーゼスイッチの解析:PolIVによるPolIII制御機構 (2007)
  • Author(s): 古郡麻子
  • Organizer: 日本遺伝学会第79回大会
  • Place of Presentation: 岡山大学理学部・創立50周年記念館
  • Year and Date: 2007-09-20
• [Presentation] 複製開始制御異常に起因する染色体異常と細胞死の誘発;rDNA領域の役割 (2007)
  • Author(s): 真木寿治
  • Organizer: 日本遺伝学会第79回大会
  • Place of Presentation: 岡山大学理学部
  • Year and Date: 2007-09-19
• [Presentation] DNAポリメラーゼDinBによるDNA複製の阻害 (2007)
  • Author(s): 秋山昌広
  • Organizer: 日本遺伝学会第79回大会
  • Place of Presentation: 岡山大学理学部
  • Year and Date: 2007-09-19
• [Presentation] 大腸菌in vitro DNA複製系を用いたDNAポリメラーゼスイッチの解析:Pol IVによるPol III制御機構 (2007)
  • Author(s): 古郡麻子
  • Organizer: 日本遺伝学会第79回大会
  • Place of Presentation: 岡山大学理学部
  • Year and Date: 2007-09-19
• [Presentation] 複製開始制御異常に起因する染色体異常と細胞死の誘発;rDNA領域の役割 (2007)
  • Author(s): 真木寿治
  • Organizer: 日本遺伝学会第79回大会
  • Place of Presentation: 岡山大学理学部・創立50周年記念館
  • Year and Date: 2007-09-19
• [Presentation] DNAポリメラーゼDinBによるDNA複製の阻害 (2007)
  • Author(s): 秋山昌広
  • Organizer: 日本遺伝学会第79回大会
  • Place of Presentation: 岡山大学理学部・創立50周年記念館
  • Year and Date: 2007-09-19
• [Presentation] A new pathway of spontaneous mutagenesis: repair DNA synthesis error during unnecessary action of nucleotide excision repair. (2007)
  • Author(s): 真木寿治
  • Organizer: 第3回日米DNA修復会議
  • Place of Presentation: クレセントホテル(仙台市)
  • Year and Date: 2007-05-08
• [Presentation] A novel activity of DNA polymerase IV (DinB) to promote the dissociation of a replicative enzyme complex, Pol III, from beta clamp subunit on primer-template DNA. (2007)
  • Author(s): 古郡麻子
  • Organizer: 第3回日米DNA修復会議
  • Place of Presentation: クレセントホテル(仙台市)
  • Year and Date: 2007-05-08
• [Presentation] 染色体複製開始異常のモニター機構 (2006)
  • Author(s): 井手聖
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2006-12-07
• [Presentation] DNAポリメラーゼスイッチングに関する生化学的解析:大腸菌DNA Pol VI(DinB)による複製酵素DNA Pol IIIの制御 (2006)
  • Author(s): 古郡麻子
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2006-12-06
• [Presentation] 大腸菌DNAポリメラーゼIIIにより誘発される配列置換変異に関する研究 (2006)
  • Author(s): 柳原芳光
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2006-12-06
• [Presentation] DNAポリメラーゼDinBの過剰発現による大腸菌のDNA複製の阻害 (2006)
  • Author(s): 秋山昌広
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2006-12-06
• [Presentation] sgs1欠損のサプレッサー遺伝子であるSHU1、SHU2の新規機能の探索 (2006)
  • Author(s): 中磯和敏
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2006-12-06
• [Presentation] リボソームRNA遺伝子のExtra-coding機構 (2006)
  • Author(s): 小林武彦
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2006-12-06
• [Presentation] sgs1欠損のサプレッサー遺伝子であるSHU1、SHU2の新規機能の探索 (2006)
  • Author(s): 中磯和敏
  • Organizer: 組換え・染色体再編ワークショップ
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2006-11-29
• [Presentation] DNAポリメラーゼスイッチングに関する生化学的解析:大腸菌DNA Pol VI(DinB)による複製酵素DNA Pol IIIの制御 (2006)
  • Author(s): 古郡麻子
  • Organizer: 第18回DNA複製・分配ワークショップ
  • Place of Presentation: KKRホテル熱海
  • Year and Date: 2006-10-31
• [Presentation] 染色体の複製開始制御異常をモニターする機構 (2006)
  • Author(s): 井手聖
  • Organizer: 第18回DNA複製・分配ワークショップ
  • Place of Presentation: KKRホテル熱海
  • Year and Date: 2006-10-30
• [Presentation] 大腸菌DNAポリメラーゼIIIにより誘発される配列置換変異に関する研究 (2006)
  • Author(s): 柳原芳光
  • Organizer: 第18回DNA複製・分配ワークショップ
  • Place of Presentation: KKRホテル熱海
  • Year and Date: 2006-10-30
• [Presentation] DNAポリメラーゼDinBの過剰発現による大腸菌のDNA複製の阻害 (2006)
  • Author(s): 秋山昌広
  • Organizer: 第18回DNA複製・分配ワークショップ
  • Place of Presentation: KKRホテル熱海
  • Year and Date: 2006-10-30
• [Presentation] 大腸菌のヌクレオチド除去修復による自然突然変異の誘発経路 (2006)
  • Author(s): 沙魚川公子
  • Organizer: 第3回21世紀大腸菌研究会
  • Place of Presentation: ウェルサンピア滋賀
  • Year and Date: 2006-10-04
• [Presentation] 染色体複製開始異常のモニター機構 (2006)
  • Author(s): 井手聖
  • Organizer: 日本遺伝学会第78回大会
  • Place of Presentation: つくば国際会議場エポカル
  • Year and Date: 2006-09-26
• [Presentation] 大腸菌のY型DNAポリメラーゼDinBの過剰発現によるDNA複製の阻害 (2006)
  • Author(s): 内田香里
  • Organizer: 日本遺伝学会第78回大会
  • Place of Presentation: つくば国際会議場エポカル
  • Year and Date: 2006-09-26
• [Presentation] 大腸菌DNAポリメラーゼIのエキソヌクレアーゼ活性は配列置換変異の発生を抑制するか? (2006)
  • Author(s): 大橋慧也
  • Organizer: 日本遺伝学会第78回大会
  • Place of Presentation: つくば国際会議場エポカル
  • Year and Date: 2006-09-26
• [Presentation] 大腸菌のヌクレオチド除去修復による自然突然変異の誘発経路 (2006)
  • Author(s): 沙魚川公子
  • Organizer: 日本遺伝学会第78回大会
  • Place of Presentation: つくば国際会議場エポカル
  • Year and Date: 2006-09-26
• [Presentation] 出芽酵母DNAポリメラーゼε(Polε)のアクセサリーサブユニットDpb3pとDpb4pの新規の生化学的機能:一本鎖DNAセンシングとPolε-DNA相互作用の制御における役割 (2005)
  • Author(s): 田島理絵
  • Organizer: 第28回日本分子生物学会年会
  • Place of Presentation: ヤフードーム
  • Year and Date: 2005-12-08
• [Presentation] 大腸菌dam mutS二重変異株における超高頻度DNA組み換え (2005)
  • Author(s): 澤井和子
  • Organizer: 第34回日本環境変異原学会大会
  • Place of Presentation: こまばエミナース
  • Year and Date: 2005-11-16
• [Presentation] Novel biochemical properties of the dnaE173 mutant a subunit of Escherichia coli DNA polymerase III. (2005)
  • Author(s): 柳原芳光
  • Organizer: The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2005-11-16
• [Presentation] DNA polymeraseηandκare responsible for error-free translesion DNA synthesis over a cis-syn thymine dimer in Xenopus laevis oocyte extracts. (2005)
  • Author(s): 秋山昌広
  • Organizer: The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2005-11-16
• [Presentation] Mechanisms of DNA polymerase switching upon translesion DNA synthesis: A novel action of DinB protein on the DNA chain elongation by DNA polymerase III holoenzyme. (2005)
  • Author(s): 古郡麻子
  • Organizer: The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2005-11-16
• [Presentation] Spontaneous Mutagenesis Associated with Nucleotide Excision Repair in Escherichia coli. (2005)
  • Author(s): 沙魚川公子
  • Organizer: The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2005-11-16
• [Presentation] Impact of Reactive Oxygen Species on Spontaneous Mutagenesis in Escherichia coli. (2005)
  • Author(s): 坂井亜紀子
  • Organizer: The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2005-11-16
• [Presentation] Involvement of rDNA locus in monitoring abnormality in the initiation program of chromosomal DNA replication by DNA damage checkpoint control. (2005)
  • Author(s): 井手聖
  • Organizer: The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2005-11-16
• [Presentation] Roles of SRS2 in genome maintenance in Saccharomyces cerevisiae. (2005)
  • Author(s): 中磯和敏
  • Organizer: The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2005-11-16
• [Presentation] Comprehensive analyses of genomic changes in mouse cells defective in DNA mismatch repair using Msh2-/- mice habouring the rpsL transgene. (2005)
  • Author(s): A. Egashira
  • Organizer: The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2005-11-16
• [Presentation] Involvement of rDNA locus in monitoring abnormality in the initiation program of chromosomal DNA replication by DNA damage checkpoint control. (2005)
  • Author(s): 真木寿治
  • Organizer: 第51回基礎生物学研究所コンファレンス
  • Place of Presentation: 基礎生物学研究所
  • Year and Date: 2005-11-06
• [Presentation] DNAポリメラーゼIV(DinB)による複製フォーク進行阻害の回復機構 (2005)
  • Author(s): 真木寿治
  • Organizer: 日本遺伝学会第77回大会
  • Place of Presentation: 国立オリンピック記念青少年総合センター
  • Year and Date: 2005-09-28
• [Presentation] 自然突然変異の発生における酸素ラジカルの役割 (2005)
  • Author(s): 坂井亜紀子
  • Organizer: 日本遺伝学会第77回大会
  • Place of Presentation: 国立オリンピック記念青少年総合センター
  • Year and Date: 2005-09-28
• [Presentation] 大腸菌のヌクレオチド除去修復による自然突然変異の誘発経路 (2005)
  • Author(s): 沙魚川公子
  • Organizer: 日本遺伝学会第77回大会
  • Place of Presentation: 国立オリンピック記念青少年総合センター
  • Year and Date: 2005-09-28
• [Presentation] 出芽酵母の染色体複製開始制御異常をモニターする機構 (2005)
  • Author(s): 井手聖
  • Organizer: 日本遺伝学会第77回大会
  • Place of Presentation: 国立オリンピック記念青少年総合センター
  • Year and Date: 2005-09-28
• [Presentation] 大腸菌のヌクレオチド除去修復による自然突然変異の誘発経路 (2005)
  • Author(s): 沙魚川公子
  • Organizer: 第2回21世紀大腸菌研究会
  • Place of Presentation: メルパール伊勢志摩
  • Year and Date: 2005-06-24
• [Presentation] 自然突然変異の発生と抑制の分子機構 (2005)
  • Author(s): 真木寿治
  • Organizer: 日本環境変異原学会公開シンポジウム
  • Place of Presentation: 共立薬科大学記念講堂
  • Year and Date: 2005-05-28
• [Book] バイオインフォマティクス辞典 (2006)
  • Author(s): 真木寿治, 他
  • Publisher: 共立出版
• [Book] 遺伝子から生命をみる-分子生物学の誕生と発展- (2006)
  • Author(s): 真木寿治, 他
  • Publisher: 共立出版