| Budget Amount *help |
¥135,000,000 (Direct Cost: ¥135,000,000)
Fiscal Year 2009: ¥29,500,000 (Direct Cost: ¥29,500,000)
Fiscal Year 2008: ¥29,500,000 (Direct Cost: ¥29,500,000)
Fiscal Year 2007: ¥26,000,000 (Direct Cost: ¥26,000,000)
Fiscal Year 2006: ¥26,000,000 (Direct Cost: ¥26,000,000)
Fiscal Year 2005: ¥24,000,000 (Direct Cost: ¥24,000,000)
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| Research Abstract |
Abnormal regulation of G2/M progression induces the drastic phenotypic changes and the genomic instability in cells. The G2/M progression is controlled by two biochemical events, protein degradation and protein phosphorylation. Therefore, regulatory factors of these two biochemical events are considered to play a critical role in development and progression of tumors. Specific aims of our project were i) to analyze molecular mechanisms regulating the transition of G2/M phase, ii) to clarify the role of abnormal regulation of the mitotic molecules and iii) to identify the targets for cancer therapies. As the results, we could elucidate the novel functions of mitotic regulating molecules including Aurora-A, WARTS, Cdh1 and Mklp2 and, furthermore, clarify the molecular mechanism of mitotic catastrophe induced by conventional chemotherapeutic agents.
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