Cancer development induced by deregulation of nuclear factors
| Project/Area Number |
17013071
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kumamoto University |
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Principal Investigator |
NAKAO Mitsuyoshi Kumamoto University, 発生医学研究所, 教授 (00217663)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥71,500,000 (Direct Cost: ¥71,500,000)
Fiscal Year 2009: ¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2008: ¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2007: ¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2006: ¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2005: ¥14,300,000 (Direct Cost: ¥14,300,000)
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| Keywords | 癌 / DNA メチル化 / クロマチン / 細胞核 / がん / ゲノム / 遺伝子 / 発現制御 / DNAメチル化 / メチル化DNA結合タンパク質 / メチルDNA結合タンパク質 |
|---|
| Research Abstract |
This study focused on investigating the molecular basis of epigenetic cell deregulation in cancer, through analyzing the abnormalities of nuclear factors including methylated DNA binding protein MBD1 and its associated factor MCAF1, CTCF-mediated chromatin insulator, HMGA proteins, SUMOylation of nuclear proteins, and nuclear substructure. These findings strongly contribute to promoting cancer diagnosis and therapy.
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Report
(6 results)
Research Products
(93 results)
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[Journal Article] Cohesin mediates transcriptional insulation by CCCTC-binding factor.2008
Author(s)
K.S. Wendt, K. Yoshida, T. Itoh, M. Bando, B. Koch, E. Schirghuber, S. Tsutsumi, G. Nagae, K. Ishihara, T. Mishiro, K. Yahata, F. Imamoto, H. Aburatani, M. Nakao, N. Imamoto, K. Maeshima, K. Shirahige, J.M. Peters
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Journal Title
Nature 451
Pages: 796-803
Related Report
Peer Reviewed
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[Journal Article] Inhibition of DNA binding of Sox2 by the SUMO conjugation.2006
Author(s)
S. Tsuruzoe, K. Ishihara, Yasuhiro Uchimura, S. Watanabe, Y. Sekita, T. Aoto, H. Saitoh, Y. Yuasa, H. Niwa, M. Kawasuji, H. Baba, M. Nakao
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Journal Title
Biochem. Biophys. Res. Commun. 351
Pages: 920-926
Related Report
Peer Reviewed
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