Molecular mechanism for faithful chromosome segregation
Project/Area Number |
17013084
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | National Institute of Genetics |
Principal Investigator |
FUKAGAWA Tatsuo National Institute of Genetics, 分子遺伝研究系, 教授 (60321600)
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Project Period (FY) |
2005 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥50,500,000 (Direct Cost: ¥50,500,000)
Fiscal Year 2009: ¥10,700,000 (Direct Cost: ¥10,700,000)
Fiscal Year 2008: ¥10,700,000 (Direct Cost: ¥10,700,000)
Fiscal Year 2007: ¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2006: ¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2005: ¥9,700,000 (Direct Cost: ¥9,700,000)
|
Keywords | 癌 / ゲノム / 遺伝学 / セントロメア / DT40細胞 / 染色体分配 / キネトコア / RNAiマシーナリー / CENPs / 染色体不安定性 / 発がん機構 |
Research Abstract |
Faithful chromosome segregation during mitosis is essential for the accurate transmission of genetic material. To facilitate this, each replicated sister chromatid assembles a kinetochore on centromeric DNA which forms a dynamic interface with microtubules from the mitotic spindle. Dysfunction of the kinetochore leads cancer. However, molecular mechanism by which the kinetochore is formed, is still unclear. In this study, we have identified more than 20 molecules, which localize to the kinetochore and characterized each molecule.
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Report
(6 results)
Research Products
(64 results)
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[Journal Article] The CENP-S complex is essential for the stable assembly of outer kinetochore structure.2009
Author(s)
Amano, M., Suzuki, A., Hori, T., Backer, C., Okawa, K., Cheeseman, I.M., Fukagawa, T.
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Journal Title
J Cell Biol 186
Pages: 173-182
Related Report
Peer Reviewed
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[Journal Article] CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore.2008
Author(s)
Hori, T., Amano, M., Suzuki, A., Backer, C., Welburn, J.P., Dong, Y., McEwen, B.F., Shang, W.H., Suzuki, E., Okawa, K., Cheeseman, I.M., Fukagawa, T.
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Journal Title
Cell 135
Pages: 1039-1052
Related Report
Peer Reviewed
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[Journal Article] The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.2006
Author(s)
Okada, M., Cheeseman, I.M., Hori, T., Okawa, K., McLeod, I.X., Yates III, J.R., Desai, A., Fukagawa, T.
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Journal Title
Nat Cell Biol 8
Pages: 446-457
Related Report
Peer Reviewed
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[Journal Article] The Constitutive Centromere Component CENP-50 is Required for Recovery from Spindle damage.2005
Author(s)
Minoshima, Y., Hori, T., Okada, M., Kimura, H., Haraguchi, T., Hiraoka, Y., Bao, Y.C., Kawashima, T., Kitamura, T., Fukagawa, T.
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Journal Title
Mol Cell Biol 25
Pages: 10315-10328
Related Report
Peer Reviewed
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