| Budget Amount *help |
¥50,500,000 (Direct Cost: ¥50,500,000)
Fiscal Year 2009: ¥10,700,000 (Direct Cost: ¥10,700,000)
Fiscal Year 2008: ¥10,700,000 (Direct Cost: ¥10,700,000)
Fiscal Year 2007: ¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2006: ¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2005: ¥9,700,000 (Direct Cost: ¥9,700,000)
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| Research Abstract |
Faithful chromosome segregation during mitosis is essential for the accurate transmission of genetic material. To facilitate this, each replicated sister chromatid assembles a kinetochore on centromeric DNA which forms a dynamic interface with microtubules from the mitotic spindle. Dysfunction of the kinetochore leads cancer. However, molecular mechanism by which the kinetochore is formed, is still unclear. In this study, we have identified more than 20 molecules, which localize to the kinetochore and characterized each molecule.
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