Research Project
Grant-in-Aid for Scientific Research on Priority Areas
To clarify the molecular mechanism of carcinogenesis, a series of disease genes that are important for cancer progression by using retrovirus insertional mutagenesis. Trib1 has been identified as a specific cooperative gene for Hoxa9/Meis1, and its modulation effects for MEK and C/Ebpa is required for leukemogenesis. Seven common integration sites have been identified as candidate cooperative genes for the mutation of Bash that is a preB-ALL tumor suppressor. Application of the mutagenesis system on non-hematopoietic neoplasms by utilizing the in vitro system of colon epithelial cells and the Piggybac transposon.
All 2010 2009 2008 2007 2006 2005 Other
All Journal Article (42 results) (of which Peer Reviewed: 32 results) Presentation (24 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results)
Am J Pathol 176
Pages: 1973-1982
Cancer Sci 101
Pages: 800-805
10026590140
Exp Cell Res 315
Pages: 2727-2740
Blood 113
Pages: 4702-4710
Clin Cancer Res 15
Pages: 1170-1176
Blood (in press)
Proc Natl Acad Sci USA 105
Pages: 19904-19909
Genes Cells 13
Pages: 931-940
Leukemia Res 32
Pages: 309-314
Cancer Sci 99
Pages: 979-985
10024006204
Leukemia Res. 32
Blood 109
Pages: 3998-4005
Blood 109・9
Proc Natl Acad Sci U S A. 104・5
Pages: 1616-1620
Hum Mol Genet 15
Pages: 2125-213
Hum Mol Genet 15・13
Pages: 2125-2137
Am J Pathol. 169・4
Pages: 1328-1342
Br J Haematol 131
Pages: 495-507
Oncogene 24
Pages: 4477-4485
Int J Hematol 82
Pages: 21-27
10016602740
Blood 105
Pages: 909-910
Cancer Sci 96
Pages: 7-12
10015523673
Genes Chromosomes Cancer 43
Pages: 217-222
Pages: 784-793
Clin Cancer Res 11
Pages: 7322-7327
J Leukocyte Biol (in press)
J Leukoc Biol (in press)
http://www.jfcr.or.jp/laboratory/tci/carcinogenesis/index.html
http://www.jfbr.or.jp/laboratory/tci/carcinogenesis/index.html