Identification of tumor suppressor genes in gastric cancers by genome-wide analysis of DNA methylation and its functional analysis
| Project/Area Number |
17013090
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
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Principal Investigator |
USHIJIMA Toshikazu National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 発がん研究部, 部長 (90232818)
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| Co-Investigator(Kenkyū-buntansha) |
MORIGUCHI Kazuki 国立がんセンター(研究所及び東病院臨床開発センター), 発がん研究部, 研究員 (30294523)
ABE Masanobu 国立がんセンター(研究所及び東病院臨床開発センター), 発がん研究部, 研究員 (10392333)
YAMASHITA Sayoshi 国立がんセンター(研究所及び東病院臨床開発センター), 発がん研究部, 室長 (80321876)
WATANABE Naoko 国立がんセンター(研究所及び東病院臨床開発センター), 発がん研究部, 研究員 (80255364)
ASADA Kiyoshi 国立がんセンター(研究所及び東病院臨床開発センター), 発がん研究部, 主任研究官 (50311410)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥41,800,000 (Direct Cost: ¥41,800,000)
Fiscal Year 2009: ¥8,300,000 (Direct Cost: ¥8,300,000)
Fiscal Year 2008: ¥8,300,000 (Direct Cost: ¥8,300,000)
Fiscal Year 2007: ¥8,300,000 (Direct Cost: ¥8,300,000)
Fiscal Year 2006: ¥8,300,000 (Direct Cost: ¥8,300,000)
Fiscal Year 2005: ¥8,600,000 (Direct Cost: ¥8,600,000)
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| Keywords | エピジェネティクス / 胃がん / DNAメチル化 / ゲノム / サイレンシング / DNAメチルヒ / ゲノム網羅的解析 / ユビジェネティクス / CpGアイランドメチル化形質 |
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| Research Abstract |
Molecular mechanisms of methylation induction and its inducing factors are still unclear. We showed that the increased methylation of scattered CpG sites could lead to dense methylation of an entire CGI, and could methylate even genes with high expression. We also showed that specific genes were methylated in gastric mucosae with Helicobacter pylori (H.pylori) infection, and that low gene transcription is an important factor to determine the specificity. Using the Mongolian gerbil model, we showed that the types of inflammations are important for induction of aberrant DNA methylation.
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Report
(6 results)
Research Products
(58 results)
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[Journal Article] RUNX3 expression correlates with chief cell differentiation in human gastric cancers.2009
Author(s)
Ogasawara N, Tsukamoto T, Mizoshita T, Inada KI, Ban H, Kondo S, Takasu S, Ushijima T, Ito K, ItoY, Ichinose M, Ogawa T, Joh T, Tatematsu M.
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Journal Title
Histol Histopathol 24
Pages: 31-40
Related Report
Peer Reviewed
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[Journal Article] The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae.2009
Author(s)
Nakajima, T., Yamashita, S., Maekita, T., Niwa, T., Nakazawa, K., and Ushijima, T.
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Journal Title
Int J Cancer 124
Pages: 905-910
Related Report
Peer Reviewed
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[Journal Article] RUNX3 expression correlates with chief cell differentiation in human gastric cancers.2009
Author(s)
Ogasawara, N., Tsukamoto, T., Mizoshita, T., Inada, KI., Ban, H., Kondo, S., Takasu, S., Ushijima, T., Ito, K., Ito, Y., Ichinose, M., Ogawa, T., Joh, T., and Tatematsu, M.
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Journal Title
Histol Histopathol 24
Pages: 31-40
Related Report
Peer Reviewed
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[Journal Article] A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory.2006
Author(s)
Murayama A, Sakura K, Nakama M, Yasuzawa-Tanaka K, Fujita E, Tateishi Y, Wang Y, Ushijima T, Baba T, Shibuya K, Shibuya A, Kawabe Y, Yanagisawa J.
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Journal Title
EMBO J 25
Pages: 1081-1092
Related Report
Peer Reviewed
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[Journal Article] Genome-wide profiling of promoter methylation in human.2006
Author(s)
Hatada I, Fukasawa M, Kimura M, Morita S, Yamada K, Yoshikawa T, Yamanaka S, Endo C, Sakurada A, Sato M, Kondo T, Horii A, Ushijima T, Sasaki H.
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Journal Title
Oncogene 25
Pages: 3059-3064
NAID
Related Report
Peer Reviewed
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[Presentation] Expression and methylation changes of APC 1A and 1B in gastric carcinogenesis.2008
Author(s)
Hosoya, K., Yamashita, S., Ando, T., Nakajima, T., Nakanishi, Y., Itoh, F., and Ushijima, T.
Organizer
67^<th> JCA meeting
Place of Presentation
Nagoya
Year and Date
2008-10-28
Related Report
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[Presentation] DNA methylation induction by Helicobacter pylori infection in human gastric mucosae and target gene specificity.2008
Author(s)
Nakajima, T., Yamashita, S., Maekita, T., Niwa, T., Nakazawa, K., and Ushijima, T.
Organizer
67^<th> JCA meeting
Place of Presentation
Nagoya
Year and Date
2008-10-28
Related Report
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