Signaling of intrinsic angiogenesis inhibition in cancer tissues

• Project/Area Number: 17014006
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tohoku University
• Principal Investigator: SATO Yasufumi Tohoku University, 加齢医学研究所, 教授 (50178779)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥56,900,000 (Direct Cost: ¥56,900,000); Fiscal Year 2009: ¥11,400,000 (Direct Cost: ¥11,400,000); Fiscal Year 2008: ¥11,400,000 (Direct Cost: ¥11,400,000); Fiscal Year 2007: ¥11,400,000 (Direct Cost: ¥11,400,000); Fiscal Year 2006: ¥11,400,000 (Direct Cost: ¥11,400,000); Fiscal Year 2005: ¥11,300,000 (Direct Cost: ¥11,300,000)
• Keywords: 腫瘍血管新生 / 内因性調節因子 / vasohibin-1 / vasohibin-2 / Vasobihin-1 / ELISA / Vasohibin-1 KOマウス / Vasohibin-2 / Vasohibin-1 / 乳癌 / SVBP / Glu-チューブリン / チューブリンチロシンリガーゼ / 微小管 / 細胞遊走 / 子宮体癌 / 非小細胞肺癌 / バイオマーカー / 標的遺伝子 / VEGF 1 型受容体 / 血管内皮細胞 / 壁細胞 / 成熟血管 / リンパ管新生 / 血管新生抑制因子 / vasohibin / VEGF

Research Abstract

The role of vasohibin-1(VASH-1), a negative feedback regulator of angiogenesis synthesized by endothelial cells(ECs), and vasohibin-2(VASH-2) which antagonizes VASH-1 was studied. Pathological analysis revealed that VASH-1 was present in ECs in tumor vessels, which was correlated with VEGF in cancer cells, pathological grading, and proliferation rate of cancer cells. Animal models revealed that endogenous VASH-1 regulates tumor angiogenesis, but exogenous supplementation of VASH-1 further exhibited anti-angiogenic and anti-lymphangiogenic activities and inhibited tumor growth and lymph node metastasis. VASH-2 was shown in mononuclear cells infiltrating in cancer stroma as well as in cancer cells, and VASH-2 promoted tumor growth by stimulating angiogenesis.

Research Products

• [Journal Article] Endogenous angiogenesis inhibitor vasohibin1 exhibits a broad-spectrum anti-lymphangiogenic activity and suppresses lymph node metastasis (2010)
  • Author(s): Heishi T, Hosaka T, Suzuki Y, Miyashita H, Oike Y, Takahashi T, Nakamura T, Arioka S, Mitsuda Y, Takakura T, Hojo K, Matsumoto M, Yamauchi C, Ohta H, Sonoda H, Sato Y.
  • Journal Title: Am. J. Pathol 176 Pages: 1950-1958
  • Peer Reviewed
• [Journal Article] Vasohibin-1 as a potential predictor of aggressive behavior of ductal carcinoma in situ of the breast (2010)
  • Author(s): Tamaki K, Sasano H, Maruo Y, Takahashi Y, Miyashita M, Moriya T, Sato Y, Hirakawa H, Tamaki N, Watanabe M, Ishida T, Ohuchi N.
  • Journal Title: Cancer Sci 101 Pages: 1051-1058
  • NAID: 10026591529
  • Peer Reviewed
• [Journal Article] Pigpen, a nuclear coiled body component protein is involved in angiogenesis (2010)
  • Author(s): Yoshida T, Sato Y, Morita I, Abe M.
  • Journal Title: Cancer Sci 101 Pages: 1170-1176
  • NAID: 10026592141
  • Peer Reviewed
• [Journal Article] Acyclic retinoid inhibits angiogenesis via suppressing MAPK pathway (2010)
  • Author(s): Komi Y, Sogabe Y, Ishibashi N, Sato Y, Moriwaki H, Shimokado K, Kojima S.
  • Journal Title: Lab. Invest 90 Pages: 52-60
  • Peer Reviewed
• [Journal Article] tility of vascular endothelial cells by Chondromodulin-I, a cartilage-derived angiogenesis inhibitor (2010)
  • Author(s): Miura S, Mitsui K, Heishi T, Shukunami C, Sekiguchi K, Kondo J, Sato Y, Hiraki Y.
  • Journal Title: Exp Cell Res 316 Pages: 775-788
  • Peer Reviewed
• [Journal Article] Endogenous angiogenesis inhibitor vasohibinl exhibits a broad-spectrum anti-lymphangiogenic activity and suppresses lymph node metastasis (2010)
  • Author(s): Heishi T, Hosaka T, Suzuki Y, Miyashita H, Oike Y, Takahashi T, Nakamura T, Arioka S, Mitsuda Y, Takakura T, Hojo K, Matsumoto M, Yamauchi C, Ohta H, Sonoda H, Sato Y.
  • Journal Title: Am.J.Pathol. 176 Pages: 1950-1958
  • Peer Reviewed
• [Journal Article] Vasohibin-1 as a potential predictor of aggressive behavior of ductal carcinoma in situ of the breast (2010)
  • Author(s): Tamaki K, Sasano H, Maruo Y, Takahashi Y, Miyashita M, Moriya T, Sato Y, Hirakawa H, Tamaki N, Watanabe M, Ishida T, Ohuchi N.
  • Journal Title: Cancer Sci. 101 Pages: 1051-1058
  • NAID: 10026591529
  • Peer Reviewed
• [Journal Article] Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by Chondromodulin-I, a cartilage-derived angiogenesis inhibitor (2010)
  • Author(s): Miura S, Mitsui K, Heishi T, Shukunami C, Sekiguchi K, Kondo J, Sato Y, Hiraki Y.
  • Journal Title: Exp Cell Res. 316 Pages: 775-788
  • Peer Reviewed
• [Journal Article] Acyclic retinoid inhibits angiogenesis via suppressing MAPK pathway (2010)
  • Author(s): Komi Y, Sogabe Y, Ishibashi N, Sato Y, Moriwaki H, Shimokado K, Kojima S.
  • Journal Title: Lab.Invest. 90 Pages: 52-60
  • Peer Reviewed
• [Journal Article] Pigpen, a nuclear coiled body component protein is involved in angiogenesis (2010)
  • Author(s): Yoshida T, Sato Y, Morita I, Abe M.
  • Journal Title: Cancer Sci. (Epub ahead of print)
  • NAID: 10026592141
  • Peer Reviewed
• [Journal Article] Vasohibin-1 in human breast carcinoma: a potential negative feedback regulator of angiogenesis (2009)
  • Author(s): Tamaki K, Moriya T, Sato Y, Ishida T, Maruo Y, Yoshinaga K, Ohuchi N, Sasano H.
  • Journal Title: Cancer Sci 100 Pages: 88-94
  • NAID: 10025141428
  • Peer Reviewed
• [Journal Article] Transcriptional silencing of ETS-1 efficiently suppresses angiogenesis of pancreatic cancer (2009)
  • Author(s): Lefter, L. P, Dima, S., Sunamura, M., Furukawa, T., Sato, Y., Abe, M., Chivu, M., Popescu, I., Horii, A
  • Journal Title: Cancer Gene Ther 16 Pages: 137-148
  • Peer Reviewed
• [Journal Article] Vitreous levels of vasohibin-1 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy (2009)
  • Author(s): Sato H, Abe T, Wakusawa R, Asai N, Kunikata H, Ohta H, Sonoda H, Sato Y, Nishida K.
  • Journal Title: Diabetologia 52 Pages: 359-361
  • Peer Reviewed
• [Journal Article] A possible role of vimentin on the cell surface for the activation of latent transforming growth factor-β (2009)
  • Author(s): Nishida Y, Shibata K, Yamasaki M, Sato Y, Abe M
  • Journal Title: FEBS Lett 583 Pages: 308-312
  • Peer Reviewed
• [Journal Article] Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population (2009)
  • Author(s): Naito H, Kidoya H, Sato Y, Takakura N
  • Journal Title: J. Biochem 145 Pages: 653-659
  • NAID: 10025589080
  • Peer Reviewed
• [Journal Article] Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis (2009)
  • Author(s): Kimura H, Miyashita H, Suzuki Y, Kobayashi M, Watanabe K, Sonoda H, Ohta H, Fujiwara T, Shimosegawa T, Sato Y
  • Journal Title: Blood 113 Pages: 4810-4818
  • Peer Reviewed
• [Journal Article] Vasohibin-1 expressed in endothelium of tumor vessels regulates angiogenesis (2009)
  • Author(s): Hosaka T, Kimura H, Heishi T, Suzuki Y, Miyashita H, Ohta H, Sonoda H, Moriya T, Suzuki S, Kondo T, Sato Y.
  • Journal Title: Am. J. Pathol 175 Pages: 430-439
  • Peer Reviewed
• [Journal Article] Suppression of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis (2009)
  • Author(s): Taniguchi K, Sasaki K, Watari K, Yasukawa H, Imaizumi T, Ayada T, Okamoto F, Ishizaki T, Kato R, Kohno R, Kimura H, Sato Y, Ono M, Yonemitsu Y, Yoshimura A
  • Journal Title: PLoS ONE 4
  • Peer Reviewed
• [Journal Article] Vasohibin-1, a negative feedback regulator of angiogenesis, ameliorates renal alterations in a mouse model of diabetic nephropathy (2009)
  • Author(s): Nasu T, Maeshima Y, Kinomura M, Hirokoshi-Kawahara K, Tanabe K, Sugiyama H, Sonoda H, Sato Y, Makino H
  • Journal Title: Diabetes 58 Pages: 2365-2375
  • NAID: 130004505699
  • Peer Reviewed
• [Journal Article] The effect of recombinant PlGF-2 on hypertension induced by full-length mouse sFlt-1 adenoviral vector in pregnant mice (2009)
  • Author(s): Suzuki H, Ohkuchi A, Matsubara S, Takei Y, Murakami M, Shibuya M, Suzuki M, Sato Y
  • Journal Title: Hypertension 54 Pages: 1129-1135
  • Peer Reviewed
• [Journal Article] Inflammatory Cytokine-induced Expression of Vasohibin-1 by Rheumatoid Synovial Fibroblasts (2009)
  • Author(s): Miyake K, Nishida K, Kadota Y, Yamasaki H, Nasu T, Saitou D, Tanabe K, Sonoda H, Sato Y, Maeshima Y, Makino H.
  • Journal Title: Acta Medica Okayama 63 Pages: 349-58
  • NAID: 120002312449
  • Peer Reviewed
• [Journal Article] The effect of recombinant PlGF-2 on hypertension induced by full-length mouse sFlt-1 adenoviral vector in pregnant mice (2009)
  • Author(s): Suzuki H, Ohkuchi A, Matsubara S, Takei Y, Murakami M, Shibuya M, Suzuki M, Sato Y.
  • Journal Title: Hypertension 54 Pages: 1129-1135
  • Peer Reviewed
• [Journal Article] Suppression of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis (2009)
  • Author(s): Taniguchi K, Sasaki K, Watari K, Yasukawa H, Imaizumi T, Ayada T, Okamoto F, Ishizaki T, Kato R, Kohno R, Kimura H, Sato Y, Ono M, Yonemitsu Y, Yoshimura A.
  • Journal Title: PLoS ONE 4
  • Peer Reviewed
• [Journal Article] Vasohibin-1 expressed in endothelium of tumor vessels regulates angiogenesis (2009)
  • Author(s): Hosaka T, Kimura H, Heishi T, Suzuki Y, Miyashita H, Ohta H, Sonoda H, Moriya T, Suzuki S, Kondo T, Sato Y.
  • Journal Title: Am.J.Pathol. 175 Pages: 430-439
  • Peer Reviewed
• [Journal Article] Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis (2009)
  • Author(s): Kimura H, Miyashita H, Suzuki Y, Kobayashi M, Watanabe K, Sonoda H, Ohta H, Fujiwara T, Shimosegawa T, Sato Y.
  • Journal Title: Blood 113 Pages: 4810-4818
  • Peer Reviewed
• [Journal Article] Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population (2009)
  • Author(s): Naito H, Kidoya H, Sato Y, Takakura N.
  • Journal Title: J.Biochem. 145 Pages: 653-659
  • NAID: 10025589080
  • Peer Reviewed
• [Journal Article] Vasohibin-1 expressed in endothelium of tumor vessels regulates angiogenesis (2009)
  • Author(s): Hosaka T, Kimura H, Heishi T, Suzuki Y, Miyashita H, Ohta H, Sonoda H, Moriya T, Suzuki S, Kondo T, Sato Y
  • Journal Title: Am J Pathol. 2009 (accepted for publication)
  • Peer Reviewed
• [Journal Article] Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis (2009)
  • Author(s): Kimura H, Miyashita H, Suzuki Y, Kobayashi M, Watanabe K, Sonoda H, Ohta H, Fujiwara T, Shimosegawa T and Sato Y
  • Journal Title: Blood (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population (2009)
  • Author(s): Naito H, Kidoya H, Sato Y, and Takakura N
  • Journal Title: J. Biochem (Epub ahead of print)
  • NAID: 10025589080
  • Peer Reviewed
• [Journal Article] A possible role of vimentin on the cell surface for the activation of latent transforming growth factor-β (2009)
  • Author(s): Nishida Y, Shibata K, Yamasaki M, Sato Y, and Abe M
  • Journal Title: FEBS Lett 583 Pages: 308-312
  • Peer Reviewed
• [Journal Article] Vitreous levels of vasohibin-1 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy (2009)
  • Author(s): Sato H, Abe T, Wakusawa R, Asai N, Kunikata H, Ohta H, Sonoda H, Sato Y, and Nishida K
  • Journal Title: Diabetologia 52 Pages: 359-361
  • Peer Reviewed
• [Journal Article] Transcriptional silencing of ETS-1 efficiently suppresses angiogenesis of pancreatic cancer (2009)
  • Author(s): Lefler LP, Dima S, Sunamura M, Furukawa T, Sato Y, Abe M, Chivu M, Popescu I, and Horii A
  • Journal Title: Cancer Gene Ther 16 Pages: 137-148
  • Peer Reviewed
• [Journal Article] Vasohibin-1 in human breast carcinoma : a potential negative feedback regulator of angiogenesis (2009)
  • Author(s): Tamaki K, Moriya T, Sato Y, Ishida T, Maruo Y, Yoshinaga K, Ohuchi N, Sasano H
  • Journal Title: Cancer Sci 100 Pages: 88-94
  • NAID: 10025141428
  • Peer Reviewed
• [Journal Article] Vasohibin, a novel endothelium-derived angiogenesis inhibitor: its expression on endometrial carcinoma in relation to tumor vascularity (2008)
  • Author(s): Yoshinaga, K., Moriya, T., Nagase, S., Takano, T., Niikura, H., Ito, K., Yaegashi, N., Sato, Y
  • Journal Title: Cancer Sci 99 Pages: 914-919
  • Peer Reviewed
• [Journal Article] Expression of vasohibin, an antiangiogenic factor, in human choroidal neovascular membranes (2008)
  • Author(s): Wakusawa, R., Abe, T., Sato, H., Yoshida, M., Kunitaka, H., Sato, Y., Nishida K
  • Journal Title: Am. J. Ophthalmol 146 Pages: 235-243
  • Peer Reviewed
• [Journal Article] Expression of vasohibin, an antiangiogenic factor, in human choroidal neovascular membranes (2008)
  • Author(s): Wakusawa, R., Abe, T., Sato, H., Yoshida, M., Kunitaka, H., Sato, Y., and Nishida K
  • Journal Title: Am. J. Ophthalmol 146 Pages: 235-243
  • Peer Reviewed
• [Journal Article] Vasohibin, a novel endothelium-derived angiogenesis inhibitor : its expression on endometrial carcinoma in relation to tumor vascularity (2008)
  • Author(s): Yoshinaga, K., Moriya, T., Nagase, S., Takano, T., Niikura, H., Ito, K., Nobuo Yaegashi, N., and Sato, Y
  • Journal Title: Cancer Sci 99 Pages: 914-919
  • Peer Reviewed
• [Journal Article] Vasohibin, a novel endothelium-derived angiogenesis inhibitor: its expression on endometrial carcinoma in relation to tumor vascularity. (2008)
  • Author(s): Yoshinaga, K., Moriya, T., Nagase, S., Takano, T., Niikura, H., Ito, K., Nobuo Yaegashi, N., and Sato, Y.
  • Journal Title: Cancer Sci. 99 Pages: 914-919
  • Peer Reviewed
• [Journal Article] VEGFR1 for lymphangiogenesis: an alternative signaling pathway? (2008)
  • Author(s): Sato, Y.
  • Journal Title: Arterioscler. Thromb. Vasc. Biol. 28 Pages: 604-605
  • Peer Reviewed
• [Journal Article] Puromycin insensitive leucyl-specific aminopeptidase (PILSAP) affects RhoA activation in endothelial cells (2007)
  • Author(s): Suzuki, T., Abe, M., Miyashita, H., Kobayashi, T., Sato, Y
  • Journal Title: J. Cell. Physiol 211 Pages: 708-715
  • Peer Reviewed
• [Journal Article] Puromycin insensitive leucyl-specific aminopeptidase (PILSAP) affects RhoA activation in endothelial cells. (2007)
  • Author(s): Suzuki, T., Abe, M., Miyashita, H., Kobayashi, T., and Sato, Y.
  • Journal Title: J. Cell. Physiol. 211 Pages: 708-715
  • Peer Reviewed
• [Journal Article] All-trans retinoic acid induces in vitro angiogenesis via retinoic acid receptor: Possible involvement of paracrine effects of endogenous vascular endothelial growth factor signaling. (2007)
  • Author(s): Saito, A., Sugawara, A., Uruno, A., Kudo, M., Kagechika, H., Sato, Y., Owada, Y., Kondo, H., Sato, M., Kurabayashi, M., Imaizumi, M., Tsuchiya, S., and Ito, S.
  • Journal Title: Endocrinology 148 Pages: 1412-1423
  • Peer Reviewed
• [Journal Article] The vasohibin family : a negative regulatory system of angiogenesis genetically programmed in endothelial cells. (2007)
  • Author(s): Sato, Y., Sonoda, H.
  • Journal Title: Arterioscler. Thromb. Vasc. Biol. 27 Pages: 37-41
  • NAID: 120003728251
• [Journal Article] Vasohibin is Up-regulated by VEGF in the Retina and Suppresses VEGF receptor 2 and Retinal Neovascularization (2006)
  • Author(s): Shen, JK., Yang, XR., Sato, Y., Campochiaro, PA.
  • Journal Title: FASEB J 20 Pages: 723-725
  • Peer Reviewed
• [Journal Article] Isolation and characterization of vasohibin-2 as a homologue of VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin (2006)
  • Author(s): Shibuya, T., Watanabe, K., Yamashita, H., Shimizu, K., Miyashita, H., Abe, M., Moriya, T., Ohta, H., Sonoda, H., Shimosegawa, T., Tabayashi, K., Sato, Y
  • Journal Title: Arterioscler. Thromb. Vasc. Biol 26 Pages: 1051-1057
  • Peer Reviewed
• [Journal Article] Vasohibin prevents arterial neointimal formation through angiogenesis inhibition (2006)
  • Author(s): Yamashita, H., Abe, M., Watanabe, K., Shimizu, K., Moriya, T., Sato, A., Satomi, S., Ohta, H., Sonoda, H., Sato, Y
  • Journal Title: Biochem. Biophys. Res. Commun 345 Pages: 919-925
  • Peer Reviewed
• [Journal Article] Metronomic scheduling of a cyclic hexapeptide RA-VII for anti-angiogenesis, tumor vessel maturation, and anti-tumor activity (2006)
  • Author(s): Koizumi, T., Abe, M., Yamakuni, T., Ohizumi, Y., Hitotsuyanagi, Y., Takeya, K., Sato, Y
  • Journal Title: Cancer Sci 97 Pages: 665-674
  • NAID: 10018175872
  • Peer Reviewed
• [Journal Article] Puromycin insensitive leucyl-specific aminopeptidase (PILSAP) is required for the development of vascular as well as hematopoietic system in embryoid bodies (2006)
  • Author(s): Abe M., Sato, Y
  • Journal Title: Genes Cells 11 Pages: 719-729
  • Peer Reviewed
• [Journal Article] Vasohibin prevents arterial neointimal formation through angiogensis inhibition. (2006)
  • Author(s): Yamashita, H., Abe, M., Watanabe, K., Shimizu, K., Moriya, T., Sato, A., Satomi, S., Ohta, H., Sonoda, H., Sato, Y.
  • Journal Title: Biochem. Biophys. Res. Commun. 345 Pages: 919-925
• [Journal Article] Multiple processing forms and their biological activities of a novel angiogenesis inhibitor vasohibin. (2006)
  • Author(s): Sonoda, H., Ohta, H., Watanabe, K., Yamashita, H., Kimura H., Sato, Y.
  • Journal Title: Biochem. Biophys. Res. Commun. 342 Pages: 640-646
• [Journal Article] Update on endogenous inhibitors of angiogensis. (2006)
  • Author(s): Sato, Y.
  • Journal Title: Endothelium 13 Pages: 147-155
• [Journal Article] Multiple processing forms and their biological activities of a novel angiogenesis inhibitor vasohibin. (2006)
  • Author(s): Sonoda, H., Ohta, H., Watanabe, K., Yamashita, H., Kimura H., Sato, Y.
  • Journal Title: Biochem.Biophys.Res.Commun. 342 Pages: 640-646
• [Journal Article] Vasohibin is Up-regulated by VEGF in the Retina an Suppresses VEGF receptor 2 and Retinal Neovascularization. (2006)
  • Author(s): Shen, JK., Yang, XR., Sato, Y., Campochiaro, PA.
  • Journal Title: FASEB J. in press
• [Journal Article] Isolation and characterization of vasohibin-2 as a homologue of VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin. (2006)
  • Author(s): Shibuya, T., Watanabe, K., Yamashita, H., Shimizu, K., Miyashita H., Abe M., Moriya, T., Ohta, H., Sonoda, H., Shimosegawa, T., Tabayashi K., Sato, Y.
  • Journal Title: Arterioscl.Thromb.Vasc.Biol. in press
• [Journal Article] Update on endogenous inhibitors of angiogenesis. (2006)
  • Author(s): Sato Y
  • Journal Title: Endothelium (in press)
• [Presentation] The Significance of Vasohibin, an Angiogenesis Inhibitor Expressed in Endothelium, in Cancers and Other Pathological Conditions (2009)
  • Author(s): Sato Y
  • Organizer: NHRI Conference Series 2009 International Conference on Vascular Biology
  • Place of Presentation: Zhunan, Taiwan
  • Year and Date: 2009-10-31
• [Presentation] Vasohibin expressed in endothelium of tumor blood vessels regulates angiogenesis (2009)
  • Author(s): Hosaka T, Kimura H, Heishi T, Suzuki Y, Miyashita H, Ohta H, Sonoda H, Moriya T, Suzuki S, Kondo T, Sato Y
  • Organizer: 7th International Symposium on the Biology of Endothelial Cells
  • Place of Presentation: Vienna, Austria
• [Presentation] Vasohibin expressed in endothelium of tumor vessels regulates angiogenesis (2009)
  • Author(s): 佐藤靖史
  • Organizer: 7^<th> International Symposium on the biology of endothelial cells
  • Place of Presentation: Viena, Austria
• [Presentation] Distinctive Localization and Opposed Roles of Vasohibin-1 and Vasohibin-2 in the Reculation of Angiogenesis (2009)
  • Author(s): 木村洋, 宮下浩輝, 鈴木康弘, 小林美穂, 渡辺和秀, 園田光, 大田英樹, 藤原隆, 下瀬川徹, 佐藤靖史
  • Organizer: 10th International Symposium on Mechanisms of Vasodilatation
  • Place of Presentation: 松島
• [Presentation] Vasohibin-1 Prevents Cellular Senescence and Maintains Vascular Endothelial Cells (2009)
  • Author(s): 宮下浩輝, 佐藤靖史
  • Organizer: 10th International Symposium on Mechanisms of Vasodilatation
  • Place of Presentation: 松島
• [Presentation] Vasohibin-1-induced detyronation of α-tubulin triggers an inhibition of endothelial cell migration (2009)
  • Author(s): 小林美穂, 鈴木康弘, 佐藤靖史
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] The roles of vasohibin, an intrinsic antiogenesis inhibitor, in cervical carcinomas (2009)
  • Author(s): 吉永浩介, 伊藤潔, 八重樫伸生, 佐藤靖史, 笹野公伸, 太田英樹, 園田光
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 血管を維持する内因性調節機構 (2009)
  • Author(s): 佐藤靖史
  • Organizer: 第17回日本血管細胞生物医学会
  • Place of Presentation: 東京
• [Presentation] 血管新生抑制因子Vasohibin-1はチューブリンの脱チロシン化を誘導することで内皮細胞の遊走阻害を引き起こす (2009)
  • Author(s): 小林美穂, 鈴木康弘, 佐藤靖史
  • Organizer: 第17回日本血管細胞生物医学会
  • Place of Presentation: 東京
• [Presentation] The significance of vasohibin, an angiogenesis inhibitor expressed in endothelium, in cancers and other pathological conditions (2009)
  • Author(s): 佐藤靖史
  • Organizer: NHRI Conference Series 2009 International Conference on Vascular Biology
  • Place of Presentation: Zhunan, Taiwan
• [Presentation] Vasohibin-2 Expressed in Tumors Accelerates Tumor Growth by Promoying Angiogenesis (2009)
  • Author(s): 高橋詳史, 中村崇宣, 小林美穂, 鈴木康弘, 宮下浩輝, 佐藤靖史
  • Organizer: The 1st International Global COE Symposium
  • Place of Presentation: 仙台
• [Presentation] Common molecular basis for the regulation of angiogenesis and vascular aging (2009)
  • Author(s): 佐藤靖史
  • Organizer: 第4回研究所ネットワーク国際シンポジウム
  • Place of Presentation: 大阪
• [Presentation] がんにおける血管新生制御の分子基盤 (2009)
  • Author(s): 佐藤靖史
  • Organizer: 平成20年度がん特定領域研究5領域合同シンポジウム
  • Place of Presentation: 東京
• [Presentation] 血管新生制御の分子基盤From Bench to Bedside (2008)
  • Author(s): 佐藤靖史
  • Organizer: 第7回婦人科がん分子標的研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-07-18
• [Presentation] The Role of Vasohibin in the Regulation of Tumor Angiogenesis. 9th International Conference Angiogenesis (2008)
  • Author(s): Sato Y
  • Organizer: Basic Science and Clinical Applications
  • Place of Presentation: Patras, Greece
  • Year and Date: 2008-06-25
• [Presentation] The Role of Vasohibin in the Regulation of Angiogenesis (2008)
  • Author(s): Sato Y
  • Organizer: 15th International Vascular Biology Meeting
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2008-06-05
• [Presentation] 血管新生制御学の分子基盤〜From Bench to Beside (2008)
  • Author(s): 佐藤靖史
  • Organizer: 第1回消化器がん先進治療研究会学術セミナー
  • Place of Presentation: 東京
  • Year and Date: 2008-04-24
• [Presentation] Vasohibin Suppresses Lymph Node Metastasis via the Inhibition of Lymphangiogenesis in Mice (2008)
  • Author(s): Heishi T, Miyashita H, Takahashi T, Oike Y, Sato Y
  • Organizer: 15th International Vascular Biology Meeting
  • Place of Presentation: Sydney, Australia
• [Presentation] 血管内皮細胞におけるvasohibin-1の標的遺伝子の解析 (2008)
  • Author(s): 宮下浩輝、佐藤靖史
  • Organizer: 第81回日本組織培養学会大会
  • Place of Presentation: つくば
• [Presentation] The Role of Vasohibin in the Regulatidn of Tumor Angiogenesis (2008)
  • Author(s): Sato, Y
  • Organizer: 9th International Conference Angiogenesis : Basic Science and Clinical Applications
  • Place of Presentation: Patras, Greece
• [Presentation] 内因性血管新生抑制因子と癌 (2008)
  • Author(s): 佐藤靖史
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] Vasohibin結合性低分子量蛋白SVBPの単離とその分泌における役割 (2008)
  • Author(s): 鈴木康弘、小林美穂、宮下浩輝、太田英樹、園田光、佐藤靖史
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] Isolation of a small Vasohibin-binding protein(SVBP)and its impormant role in the secretion of Vasohibin (2008)
  • Author(s): 鈴木康弘、小林美穂、宮下浩輝、太田英樹、園田光、佐藤靖史
  • Organizer: 第16回日本血管生物医学会学術総会
  • Place of Presentation: 金沢
• [Presentation] Vasohibin-1 is involved in the mainrenance of vascular endothelial cells (2008)
  • Author(s): 宮下浩輝、佐藤靖史
  • Organizer: 第16回日本血管生物医学会学術総会
  • Place of Presentation: 金沢
• [Presentation] The role of vasohibin in the regulation of angiogenesis in tumors. (2008)
  • Author(s): 佐藤靖史
  • Organizer: The U.S.-Japan Cooperative Cancer Research Program
  • Place of Presentation: 京都
• [Presentation] Vasohibin suppresses lymph node metastasis via the inhibition of lymph angiogenesis in mice. (2008)
  • Author(s): 瓶子隆弘、宮下浩輝、高橋隆、尾池雄一、佐藤靖史
  • Organizer: The U.S.-Japan Cooperative Cancer Research Program
  • Place of Presentation: 京都
• [Presentation] Role of vasohibin family in the regulation of angiogenesis (2007)
  • Author(s): Sato Y
  • Organizer: The Joint Meeting of Vascular Biology Organizations in Asia Pacific Region
  • Place of Presentation: Tainan, Taiwan
  • Year and Date: 2007-10-21
• [Presentation] The vasohibin family: novel regulators of angiogenesis and lymphangiogenesis (2007)
  • Author(s): Sato Y
  • Organizer: OLS/NUS-Tohoku/COE Joint Symposium
  • Place of Presentation: Singapore/Bintan
  • Year and Date: 2007-09-06
• [Presentation] The role of vasohibin family in the regulation of angiogenesis (2007)
  • Author(s): Sato Y
  • Organizer: Angiogenesis, Microcriculation
  • Place of Presentation: Newport, USA
  • Year and Date: 2007-08-22
• [Presentation] The role of vasohibin family in the regulation of angiogenesis (2007)
  • Author(s): Sato Y
  • Organizer: Seventh ESH Euroconference on Angiogenesis
  • Place of Presentation: Albufeira, Portugal
  • Year and Date: 2007-05-12
• [Presentation] Significence of Endothelium-derived Angiogenesis Inhibitors in Tumors (2007)
  • Author(s): Sato Y
  • Organizer: 7th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2007-01-24
• [Presentation] Vasohibin inhibits lymphangiogenesis in mouse cornea and xenograft cancer model (2007)
  • Author(s): Heishi T, Tamai T, Suzuki H, Hosaka T, Kimura H, Kobayashi M, Suzuki Y, Miyashita H, Takahashi T, Sato Y
  • Organizer: OLS/NUS-Tohoku/COE Joint Symposium
  • Place of Presentation: Singapore/Bintan
• [Presentation] The role of vasohibin family in the regulation of angiogenesis. (2007)
  • Author(s): Sato, Y.
  • Organizer: Seventh ESH Euroconference on Angiogenesis
  • Place of Presentation: Albufeira, Portugal
• [Presentation] 血管新生制御におけるvasohibin familyの役割 (2007)
  • Author(s): 佐藤靖史
  • Organizer: 第39回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] 血管新生制御におけるvasohibin familyの役割 (2007)
  • Author(s): 佐藤靖史
  • Organizer: 第28回日本炎症・再生医学会
  • Place of Presentation: 東京
• [Presentation] The role of vasohibin family in the regulation of angiogenesis. (2007)
  • Author(s): Sato, Y.
  • Organizer: Cordon Research Conference Angiogenesis & Microcirculation
  • Place of Presentation: Newport, USA
• [Presentation] 転写因子VEZFの標的遺伝子であるメタロチオネインは血管新生制御に関与する (2007)
  • Author(s): 宮下浩輝、佐藤靖史
  • Organizer: メタロチオネインおよびメタルバイオサイエンス研究会
  • Place of Presentation: 徳島
• [Presentation] 血管新生調節と疾患 (2007)
  • Author(s): 佐藤靖史
  • Organizer: 第57回日本体質医学会総会
  • Place of Presentation: 大分
• [Presentation] The role of vasohibin in the regulation of angiogenesis. (2007)
  • Author(s): 佐藤靖史
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Vasohibin inhibits lymphangiogenesis in mouse cornea and xenograft cancer model. (2007)
  • Author(s): 瓶子隆弘、保坂智子、木村洋、宮下浩輝、高橋隆、佐藤靖史
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Study on the mechanism of suppression of blood vessel formation by acyclic retinoid. (2007)
  • Author(s): Komi, Y., Sogabe, Y., Ishibashi, N., Nishiwaki, R., Moriwaki, H., Sato, Y., Shimokado, K., and Kojima, S.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Role of vasohibin family in the regulation of angiogenesis. (2007)
  • Author(s): Sato, Y.
  • Organizer: The Joint Meeting of Vascular Biology Organizations in Asia Pacific Region
  • Place of Presentation: Tainan, Taiwan
• [Presentation] リンパ管新生の内因性抑制因子に関する研究 (2007)
  • Author(s): 佐藤靖史
  • Organizer: 第15回日本血管生物医学会学術大会
  • Place of Presentation: 福岡
• [Presentation] Vasohibin familyの血管新生制御における意義 (2007)
  • Author(s): 木村洋、宮下浩輝、佐藤靖史
  • Organizer: 第15回日本血管生物医学会学術大会
  • Place of Presentation: 福岡
• [Presentation] Significance of Endothelium-derived Angiogenesis Inhibitor Vasohibin in Tumors (2006)
  • Author(s): Sato Y
  • Organizer: The Thirty-seventh International Symposium of The Princess Takamatsu Cancer Research Fund
  • Place of Presentation: Tokyo
  • Year and Date: 2006-11-16
• [Presentation] Vasohibin, a Novel Angiogenesis Inhibitor in Vascular Endothelium (2006)
  • Author(s): Sato Y
  • Organizer: 5th Congress of Asian Pacific Society of Atherosclerosis and Vascular Diseases
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2006-04-13
• [Presentation] Endogenous Inhibitors of Angiogenesis (2006)
  • Author(s): Sato Y
  • Organizer: 97th Annual Meeting of American Association for Cancer Research 2006
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2006-04-05
• [Presentation] An Endothelium-derived Angiogenesis Inhibitor Vasohibin and its Significance in Tumor Angiogenesis (2006)
  • Author(s): Sato Y
  • Organizer: 21th Bristol-myers Squibb Nagoya International Symposium on Cancer Chemotherapy
  • Place of Presentation: Nagoya
  • Year and Date: 2006-02-25
• [Presentation] An endothelium-derived angiogenesis inhibitor vasohibin and its significance in tumor angiogenesis (2006)
  • Author(s): Sato Y
  • Organizer: The 10th International Symposium on Cancer Chemotherapy
  • Place of Presentation: Tokyo
  • Year and Date: 2006-01-27
• [Presentation] Vasohibin, a novel endothelium-derived angiogenesis inhibitor: its expression on endometrial carcinoma in relation to tumor vascularity (2006)
  • Author(s): Kousuke Y, Takuya M, Satoru N, Tadao T, Hitoshi N, Kiyoshi I, Nobuo Y, Yasufumi S
  • Organizer: 97th Annual Meeting American Association for Cancer Research 2006
  • Place of Presentation: Washington DC, USA
• [Presentation] Vasohibin, a VEGF-inducible endothelium-derived angiogenesis inhibitor, may act as a terminator of angiogenesis (2006)
  • Author(s): Kimura H, Miyashita H, Ota H, Sonoda H, Shimosegawa T, Sato Y
  • Organizer: XIVth International Vascular Biology Meeting
  • Place of Presentation: Noordwijkerhout, Netherlands
• [Presentation] Application of vasohibin for prevention of adventitial angiogenesis and arterial neointimal formation (2006)
  • Author(s): Yamashita H, Abe M, Shibuya T, Watanabe K, Shimizu K, Sato Y
  • Organizer: XIVth International Symposium on Atherosclerosis
  • Place of Presentation: Rome, Italy
• [Presentation] The Endothelium-Derived Angiogenesis Inhibitor Vasohibin and its Significance in Tumor Angiogenesis (2005)
  • Author(s): Sato Y
  • Organizer: 10th Japanese-German Workshop on Molecular and Cellular Aspects on Carcinogenesis
  • Place of Presentation: Essen, Germany
  • Year and Date: 2005-09-30
• [Presentation] Transcriptome of Vascular Endothelium in Angiogenesis: Isolation and Characterization of a Novel Endothelium-Derived Angiogenesis Inhibitor, Vasohibin (2005)
  • Author(s): Sato Y
  • Organizer: The International Society on Thrombosis, Haemostasis XXth Congress
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2005-08-09
• [Presentation] An endothelium-derived angiogenesis inhibitor vasohibin and its significance in tumor angiogenesis (2005)
  • Author(s): Sato Y
  • Organizer: The Ascona Conference on Angiogenesis
  • Place of Presentation: Ascona, Switzerland
• [Presentation] A comparative study on the expression of vasohibin, an endothelium-derived negative-feedback angiogenesis regulator, and its sole homologue basohivin-2 (2005)
  • Author(s): Shibuya T, Watanabe K, Yamashita H, Shimizu K, Abe M, Moriya T, Ohta H, Sonoda H, Tabayashi K, Sato Y
  • Organizer: Japan-Korea Joint Symposium on Vascular Biology
  • Place of Presentation: Doosan, Korea
• [Book] Endogenous inhibitors of angiogenesis.(In "Angiogenesis. Basic Science and Clinical Applications") (2007)
  • Author(s): Sato, Y
  • Publisher: Transworld Research Network
• [Book] Angiogenesis: Basic Science and Clinical Applications (2007)
  • Author(s): ME Maragoudakis, E Papadimittiou (編集者)
  • Publisher: Transworld Research Network
• [Remarks]
  • URL: http://www.idac.tohoku.ac.jp/dep/vascbio/
• [Remarks]
  • URL: http://www.idac.tohoku.ac.jp/dep/vascbio/
• [Remarks]
  • URL: http://www.idac.tohoku.ac.jp/dep/vascbio/
• [Patent(Industrial Property Rights)] 抗バゾヒビンモノクローナル抗体のセット (2009)
  • Inventor(s): 佐藤靖史、近藤丘
  • Industrial Property Rights Holder: 東北大学
  • Filing Date: 2009-08-26
• [Patent(Industrial Property Rights)] 固形癌の存在の検出法 (2009)
  • Inventor(s): 佐藤靖史
  • Industrial Property Rights Holder: 東北大学
  • Industrial Property Number: 2009-190830
  • Filing Date: 2009-08-20
• [Patent(Industrial Property Rights)] 血管新生促進因子バゾヒビン2 (2009)
  • Inventor(s): 佐藤靖史
  • Industrial Property Rights Holder: 東北大学
  • Filing Date: 2009-01-28
• [Patent(Industrial Property Rights)] 抗バゾヒビンモノクローナル抗体のセット (2009)
  • Inventor(s): 佐藤靖史、近藤丘
  • Industrial Property Rights Holder: 東北大学
  • Filing Date: 2009-08-26
• [Patent(Industrial Property Rights)] バゾヒビン修飾体 (2008)
  • Inventor(s): 佐藤靖史
  • Industrial Property Rights Holder: 東北大学
  • Industrial Property Number: 2008-328406
  • Filing Date: 2008-12-24
• [Patent(Industrial Property Rights)] 抗バソヒビンモノクローナル抗体のセット (2008)
  • Inventor(s): 佐藤靖史近藤丘
  • Industrial Property Rights Holder: 東北大学塩野義製薬
  • Industrial Property Number: 2008-218581
  • Filing Date: 2008-08-27
• [Patent(Industrial Property Rights)] リンパ管新生を抑制する蛋白質 (2007)
  • Inventor(s): 佐藤靖史
  • Industrial Property Rights Holder: 東北大学
  • Filing Date: 2007-11-27
• [Patent(Industrial Property Rights)] 「バソヒビンからなるリンパ管新生抑制剤」 (2007)
  • Inventor(s): 佐藤靖史 園田光
  • Industrial Property Rights Holder: 東北大学
  • Filing Date: 2007-11-27
  • Overseas
• [Patent(Industrial Property Rights)] リンパ管新生を抑制する蛋白質 (2006)
  • Inventor(s): 佐藤靖史
  • Industrial Property Rights Holder: 東北大学
  • Filing Date: 2006-11-30