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Molecular mechanism of tumor cell growth

Research Project

Project/Area Number 17014011
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

AKIYAMA Tetsu  The University of Tokyo, 分子細胞生物学研究所, 教授 (70150745)

Co-Investigator(Kenkyū-buntansha) NASU Ryo  東京大学, 分子細胞生物学研究所, 助教 (30466859)
KAWASAKI Yoshihiro  東京大学, 分子細胞生物学研究所, 助教 (10376642)
NAKAMURA Tsutomu  東京大学, 分子細胞生物学研究所, 助教 (30302798)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥387,600,000 (Direct Cost: ¥387,600,000)
Fiscal Year 2009: ¥78,800,000 (Direct Cost: ¥78,800,000)
Fiscal Year 2008: ¥78,800,000 (Direct Cost: ¥78,800,000)
Fiscal Year 2007: ¥79,000,000 (Direct Cost: ¥79,000,000)
Fiscal Year 2006: ¥79,000,000 (Direct Cost: ¥79,000,000)
Fiscal Year 2005: ¥72,000,000 (Direct Cost: ¥72,000,000)
Keywordsがん抑制遺伝子 / がん遺伝子 / アポトーシス / 増殖 / p53 / APC / Asef / がん幹細胞 / Wnt / 細胞がん化 / 細胞運動・浸潤 / beta-catenin / カドヘリン / RICS / 癌抑制遺伝子 / 神経突起伸長 / 血管新生 / GEF / G蛋白質 / Dlg / 細胞運動 / Sam68 / B9L / β-catenin
Research Abstract

We identified D8 as a p53 target gene and found that D8 is involved in genome stress-induced apoptotic cell death. We also identified Asef and Asef2, guanine nucleotide exchange factors that are activated by the tumor suppressor APC, and found that they are critically involved in intestinal adenoma formation and tumor progression and may be promising molecular targets for therapy of colorectal tumors.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report

Research Products

(79 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book Remarks Patent(Industrial Property Rights)

  • [Journal Article] The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis.2010

    • Author(s)
      Kawasaki Y., Jigami T., Furukawa S., Sagara M., Echizen K., Shibata Y., Sato R., Akiyama T.
    • Journal Title

      J Biol Chem. 285

      Pages: 1199-207

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sunspot, a link between Wingless signaling and endoreplication in Drosophila.2010

    • Author(s)
      Taniue K., Nishida A., Hamada F., Sugie A., Oda T., Ui-Tei K., Tabata T., Akiyama T.
    • Journal Title

      Development 137

      Pages: 1755-1764

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis2010

    • Author(s)
      Kawasaki Y
    • Journal Title

      J Biol Chem. 285

      Pages: 1199-207

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sunspot, a link between Wingless signaling and endoreplication in Drosophila2010

    • Author(s)
      K.Taniue
    • Journal Title

      Development 137

      Pages: 1755-1764

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of LKB1 in epithelial-mesenchymal transition(EMT)of human lung cancer cells2010

    • Author(s)
      Kohno T
    • Journal Title

      Lung cancer (掲載確定, in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The PX-RICS/14-3-3ζ/θ complex couples N-cadherin/β-catenin with dynein/dynactin to mediate its export from the endoplasmic reticulum2010

    • Author(s)
      T.Nakamura
    • Journal Title

      J.Biol.Chem (掲載確定, in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration.2009

    • Author(s)
      Sagara M., Kawasaki Y., Iemura S., Natsume T., Takai Y., Akiyama T.
    • Journal Title

      Oncogene 28

      Pages: 1357-1365

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] APC and Asef function downstream of the HGF receptor and phosphatidylinositol 3-kinase.2009

    • Author(s)
      Kawasaki Y., Tsuji S., Sagara M., Echizen K., Shibata Y., Akiyama T.
    • Journal Title

      J. Biol. Chem. 284

      Pages: 22436-22443

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The APC-associated exchange factors Asef and Asef2 are required for adenoma formation in ApcMin/+ mice.2009

    • Author(s)
      Kawasaki Y., Tsuji S., Muroya K., Furukawa S., Shibata Y., Okuno M., Ohwada S., Akiyama T.
    • Journal Title

      EMBO Rep. 10

      Pages: 1355-1362

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration2009

    • Author(s)
      Sagara M.
    • Journal Title

      Oncogene 28

      Pages: 1357-1365

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene set-based module discovery in the breast cancer transcriptome2009

    • Author(s)
      Niida A.
    • Journal Title

      BMC Bioinformatics 10

      Pages: 71-71

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] APC and Asef function downstream of the HGF receptor and phosphatidylinositol 3-kinase2009

    • Author(s)
      Kawajiri K
    • Journal Title

      J.Biol.Chem. 284

      Pages: 22436-22443

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands2009

    • Author(s)
      Kawajiri K
    • Journal Title

      Proc Natl Acad Sci USA. 106

      Pages: 13481-13486

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The transmembrane nucleoporin NDC1 is required for targeting of ALADIN to nuclear pore complexes2009

    • Author(s)
      Yamazumi, Y
    • Journal Title

      Biochem.Biophys.Res.Commun. 389

      Pages: 100-104

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The APC-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc^<Min/+> mice2009

    • Author(s)
      Kawasaki, Y.
    • Journal Title

      EMBO Rep. 27

      Pages: 1355-1362

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration2009

    • Author(s)
      Sagara M.
    • Journal Title

      Oncogene 14

      Pages: 14-14

    • Related Report
      2008 Annual Research Report
  • [Journal Article] PX-RICS mediates ER-to-Golgi transport of the N-cadherin/-catenin complex.2008

    • Author(s)
      Nakamura T., Hayashi T., Nasu-Nishimura Y., Sakaue F., Okabe T., Ohwada S., Matsuura K., Akiyama T.
    • Journal Title

      Genes Dev. 22

      Pages: 1244-1256

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3β-mediated phosphorylation of β-catenin2008

    • Author(s)
      Haraguchi K.
    • Journal Title

      Oncogene 27

      Pages: 274-284

    • Related Report
      2008 Annual Research Report
  • [Journal Article] PX-RICS mediates ER-to-Golgi transport of the N-cadherin/β-catenin complex2008

    • Author(s)
      Nakamura T.
    • Journal Title

      Genes Dev. 22

      Pages: 1244-1256

    • Related Report
      2008 Annual Research Report
  • [Journal Article] A human homolog of Notum, over-expressed in hepatocellular carcinoma, is transcriptionally regulated by β-catenin/TCF2008

    • Author(s)
      Torisu, Y.
    • Journal Title

      Cancer Sci. 99

      Pages: 1139-1146

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Integrative bioinformatics analysis of transcriptional regulatory programs in breast cancer cells2008

    • Author(s)
      Niida A.
    • Journal Title

      BMC Bioinformatics. 9

      Pages: 404-404

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer2008

    • Author(s)
      Togo N.
    • Journal Title

      World J. Gastroenterol. 14

      Pages: 4880-4888

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Phosphorylation and activation of a Racl/Cdc42 guanine nucleotide exchange factor Asef in A431 cells stimulated by epidermal growth factor2008

    • Author(s)
      Itoh, R.
    • Journal Title

      J Cell Sci. 121

      Pages: 2635-2642

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Ligand-dependent interaction between estrogen receptor alpha and adenomatous polyposis coli2008

    • Author(s)
      Kouzmenko, A. P.
    • Journal Title

      Genes Cells. 13

      Pages: 723-730

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Gene set-based module discovery in the breast cancer transcriptome2008

    • Author(s)
      Niida A.
    • Journal Title

      BMC Bioinformatics 10

      Pages: 71-71

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli2008

    • Author(s)
      Kouzmenko, A. P.
    • Journal Title

      Oncogene 27

      Pages: 4888-4899

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3β-mediated phosphorylation of β-catenin.2008

    • Author(s)
      Haraguchi K.
    • Journal Title

      Oncogene 27

      Pages: 274-284

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and Characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42.2007

    • Author(s)
      Kawasaki Y., Sagara M., Shibata S., Shirouzu M., Yokoyama S., Akiyama T.
    • Journal Title

      Oncogene 26

      Pages: 7620-7627

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of the rac activator, asef, reveals its autoinhibitory mechanism.2007

    • Author(s)
      Murayama K.
    • Journal Title

      J Biol Chem. 282

      Pages: 4238-4242

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical expression of the beta-catenin-interacting protein B9L is associated with histological high nuclear grade and immunohistochemical ErbB2/HER-2 expression in breast cancers.2007

    • Author(s)
      Toya H.
    • Journal Title

      Cancer Sci. 98

      Pages: 484-490

    • Related Report
      2007 Annual Research Report 2006 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal development of urogenital organs in Dlghl-deficient mice.2007

    • Author(s)
      Iizuka-Kogo A
    • Journal Title

      Development 134

      Pages: 1799-1807

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of a BCL9-related beta-catenin-binding protein, B9L, indifferent stages of sporadic colorectal adenoma.2007

    • Author(s)
      Sakamoto I.
    • Journal Title

      Cancer Sci. 98

      Pages: 83-87

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PH-domain-mediated membrane targeting of Asef. Biochem. Biophys. Res.2007

    • Author(s)
      Muroya, K.
    • Journal Title

      Biophys. Res. Commun. 355

      Pages: 85-88

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PX-RIGS, a novel splicing variant of RIGS, is a main isoform expressed during neural development.2007

    • Author(s)
      Hayashi T.
    • Journal Title

      Genes Cells 12

      Pages: 929-939

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of the rac activator, asef, reveals its autoinhibitory mechanism.2007

    • Author(s)
      Murata-Kamiya, N.
    • Journal Title

      The Journal of biological chemistry 282

      Pages: 4238-4242

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and Characterization of Asef2, a guanine-nucleotide exchange factor specific for Racl and Cdc42.2007

    • Author(s)
      Kawasaki Y.
    • Journal Title

      Oncogene 26

      Pages: 7620-7627

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] α-catenin is essential in intestinal adenoma formation.2007

    • Author(s)
      Shibata H.
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 104

      Pages: 18199-18204

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel clusters of highly expressed genes accompany genomic amplification in breast cancers.2007

    • Author(s)
      Ito E.
    • Journal Title

      FEBS Letters 581

      Pages: 3909-3914

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of the tumor suppressor APC for the clustering of PSD-95 and AMPA receptors in hippocampal neurons.2007

    • Author(s)
      Shimomura A.
    • Journal Title

      Eur. J. Neurosci 26

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of ICAT gene function leads to arrest of ureteric bud branching and renal agenesis.2007

    • Author(s)
      Hasegaw Y.
    • Journal Title

      Biochem. Biophys. Res. Commun. 362

      Pages: 988-994

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toyama M., Terada T., Taiji M., Akiyama T., Yokoyama S. Crystal structure of the rac activator, asef, reveals its autoinhibitory mechanism.2007

    • Author(s)
      Murayama K.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 4238-4242

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Abnormal development of urogenital organs in Dlgh1-deficient mice.2007

    • Author(s)
      Iizuka-Kogo A.
    • Journal Title

      Development 134

      Pages: 1799-1807

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Up-regulation of a BCL9-related beta-catenin-binding protein, B9L, in different stages of sporadic colorectal adenoma.2007

    • Author(s)
      Sakamoto I.
    • Journal Title

      Cancer Sci. 98

      Pages: 83-87

    • Related Report
      2006 Annual Research Report
  • [Journal Article] PH-domain-mediated membrane targeting of Asef.2007

    • Author(s)
      Muroya K.
    • Journal Title

      Biochem. Biophys. Res. Commun. 355

      Pages: 85-88

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Role of the kinesin-2 family protein, KIF3, during mitosis.2006

    • Author(s)
      Haraguchi K., Hayashi T., Jimbo T., Yamamoto T., Akiyama T.
    • Journal Title

      J Biol. Chem. 281

      Pages: 4094-4099

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of the kinesin-2 family protein, KIF3, during mitosis.2006

    • Author(s)
      Haraguchi K.
    • Journal Title

      J Biol. Chem. 281

      Pages: 4094-4099

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Role of the Rho GTPase-activating protein RICS in neurite outgrowth.2006

    • Author(s)
      Nasu-Nishimura Y.
    • Journal Title

      Genes Cells 11

      Pages: 607-614

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, GATA-6 and Ldb1.2006

    • Author(s)
      Setogawa T.
    • Journal Title

      Biochem. Biophys. Res. Commun. 343

      Pages: 1186-1190

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli.2006

    • Author(s)
      Takizawa S.
    • Journal Title

      Genes Cells 11

      Pages: 453-464

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Human T-cell leukemia virus type 1 tax dysregulates β-catenin signaling.2006

    • Author(s)
      Tomita M.
    • Journal Title

      J. Virol. 80

      Pages: 10497-10505

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Wnt signaling and the actin cytoskeleton.2006

    • Author(s)
      Akiyama T.
    • Journal Title

      Oncogene 25

      Pages: 7538-7544

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.2006

    • Author(s)
      Okada K.
    • Journal Title

      Science. 312

      Pages: 1802-1805

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Role of the second-largest subunit of DNA polymerase alpha in the interaction between the catalytic subunit and hyperphosphorylated retinoblastoma protein in late S phase.2006

    • Author(s)
      Takemura M.
    • Journal Title

      Biochim Biophys Acta. 1764

      Pages: 1447-14453

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Wnt signaling and the tumor suppressor APC.2006

    • Author(s)
      Akiyama T.
    • Journal Title

      Recent Advances in Gastrointestinal Carcinogenesis

      Pages: 99-113

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Subcellular localization of the tumor suppressor protein APC in developing cultured neurons.2005

    • Author(s)
      Shimomura, A.
    • Journal Title

      Neurosci.Lett. 375

      Pages: 81-86

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cloning of novel LERGU mRNAs in GPR30 3' untranslated region and deletion of 2 bp-deletion polymorphism in gastric cancer.2005

    • Author(s)
      Kakinuma, N.
    • Journal Title

      Cancer Sci. 96

      Pages: 191-196

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Wnt signaling regulates the sequential onset of neurogenesis and gliogenesis via induction of BMPs.2005

    • Author(s)
      Kasai, M.
    • Journal Title

      Genes Cells 25

      Pages: 777-784

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Viral FLIP enhances Wnt signaling downstream of stabilized β-catenin, leading to control of cell growth.2005

    • Author(s)
      Nakagiri, S.
    • Journal Title

      Mol.Cell.Biol. 25

      Pages: 9249-9258

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The mammalian homolog of the Drosophia discs large tumor suppressor protein upregulates expression of the ELR+ CXC chemokine Scyb5.2005

    • Author(s)
      Aiba, T.
    • Journal Title

      Biochem.Biophys.Res.Commun. 337

      Pages: 191-194

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A functional link between Disrupted-in-schizophrenia 1(DISK1) and the eukaryotic translation initiation factor 3 (eIF3).Biochem.2005

    • Author(s)
      F.Ogawa
    • Journal Title

      Biochem.Biophys.Res.Commun. 338

      Pages: 771-776

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Role of the kinesin-2 family protein, KIF3, during mitosis.2005

    • Author(s)
      K.Haraguchi
    • Journal Title

      J Biol.Chem. 281

      Pages: 4094-4099

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The PX-RICS/14-3-3ζ/θcomplex couples N-cadherin/ β-catenin with dynein/dynactin to mediate its export from the endoplasmic reticulum.

    • Author(s)
      Nakamura T., Hayashi T., Mimori-Kiyosue Y., Sakaue F., Matsuura K., Imura S., Natsume T., T. Akiyama.
    • Journal Title

      J. Biol. Chem. (in press)

    • Related Report
      2009 Final Research Report
  • [Journal Article] A human homolog of Notum, over-expressed in hepatocellular carcinoma, is transcriptionally regulated by b-catenin/TCF.

    • Author(s)
      Torisu Y.
    • Journal Title

      Cancer Sci. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PX-RICS mediates ER-to-Golgi transport of the N-cadherin/b-catenin complex.

    • Author(s)
      Nakamura T.
    • Journal Title

      Genes Dev (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development.

    • Author(s)
      Hayashi T.
    • Journal Title

      Genes Cells (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Wnt signaling and the tumor suppressor APC.

    • Author(s)
      T.Akiyama
    • Journal Title

      Recent Advances in Gastrointestinal Carcinogenesis. (in press.)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Role of the Rho GTPhase-activating protein RICS in neurite outgrowth.

    • Author(s)
      Nasu-Nishimura, Y.
    • Journal Title

      Genes Cells (in press.)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, GATA-6 and Ldb1.

    • Author(s)
      Setogawa, T.
    • Journal Title

      Biochem.Biophys.Res.Commun. (in press.)

    • Related Report
      2005 Annual Research Report
  • [Presentation] Role of the APC-associated guanine nucleotide exchange factor Asef/Asef2 in intestinal adenoma formation2009

    • Author(s)
      川崎善博, 辻真之介, 室谷研, 古川史織, 大和田進, 秋山徹
    • Organizer
      分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Role of the APC-associated guanine nucleotide exchange factor Asef/Asef2 in intestinal adenoma formation2009

    • Author(s)
      川崎善博, 辻真之介, 室谷研, 古川史織大和田進, 秋山徹
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Role of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc422008

    • Author(s)
      相良将樹, 川崎善博, 秋山徹
    • Organizer
      日本癌学会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] Role of the APC-associated guanine nucleotide exchange factor Asef in signal transduction and angiogenesis2008

    • Author(s)
      川崎善博, 地神貴史, 古川史織, 相良将樹, 柴田葉子, 佐藤梨奈, 秋山徹
    • Organizer
      分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Role of the APC-associated guanine nucleotide exchange factor Asef in intestinal adenoma formation, dentification and Characterization of2007

    • Author(s)
      辻真之介, 川崎善博, 秋山徹, 相良将樹, 川崎善博, 秋山徹
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Book] 細胞・培地活用ハンドブック2007

    • Author(s)
      秋山徹, 河府和義
    • Total Pages
      397
    • Publisher
      羊土社
    • Related Report
      2009 Final Research Report
  • [Book] がん細胞の生物学2006

    • Author(s)
      高井義美, 秋山徹
    • Total Pages
      179
    • Publisher
      東京大学出版会
    • Related Report
      2009 Final Research Report
  • [Book] 阻害剤活用ハンドブック2006

    • Author(s)
      秋山徹, 河府和義
    • Total Pages
      468
    • Publisher
      羊土社
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.iam.u-tokyo.ac.jp/5ken/index.html

    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] アポトーシス誘導遺伝子およびその利用2010

    • Inventor(s)
      秋山徹
    • Industrial Property Rights Holder
      秋山徹, 大正製薬株式会社
    • Acquisition Date
      2010-03-10
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 大腸癌抑制遺伝子関連蛋白質2009

    • Inventor(s)
      秋山徹, 川崎善博
    • Industrial Property Rights Holder
      第一三共株式会社
    • Filing Date
      2009-09-10
    • Related Report
      2009 Final Research Report

URL: 

Published: 2005-03-31   Modified: 2018-03-28  

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