| Budget Amount *help |
¥69,100,000 (Direct Cost: ¥69,100,000)
Fiscal Year 2009: ¥14,200,000 (Direct Cost: ¥14,200,000)
Fiscal Year 2008: ¥14,200,000 (Direct Cost: ¥14,200,000)
Fiscal Year 2007: ¥13,200,000 (Direct Cost: ¥13,200,000)
Fiscal Year 2006: ¥13,200,000 (Direct Cost: ¥13,200,000)
Fiscal Year 2005: ¥14,300,000 (Direct Cost: ¥14,300,000)
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| Research Abstract |
The proto-oncogene Akt is a key regulator of various biological processes such as cell proliferation, survival, metabolism and motility, as well as tumorigenesis. We have shown that the serine/threonine kinase PAK serves as a scaffold protein in the Akt signaling pathway. We also found that inactivation of PAK1 reduced phosphorylation of only a subset of Akt substrates and suppressed Akt-mediated cell motility but not cell survival or protein synthesis. PAK thus appears to contribute to the signaling specificity of Akt, in addition to its signaling efficiency. PAK appears to affect the signaling specificity of Akt by regulating subcellular localization of a specific isoform of Akt as well as by associating with a subset of Akt substrates related to cell motility regulation. We are now further examining the mechanism by which Akt regulates cell motility.
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