Functions of protein kinases in tumorigenesis
| Project/Area Number |
17014012
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
GOTOH Yukiko The University of Tokyo, 分子細胞生物学研究所, 教授 (70252525)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥69,100,000 (Direct Cost: ¥69,100,000)
Fiscal Year 2009: ¥14,200,000 (Direct Cost: ¥14,200,000)
Fiscal Year 2008: ¥14,200,000 (Direct Cost: ¥14,200,000)
Fiscal Year 2007: ¥13,200,000 (Direct Cost: ¥13,200,000)
Fiscal Year 2006: ¥13,200,000 (Direct Cost: ¥13,200,000)
Fiscal Year 2005: ¥14,300,000 (Direct Cost: ¥14,300,000)
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| Keywords | Akt / がん遺伝子 / Mdm2 / 細胞運動 / 生存シグナル / アポトーシス / JNK / 14-3-3 |
|---|
| Research Abstract |
The proto-oncogene Akt is a key regulator of various biological processes such as cell proliferation, survival, metabolism and motility, as well as tumorigenesis. We have shown that the serine/threonine kinase PAK serves as a scaffold protein in the Akt signaling pathway. We also found that inactivation of PAK1 reduced phosphorylation of only a subset of Akt substrates and suppressed Akt-mediated cell motility but not cell survival or protein synthesis. PAK thus appears to contribute to the signaling specificity of Akt, in addition to its signaling efficiency. PAK appears to affect the signaling specificity of Akt by regulating subcellular localization of a specific isoform of Akt as well as by associating with a subset of Akt substrates related to cell motility regulation. We are now further examining the mechanism by which Akt regulates cell motility.
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Report
(6 results)
Research Products
(54 results)
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[Journal Article] Wnt signaling and its downstream target N-Myc regulate basal progenitors in the developing neocortex.2010
Author(s)
Kuwahara, A., Hirabayashi, Y., Knoepfler, P.S., Taketo, M.M., Sakai, J., Kodama, T., Gotoh, Y.
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Journal Title
Development 137(7)
Pages: 35-44
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Peer Reviewed
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[Journal Article] Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition.2009
Author(s)
Hirabayashi, Y., Suzki, N., Tsuboi, M., Endo, T.A., Toyoda, T., Shinga, J., Koseki, H., Vidal, M., Gotoh, Y.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1.2009
Author(s)
Oishi, K., Watatani, K., Itoh, Y., Okano, H., Guillemot, F., Nakajima, K., Gotoh, Y.
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Journal Title
Proc. Natl. Acad. Sci. USA 106
Pages: 3064-13069
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Peer Reviewed
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[Journal Article] he PI3K-Akt pathway promotes microtubule stabilization in migrating fibroblasts.2007
Author(s)
Onishi, K., Higuchi, M., Asakura, T., Masuyama, N.,, Gotoh, Y.
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Journal Title
Genes to Cells 12
Pages: 535-546
Related Report
Peer Reviewed
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[Journal Article] Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex.2006
Author(s)
Yoshimatsu, T., Kawaguchi, D., Oishi, K., Takeda, K., Akira, S., Masuyama, N., Gotoh, Y.
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Journal Title
Development 133
Pages: 2553-2563
Related Report
Peer Reviewed
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[Presentation] Regulation and function of Akt2007
Author(s)
Yukiko Gotoh
Organizer
The Federation of American Societies for Experimental Biology (FASEB), SUMMER RESEARCH CONFERENCES.
Place of Presentation
Hyatt Grand Champions Resort & Spa, Indian Wells Lane, Indian Wells, CA.
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