Regulation of cell proliferation and cell death by stress signaling in cancer

• Project/Area Number: 17014013
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: ICHIJO Hidenori The University of Tokyo, 大学院・薬学系研究科, 教授 (00242206)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥55,000,000 (Direct Cost: ¥55,000,000); Fiscal Year 2009: ¥12,800,000 (Direct Cost: ¥12,800,000); Fiscal Year 2008: ¥12,800,000 (Direct Cost: ¥12,800,000); Fiscal Year 2007: ¥9,800,000 (Direct Cost: ¥9,800,000); Fiscal Year 2006: ¥9,800,000 (Direct Cost: ¥9,800,000); Fiscal Year 2005: ¥9,800,000 (Direct Cost: ¥9,800,000)
• Keywords: ASK1 / ASK2 / MAPキナーゼ / アポトーシス / ASKファミリー / ASKI

Research Abstract

This study aimed at analyzing the mechanisms by which cancer cells acquire abnormal proliferation and death-resistant phenotypes in the context of perturbation of stress signaling. By using ASK family knockout mice, we found that stress-activated MAP kinases play pivotal roles in development and expansion of human cancer.

Research Products

• [Journal Article] Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation. (2010)
  • Author(s): Seong, H.A., Jung, H., Ichijo, H., Ha, H.
  • Journal Title: J. Biol. Chem. 285 Pages: 2397-2414
• [Journal Article] Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1(ASK1)-deficient mice (2010)
  • Author(s): Kumakura, K., et al.
  • Journal Title: Neurosci.Res. 66 Pages: 313-320
  • Peer Reviewed
• [Journal Article] Apoptosis Signal-Regulating Kinase 1 regulates colitis and colitis-associated tumorigenesis via the innate immune responses (2010)
  • Author(s): Hayakawa, Y., et al.
  • Journal Title: Gastroenterology 138 Pages: 1055-1067
  • Peer Reviewed
• [Journal Article] Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation (2010)
  • Author(s): Seong, H.A., et al.
  • Journal Title: J.Biol.Chem. 285 Pages: 2397-2414
  • Peer Reviewed
• [Journal Article] Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A. (2009)
  • Author(s): Cekic, C., Casella, C.R., Eaves, C.A., Matsuzawa, A., Ichijo, H., d Mitchell, T.C.
  • Journal Title: J. Biol. Chem. 284 Pages: 31982-31991
• [Journal Article] Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death. (2009)
  • Author(s): Nagai, H,, Noguchi, T., Homma, K., Katagiri, K., Takeda, K., Matsuzawa, A., Ichijo, H.
  • Journal Title: Mol. Cell 36 Pages: 805-818
• [Journal Article] TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis. (2009)
  • Author(s): Kundu M, Pathak SK, Kumawat K, Basu S, Chatterjee G, Pathak S, Noguchi T, Takeda K, Ichijo, H, Thien CB, Langdon WY, Basu J. A
  • Journal Title: Nat. Immunol. 10 Pages: 918-926
• [Journal Article] Mitochondrial Phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. (2009)
  • Author(s): Takeda, K., Komuro, Y., Hayakawa, T., Oguchi, H., Ishida, Y., Murakami, S., Noguchi, T., Kinoshita, H., Sekine, Y., Iemura, S., Natsume, T., Ichijo, H.
  • Journal Title: Proc. Natl. Acad. Sci. USA. 106 Pages: 12301-12305
• [Journal Article] Serine 58 of 14-3-3{zeta} is a molecular switch regulating ASK1 and oxidant stress-induced cell death. (2009)
  • Author(s): Zhou, J., Shao, Z., Kerkela, R., Ichijo, H., Muslin, A., Pombo, C., Force, T.
  • Journal Title: Mol. Cell. Biol. 29 Pages: 4167-4176
• [Journal Article] Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1. (2009)
  • Author(s): Waak, J., Weber, S.S., Gorner, K., Schall, C., Ichijo, H., Stehle, T., Kahle, P.J.
  • Journal Title: J. Biol. Chem. 284 Pages: 14245-14257
• [Journal Article] ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. (2009)
  • Author(s): Iriyama, T., Takeda, K., Nakamura, H.,Morimoto, Y., Kuroiwa, T., Mizukami, J.,Umeda, T., Noguchi, T., Naguro, I.,Nishitoh, H., Saegusa, K., Tobiume, K.,Homma, T., Shimada, Y., Tsuda, H., Aiko, S.,Imoto, I., Inazawa, J., Chida, K., Kamei, Y.,Kozuma, S., Taketani, Y., Matsuzawa, A., Ichijo, H.
  • Journal Title: EMBO J. 28 Pages: 843-853
• [Journal Article] Apoptosis Signal-Regulating Kinase(ASK)-1 Mediates Apoptosis through activation of JNK1 following Engagement of Membrane Immunoglobulin (2009)
  • Author(s): Furuhata, M.
  • Journal Title: Exp.Cell.Res. 315 Pages: 3467-3476
  • Peer Reviewed
• [Journal Article] Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A (2009)
  • Author(s): Cekic, C., et al.
  • Journal Title: J.Biol.Chem. 284 Pages: 31982-31991
  • Peer Reviewed
• [Journal Article] Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death (2009)
  • Author(s): Nagai, H, et al.
  • Journal Title: Mol.Cell 36 Pages: 805-818
  • Peer Reviewed
• [Journal Article] A TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis (2009)
  • Author(s): Kundu M, et al.
  • Journal Title: Nat.Immunol. 10 Pages: 918-926
  • Peer Reviewed
• [Journal Article] Critical role of apoptosis signal-regulating kinase 1 in aldosterone/salt-induced cardiac inflammation and fibrosis (2009)
  • Author(s): Nakamura, T., et al.
  • Journal Title: Hypertension 54 Pages: 544-551
  • Peer Reviewed
• [Journal Article] Mitochondrial Phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1 (2009)
  • Author(s): Takeda, K., et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA. 13 Pages: 653-664
  • Peer Reviewed
• [Journal Article] Serine 58 of 14-3-3{zeta} is a molecular switch regulating ASK1 and oxidant stress-induced cell death (2009)
  • Author(s): Zhou, J., et al.
  • Journal Title: Mol.Cell.Biol. 29 Pages: 4167-4176
  • Peer Reviewed
• [Journal Article] Targeting ASK1 in ER stress-related Neurodegenerative Diseases (2009)
  • Author(s): Homma, K., et al.
  • Journal Title: Expert Opinion on Therapeutic Targets 13 Pages: 653-664
  • Peer Reviewed
• [Journal Article] Signaling pathways in invertebrate immune and stress response (2009)
  • Author(s): Hatanaka, R., et al.
  • Journal Title: Invertebrate Survival Journal 6 Pages: 32-43
  • Peer Reviewed
• [Journal Article] The roles of ASK family proteins in stress responses and diseases (2009)
  • Author(s): Hattori, K., et al.
  • Journal Title: Cell Communication and Signaling 7 Pages: 9-9
  • Peer Reviewed
• [Journal Article] Stress-Activated MAP Kinase Cascades in Cellular Senescence (2009)
  • Author(s): Maruyama, J., et al.
  • Journal Title: Curr.Med.Chem. 16 Pages: 1229-1235
  • Peer Reviewed
• [Journal Article] Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes (2009)
  • Author(s): Galluzzi, L., et al.
  • Journal Title: Cell Death Differ. 16 Pages: 1093-1107
  • Peer Reviewed
• [Journal Article] Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase1 (2009)
  • Author(s): Waak, J., et al
  • Journal Title: J.Biol.Chem. 284 Pages: 14245-14257
  • Peer Reviewed
• [Journal Article] ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis (2009)
  • Author(s): Iriyama, T., et al.
  • Journal Title: EMBO J. 28 Pages: 843-853
  • Peer Reviewed
• [Journal Article] USP14 inhibits ER-associated degradation via interaction with IRE1 alpha (2009)
  • Author(s): Nagai, A., et al.
  • Journal Title: Biochem.Biophys.Res.Commun. 379 Pages: 995-1000
  • Peer Reviewed
• [Journal Article] Signaling pathways in invertebrate immune and stress response (2009)
  • Author(s): Hatanaka, R., et.al.
  • Journal Title: Invertebrate Survival Journal 6 Pages: 32-43
  • Peer Reviewed
• [Journal Article] The roles of ASK family proteins in stress responses and diseases (2009)
  • Author(s): Hattori, K., et.al.
  • Journal Title: Cell Communication and Signaling (In press)
  • Peer Reviewed
• [Journal Article] Stress-Activated MAP Kinase Cascades in Cellular Senescence (2009)
  • Author(s): Maruyama, J., et.al.
  • Journal Title: Curr. Med. Chem. 16 Pages: 1229-1235
  • Peer Reviewed
• [Journal Article] Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes (2009)
  • Author(s): Galluzzi, L., et.al.
  • Journal Title: Cell Death Differ. (In press)
  • Peer Reviewed
• [Journal Article] Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1 (2009)
  • Author(s): Waak, J., et.al.
  • Journal Title: J. Biol. Chem. (In press)
  • Peer Reviewed
• [Journal Article] ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis (2009)
  • Author(s): Iriyama, T., et.al.
  • Journal Title: EMBO J. 28 Pages: 843-853
  • Peer Reviewed
• [Journal Article] USP14 inhibits ER-associated degradation via interaction with IRE1a 1pha (2009)
  • Author(s): Nagai, A., et.al.
  • Journal Title: Biochem. Biophys. Res. Commun. 379 Pages: 995-1000
  • Peer Reviewed
• [Journal Article] ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1. (2008)
  • Author(s): Nishitoh, H., Kadowaki, H., Nagai, A., Maruyama, T., Yokota, T., Fukutomi, H., Noguchi, T., Matsuzawa, A., Takeda, K., Ichijo, H.
  • Journal Title: Genes Dev. 22 Pages: 1451-1464
• [Journal Article] Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAP kinase pathway for extracelluler ATP-induced apoptosis in macrophage. (2008)
  • Author(s): Noguchi, T., Ishii, K., Fukutomi, H., Naguro, I., Matsuzawa, A., Takeda, K., Ichijo, H.
  • Journal Title: J. Biol. Chem. 283 Pages: 7657-7665
• [Journal Article] Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-jun n-terminal kinase activation (2008)
  • Author(s): Nakagawa, H., et.al.
  • Journal Title: Gastroenterology 135 Pages: 1047-1051
  • Peer Reviewed
• [Journal Article] Olmesartan prevents cardiovascular injury and hepatic steatosis in obesity and diabetes, accompanied by Apoptosis Signal regulating Kinase-1 inhibition (2008)
  • Author(s): Yamamoto, E., et.al.
  • Journal Title: Hypertension 52 Pages: 573-580
  • Peer Reviewed
• [Journal Article] Molecular Mechanism of Reactive Oxygen Species-dependent ASKI Activation in Innate Immunity (2008)
  • Author(s): Yamauchi, S., et.al.
  • Journal Title: Immune Network 8 Pages: 1-6
  • Peer Reviewed
• [Journal Article] ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1 (2008)
  • Author(s): Nishitoh, H., et.al.
  • Journal Title: Genes Dev. 22 Pages: 1451-1464
  • Peer Reviewed
• [Journal Article] Requirement of reactive oxygen species-dependent activation of ASK 1-p38 MAP kinase pathway for extracelluler ATP-induced apoptosis in macronhage (2008)
  • Author(s): Noguchi, T., et.al.
  • Journal Title: J. Biol. Chem. 283 Pages: 7657-7665
  • Peer Reviewed
• [Journal Article] Redox control of cell fate by MAP kinase : physiological roles of ASK1-MAP kinase pathway in stress signaling (2008)
  • Author(s): Matsuzawa, A., et.al.
  • Journal Title: Biochim. Biophys. Acta. 1780 Pages: 1325-1336
  • Peer Reviewed
• [Journal Article] Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death (2008)
  • Author(s): Wu, Y., et.al.
  • Journal Title: Cell Death Differ. 15 Pages: 386-397
  • Peer Reviewed
• [Journal Article] Apoptosis signal-regulating kinase 1 (ASK1)/p38 signaling pathway negatively regulates physiological hypertrophy (2008)
  • Author(s): Taniike, M., et.al.
  • Journal Title: Circulation 117 Pages: 545-552
  • Peer Reviewed
• [Journal Article] Apoptosis Signal-regulating Kinase 1 (ASK1) in stress and immune response (2008)
  • Author(s): Takeda, K., et.al.
  • Journal Title: Annu. Rev. Pharmacol. Toxicol. 48 Pages: 199-225
  • Peer Reviewed
• [Journal Article] Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAP kinase pathway for extracelluler ATP-induced apoptosis in macrophage. (2008)
  • Author(s): Noguchi, T., et. al.
  • Journal Title: J. Biol. Chem. 283 Pages: 7657-7665
  • Peer Reviewed
• [Journal Article] Apoptosis Signal-regulating kinase l (ASK1) in stress and immune response. (2008)
  • Author(s): Takeda, K., et. al.
  • Journal Title: Annu. Rev. Pharmacol. Toxicol. 48 Pages: 199-225
  • Peer Reviewed
• [Journal Article] Apoptosis signal-regulating kinase 1 (ASK1)/p38 signaling pathway negatively regulates physiological hypertrophy. (2008)
  • Author(s): Taniike, M., et. al.
  • Journal Title: Circulation 117 Pages: 545-552
  • Peer Reviewed
• [Journal Article] Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death. (2008)
  • Author(s): Wu, Y. T., et. al.
  • Journal Title: Cell Death Differ. 15 Pages: 386-397
  • Peer Reviewed
• [Journal Article] Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling (2008)
  • Author(s): Matsuzawa A., et. al.
  • Journal Title: Biochim. Biophys. Acta. special issue Redox Control of Cell Function (掲載確定)
  • Peer Reviewed
• [Journal Article] Thioredoxin and TRAF family proteins regulate ROS-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1. (2007)
  • Author(s): Fujino, G., Noguchi, T., Matsuzawa, A., Yamauchi, S., Saitoh, M., Takeda, K., Ichijo, H.
  • Journal Title: Mol. Cell. Biol. 27 Pages: 8152-8163
• [Journal Article] ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds. (2007)
  • Author(s): Osaka, N., Takahashi, T., Murakami, S., Matsuzawa, A., Noguchi, T., Fujiwara, T., Aburatani, H., Moriyama, K., Takeda, K., Ichijo, H.
  • Journal Title: J. Cell Biol. 176 Pages: 903-909
• [Journal Article] Apoptosis signal-regulating kinase 2 (ASK2) functions as a MAP3K in a heteromeric complex with ASK1. (2007)
  • Author(s): Takeda, K., Shimozono, R., Noguchi, T., Umeda, T., Morimoto, Y., Naguro, I., Tobiume, K., Saitoh, M., Matsuzawa, A., Ichijo, H.
  • Journal Title: J. Biol. Chem. 282 Pages: 7522-7531
• [Journal Article] Stress signaling in cancer. (2007)
  • Author(s): Murakami, S., et. al.
  • Journal Title: Cancer Sci. 98 Pages: 1521-1527
  • Peer Reviewed
• [Journal Article] Thioredoxin and TRAF family proteins regulate ROS-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1. (2007)
  • Author(s): Fujino, G., et. al.
  • Journal Title: Mol. Cell. Biol. 27 Pages: 8152-8163
  • Peer Reviewed
• [Journal Article] ASK family proteins in stress response and disease. (2007)
  • Author(s): Fujisawa, T., et. al.
  • Journal Title: Mol. Biotechnol. 27 Pages: 8152-8163
  • Peer Reviewed
• [Journal Article] Growth inhibition of colon cancer cells by transfection of dominant-negative apoptosis signal-regulating kinase-1. (2007)
  • Author(s): Kuwamura, H., et. al.
  • Journal Title: Oncol Rep. 17 Pages: 781-786
  • Peer Reviewed
• [Journal Article] ASK1 is activated by arsenic trioxide in leukemic cells through accumulation of reactive oxygen species and may play a egative role in induction of apoptosis. (2007)
  • Author(s): Yan, W., et. al.
  • Journal Title: Biochem. Biophys. Res. Commun. 355 Pages: 1038-1044
  • Peer Reviewed
• [Journal Article] Regulation of Apoptosis Signal-regulating Kinase 1 by Protein Phosphatase 2Cε. (2007)
  • Author(s): Saito, J., et. al.
  • Journal Title: Biochem. J. 405 Pages: 591-596
  • Peer Reviewed
• [Journal Article] Chk2 kinase is required for methylglyoxal-induced G2/M cell-cycle checkpoint arrest: implication of cell-cycle checkpoint regulation in diabetic oxidative stress signaling. (2007)
  • Author(s): Kani, S., et. al.
  • Journal Title: Genes Cells 12 Pages: 919-928
  • Peer Reviewed
• [Journal Article] Apoptosis Signal-regulating Kinase-1 is involved in vascular endothelial and cardiac remodeling caused by nitric oxide deficiency. (2007)
  • Author(s): Yamashita, T., et. al.
  • Journal Title: Hypertension. 50 Pages: 519-524
  • Peer Reviewed
• [Journal Article] Interaction of ASK1 and the beta-amyloid precursor protein in a stress-signaling complex. (2007)
  • Author(s): Galvan V., et. al.
  • Journal Title: Neurobiol Dis. 28 Pages: 65-75
  • Peer Reviewed
• [Journal Article] Novel Mechanism and Role of Angiotensin II-Induced Vascular Endothelial Injury in Hypertensive Diastolic Heart Failure. (2007)
  • Author(s): Yamamoto, E., et. al.
  • Journal Title: Arterioscler. Thromb. Vasc. Biol. 27 Pages: 2569-2575
  • Peer Reviewed
• [Journal Article] Critical roles of the apoptosis signal-regulating kinase 1 and NADPH oxidase subunit p47phox for tuberculin PPD/Toll-like receptor 2-mediated inflammatory signaling during human tuberculosis. (2007)
  • Author(s): Yang, C.-S., et. al.
  • Journal Title: Cell. Microbiol. 10 Pages: 741-754
  • Peer Reviewed
• [Journal Article] Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury. (2007)
  • Author(s): Terada, Y., et. al.
  • Journal Title: Biochem. Biophys. Res. Commun. 364 Pages: 1043-1049
  • Peer Reviewed
• [Journal Article] ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds. (2007)
  • Author(s): Osaka, N. et al.
  • Journal Title: J. Cell Biol. 176 Pages: 903-909
• [Journal Article] Apoptosis signal-regulating kinase 2 (ASK2) functions as a MAP3K in a heteromeric complex with ASK1. (2007)
  • Author(s): Takeda, K. et al.
  • Journal Title: J. Biol. Chem. 282 Pages: 7522-7531
• [Journal Article] Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. (2007)
  • Author(s): Kitagawa, D. et al.
  • Journal Title: EMBO J. 25 Pages: 3286-3297
• [Journal Article] Pathophysiological Roles of ASK1-MAP Kinase Signaling Pathways. (2007)
  • Author(s): Nagai, H. et al.
  • Journal Title: J. Biochem. Mol. Biol. 40 Pages: 1-6
• [Journal Article] GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial parkinson's disease. (2007)
  • Author(s): Ito, G.et al.
  • Journal Title: Biochemistry 46 Pages: 1380-1388
• [Journal Article] Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. (2006)
  • Author(s): Kitagawa, D., Kajiho, H., Negishi, T., Ura, S., Watanabe, T., Wada, T., Ichijo, H., Katada, T., Nishina, H.
  • Journal Title: Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. EMBO J. 25 Pages: 3286-3297
• [Journal Article] Apoptosis- regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide. (2006)
  • Author(s): Chiang, E., Dang, O., Anderson, K., Matsuzawa, A., Ichijo, H., David, M.
  • Journal Title: J. Immunol. 176 Pages: 5720-5724
• [Journal Article] Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. (2006)
  • Author(s): Liu, Q., Wilkins, B.J., Lee, Y.J., Ichijo, H., Molkentin, J.D.
  • Journal Title: Mol. Cell. Biol. 26 Pages: 3785-3797
• [Journal Article] Apoptosis signal regulating kinase-1 connects reactive oxygen species to p38 MAPK-induced mitochondrial apoptosis in UVB-irradiated human keratinocytes. (2006)
  • Author(s): Van Laethem, A. et al.
  • Journal Title: Free Radic. Biol. Med. 41 Pages: 1361-1371
• [Journal Article] Apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide. (2006)
  • Author(s): Chiang, E. et al.
  • Journal Title: J. Immunol. 176 Pages: 5720-5724
• [Journal Article] Thioredoxin and protein kinases in redox signaling. (2006)
  • Author(s): Fujino, G. et al.
  • Journal Title: Semin. Cancer Biol. 16 Pages: 427-435
• [Journal Article] Apoptosis Signal-regulating Kinase 1 mediates cellular senescence induced by high glucose in endothelial cells. (2006)
  • Author(s): Yokoi, T. et al.
  • Journal Title: Diabetes 55 Pages: 1660-1665
• [Journal Article] Impact of mitochondrial reactive oxygen species and apoptosis signal-regulating kinase 1 on insulin. Signaling. (2006)
  • Author(s): Imoto, K. et al.
  • Journal Title: Diabetes 55 Pages: 1197-1204
• [Journal Article] ASK1 Signalosome : a Signaling Complex Essential for Cellular Stress Responses. (2006)
  • Author(s): Takeda, K. et al.
  • Journal Title: J. Oral Biosci. 48 Pages: 7-11
• [Journal Article] Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. (2006)
  • Author(s): Liu, Q.et al.
  • Journal Title: Mol. Cell. Biol. 26 Pages: 3785-3797
• [Journal Article] The ASK1-MAP kinase pathways in the immune and stress responses. (2006)
  • Author(s): Hayakawa, T. et al.
  • Journal Title: Microbes Infect. 8 Pages: 1098-1107
• [Journal Article] The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases. (2006)
  • Author(s): Sekine, Y. et al.
  • Journal Title: Curr. Mol. Med. 6 Pages: 87-97
• [Journal Article] Induction of a ribotoxic stress response that stimulates stress-activated protein kinases by 13-deoxytedanolide, an antitumor marine macrolide. (2006)
  • Author(s): Lee, KH. et al.
  • Journal Title: Biosci. Biotechnol. Biochem. 70 Pages: 161-171
• [Journal Article] Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo. (2006)
  • Author(s): Harada, C. et al.
  • Journal Title: Am. J. Pathol. 168 Pages: 261-269
• [Journal Article] Identification of Op18/stathmin as a potential target of ASK1-p38 MAP kinase cascade. (2006)
  • Author(s): Mizumura, K. et al.
  • Journal Title: J. Cell. Physiol. 206 Pages: 363-370
• [Journal Article] Recruitment of TRAF family proteins to the ASK1 signalosome is essential for oxidative stress-induced cell death. (2005)
  • Author(s): Noguchi, T., Takeda, K., Matsuzawa, A., Saegusa, K., Nakano, H., Gohda, J., Inoue, J., Ichijo, H.
  • Journal Title: J. Biol. Chem. 280 Pages: 37033-37040
• [Journal Article] Interaction of DJ-1 with Daxx inhibits ASK1 activity and cell death. (2005)
  • Author(s): Junn, E., Taniguchi, H., Jeong, B.S., Zhao, X., Ichijo, H., Mouradian, M., M.
  • Journal Title: Proc. Natl. Acad. Sci. USA. 102 Pages: 9691-9696
• [Journal Article] ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR-4 mediated innate immunity. (2005)
  • Author(s): Matsuzawa, A., Saegusa, K., Noguchi, T., Sadamitsu, C., Nishitoh, H., Nagai, S., Koyasu, S., Matsumoto, K., Takeda, K., Ichijo, H.
  • Journal Title: ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR-4 mediated innate immunity. Nature Immunol. 6 Pages: 587-592
• [Journal Article] ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR-4 mediated innate immunity. (2005)
  • Author(s): Matsuzawa, A. et al.
  • Journal Title: Nat.Immunol. 6 Pages: 587-592
• [Journal Article] Recruitment of TRAF family proteins to the ASK1 signalosome is essential for oxidative stress-induced cell death. (2005)
  • Author(s): Noguchi, T. et al.
  • Journal Title: J.Biol.Chem. 280 Pages: 37033-37040
• [Journal Article] Interaction of DJ-1 with Daxx inhibits ASK1 activity and cell death. (2005)
  • Author(s): Junn, E. et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA. 102 Pages: 9691-9691
• [Journal Article] Enhanced TNF-α induced apoptosis in fanconi anemia type C deficient cells is dependent on Apoptosis Signal-regulating Kinase 1. (2005)
  • Author(s): Bijangi-Vishehsaraei, K. et al.
  • Journal Title: Blood 106 Pages: 4124-4130
• [Journal Article] Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation. (2005)
  • Author(s): Kadowaki, H. et al.
  • Journal Title: Cell Death Differ. 12 Pages: 19-24
• [Journal Article] Fatty acids liberated from low density lipoprotein trigger endothelial apoptosis via mitogen activated protein kinases. (2005)
  • Author(s): Dersch, K. et al.
  • Journal Title: Cell Death Differ. 12 Pages: 1107-1114
• [Journal Article] CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.
  • Author(s): Maruyama, T., Kadowaki, H., Okamoto, N., Nagai, A., Naguro, I., Matsuzawa, A., Shibuya, H., Tanaka, K., Murata, S., Takeda, K., Nishitoh, H., Ichijo, H.
  • Journal Title: EMBO J. (in press)
• [Presentation] ASK family signaling in stress and disease (2010)
  • Author(s): 一條秀憲
  • Organizer: University of Lausanne Seminar
  • Place of Presentation: Zurich, Switzerland
  • Year and Date: 2010-03-31
• [Presentation] ASK family signaling in stress and disease (2010)
  • Author(s): 一條秀憲
  • Organizer: Emory University Seminar
  • Place of Presentation: Atlanta, USA
  • Year and Date: 2010-03-15
• [Presentation] ASK family signaling in stress and disease (2010)
  • Author(s): 一條秀憲
  • Organizer: 第15回愛知県がん国際シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2010-03-06
• [Presentation] ASKファミリーによるストレス応答機構と疾患 (2010)
  • Author(s): 一條秀憲
  • Organizer: 第9回細胞死研究会
  • Place of Presentation: 京都
• [Presentation] ASKファミリーによるストレス応答機構～浸透圧ストレス応答と血圧制御～ (2009)
  • Author(s): 一條秀憲
  • Organizer: 第8回 Vascular and Brain Conference
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-09
• [Presentation] ASK-dependent stress signaling in cell death inflammation, and disease (2009)
  • Author(s): 一條秀憲
  • Organizer: pfizer Seminar
  • Place of Presentation: USA, St.Louis
  • Year and Date: 2009-03-23
• [Presentation] Stress Signaling in Cell Death, Inflammation and Disease (2009)
  • Author(s): 一條秀憲
  • Organizer: 日米シンポジウム
  • Place of Presentation: 新潟
• [Presentation] ストレス応答の制御機構〜細胞がストレスを感じる仕組うと疾患〜 (2008)
  • Author(s): 一條秀憲
  • Organizer: 第6回幹細胞シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-05-27
• [Presentation] ストレスシグナルと発がん(モーニングレクチャー) (2008)
  • Author(s): 一條秀憲
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 筋萎縮性側索硬化症における小胞体ストレス (2008)
  • Author(s): 一條秀憲
  • Organizer: BMB2008第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] Stress response by the ASK family kinases and their roles in tumorigenesis (2008)
  • Author(s): Kohsuke Takeda, et. al.
  • Organizer: CNU symposium on Microbiology and Molecular Genetics
  • Place of Presentation: Korea
• [Presentation] Roles of ASK1 in ER stress-induced neurodegeneration (2008)
  • Author(s): Hidenori Ichijo
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
• [Presentation] ASKファミリーによるストレスシグナルの制御と疾患 (2007)
  • Author(s): 一條秀憲
  • Organizer: 第8回循環器薬理セミナー
  • Place of Presentation: 熊本
  • Year and Date: 2007-11-19
• [Presentation] ASK family kinases in stress response and disease (2007)
  • Author(s): Hidenori Ichijo
  • Organizer: The 55th Fall Conference of The Korean Association of Immunobiologists
  • Place of Presentation: Korea
• [Presentation] ASK family proteins in stress-induced apoptosis and disease (2007)
  • Author(s): Hidenori Ichijo
  • Organizer: FASEB Summer Research Conferences - From unfolded proteins in the endoplasmic reticulum to disease
  • Place of Presentation: USA
• [Presentation] ASK family proteins in stress response and disease (2007)
  • Author(s): Hidenori Ichijo
  • Organizer: The International Conference on Free Radicals in Biosystems
  • Place of Presentation: Kuwait
• [Presentation] ASK family proteins in stress-induced apoptosis and disease (2007)
  • Author(s): Ichijo, H., et. al.
  • Organizer: FASEB Summer Research Conferences-From unfolded proteins in the endoplasmic reticulum to disease
  • Place of Presentation: California, USA.
• [Presentation] がんとストレスシグナル (2007)
  • Author(s): 一條秀憲
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] ASKファミリーによるストレス応答の制御 (2007)
  • Author(s): 一條秀憲
  • Organizer: 第30回日本分子生物学会年会、第80回日本生化学会大会合同大会(BMB2007)
  • Place of Presentation: 横浜
• [Presentation] ASK family proteins in stress response and disease (2006)
  • Author(s): Hidenori Ichijo
  • Organizer: 63rd KSBMB Annual Meeting in 2006
  • Place of Presentation: Korea
  • Year and Date: 2006-05-25
• [Presentation] ASK family proteins in stress response and disease (2006)
  • Author(s): Hidrnoi Ichijo
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: Kyoto
• [Presentation] Redox controls of ASK1-MAP kinase signaling pathway in apoptosis and immunity (2005)
  • Author(s): Hidenori Ichijo
  • Place of Presentation: Italy
  • Year and Date: 2005-09-09
• [Book] 創薬科学の魅力-東京大学大学院薬学系研究科からの発信- (2010)
  • Author(s): 竹田弘資, 他
  • Publisher: 廣川書店
• [Book] Protein Misfolding Disorders : A Trip into the ER(ed Hetz, C.) (2009)
  • Author(s): Nishitoh, H., et al.
  • Publisher: Bentham Science Publishers