| Budget Amount *help |
¥241,200,000 (Direct Cost: ¥241,200,000)
Fiscal Year 2009: ¥48,500,000 (Direct Cost: ¥48,500,000)
Fiscal Year 2008: ¥48,500,000 (Direct Cost: ¥48,500,000)
Fiscal Year 2007: ¥48,600,000 (Direct Cost: ¥48,600,000)
Fiscal Year 2006: ¥48,600,000 (Direct Cost: ¥48,600,000)
Fiscal Year 2005: ¥47,000,000 (Direct Cost: ¥47,000,000)
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| Research Abstract |
As newly developed blood vessels in tumor environment supply oxygen and nutrient to cancer cells resulted in growth of tumor, we analyzed the molecular mechanisms of blood vessel formation in cancer to develop a good strategy for inhibition of tumor angiogenesis. We found that cancer stem cells locate near the mature blood vessels in the tumor edge that show resistance against angiogenesis inhibitors. Moreover, we found that maturation of blood vessels in tumor is caused by the transdifferentiation of hematopoietic stem cells into mural cells which support stability of blood vessels and associates with activation of receptors, Tie2 and APJ expressed on endothelial cells.
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