| Budget Amount *help |
¥47,400,000 (Direct Cost: ¥47,400,000)
Fiscal Year 2009: ¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2008: ¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2007: ¥9,800,000 (Direct Cost: ¥9,800,000)
Fiscal Year 2006: ¥9,800,000 (Direct Cost: ¥9,800,000)
Fiscal Year 2005: ¥8,400,000 (Direct Cost: ¥8,400,000)
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| Research Abstract |
Point mutations and structural alterations of receptor tyrosine kinase genes cause cancer and developmental abnormalities. Mutations of the RET tyrosine kinase gene is responsible for the development of multiple endocrine neoplasia type 2 and Hirschsprung's disease. The mutations result in RET activation and inactivation by various mechanisms. In this study, we elucidated the roles of each downstream signaling of RET in cancer cell growth, invasion and metastasis using RET-expressing cancer cell lines and transgenic mice.
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