Regulation of cell proliferation by receptor tyrosine kinase
| Project/Area Number |
17014039
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Nagoya University |
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Principal Investigator |
TAKAHASHI Masahide Nagoya University, 大学院・医学系研究科, 教授 (40183446)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥47,400,000 (Direct Cost: ¥47,400,000)
Fiscal Year 2009: ¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2008: ¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2007: ¥9,800,000 (Direct Cost: ¥9,800,000)
Fiscal Year 2006: ¥9,800,000 (Direct Cost: ¥9,800,000)
Fiscal Year 2005: ¥8,400,000 (Direct Cost: ¥8,400,000)
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| Keywords | 受容体型チロシンキナーゼ / RETチロシンキナーゼ / シグナル伝達 / 細胞増殖 / 細胞運動 / CD109 / Akt / Girdin / DOK-6 / MEN2A / トランスジェニックマウス / MKP2脱リン酸化酵素 / 細胞周期 / AKT / 乳癌 / がん転移 / Aktキナーゼ / アクチン結合蛋白 / アクチンストレスファイバー / 腫瘍増殖 / GDNF / Dok-4 / 細胞分化 |
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| Research Abstract |
Point mutations and structural alterations of receptor tyrosine kinase genes cause cancer and developmental abnormalities. Mutations of the RET tyrosine kinase gene is responsible for the development of multiple endocrine neoplasia type 2 and Hirschsprung's disease. The mutations result in RET activation and inactivation by various mechanisms. In this study, we elucidated the roles of each downstream signaling of RET in cancer cell growth, invasion and metastasis using RET-expressing cancer cell lines and transgenic mice.
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Report
(6 results)
Research Products
(72 results)
