| Budget Amount *help |
¥45,400,000 (Direct Cost: ¥45,400,000)
Fiscal Year 2009: ¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 2008: ¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 2007: ¥9,800,000 (Direct Cost: ¥9,800,000)
Fiscal Year 2006: ¥9,800,000 (Direct Cost: ¥9,800,000)
Fiscal Year 2005: ¥8,400,000 (Direct Cost: ¥8,400,000)
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| Research Abstract |
The Src kinase is often activated in breast cancer and colon cancer. We have been investigating the mechanisms of how Src kinase activates MMP secretion and enhances cell invasion. We have found cytokines such as TNFalpha and IL-1beta activated Src and FAK, which was required for the stimulation of MMP-9 secretion and cell invasion. We also found that nitric oxide induced cell invasion, which was dependent on the activation of FAK and Src by S-nitrosylation.
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