Mechanisms for the regulation of growth and cell death in cancer cells

• Project/Area Number: 17014043
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: KAKIZUKA Akira Kyoto University, 大学院・生命科学研究科, 教授 (80204329)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥43,400,000 (Direct Cost: ¥43,400,000); Fiscal Year 2009: ¥8,200,000 (Direct Cost: ¥8,200,000); Fiscal Year 2008: ¥8,200,000 (Direct Cost: ¥8,200,000); Fiscal Year 2007: ¥9,300,000 (Direct Cost: ¥9,300,000); Fiscal Year 2006: ¥9,300,000 (Direct Cost: ¥9,300,000); Fiscal Year 2005: ¥8,400,000 (Direct Cost: ¥8,400,000)
• Keywords: 細胞死 / AAA / ATPase / アミノ酸修飾 / VCP / リン酸化 / アセチル化 / Cdc48 / 脱ユビキチン化 / フィードバック機構 / ペウルオキシゾーム / カタラーゼ / ROS / 癌の悪性化 / 細胞内局在 / 細胞周期 / 紡錘体極 / タイムラプス解析 / p47 / DNA合成 / 細胞増殖 / AAA ATPase / 出芽酵母 / 温度感受性株

Research Abstract

In order to build fundamentals for developing novel cancer treatment, we have analyzed the functions of VCP (an ATPase), which is involved in cell growth and cell death. Resultantly, we identified VCP being modified at many amino acid residues, by which VCP is involved in the cellular functions such as controls of cell cycle and reactive oxygen species. In most of examined advanced adeno-carcinomas and squamous cell carcinomas, we observed highly elevated expression of VCP and p47, a VCP co-factor, suggesting their involvement in the invasion and metastasis.

Research Products

• [Journal Article] Enhanced ATPase activities as a primary defect of mutant valosin-containing proteins (VCPs) that cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia (IBMPFD). (2010)
  • Author(s): Manno, A., Noguchi, M., Fukushi, J., Motohashi, Y., Kakizuka, A.
  • Journal Title: Genes Cells (in press)
• [Journal Article] Valosin-containing protein (VCP) in novel feedback machinery between abnormal protein accumulation and transcriptional suppression. (2010)
  • Author(s): Koike M, Fukushi J, Ichinohe Y, Higashimae N, Fujishiro M, Sasaki C, Yamaguchi M, Uchihara T, Yagishita S, Ohizumi H, Hori S, Kakizuka A.
  • Journal Title: J Biol Chem. (In press)
• [Journal Article] Maintaining ATP levels via the suppression of PERK-mediated rRNA synthesis at ER stress. (2010)
  • Author(s): Okamoto, A., Koike, M., Yasuda, K., Kakizuka A.
  • Journal Title: Biochem. Biophys. Res. Commun. Pages: 42-47
• [Journal Article] Glucosamine induces autophagy via an mTOR-independent pathway. (2010)
  • Author(s): Shintani, T., Yamazaki, F., Katoh, T., Umekawa, M., Matahira, Y., Hori, S., Kakizuka, A., Totani, K., Yamamoto, K., Ashida, H.
  • Journal Title: Biochem. Biophys. Res. Commun. 391 Pages: 1775-1779
• [Journal Article] Valosin-containing protein (VCP) in novel feedback machinery between abnormal protein accumulation and transcriptional suppression. (2010)
  • Author(s): Koike, M., et. al.
  • Journal Title: J.Biol. Chem.
  • Peer Reviewed
• [Journal Article] Maintaining ATP levels via the suppression of PERK-mediated rRNA synthesis at ER stress. (2010)
  • Author(s): Okamoto, A., et. al.
  • Journal Title: Biochem Biophys Res. Commun. 394 Pages: 42-47
  • Peer Reviewed
• [Journal Article] Glucosamine induces autophagy via an mTOR-independent pathway. (2010)
  • Author(s): Shintani, T., et. al
  • Journal Title: Biochem Biophys Res. Commun. 391 Pages: 1775-1779
  • Peer Reviewed
• [Journal Article] p97/valosine-containing protein (VCP) is highly modulated by phosphorylation and acetylation. (2010)
  • Author(s): Mori-Konya, C., et. al.
  • Journal Title: Genes Cells. 14 Pages: 483-497
  • Peer Reviewed
• [Journal Article] Listeria monocytogenes ActA-mediated escape from autophagic recognition. (2009)
  • Author(s): Yoshikawa, Y., Ogawa, M., Hain T., Yoshida, M., Fukumatsu, M., Kim, M., Mimuro, H., Nakagawa, I., Yanagawa, T., Ishii, T., Kakizuka, A., Sztul, E., Chakraborty, T., Sasakawa, C.
  • Journal Title: Nat Cell Biol. Pages: 1233-1240
• [Journal Article] p97/valosine- containing protein (VCP) is highly modulated by phosphorylation and acetylation. (2009)
  • Author(s): Mori-Konya, C., Kato, N., Maeda, R., Yasuda, K., Higashimae, N., Noguchi, M., Koike, M., Kimura, Y., Ohizumi, H., Hori, S., Kakizuka, A.
  • Journal Title: Genes Cells 14 Pages: 483-497
• [Journal Article] An inhibitor of a deubiquitingating enzyme regulates ubiquitin homeostasis. (2009)
  • Author(s): Kimura Y, Yashiroda H, Kudo T, Koitabashi S, Murata S, Kakizuka A, Tanaka K.
  • Journal Title: Cell 137 Pages: 549-559
• [Journal Article] Listeria monocytogenes ActA-mediated escape from autophagic recognition. (2009)
  • Author(s): Yoshikawa, Y., et. al.
  • Journal Title: NatCellBiol. 11 Pages: 1233-1240
  • Peer Reviewed
• [Journal Article] An inhibitor of a deubiquitingating enzyme regulates ubiquitin homeostasis. (2009)
  • Author(s): Kimura, Y., et. al.
  • Journal Title: Cell 137 Pages: 549-559
  • Peer Reviewed
• [Journal Article] 神経変性疾患とVCP (2009)
  • Author(s): 垣塚彰
  • Journal Title: Clinical Neuroscience 27 Pages: 964-965
• [Journal Article] 神経変性疾患における異常タンパク質の凝集と除去に関与するVCP (2009)
  • Author(s): 垣塚彰
  • Journal Title: 生体の科学 60 Pages: 579-581
• [Journal Article] ヒトの分子生物学 (2009)
  • Author(s): 垣塚彰
  • Journal Title: 分子生物学第2版(編集:柳田光弘、西田栄介、野田亮) Pages: 261-273
• [Journal Article] p97/valosin-containing protein (VCP) is highly modulated by phosphorylation and acetylation (2009)
  • Author(s): Alor i-Konva. C., et.al.
  • Journal Title: Genes Cells 14 Pages: 483-497
  • Peer Reviewed
• [Journal Article] An inhibitor of deubiquitinating enzyme regulates ubiquitin homeostasis (2009)
  • Author(s): Kimura, Y., et.al.
  • Journal Title: Cell
  • Peer Reviewed
• [Journal Article] Roles of VCP in human neurodegenerative disorders. (2008)
  • Author(s): Kakizuka A.
  • Journal Title: Biochem. Soc. Trans. 36 Pages: 105-10
• [Journal Article] Direct detection of the interaction between recombinant soluble extracellular regions in the heterodimeric metabotropic gamma- aminobutyric acid receptor. (2008)
  • Author(s): Nomura, R., Suzuki, Y., Kakizuka, A., Jingami, H.
  • Journal Title: J Biol Chem. 283 Pages: 4665-4673
• [Journal Article] Roles of VCP in human neurodegenerative disorders (2008)
  • Author(s): Kaki zuka A.
  • Journal Title: Biochem. Soc. Trans. 36 Pages: 105-108
• [Journal Article] Direct detection of the interaction between recombinantsoluble extracellular regions in the heterodimeric metabotropic gamma-aminobutyric acid receptor. (2008)
  • Author(s): Nomura R, Suzuki Y, Kakizuka A, Jingami H.
  • Journal Title: J Biol Chem. 283 Pages: 4665-4673
  • Peer Reviewed
• [Journal Article] Roles of VCP in human neurodegenerative disorders. (2008)
  • Author(s): Kakizuka A.
  • Journal Title: Biochem Soc Trans. 36 Pages: 105-108
  • Peer Reviewed
• [Journal Article] Involvement of valosin-containing protein (VCP)/p97 in the formation and clearance of abnormal protein aggregates. (2007)
  • Author(s): Kobayashi, T., Manno, A., Kakizuka, A.
  • Journal Title: Genes Cells. 12 Pages: 889-901
• [Journal Article] Involvement of valosin-containing protein(VCP)/p97 in the formation and clearance of abnormal protein aggregates. (2007)
  • Author(s): Kobayashi T, Manno A, Kakizuka A.
  • Journal Title: Genes Cells 12 Pages: 889-901
  • Peer Reviewed
• [Journal Article] 神経変性疾患にかかわる蛋白質の種々の修飾 (2007)
  • Author(s): 垣塚 彰、小池雅昭
  • Journal Title: 蛋白質・核酸・酵素 52 Pages: 768-773
• [Journal Article] Involvement of VCP/p97 in the formation and clearance of abnormal protein aggregates. (2007)
  • Author(s): Kobayashi, T.et al.
  • Journal Title: Genes to Cells (印刷中)
• [Journal Article] 神経変性疾患に関わる蛋白質の種々の修飾 (2007)
  • Author(s): 垣塚 彰
  • Journal Title: 蛋白質・核酸・酵素 (印刷中)
• [Journal Article] In vivo analysis of the role of aberrant histone deacetylase recruitment and RAR alpha blockade in the pathogenesis of acute promyelocytic leukemia. (2006)
  • Author(s): Matsushita, H., Scaglioni, P.P., Bhaumik, M., Rego, E.M., Cai, L. F, Majid, S.M., Miyachi, H., Kakizuka, A., Miller, W.H. Jr., Pandolfi, P.P.
  • Journal Title: J Exp Med. 203 Pages: 821-828
• [Journal Article] Dominant-negative effect of mutant valosin-containing protein in aggresome formation. (2006)
  • Author(s): Kitami, M.I., Kitami, T., Nagahama, M., Tagaya, M., Hori, S., Kakizuka, A., Mizuno, Y., Hattori, N.
  • Journal Title: FEBS Lett. 580 Pages: 474-478
• [Journal Article] Dominant-negative effect of mutant valosin-cont aining protein in aggresome formation. (2006)
  • Author(s): Kitami, M.I. et al.
  • Journal Title: FEBS Lett. 580 Pages: 474-478
• [Journal Article] In vivo analysis of the role of aberrant histone deacetylase recruitment and RAR alpha blockade in the pathogenesis of acute promyelocytic leukemia. (2006)
  • Author(s): Matsushita, H., et al.
  • Journal Title: J Exp Med. 203 Pages: 821-828
• [Journal Article] PGC 1ファミリーと糖・脂質代謝 (2006)
  • Author(s): 大泉 宏, 垣塚 彰
  • Journal Title: 内分泌・糖尿病科 23 Pages: 40-47
• [Journal Article] 神経変性疾患と核 (2006)
  • Author(s): 垣塚 彰
  • Journal Title: 蛋白質・核酸・酵素 51 Pages: 2269-2273
• [Journal Article] Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-xL. (2006)
  • Author(s): Chou, A.H., et al.
  • Journal Title: Neurobiol Dis. vol.21 Pages: 333-345
• [Journal Article] Dominant-negative effect of mutation valosin-containing protein in aggresome formation. (2006)
  • Author(s): Kitami, MI., et al.
  • Journal Title: FEBS Lett. vol.580 Pages: 474-478
• [Journal Article] 神経変性疾患と小胞体ストレス (2006)
  • Author(s): 野口昌克, 垣塚 彰
  • Journal Title: 医学のあゆみ vol.216 Pages: 4033-4039
• [Journal Article] Induction of murine leukemia and lymphoma by dominant negative retinoic acid receptor alpha. (2005)
  • Author(s): Wang, Y.A., Shen, K., Ishida, Y., Wang, Y., Kakizuka, A., Brooks, S.C.
  • Journal Title: Mol Carcinog. 44 Pages: 252-261
• [Journal Article] ATPase activity of Valosin-containing protein (VCP) is regulated by oxidative modification of the evolutionally conserved 522nd cysteine residue in Walker A motif. (2005)
  • Author(s): Noguchi, M., Takata, T. Kimura, Y., Manno, A., Murakami, K., Koike, M., Ohizumi, H., Hori, S., Kakizuka A.
  • Journal Title: J. Biol. Chem. 280 Pages: 41332-41341
• [Journal Article] Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-x(L). (2005)
  • Author(s): Chou, A.H., Yeh, T.H., Kuo, Y.L., Kao, Y.C., Jou, M.J., Hsu, C, Y., Tsai, S.R., Kakizuka, A., Wang, H.L.
  • Journal Title: Neurobiol Dis. 21 Pages: 333-345
• [Journal Article] Retinoid signaling competence and RARbeta-mediated gene regulation in the developing mammalian telencephalon. (2005)
  • Author(s): Liao, W.L., Wang, H.F., Tsai, H.C., Chambon, P., Wagner, M., Kakizuka, A., Liu, F.C.
  • Journal Title: Dev. Dyn. 232 Pages: 887-900
• [Journal Article] - alpha, beta -unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor gamma. (2005)
  • Author(s): Shiraki, T., Kamiya, N., Shiki, S., Kodama, T.S., Kakizuka, A., Jingami, H.
  • Journal Title: J. Biol. Chem. 279 Pages: 51376-51385
• [Journal Article] α,β-unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor γ. (2005)
  • Author(s): Shiraki, T., et al.
  • Journal Title: J.Biol.Chem. vol.279 Pages: 51376-51385
• [Journal Article] Retinoid signaling competence and RARbeta-mediated gene regulation in the developing mammalian telencephalon. (2005)
  • Author(s): Liao, W.L., et al.
  • Journal Title: Dev Dyn. vol.232 Pages: 887-900
• [Journal Article] ATPase activity of p97/Valosin-containing protein (VCP) is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motif. (2005)
  • Author(s): Noguchi, M., et al.
  • Journal Title: J.Biol.Chem. vol.280 Pages: 41332-41341
• [Journal Article] Induction of murine leukemia and lymphoma by dominant negative retinoic acid receptor α. (2005)
  • Author(s): Wang, Y.A., et al.
  • Journal Title: Mol.Carcinog. vol.44 Pages: 252-261
• [Journal Article] ポリグルタミン病 (2005)
  • Author(s): 垣塚 彰
  • Journal Title: 脳神経外科速報 vol.15 Pages: 543-549
• [Presentation] ストレス応答におけるVCP蛋白質の役割, ストレス応答の新機軸 (2009)
  • Author(s): 垣塚彰
  • Organizer: 第82回日本生化学会シンポジウム
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2009-10-24
• [Presentation] ストレス応答におけるVCP蛋白質の役割 (2009)
  • Author(s): 垣塚彰
  • Organizer: 第82回日本生化学会シンポジウム「ストレス応答の新機軸」
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2009-10-24
• [Presentation] 細胞周期におけるVCP/p97のリン酸化の役割の解析: Roles of VCP phosphorylation in cell cycle progression (2009)
  • Author(s): 加藤成芳、村上克洋、紺谷千穂、堀清次、垣塚彰
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2009-10-23
• [Presentation] 酵母のGP110温度感受性変異株で見られる出芽阻害とDNA過剰複製: Budding defect and DNA over-replication in a yeast GP110 temperature-sensitive mutant (2009)
  • Author(s): 大沼洋平、高田尚寛、安田邦彦、垣塚彰
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2009-10-23
• [Presentation] p97/VCPのATPase活性に作用する新規翻訳後修飾の同定: Identification of novel post-translational modifications which affect the ATPase activity of p97/VCP (2009)
  • Author(s): 紺谷千穂、加藤成芳、前田良太、小池雅昭、安田邦彦、野口昌克、東前直樹、木村洋子、大泉宏、堀清次、垣塚彰
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2009-10-22
• [Presentation] 細胞機能におけるVCP蛋白質の役割 (2009)
  • Author(s): 垣塚彰
  • Organizer: 第10回京都大学生命科学研究科シンポジウム
  • Place of Presentation: 芝蘭会館
  • Year and Date: 2009-07-02
• [Presentation] 細胞機能におけるVCP蛋白質の役割 (2009)
  • Author(s): 垣塚彰
  • Organizer: 第10回京都大学生命科学研究科シンポジウム
  • Place of Presentation: 京都大学芝蘭会館
  • Year and Date: 2009-07-02
• [Presentation] A novel feedback machinery between abnormal protein accumulation and transcriptional suppression. (2009)
  • Author(s): Akira Kakizuka
  • Organizer: The 5th NTU-Kyoto-U mini-symposium on molecular and cellular biology.
  • Place of Presentation: Raku-yu Kaikan, Kyoto, Japan.
  • Year and Date: 2009-05-23
• [Presentation] 癌ってどうゆうもの? (2009)
  • Author(s): 垣塚彰
  • Organizer: 膳所高等学校・京都大学公開講義
  • Place of Presentation: 京都大学
  • Year and Date: 2009-05-08
• [Presentation] 小胞体ストレスに対する新規応答機構 : Inhibition of rRNA synthesis in response to ER stress (2008)
  • Author(s): 岡本暁彦、安田邦彦、垣塚彰
  • Organizer: BMB2008
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-12-11
• [Presentation] ヒト子宮頸癌及び食道癌におけるVCP co-factor p47の発現上昇による浸潤能の獲得 : Overexpression of p47, a VCP co-factor, in potential acquisition of invasion activities in human esophageal and cervical cancer (2008)
  • Author(s): 一戸勇弦、東前直樹、大泉宏、垣塚彰
  • Organizer: BMB2008
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-12-10
• [Presentation] VCPはペルオキシソームマトリックスタンパク質の輸送と分解に関与する : VCP is involved in peroxisomal matrix protein import and degradation (2008)
  • Author(s): 村上克洋、垣塚彰
  • Organizer: BMB2008
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-12-09
• [Presentation] 異常蛋白質の蓄積がもたらすフィードバック機構 (2008)
  • Author(s): 垣塚彰
  • Organizer: 第9回京都大学生命科学研究科シンポジウム
  • Place of Presentation: 京大会館
  • Year and Date: 2008-06-26
• [Presentation] 分子が織りなす生命の不思議-どうして病気になるの? 運動しても肥満は防げない? がん・神経難病、肥満・糖尿病をめぐって- (2008)
  • Author(s): 垣塚彰
  • Organizer: 徳島県立総合大学校まなーびあ徳島開校記念講演
  • Place of Presentation: 徳島県立総合教育センター(徳島県板野郡)
  • Year and Date: 2008-06-08
• [Presentation] 分子が織りなす生命の不思議-どうして病気になるの? 運動しても肥満は防げない? がん・神経難病、肥満・糖尿病をめぐって- (2008)
  • Author(s): 垣塚彰
  • Organizer: 徳島県立総合大学校まな-びあ徳島開校記念講演
  • Place of Presentation: 徳島県立総合教育センター
  • Year and Date: 2008-06-08
• [Presentation] Analysis of the epitope of an ER-residing VCP (2008)
  • Author(s): Hamaguchi, M., Manno A., Kkaizuka A.
  • Organizer: The 6th International Student Seminar
  • Place of Presentation: Shiran Kaikan, Kyoto University
• [Presentation] Involvement of VCP/p97 and co-factors in the formation of abnormal protein aggregates (2008)
  • Author(s): Manno A., Noguchi, M., Fukushi, J., Motohashi, Y., Murakami, K., Kkaizuka A.
  • Organizer: The 6th International Student Seminar
  • Place of Presentation: Shiran Kaikan, Kyoto University
• [Presentation] Roles of VCP in human neurodegenerative disorders (2007)
  • Author(s): Akira Kakizuka
  • Organizer: 7th international conference on AAA proteins.
  • Place of Presentation: Royal Agricultural College, Cirencester (England)
  • Year and Date: 2007-09-11
• [Presentation] Roles of VCP in human neurodegenerative disorders (2007)
  • Author(s): Kakizuka A.
  • Organizer: 7th international conference on AAA proteins
  • Place of Presentation: Royal Agricultural College, Cirencester(England)
  • Year and Date: 2007-09-11
• [Presentation] 癌ってどうゆうもの (2007)
  • Author(s): 垣塚 彰
  • Organizer: 膳所高等学校・京都大学公開講義
  • Place of Presentation: 京都大学
  • Year and Date: 2007-04-27
• [Presentation] Modificaions of VCP via abnormal protein accumulationlead to neuronal cell atrophy and neurodegeneration (2007)
  • Author(s): Koike, M., Higashimae, N., Fujishiro, M., Fukushi, J., Kkaizuka A.
  • Organizer: 7th international conference on AAA proteins
  • Place of Presentation: Royal Agricultural College, Cirencester(England)
• [Presentation] 「癌ってどういうもの?」文部科学省科学研究費補助金特定領域研究「がん特定」公開シンポジウム 「高校生の諸君に伝えたい、がん研究の今!」 (2006)
  • Author(s): 垣塚彰
  • Organizer: 第3回出前授業
  • Place of Presentation: 徳島県立城南高等学校
  • Year and Date: 2006-11-20
• [Presentation] VCP蛋白質の機能解析, 細胞死研究の新たな展開と関連する素過程 (2006)
  • Author(s): 垣塚彰
  • Organizer: 平成18年度生理学研究所研究会
  • Place of Presentation: 生理学研究所
  • Year and Date: 2006-10-31
• [Presentation] 細胞周期におけるVCP蛋白質の機能解析 (2005)
  • Author(s): 垣塚彰
  • Organizer: 第78回日本生化学会大会ランチョンセミナー
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2005-10-20
• [Presentation] ATPase activity of Valosin-containing protein (VCP) is regulated by oxidative modification of the evolutionally conserved 522nd cysteine residue in Walker A motif (2005)
  • Author(s): Akira Kakizuka
  • Organizer: 6th international conference on AAA proteins.
  • Place of Presentation: Schloss Seggau, Austria
  • Year and Date: 2005-09-15
• [Book] ヒトの分子生物学(分子生物学第2版(編集:柳田光弘、西田栄介、野田亮)) (2009)
  • Author(s): 垣塚彰
  • Publisher: 東京科学同人
• [Book] ポリグルタミン病(脳神経科学イラストレイテッド改訂第2版(編集:森寿、真鍋俊也、渡辺雅彦、岡野栄之、宮川剛)) (2006)
  • Author(s): 垣塚彰
  • Publisher: 羊土社
• [Book] 脳神経科学 イラストレイテッド 改訂第2版(第7章-6 ポリグルタミン病) (2006)
  • Author(s): 垣塚 彰他(編集:森 寿, 真鍋俊也, 渡辺雅彦, 岡野栄之, 宮川 剛)
  • Total Pages: 372
  • Publisher: 羊土社
• [Remarks]
  • URL: http://www.lif.kyoto-u.ac.jp/labs/funcbiol/
• [Patent(Industrial Property Rights)] ペルオキシゾーム増殖剤応答性受容体活性剤および組成物 (2008)
  • Inventor(s): 垣塚彰、大滝佳代、大泉宏、庭野吉己、別府史章、鈴木尚志
  • Industrial Property Rights Holder: 京都大学、(株)サニーヘルス
  • Industrial Property Number: 2008-227635
  • Filing Date: 2008-09-04
• [Patent(Industrial Property Rights)] 蛋白質切断活性を有する細胞のスクリーニング方法 (2007)
  • Inventor(s): 垣塚彰、山本幸男
  • Industrial Property Rights Holder: JST
  • Acquisition Date: 2007-11-02
• [Patent(Industrial Property Rights)] 蛋白質切断活性を有する細胞のスクリーニング方法 (2007)
  • Inventor(s): 垣塚彰、山本幸男
  • Industrial Property Rights Holder: JST
  • Acquisition Date: 2007-11-02