| Budget Amount *help |
¥45,400,000 (Direct Cost: ¥45,400,000)
Fiscal Year 2009: ¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 2008: ¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 2007: ¥9,800,000 (Direct Cost: ¥9,800,000)
Fiscal Year 2006: ¥9,800,000 (Direct Cost: ¥9,800,000)
Fiscal Year 2005: ¥8,400,000 (Direct Cost: ¥8,400,000)
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| Research Abstract |
To find the way of the inhibition of metastasis is important for cancer therapy. We found 2 important mechanisms in metastasis; 1) the role of lymphagiogenesis, 2) the induction of cancer stem cells from non-cancer stem cells. Lymphangiogenesis promotes the metastasis. We succeeded the inhibition of metastasis by anti-lymphangiogenesis therapy in mouse model. However, we found that cancer stem cells don't have the potential of lymphangiogenesis. To inhibit the metastasis, it could be important to target the induction of cancer stem cells in the metastatic sites.
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