Lymphangiogenesis in cancer
Project/Area Number |
17014047
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Kyoto University |
Principal Investigator |
KUBO Hajime Kyoto University, 医学研究科, 講師 (50362520)
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Project Period (FY) |
2005 – 2009
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Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥45,400,000 (Direct Cost: ¥45,400,000)
Fiscal Year 2009: ¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 2008: ¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 2007: ¥9,800,000 (Direct Cost: ¥9,800,000)
Fiscal Year 2006: ¥9,800,000 (Direct Cost: ¥9,800,000)
Fiscal Year 2005: ¥8,400,000 (Direct Cost: ¥8,400,000)
|
Keywords | リンパ管新生 / 転移 / がん幹細胞 / リンパ管 / がん間質細胞 / リンパ節転移 / 大腸癌 / 癌幹細胞 / 癌 / Prox1 / 癌抑制遺伝子 / RNA編集 / ES細胞 |
Research Abstract |
To find the way of the inhibition of metastasis is important for cancer therapy. We found 2 important mechanisms in metastasis; 1) the role of lymphagiogenesis, 2) the induction of cancer stem cells from non-cancer stem cells. Lymphangiogenesis promotes the metastasis. We succeeded the inhibition of metastasis by anti-lymphangiogenesis therapy in mouse model. However, we found that cancer stem cells don't have the potential of lymphangiogenesis. To inhibit the metastasis, it could be important to target the induction of cancer stem cells in the metastatic sites.
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Report
(6 results)
Research Products
(45 results)
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[Journal Article] Hepatic Stellate Cells Promote Liver Metastasis of Colon Cancer Cells by the Action of SDF-1/CXCR4 Axis.2009
Author(s)
Matsusue R, * Kubo H, Hisamori S, Okoshi K, Takagi H, Hida K, Nakano K, Itami A, Kawada K, Nagayama S, Sakai Y.
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Journal Title
Ann Surg Oncol. 16(9)
Pages: 2645-53
Related Report
Peer Reviewed
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[Journal Article] Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors.2008
Author(s)
Nagayama S, Yamada E, Kohno Y, Aoyama T, Fukukawa C, Kubo H, Watanabe G, Katagiri T, Nakamura Y, Sakai Y, Toguchida J.
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Journal Title
Cancer Sci. 2009 Mar 100(3)
Pages: 405-12
Related Report
Peer Reviewed
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[Journal Article] All-trans-retinoic acid attenuates radiation-induced intestinal fibrosis in mice.2008
Author(s)
Kae Okoshi, * Hajime Kubo, Satoshi Nagayama, Chiharu Tabata, Yoshio Kadokawa, Shigeo Hisamori, Yoshikuni Yonenaga, Akihisa Fujimoto, Akira Mori, Hisashi Onodera, Go Watanabe, Yoshiharu Sakai
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Journal Title
J Surg Res. 150
Pages: 53-59
Related Report
Peer Reviewed
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[Journal Article] Prox1 Induces Lymphatic Endothelial Differentiation via Integrin {alpha}9 and Other Signaling Cascades.2007
Author(s)
Mishima K, Watabe T, Saito A, Yoshimatsu Y, Imaizumi N, Masui S, Hirashima M, Morisada T, Oike Y, Araie M, Niwa H, Kubo H, Suda T, Miyazono K
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Journal Title
Mol Biol Cell. 18(4)
Pages: 1421-9
Related Report
Peer Reviewed
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[Journal Article] Two populations of Thy1-positive mesenchymal cells regulate the in vitro maturation of hepatic progenitor cells.2007
Author(s)
Kamo N, Yasuchika K, Fujii H, Hoppo T, Machimoto T, Ishii T, Fujita N, Tsuruo T, Yamashita JK, *Kubo H, Ikai I
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Journal Title
Am J Physiol Gastr Liver Physiol. 292
Related Report
Peer Reviewed
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[Journal Article] Two populations of Thyl-positive mesenchymal cells regulate the in vitro maturation of hepatic progenitor cells.2007
Author(s)
Kamo N, Yasuchika K, Fujii H, Hoppo T, Machimoto T, Ishii T, Fujita N, Tsuruo T, Yamashita JK, Kubo H, Ikai I
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Journal Title
Am J Physiol Gastr Liver Physiol. 292
Related Report
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[Journal Article] Loss of function of the candidate tumor suppressor proxl by RNA mutation in human cancer cells.2006
Author(s)
Takahashi, M., Yoshimoto, T., Shimoda, M., Kono, T., Koisumi, M., Yazumi, S., Shimada, Y., Doi, R., Chiba, T., Kubo.H
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Journal Title
Neoplasia 8(12)
Pages: 1003-1010
Related Report
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[Journal Article] A homeobox protein proxl is involved in the differentiation, proliferation and prognosis in hepatocellular carcinoma2006
Author(s)
Shimoda, M., Takahashi, M., Yoshimoto, T., Kono, T, Ikai, I., Kubo, H
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Journal Title
Clin Can Res 12(20)
Pages: 6005-6011
Related Report
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[Journal Article] Differentiation of lymphatic endothelial cells from Embryonic Stem cells on OP9 stromal cells.2006
Author(s)
Kono, T., Kubo, H., Shimazu, C., Ueda Y., Takahashi, M., Yanagi, K., Fujita, N., Tsuruo.T., Wada, H., Yamashita, JK
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Journal Title
Arterioscler Thromb Vasc Biol 26(9)
Pages: 2070-2076
Related Report
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[Journal Article] Lymphangiogenesis-Mediated Shedding of LAM Cell Clusters as a Mechanism for Dissemination in Lymphangioleiomyomatosis.2005
Author(s)
Kumasaka T, Seyama K, Mitani K, Souma S, Kashiwagi S, Hebisawa A, Sato T, Kubo H, Gomi K, Shibuya K, Fukuchi Y, Suda K
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Journal Title
Am J Surg Pathol. 29
Pages: 1356-1366
Related Report
Peer Reviewed
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