Stromal factors regulating tumor cell motility

• Project/Area Number: 17014056
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University
• Principal Investigator: MIYASAKA Masayuki Osaka University, 医学系研究科, 教授 (50064613)
• Co-Investigator(Kenkyū-buntansha): HAYASAKA Haruko 大阪大学, 医学系研究科, 助教 (70379246) ; UMEMOTO Eui 大阪大学, 医学系研究科, 助教 (90452440) ; JANG Myoung-ho 大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤) (70420453) ; BAI Zhongbin 大阪大学, 免疫学フロンティア研究センター, 特任研究員 (10512840) ; VERJAN-GARCIA Noel 大阪大学, 免疫学フロンティア研究センター, 特任研究員 (90533216) ; HIRATA Takako 京都大学, 医学研究科, 特定准教授 (00346199) ; TANAKA Toshiyuki 兵庫医療大学, 薬学部, 教授 (30217054)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥100,300,000 (Direct Cost: ¥100,300,000); Fiscal Year 2009: ¥19,300,000 (Direct Cost: ¥19,300,000); Fiscal Year 2008: ¥19,300,000 (Direct Cost: ¥19,300,000); Fiscal Year 2007: ¥20,400,000 (Direct Cost: ¥20,400,000); Fiscal Year 2006: ¥20,400,000 (Direct Cost: ¥20,400,000); Fiscal Year 2005: ¥20,900,000 (Direct Cost: ¥20,900,000)
• Keywords: 癌 / 糖鎖 / バイオテクノロジー / 免疫学 / 転移 / 細胞外基質 / 接着分子 / 生体分子 / ケモカイン

Research Abstract

We have identified tumor stroma-derived molecules that upregulate tumor cell motility via cell surface CD44 ; they include low-molecular-weight hyaluronic acid and chondroitin sulfate E. They are produced by the enzymes produced by tumor cells and act on the tumor cells in an autocrine/paracrine manner. We also found that a number of the stroma-derived molecules bind chemokines and that certain combinations of chemokines modulate tumor cell motility, implying that certain stroma-derived molecules and chemokines upregulate tumor cell motility synergistically.

Research Products

• [Journal Article] Rap1 controls lymphocyte adhesion cascades and interstitial migration within lymph nodes in a RAPL-dependent and independent manner. (2010)
  • Author(s): *Ebisuno, Y., *Katagiri, K., Katakai, T., Ueda, Y., Nemoto, T., Inada, H., Nabekura, J., Okada, T., Kannagi, R., Tanaka, T., Miyasaka, M., Hogg, N., Kinashi, T. (*equal contribution)
  • Journal Title: Blood 115 Pages: 804-814
  • Peer Reviewed
• [Journal Article] A LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin. (2010)
  • Author(s): Tanaka, T., Moriwaki, K., Murata, S., Miyasaka, M.
  • Journal Title: Cancer Sci. 101 Pages: 363-368
  • NAID: 10026587701
  • Peer Reviewed
• [Journal Article] Rap1 controls lymphocyte adhesion cascades and interstitial migration within lymph nodes in a RAPL-dependent and independent manner. (2010)
  • Author(s): Ebisuno, Y., Katagiri, K.(equal contribution)
  • Journal Title: Blood 115 Pages: 804-814
  • Peer Reviewed
• [Journal Article] LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin. (2010)
  • Author(s): Tanaka, T.
  • Journal Title: Canser Sci. 101 Pages: 363-368
  • NAID: 10026587701
  • Peer Reviewed
• [Journal Article] P-selectin glycoprotein ligand-1 negatively regulates T-cell immune responses. (2009)
  • Author(s): Matsumoto, M., Miyasaka, M., Hirata, T.
  • Journal Title: J. Immunol. 183 Pages: 7204-7211
  • Peer Reviewed
• [Journal Article] Involvement of chondroitin sulfate E in the liver tumor focal formation of murine osteosarcoma cells. (2009)
  • Author(s): Basappa, Murugan, S., Sugahara, K.N., Lee, C.M., ten Dam, G.B., van Kuppevelt, T.H., Miyasaka, M., Yamada, S., Sugahara, K.
  • Journal Title: Glycobiology 19 Pages: 735-742
  • NAID: 120002223709
  • Peer Reviewed
• [Journal Article] CXCL12 promotes CCR7-dependent naive T-cell trafficking to lymph nodes and Peyer's patches. (2009)
  • Author(s): *Bai, Z., *Hayasaka, H., Kobayashi, M., Li, W., Guo, Z., Jang, M.H., Kondo, A., Choi, B., Iwakura, Y., Miyasaka, M. (*equal contribution)
  • Journal Title: J. Immunol. 182 Pages: 1287-1295
  • Peer Reviewed
• [Journal Article] P-selectin glycoprotein ligand-1 negatively regulates T-cell immune responses. (2009)
  • Author(s): Matsumoto, M.
  • Journal Title: J.Immunol. 183 Pages: 7204-7211
  • Peer Reviewed
• [Journal Article] Constitutive expression of IDO by dendritic cells of mesenteric lymphnodes : functional involvement of the CTLA-4/B7 and CCL22/CCR4 interactions. (2009)
  • Author(s): Onodera, T.
  • Journal Title: J.Immunol. 183 Pages: 5608-5614
  • Peer Reviewed
• [Journal Article] Involvement of chondroitin sulfate E in the liver tumor focal formation of murine osteosarcoma cells. (2009)
  • Author(s): Basappa, Murugan, S.
  • Journal Title: Glycobiology 19: Pages: 735-742
  • Peer Reviewed
• [Journal Article] CXCL12 promotes CCR7-dependent naive T-cell trafficking to lymphnodes and Peyer's patches. (2009)
  • Author(s): ^*Bai, Z., ^*Hayasaka, H (^*equal contribution)
  • Journal Title: J.Immunol. 182 Pages: 1287-1295
  • Peer Reviewed
• [Journal Article] CXCL12 promotes CCR7-dependent naive T-cell trafficking to lymph nodes and Peyer's patches (2009)
  • Author(s): Bai, Z., Hayasaka, H.(equal contribution)
  • Journal Title: J. Immunol 182 Pages: 1287-1295
  • Peer Reviewed
• [Journal Article] Nepmucin/CLM-9, an Ig domain-containing sialomucin in vascular endothelial cells, promotes lymphocyte transendothelial migration in vitro. (2008)
  • Author(s): Jin, S., Umemoto, E., Tanaka, T., Shimomura, Y., Tohya, K., Kunizawa, K., Yang, B. -G., Jang, M.H., Hirata, T., Miyasaka, M.
  • Journal Title: FEBS Lett. 582 Pages: 3018-3024
  • Peer Reviewed
• [Journal Article] Involvement of a lysophosphatidic-acid generating enzyme autotaxin in lymphocyte-endothelial cell interactions. (2008)
  • Author(s): *Nakasaki, T., *Tanaka, T., Okudaira, S., Hirosawa, M., Umemoto, E., Otani, K., Jin, S., Bai, Z., Hayasaka, H., Fukui, Y., Aozasa, K., Fujita, N., Tsuruo, T., Ozono, K., Aoki, J., Miyasaka, M. (*equal contribution)
  • Journal Title: Am. J. Pathol. 173 Pages: 1566-1576
  • Peer Reviewed
• [Journal Article] CD43 plays both antiadhesive and proadhesive roles in neutrophil rolling in a context-dependent manner. (2008)
  • Author(s): Matsumoto, M., Shigeta, A., Miyasaka, M., Hirata, T.
  • Journal Title: J. Immunol. 181 Pages: 3628-3635
  • Peer Reviewed
• [Journal Article] Chondroitin sulfate E fragments enhance CD44 cleavage and CD44-dependent motility in tumor cells. (2008)
  • Author(s): Sugahara, K.N., Hirata, T., Tanaka, T., Ogino, S., Takeda, M., Terasawa, H., Shimada, I., Tamura, J., Ten Dam, G.B., Van Kuppevelt, T.H., Miyasaka, M.
  • Journal Title: Cancer Res. 68 Pages: 7191-7199
  • Peer Reviewed
• [Journal Article] Identification of novel isoforms of mouse L-selectin with different carboxy-terminal tails. (2008)
  • Author(s): Furukawa, Y., Umemoto, E., Jang, M.H., Tohya, K., Miyasaka, M., Hirata, T.
  • Journal Title: J. Biol. Chem. 283 Pages: 12112-12119
  • Peer Reviewed
• [Journal Article] L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation (2008)
  • Author(s): Shigeta, A.
  • Journal Title: Blood 112 Pages: 4915-4923
  • Peer Reviewed
• [Journal Article] Nepmucin/CLM-9, an Ig domain-containing sialomucin in vascular endothelial cells, promotes lymphocyte transendothelial migration in vitro (2008)
  • Author(s): Jin, S.
  • Journal Title: FEBS Lett 582 Pages: 3018-3024
  • Peer Reviewed
• [Journal Article] Involvement of a lysophosphatidic-acid generating enzyme autotaxin in lymphocyte-endothelial cell interactions (2008)
  • Author(s): Nakasaki, T., Tanaka, T.(equal contribution)
  • Journal Title: Am. J. Pathol 173 Pages: 1566-1576
  • Peer Reviewed
• [Journal Article] CD43 plays both antiadhesive and proadhesive roles in neutrophil rolling in a context-dependent manner (2008)
  • Author(s): Matsumoto, M.
  • Journal Title: J. Immunol 181 Pages: 3628-3635
  • Peer Reviewed
• [Journal Article] Chondroitin sulfate E fragments enhance CD44 cleavage and CD44-dependent motility in tumor cells (2008)
  • Author(s): Sugahara, K. N.
  • Journal Title: Cancer Res 68 Pages: 7191-7199
  • Peer Reviewed
• [Journal Article] Regulation of leukocyte migration across endothelial barriers by ecto-5'-nucleotidase-generated adenosine (2008)
  • Author(s): Thompson, L. F.
  • Journal Title: Nucleosides Nucleotides Nucleic Acids 27 Pages: 755-760
  • Peer Reviewed
• [Journal Article] Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5 (2008)
  • Author(s): Uematsu., S.
  • Journal Title: Nat. Immunol 9 Pages: 769-776
  • Peer Reviewed
• [Journal Article] Identification of novel isoforms of mouse L-selectin with different carboxy-terminal tails (2008)
  • Author(s): Furukawa, Y.
  • Journal Title: J. Biol. Chem 283 Pages: 12112-12119
  • Peer Reviewed
• [Journal Article] CD73-generated adenosine restricts lymphocyte migration into draining lymph nodes (2008)
  • Author(s): Takedachi, M.
  • Journal Title: J. Immunol 180 Pages: 6288-6296
  • Peer Reviewed
• [Journal Article] CD4^+CD25^+ regulatory T cells in the small intestinal lamina propria show an effector/memorv phenotype. (2008)
  • Author(s): *Guo, Z.・*Jang, M.H. (*equal contribution)
  • Journal Title: lnt. lmmunol. 20 Pages: 307-315
  • Peer Reviewed
• [Journal Article] Human eosinophils show chemotaxis to lymphoid chemokines and exhibit antigen-presenting-cell-like properties upon stimulation with IFN-y, lL-3 and GM-CSF. (2008)
  • Author(s): Jung, Y.-J.
  • Journal Title: lnt. Arch. Allergy Immunol. 146 Pages: 227-234
  • Peer Reviewed
• [Journal Article] Binding of lymphoid chemokines to collagen IV that accumulates in the basal lamina of high endothelial venules; its implication in lymphocyte trafficking. (2007)
  • Author(s): Yang, B. -G., Tanaka, T., Jang, M.H., Bai, Z., Hayasaka, H., Miyasaka, M.
  • Journal Title: J. Immunol. 179 Pages: 4376-4382
  • Peer Reviewed
• [Journal Article] Plasmacytoid dendritic cells employ multiple cell adhesion molecules sequentially to interact with high endothelial venule cells - Molecular basis of their trafficking to lymph nodes. (2007)
  • Author(s): *Matsutani, T., *Tanaka, T., Tohya, K., Otani, K., Jang, M.H., Umemoto, E., Taniguchi, K., Hayasaka, H., Ueda, K., Miyasaka, M. (*equal contribution)
  • Journal Title: Int. Immunol. 19 Pages: 1031-1037
  • NAID: 10020107880
  • Peer Reviewed
• [Journal Article] CD43 collaborates with P-selectin glycoprotein ligand-1 to mediate E-selectin-dependent T cell migration into inflamed skin. (2007)
  • Author(s): Matsumoto, M., Shigeta, A., Furukawa, Y., Tanaka, T., Miyasaka, M., Hirata, T.
  • Journal Title: J. Immunol. 178 Pages: 2499-2506
  • Peer Reviewed
• [Journal Article] Binding of lymphoid chemokines to collagen IV that accumulates in the basal lamina of high endothelial venules; its implication in lymphocyte trafficking. (2007)
  • Author(s): Yang, B .-G.
  • Journal Title: J. lmmunol. 179 Pages: 4376-4382
  • Peer Reviewed
• [Journal Article] Plasmacytoid dendritic cells employ multiple cell adhesion molecules sequentially to interact with high endothelial venule cells - Molecular basis of their trafficking to lymphnodes. (2007)
  • Author(s): *Mautani, T.・*Tanaka, T.(*equal contribution)
  • Journal Title: lnt. lmmunol. 19 Pages: 1031-1037
  • Peer Reviewed
• [Journal Article] CD43 collaborates with P-selectin glycoprotein ligand-1 to mediate E-setectin-dependen T cell migration into inflamed skin. (2007)
  • Author(s): Matsumoto, M.
  • Journal Title: J. lmmunol. 178 Pages: 2499-2506
  • Peer Reviewed
• [Journal Article] P-selectin glycoprotein ligand-1 L-selectin-independent leukocyte rolling in high eridothelial venules of peripheral lymph nodes. (2007)
  • Author(s): Harakawa, N.
  • Journal Title: lnt. Immunol. 19 Pages: 321-329
  • Peer Reviewed
• [Journal Article] Ligand-induced structural changes of the CD44 hyaluronan-binding domain revealed by NMR. (2006)
  • Author(s): Takeda, M., Ogino, S., Umemoto, R., Sakakura, M., Kajiwara, M., Sugahara, K.N., Miyasaka, M., Terasawa, H., Shimada, I.
  • Journal Title: J. Biol. Chem. 281 Pages: 40089-40095
  • Peer Reviewed
• [Journal Article] Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow. (2006)
  • Author(s): Umemoto, E., Tanaka, T., Kanda, H., Jin, S., Tohya, K., Otani, K., Matsutani, T., Matsumoto, M., Ebisuno, Y., Jang, M.H., Fukuda, M., Hirata, T., Miyasaka, M.
  • Journal Title: J. Exp. Med. 203 Pages: 1603-1614
  • Peer Reviewed
• [Journal Article] Tumor cells enhance their own CD44 cleavage and motility by generating hyaluronan fragments. (2006)
  • Author(s): Sugahara, K.N., Hirata, T., Hayasaka, H., Stern, R., Murai, T., Miyasaka, M.
  • Journal Title: J. Biol. Chem. 281 Pages: 5861-5868
  • Peer Reviewed
• [Journal Article] Ligand-induced structural changes of the CD44 hyaluronan-binding domain revealed by NMR. (2006)
  • Author(s): Takeda, M. et al.
  • Journal Title: J. Biol. Chem. 281 Pages: 40089-40095
• [Journal Article] Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow. (2006)
  • Author(s): Umemoto, E. et al.
  • Journal Title: J. Exp. Med. 203 Pages: 1603-1614
• [Journal Article] TLR5 is highly expressed on intestinal CD11c^+ lamina propria cells and utilized by S. typhimurium for systemic infection. (2006)
  • Author(s): *Uematsu, S., *Jang, M.H.(*equal contribution)
  • Journal Title: Nat. Immunol. 7 Pages: 868-874
• [Journal Article] Cytokines, chemokines, and their receptors : targets for immunomodulation. Conference report : International Cytokine Society Conference 2005. (2006)
  • Author(s): Jang, M.H.et al.
  • Journal Title: J. Leuk. Biol. 80 Pages: 217-219
• [Journal Article] Tumor cells enhance their own CD44 cleavage and motility by generating hyaluronan fragments. (2006)
  • Author(s): Sugahara, K.N. et al.
  • Journal Title: J. Biol. Chem. 281 Pages: 5861-5868
• [Journal Article] CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. (2006)
  • Author(s): *Jang, M.H., *Sougawa, N.et al.(*equal contribution)
  • Journal Title: J. Immunol. 176 Pages: 803-810
• [Journal Article] Tumor cells enhance their own CD44 cleavage and motility by generating hyaluronan fragments. (2006)
  • Author(s): Sugahara, K.N. et al.
  • Journal Title: J.Biol.Chem. 281 Pages: 5861-5868
• [Journal Article] CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. (2006)
  • Author(s): ^*Jang, M, ^*Sougawa, N.et al.(^*equal contribution)
  • Journal Title: J.Immunol. 176 Pages: 803-810
• [Journal Article] Invasive human pancreatic carcinoma cells adhere to endothelial tri-cellular corners and increase endothelial permeability. (2005)
  • Author(s): Nakai, K., Tanaka, T., Murai, T., Ohguro, N., Tano, Y., Miyasaka, M.
  • Journal Title: Cancer Sci. 96 Pages: 766-773
  • NAID: 10017091610
  • Peer Reviewed
• [Journal Article] CXCL13 is an arrest chemokine for B cells in high endothelial venules. (2005)
  • Author(s): *Kanemitsu, N., *Ebisuno, Y., *Tanaka, T., Otani, K., Hayasaka, H., Kaisho, T., Akira, S., Katagiri, K., Kinashi, T., Fujita, N., Tsuruo, T., Miyasaka, M. (*equal contribution)
  • Journal Title: Blood 106 Pages: 2613-2618
  • Peer Reviewed
• [Journal Article] Chemokines in tumor progression and metastasis. (2005)
  • Author(s): Tanaka, T., Bai, Z., Srinoulprasert, Y., Yang, B. -G., Hayasaka, H., Miyasaka, M.: Review
  • Journal Title: Cancer Sci. 96 Pages: 317-322
  • Peer Reviewed
• [Journal Article] Review : Chemokines in tumor progression and metastasis. (2005)
  • Author(s): Tanaka, T. et al.
  • Journal Title: Cancer Sci. 96 Pages: 317-322
• [Journal Article] Invasive human pancreatic carcinoma cells adhere to endothelial tri-cellular corners and increase endothelial permeability. (2005)
  • Author(s): Nakai, K. et al.
  • Journal Title: Cancer Sci. 96 Pages: 766-773
• [Journal Article] CD43 functions as a ligand for E-selectin on activated T cells. (2005)
  • Author(s): Matsumoto, M. et al.
  • Journal Title: J.Immunol. 175 Pages: 8042-8050
• [Journal Article] CXCL13 is an arrest chemokine for B cells in high endothelial venules. (2005)
  • Author(s): ^*Kanemitsu, N., ^*Ebisuno, Y., ^*Tanaka, T.et al.(^*equal contribution)
  • Journal Title: Blood 106 Pages: 2613-2618
• [Presentation] CD44-mediated cell rolling regulated by two-state conformational equilibrium of the hyaluronan-binding domain. (2009)
  • Author(s): Suzuki, M., et al.
  • Organizer: The 39th Annual Meeting of the Japanese Society for Immunology. Dec.
  • Place of Presentation: Osaka
• [Presentation] Characterization of CXCR4+ cells with prominent membrane blebbing in a human colon adenocarcinoma cell line LoVo. (2009)
  • Author(s): Matsumoto, M., et al.
  • Organizer: The 68th Annual Meeting of the Japanese Cancer Association.
  • Place of Presentation: Yokohama
• [Presentation] Attempts to identify the cell population directly involved in invasion/metastasis in human malignant mesothelioma. (2009)
  • Author(s): Kubota, H., et al.
  • Organizer: The 68th Annual Meeting of the Japanese Cancer Association.
  • Place of Presentation: Yokohama
• [Presentation] The E-type structure of chondroitin/dermatan sulfate on tumor cell surfaces is involved in lung and liver metastases. (2009)
  • Author(s): Sugahara, K., et al.
  • Organizer: 6th International Conference on Preteoglycan.
  • Place of Presentation: Aix-les-Bains, France
• [Presentation] マウス癌細胞株の肺および肝臓への転移にはコンドロイチン硫酸E様構造が関与する. (2009)
  • Author(s): 菅原一幸, 他.
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 岐阜
• [Presentation] 乳癌細胞におけるCXCL12とCCR7リガンド協働作用の解析. (2009)
  • Author(s): 早坂晴子, 他
  • Organizer: 第18回日本がん転移学会学術集会・総会
  • Place of Presentation: 旭川
• [Presentation] The role of CD44-ECM interactions in tumor invasion. (2009)
  • Author(s): Miyasaka, M., et al.
  • Organizer: Yokosuka Science Festa 2009
  • Place of Presentation: Yokosuka
• [Presentation] Identification of nepmucin as a phosphatidylserine receptor. (2009)
  • Author(s): Umemoto, E.
  • Organizer: 17th International Symposium on Molecular Cell Biology of Macrophage.
  • Place of Presentation: Kanazawa
• [Presentation] Plasmacytoid dendritic cells : their constitutive migration patterns to peripheral lymphoid tissues. (2009)
  • Author(s): Verjan Garcia, N.
  • Organizer: The 4th RCAI International Summer Program 2009
  • Place of Presentation: Yokohama
• [Presentation] 乳癌細胞におけるCXCL12とCCR7リガンド協働作用の解析 (2009)
  • Author(s): 早坂晴子
  • Organizer: 第18回日本がん転移学会学術集会・総会
  • Place of Presentation: 旭川
• [Presentation] マウス癌細胞株の肺および肝臓への転移にはコンドロイチン硫酸E様構造が関与する (2009)
  • Author(s): 菅原一幸
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 岐阜
• [Presentation] The E-type structure of chondroitin/dermatan sulfate on tumor cell surfaces is involved in lung and liver metastases. (2009)
  • Author(s): Sugahara, K.
  • Organizer: 6th International Conference on Preteoglycan
  • Place of Presentation: Aix-les-Bains, France
• [Presentation] Attempts to identify the cell population directly involved in invasion/metastasis in human malignant mesothelioma. (2009)
  • Author(s): Kubota, H.
  • Organizer: The 68th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
• [Presentation] Characterization of CXCR4^+ cells with prominent membrane blebbing in a human colon adenocarcinoma cell line LoVo. (2009)
  • Author(s): Matsumoto, M.
  • Organizer: The 68th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
• [Presentation] Nepmucin mediates uptake of apoptotic cells in endothelial cells of high endothelial venules. (2009)
  • Author(s): Umemoto, E.
  • Organizer: The 39th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Osaka
• [Presentation] CD44-mediated cell rolling regulated by two-state conformational equilibrium of the hyaluronan-binding domain. (2009)
  • Author(s): Suzuki, M.
  • Organizer: The 39th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Osaka
• [Presentation] リンパ球動態研究における動物実験の重要性 (2008)
  • Author(s): 宮坂、昌之
  • Organizer: 第99回関西実験動物研究会
  • Place of Presentation: 大阪
  • Year and Date: 2008-09-12
• [Presentation] 最近の免疫学の進歩-自然免疫から適応免疫まで、そしてその臨床応用は? (2008)
  • Author(s): 宮坂昌之
  • Organizer: 豊中皮膚科の会
  • Place of Presentation: 豊中
  • Year and Date: 2008-06-21
• [Presentation] A novel endothelial cell adhesion molecule, nepmucin:lts absence of expression in immunologically privileged sites and tumor tissues. (2008)
  • Author(s): Umemoto, E
  • Organizer: The U.S.- Japan Cooperative Cancer Research Program Workshop 2008
  • Place of Presentation: Kyoto
  • Year and Date: 2008-03-21
• [Presentation] 癌細胞におけるCXCL12及びCCL19/CCL21の協働作用の検討. (2008)
  • Author(s): 岩本由希, 他
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] 癌細胞の動態を制御する間質因子. (2008)
  • Author(s): 宮坂昌之
  • Organizer: 第49回日本肺癌学会総会
  • Place of Presentation: 福岡
• [Presentation] Characterization of SP and non-SP in a human colon adenocarcinoma cell line LoVo. (2008)
  • Author(s): Nishiyama, M., et al.
  • Organizer: The 67th Annual Meeting of the Japanese Cancer Association.
  • Place of Presentation: Nagoya
• [Presentation] A novel endothelial cell adhesion molecule, nepmucin: Its absence of expression in immunologically privileged sites and tumor tissues. (2008)
  • Author(s): Umemoto, E., et al.
  • Organizer: The U.S. - Japan Cooperative Cancer Research Program Workshop 2008
  • Place of Presentation: Kyoto
• [Presentation] リンパ節へのT細胞トラフィッキングにおけるCCR7とCXCR4の共同作用 (2008)
  • Author(s): 白忠彬
  • Organizer: 第32回日本リンパ学会総会
  • Place of Presentation: 東京
• [Presentation] The role of an LPA-generating enzyme, autotaxin, at high endothelial venules (2008)
  • Author(s): Miyasaka, M.
  • Organizer: Gordon Research Conference Endothlial Cell Phenotypes in Health & Disease
  • Place of Presentation: Biddeford, U.S.A.
• [Presentation] 免疫細胞は自分の行き先をどのようにして知るのか? (2008)
  • Author(s): 宮坂昌之
  • Organizer: 日本免疫学会免疫サマースクール2008
  • Place of Presentation: 淡路島
• [Presentation] A new modulator of lymphocyte trafficking, autotaxin (2008)
  • Author(s): Miyasaka, M.
  • Organizer: FIMSA 2008
  • Place of Presentation: Taipei, Taiwan
• [Presentation] Characterization of SP and non-SP in a human colon adenocarcinoma cell line LoVo (2008)
  • Author(s): Nishiyama, M.
  • Organizer: The 6^<7th> Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Nagoya
• [Presentation] 癌細胞の動態を制御する間質因子 (2008)
  • Author(s): 宮坂昌之
  • Organizer: 第49回日本肺癌学会総会
  • Place of Presentation: 福岡
• [Presentation] 免疫細胞は自分の行き先をどのようにして知るのか? (2008)
  • Author(s): 宮坂昌之
  • Organizer: 第38回日本免疫学会総会-学術集会
  • Place of Presentation: 京都
• [Presentation] Synergy between CCR7 and CXCR4 signaling in T lymphocyte Migration ; HIV-1 gp120 facilitates CCL21-induced chernotaxis in T lymphocytes in a CXCR4-dependent manlier (2008)
  • Author(s): Hayasaka, H.
  • Organizer: The 38th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kyoto
• [Presentation] PSGL-1 negatively regulates T cell immune responses in vivo (2008)
  • Author(s): Matsumoto, M.
  • Organizer: The 38th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kyoto
• [Presentation] Promotion of CCR7 ligand-dependent T cell trafficking to LNs and PPs by CXCL12 (2008)
  • Author(s): Bai, Z.
  • Organizer: The 38th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kyoto
• [Presentation] Nepmucin/CLM-9, an Ig domain-containing sialomucin in vascular endothelial cells ; promotes lymphocyte transendothelial migration (2008)
  • Author(s): Jin, S.
  • Organizer: The 38th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kyoto
• [Presentation] The role of intestinal eosinophils in acquired immunity in the gut (2008)
  • Author(s): Fukamizu, R.
  • Organizer: The 38th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kyoto
• [Presentation] Nepmucin mediates uptake of apoptotic cells through binding to phosphatidylserine (2008)
  • Author(s): Kunizawa, K.
  • Organizer: The 38th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kyoto
• [Presentation] Generation of specific monoclonal antibodies against mouse eosinophils (2008)
  • Author(s): Yamasaki, M.
  • Organizer: The 38th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kyoto
• [Presentation] Peripheral lymphopenia in moesin-deficient mice (2008)
  • Author(s): Serigano, N.
  • Organizer: The 38th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kyoto
• [Presentation] Critical role of Peyer's patch CD11b^+ dendritic cells for the induction of antigen-specific mucosal lgA antibody responses to recombinant Salmonella (2008)
  • Author(s): Hashizume, T.
  • Organizer: The 38th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kyoto
• [Presentation] Antibody-mediated blockade of IL-15 signaling reverses autoimmune intestinal damage in a transgenic mouse model of celiac disease (2008)
  • Author(s): Yokoyama, S.
  • Organizer: The 38th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kyoto
• [Presentation] 嘉細胞におけるCXCL12及びCCL191CCL21の協働作用の検討 (2008)
  • Author(s): 岩本由希
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] Nepmucin that shows homophilic binding plays a role in lymphocyte transmigration across vascular endothelial cells (2007)
  • Author(s): Jin, S.
  • Organizer: The 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Tokyo
  • Year and Date: 2007-11-20
• [Presentation] Enhancement of CCR7 ligand-induced T cell chemotaxis by CXCLI2: The mode of action of CXCL12 (2007)
  • Author(s): Bai, Z.
  • Organizer: The 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Tokyo
  • Year and Date: 2007-11-20
• [Presentation] Ligation of CXCR4 upregulates CCL19 or CCL21-induced chemotaxis and actinpolymerization in T lymphocytes (2007)
  • Author(s): Kobayashi, M.
  • Organizer: The 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Tokyo
  • Year and Date: 2007-11-20
• [Presentation] A novel endothelial cell adhesion molecule, nepmucin:lts absence of expression in immunologically privileged sites and tumor tissues. Lnvited lecture (2007)
  • Author(s): Umemoto, E
  • Organizer: The 6th Sino-Japan Joint Conference for Cancer Research
  • Place of Presentation: Toya
  • Year and Date: 2007-10-06
• [Presentation] Search for endothelial molecules that inhibit lymphocyte entry into tumor tissues (2007)
  • Author(s): Hayasaka, H.
  • Organizer: The 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Year and Date: 2007-10-03
• [Presentation] Nepmucin may regulate lymphoma infiltration by two distinct mechanisms (2007)
  • Author(s): Umemoto, E
  • Organizer: The 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Year and Date: 2007-10-03
• [Presentation] 癌細胞のケモタキシスにおけるケモカイン協働作用の解析 (2007)
  • Author(s): 早坂晴子
  • Organizer: 第16回日本がん転移学会学術集会
  • Place of Presentation: 富山
  • Year and Date: 2007-07-09
• [Presentation] 血管内皮細胞に発現する新規シアロムチンnepmucinへの造血腫細胞の接着機構の解析 (2007)
  • Author(s): 梅本英司
  • Organizer: 第16回日本がん転移学会学術集会
  • Place of Presentation: 富山
  • Year and Date: 2007-07-09
• [Presentation] 血管内皮細胞に発現する新規シアロムチンnepmucinは、lgドメインを介してホモフィリックに結合する (2007)
  • Author(s): 陳 秀晶
  • Organizer: 第16回日本がん転移学会学術集会
  • Place of Presentation: 富山
  • Year and Date: 2007-07-09
• [Presentation] Nepmucin is selectively expressed in certain myeloid-lineage cells including immature dendritic cells (2007)
  • Author(s): Umemoto, E.
  • Organizer: 16thInternational Symposium on Molecular Cell Biology of Macrophages
  • Place of Presentation: Shizuoka
  • Year and Date: 2007-06-14
• [Presentation] リンフォイドケモカインの協働作用による丁リンパ球ケモタキシスの促進 (2007)
  • Author(s): 白 忠彬
  • Organizer: 第31回日本リンパ学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-06-08
• [Presentation] リンパ球、樹状細胞の動態制御機構研究の最前線-ケカインは新しい治標的となりうるか (2007)
  • Author(s): 宮坂昌之
  • Organizer: 第15回新潟移植再生研究会
  • Place of Presentation: 新潟
  • Year and Date: 2007-06-04
• [Presentation] Nepmucin that shows homophilic binding plays a role in lymphocyte transmigration across vascular endothelial cells. (2007)
  • Author(s): Jin, S., et al.
  • Organizer: The 37th Annual Meeting of the Japanese Society for Immunology.
  • Place of Presentation: Tokyo
• [Presentation] A novel endothelial cell adhesion molecule, nepmucin: Its absence of expression in immunologically privileged sites and tumor tissues. (2007)
  • Author(s): Umemoto, E., et al.
  • Organizer: Invited lecture. The 6th Sino-Japan Joint Conference for Cancer Research.
  • Place of Presentation: Toya
• [Presentation] 癌細胞のケモタキシスにおけるケモカイン協働作用の解析. (2007)
  • Author(s): 早坂晴子, 他
  • Organizer: 第16回日本がん転移学会学術集会
  • Place of Presentation: 富山
• [Patent(Industrial Property Rights)] 低分子コンドロイチン硫酸を含む医薬 (2005)
  • Inventor(s): 宮坂昌之、前田浩、村松信、松本太郎
  • Industrial Property Rights Holder: 大正製薬株式会社
  • Industrial Property Number: 2005-150820
  • Filing Date: 2005-05-24
• [Patent(Industrial Property Rights)] コンドロイチン硫酸Eフラグメント (2005)
  • Inventor(s): 宮坂昌之, 前田 浩, 村松 信, 松本太郎
  • Industrial Property Rights Holder: 大正製薬株式会社
  • Industrial Property Number: 2005-150820
  • Filing Date: 2005-05-24