| Project/Area Number |
17014058
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka University |
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Principal Investigator |
YONEDA Toshiyuki Osaka University, 大学院・歯学研究科, 教授 (80142313)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIMURA Riko 大阪大学, 大学院・歯学研究科, 准教授 (60294112)
平賀 徹 大阪大学, 大学院・歯学研究科, 講師 (70322170)
若林 弘樹 三重大学, 大学院・医学系研究科, 助手 (50362687)
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| Project Period (FY) |
2005 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥43,400,000 (Direct Cost: ¥43,400,000)
Fiscal Year 2009: ¥8,200,000 (Direct Cost: ¥8,200,000)
Fiscal Year 2008: ¥8,200,000 (Direct Cost: ¥8,200,000)
Fiscal Year 2007: ¥9,300,000 (Direct Cost: ¥9,300,000)
Fiscal Year 2006: ¥9,300,000 (Direct Cost: ¥9,300,000)
Fiscal Year 2005: ¥8,400,000 (Direct Cost: ¥8,400,000)
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| Keywords | 癌 / 骨 / 破骨細胞 / 骨芽細胞 / クロストーク / サイトカイン / 増殖因子 / 疼痛 / 骨転移 / レプチン |
|---|
| Research Abstract |
Along with increasing of breast and prostate cancer patients, the metastases of cancer into bone has been important issues. It is, therefore, necessary to establish effective solutions for the metastases. Bone resorption and bone formation are active in bone tissues where several types of cells, including immune cells, hematopoietic cells, adipocytes and neural cells, are present. In this study, we examined cross-talk between cancer and bone tissues at molecular level, cell level, and in vivo. Furthermore, we revealed the mechanisms of bone pain associated with bone metastases.
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