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Abnormal differentiation of tumor cells and tyrosine kinase regulation

Research Project

Project/Area Number 17014069
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKeio University (2008-2009)
Kyushu University (2005-2007)

Principal Investigator

YOSHIMURA Akihiko  Keio University, 医学部, 教授 (90182815)

Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥59,900,000 (Direct Cost: ¥59,900,000)
Fiscal Year 2009: ¥12,900,000 (Direct Cost: ¥12,900,000)
Fiscal Year 2008: ¥12,900,000 (Direct Cost: ¥12,900,000)
Fiscal Year 2007: ¥11,400,000 (Direct Cost: ¥11,400,000)
Fiscal Year 2006: ¥11,400,000 (Direct Cost: ¥11,400,000)
Fiscal Year 2005: ¥11,300,000 (Direct Cost: ¥11,300,000)
Keywordsサイトカイン / シグナル伝達 / チロシンキナーゼ / 転写因子 / STAT / 炎症 / Ras / ERK / 家族性変異 / 発がん / Spred / 神経繊維腫I型 / SOCS / Sred / 肝炎 / 肝がん / チロシンりん酸化 / インターフェロン
Research Abstract

Inflammatory cells are involved in tumor growth and development through various inflammatory mediators. Inflammatory cytokines activate the NF-kB and JAK/STAT pathways. We have investigated the function of SOCS family and Spred family proteins which regulate cytokine signaling, on tumorigenesi. In model mice lacking SOCS1 or SOCS3 genes, we found that carcinogen-induced tumorigensis was promoted. In human hepatocellular carcinoma, SOCS1 and SOCS3 gene expression was silenced. We also found that human SPRED1 is responsible for neurofibromatosis type I like disease.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (62 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (55 results) (of which Peer Reviewed: 19 results) Presentation (5 results) Remarks (2 results)

  • [Journal Article] Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury.2009

    • Author(s)
      Shichita T, Sugiyama Y, Ooboshi H, Sugimori H, Nakagawa R, Takada I, Iwaki T, Okada Y, Iida M, Cua DJ, Iwakura Y, Yoshimura A
    • Journal Title

      Nature Med. 15(8)

      Pages: 946-950

    • Related Report
      2009 Final Research Report
  • [Journal Article] SOCS3 in T and NKT cells negatively regulates cytokine production and ameliorates ConA-induced hepatitis.2009

    • Author(s)
      Nakaya M, Hashimoto M, Nakagawa R, Wakabayashi Y, Ishizaki T, Takada I, Komai K, Yoshida H, Yoshimura A
    • Journal Title

      J Immunol 183(11)

      Pages: 7047-7053

    • Related Report
      2009 Final Research Report
  • [Journal Article] Clinical and mutational spectrum of Legius syndrome2009

    • Author(s)
      Messiaen L, Yao S, (他30名), Taniguchi K, Ayada T, Okamoto F, Yoshimura A, Parret A, Korf B, Legius E
    • Journal Title

      JAMA 302(19)

      Pages: 2111-2118

    • Related Report
      2009 Final Research Report
  • [Journal Article] Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis.2009

    • Author(s)
      Taleb S, Romain M, Ramkhelawon B, Uyttenhove C, Pasterkamp G, Herbin O, Esposito B, Perez N, Yasukawa H, Van Snick J, Yoshimura A, Tedgui A, Mallat Z
    • Journal Title

      J Exp Med. 206(10)

      Pages: 2067-2077

    • Related Report
      2009 Final Research Report
  • [Journal Article] Suppression of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis.2009

    • Author(s)
      Taniguchi K, Sasaki K, Watari K, Yasukawa H, Imaizumi T, Ayada T, Okamoto F, Ishizaki T, Kato R, Kohno R, Kimura H, Sato Y, Ono M, Yonemitsu Y, Yoshimura A
    • Journal Title

      PLoS ONE 4(5)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the c-Fos protein phosphorylated by IKKbeta2009

    • Author(s)
      Koga K, Takaesu G, Yoshida R, Nakaya M, Kobayashi T, Kinjyo I, Yoshimura A
    • Journal Title

      Immunity 30(3)

      Pages: 372-383

    • Related Report
      2009 Final Research Report
  • [Journal Article] Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation2009

    • Author(s)
      Hashimoto M, Ayada T, Kinjyo I, Hiwatashi K, Yoshida H, Okada Y Kobayashi T, Yoshimura A
    • Journal Title

      Cancer Sci 100(4)

      Pages: 730-736

    • NAID

      10025144745

    • Related Report
      2009 Final Research Report
  • [Journal Article] Rudensky AY. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein.2009

    • Author(s)
      Lu LF, Thai TH, Calado DP, Chaudhry A, Kubo M, Tanaka K, Loeb GB, Lee H, Yoshimura A, Rajewsky K
    • Journal Title

      Immunity 30(1)

      Pages: 80-91

    • Related Report
      2009 Final Research Report
  • [Journal Article] Sprouty4 negatively regulates protein kinase C activation by inhibiting phosphatidylinositol 4, 5-biphosphate hydrolysis.2009

    • Author(s)
      Ayada T, Taniguchi K, Okamoto F, Kato R, Komune S, Takaesu G, Yoshimura A
    • Journal Title

      Oncogene 28(8)

      Pages: 1076-88

    • Related Report
      2009 Final Research Report
  • [Journal Article] Cyclic Adenosine Monophosphate Suppresses the Transcription of Proinflammatory Cytokines via the Phosphorylated c-Fos Protein2009

    • Author(s)
      Keiko Koga, et al.
    • Journal Title

      Immunity 30

      Pages: 372-383

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Signal-Transducing Adaptor Protein-2 Regulates Stromal Cell-Derived Factor-1{alpha}-Induced Chemotaxis in T Cells.2009

    • Author(s)
      Sekine Y, Ikeda O, Tsuji S, et al.
    • Journal Title

      J Immunol. 183(12)

      Pages: 7966-7974

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and mutational spectrum of Legius syndrome2009

    • Author(s)
      Messiaen L, Yao S, Brems H, et al.
    • Journal Title

      JAMA 206(10)

      Pages: 2067-2077

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury.2009

    • Author(s)
      Shichita T, Sugiyama Y, Ooboshi H., et al.
    • Journal Title

      Nature Med. 15(8)

      Pages: 946-950

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sprouty4 negatively regulates protein kinase C activation by inhibiting phoshatidylinositol 4,5-biphosphate hydrolysis.2009

    • Author(s)
      Ayata T, Taniguchi K, et al.
    • Journal Title

      Oncogene 28

      Pages: 1076-1088

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sprouty4 deficiency potentiates Ras-independent angiogenic signals and tumor growth.2009

    • Author(s)
      Taniguchi K, Ishizaki T, Ayada T, et al.
    • Journal Title

      Cancer Sci. 100(9)

      Pages: 1648-1654

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic Adenosine Monophosphate Suppresses the Transcription of Prninflammatnry Cvtokines via the Phosnhorvlated c-Fos Protein2009

    • Author(s)
      Keiko Koga, et.al.
    • Journal Title

      Immunity 30

      Pages: 372-383

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sprouty4 negatively regulates protein kinase C activation by inhibiting phosnhatidvlinositol 4.5-biphosphate hydrolysis2009

    • Author(s)
      Ayata T, Taniguchi K, et.al.
    • Journal Title

      Oncogene 28

      Pages: 1076-1088

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] STAT6 inhibits TGF-beta 1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor.2008

    • Author(s)
      Takaki H, Ichiyama K, Koga K, Chinen T, Takaesu G, Sugiyama Y, Kato S, Yoshimura A, Kobayashi T
    • Journal Title

      J Biol Chem. 283(22)

      Pages: 14955-14962

    • Related Report
      2009 Final Research Report
  • [Journal Article] TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like Helicase Antiviral Pathway.2008

    • Author(s)
      Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
    • Journal Title

      J Biol Chem. 283(52)

      Pages: 36211-36220

    • Related Report
      2009 Final Research Report
  • [Journal Article] FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicases signaling pathway.2008

    • Author(s)
      Sanada T, Takaesu G, Mashima R, Yoshida R, Kobayashi T, Yoshimura A
    • Journal Title

      J Biol Chem. 283(49)

      Pages: 33858-33864

    • Related Report
      2009 Final Research Report
  • [Journal Article] Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis.2008

    • Author(s)
      Torisu T, Nakaya M, Watanabe S, Hashimoto M, Yoshida H, Chinen T, Yoshida R, Okamoto F, Hanada T, Torisu K, Takaesu G, Kobayashi T, Yasukawa H, Yoshimura A
    • Journal Title

      Hepatology 47(5)

      Pages: 1644-1654

    • Related Report
      2009 Final Research Report
  • [Journal Article] Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-{gamma} on STAT3 and Smads.2008

    • Author(s)
      Tanaka K, Ichiyama K, Hashimoto M, Yoshida H, Takimoto T, Takaesu G, Torisu T, Hanada T, Yasukawa H, Fukuyama S, Inoue H, Nakanishi Y, Kobayashi T, Yoshimura A
    • Journal Title

      J Immunol 180(6)

      Pages: 3746-3756

    • Related Report
      2009 Final Research Report
  • [Journal Article] SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag.2008

    • Author(s)
      Ryo A, Tsurutani N, Ohba K, Kimura R, Komano J, Nishi M, Soeda H, Hattori S, Perrem K, Yamamoto M, Chiba J, Mimaya J, Yoshimura K, Matsushita S, Honda M, Yoshimura A, Sawasaki T, Aoki I, Morikawa Y, Yamamoto N
    • Journal Title

      Proc Natl Acad Sci U S A 105(1)

      Pages: 294-299

    • Related Report
      2009 Final Research Report
  • [Journal Article] FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicases signaling pathway2008

    • Author(s)
      Sanada T, Takaesu G, Yoshida R, Kobayashi T, et.al.
    • Journal Title

      Journal of Biological Chemistry 283

      Pages: 33858-33864

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat2008

    • Author(s)
      Ichiyama K, Chinen, T, Kobayashi T, et.al.
    • Journal Title

      J Biological Chemistry 283

      Pages: 10773-10778

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SOCS1 protects mice against concanavalin-A-induced hepatitis by inhibiting Fas, STAT1 and JNK-mediated apoptosis2008

    • Author(s)
      Torisu T, Chinen T, Yasukawa H. Kobayashi T, et.al.
    • Journal Title

      Hepatology 47

      Pages: 1644-1654

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or aging2008

    • Author(s)
      Miyamoto K, Miyamoto T, Kato R
    • Journal Title

      Blood 112

      Pages: 4485-4493

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-{gamma} on STAT3 and Smads.2008

    • Author(s)
      Tanaka, K・Kobayashi, T・Yoshimura, A, et. al.
    • Journal Title

      J Immunol. 180

      Pages: 3746-56

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellualt trafficking and stability of HIV-1 Gag.2008

    • Author(s)
      Ryo, A・Yoshimura, A・Aoki, I・Morikawa, Y・Yamamoto, N., et. al.
    • Journal Title

      Porc Natl Acad Sci USA. 105

      Pages: 294-9

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SOCS proteins, cytokine signalling and immune regulation.2007

    • Author(s)
      Yoshimura A, Naka T, Kubo M
    • Journal Title

      Nat Rev Immunol 7(6)

      Pages: 454-465

    • Related Report
      2009 Final Research Report
  • [Journal Article] Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype.2007

    • Author(s)
      Brems H, Chmara M, Sahbatou M, Denayer E, Taniguchi K, Kato R, Somers R, Messiaen L, De Schepper S, Fryns JP, Cools J, Marynen P, Thomas G, Yoshimura A, Legius E
    • Journal Title

      Nature Genet 39(9)

      Pages: 1120-1126

    • Related Report
      2009 Final Research Report
  • [Journal Article] Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling.2007

    • Author(s)
      Taniguchi K, Kohno R, Ayada T, Kato R, Ichiyama K, Morisada T, Oike Y, Yonemitsu Y, Maehara Y, Yoshimura A
    • Journal Title

      Mol Cell Biol. 27(12)

      Pages: 4541-4550

    • Related Report
      2009 Final Research Report
  • [Journal Article] Germline loss-of-function mutations in SPRED1 cause a neuofibromatosis 1-like phenotype.2007

    • Author(s)
      Brems, H・Marynen, P・Thomas, G・Yoshimura, A・Legius, E, et. al.
    • Journal Title

      Nature Genet. 39

      Pages: 1120-6

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokin signaling 3-deficient dendritic cells.2007

    • Author(s)
      Matsumura, Y・Wyss-Coray, T・Sato, K・Yoshimura, A, et. al.
    • Journal Title

      J Immunol. 179

      Pages: 2170-9

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SOCS3 Protein Developmentally Regulates the Chemokine Receptor CXCR4-FAK Signaling Pathway during B Lymphopoiesis.2007

    • Author(s)
      Le, Y・Yoshimura, A・Silberstein, LE, et. al.
    • Journal Title

      Immunity. 27

      Pages: 811-823

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SOCS proteins, cytokine signalling and immune regulation.2007

    • Author(s)
      Yoshimura, A・Naka, T・Kubo, M
    • Journal Title

      Nat Rev Immunol. 7

      Pages: 454-65

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling.2007

    • Author(s)
      Taniguchi, K・Maehara, Y・Yoshimura, A., et. al.
    • Journal Title

      Mol Cell Biol 27

      Pages: 4541-50

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling.2007

    • Author(s)
      Taniguchi K, Ayada T, Ichiyama K, Yoshimura A, et al.
    • Journal Title

      Biochem Biophys Res Commun. 352(4)

      Pages: 896-902

    • Related Report
      2006 Annual Research Report
  • [Journal Article] IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice.2006

    • Author(s)
      Hanada T, Kobayashi T, Chinen T, Saeki K, Takaki H, Koga K, Minoda Y, Sanada T, Yoshioka T, Mimata H, Kato S, Yoshimura A
    • Journal Title

      J Exp Med. 203(6)

      Pages: 1391-1397

    • Related Report
      2009 Final Research Report
  • [Journal Article] Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.2006

    • Author(s)
      Ogata H, Kobayashi T, Chinen T, Takaki H, Sanada T, Minoda Y, Koga K, Takaesu G, Maehara Y, Iida M, Yoshimura A
    • Journal Title

      Gastroenterology 131(1)

      Pages: 179-193

    • Related Report
      2009 Final Research Report
  • [Journal Article] Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors.2006

    • Author(s)
      Yoshida T, Hisamoto T, Akiba J, Koga H, Nakamura K, Tokunaga Y, Hanada S, Kumemura H, Maeyama M, Harada M, Ogata H, Yano H, Kojiro M, Ueno T, Yoshimura A, Sata M
    • Journal Title

      Oncogene 25(45)

      Pages: 6056-6066

    • Related Report
      2009 Final Research Report
  • [Journal Article] Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.2006

    • Author(s)
      Okada S, Nakamura M, Katoh H, Miyao T, Shimazaki T, Ishii K, Yamane J, Yoshimura A, Iwamoto Y, Toyama Y, Okano H
    • Journal Title

      Nature Med. 12(7)

      Pages: 829-834

    • Related Report
      2009 Final Research Report
  • [Journal Article] Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1.2006

    • Author(s)
      Kinjyo I, Inoue H, Hamano S, Fukuyama S, Yoshimura T, Koga K, Takaki H, Himeno K, Takaesu G, Kobayashi T, Yoshimura A
    • Journal Title

      J Exp Med. 203(4)

      Pages: 1021-1031

    • Related Report
      2009 Final Research Report
  • [Journal Article] Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production.2006

    • Author(s)
      Ogata H, Chinen T, Yoshida T, Kinjyo I, Takaesu G, Shiraishi H, Iida M, Kobayashi T, Yoshimura A
    • Journal Title

      Oncogene 25(17)

      Pages: 2520-2530

    • Related Report
      2009 Final Research Report
  • [Journal Article] Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic.2006

    • Author(s)
      Lu Y, Fukuyama S, Yoshida R, Yoshimura A, Takaesu G, et al.
    • Journal Title

      J Biol Chem. 281(48)

      Pages: 36683-36690

    • Related Report
      2006 Annual Research Report
  • [Journal Article] TGF-beta1 suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation.2006

    • Author(s)
      Takaki H, Minoda Y, Yoshimura A, Kobayashi T, et al.
    • Journal Title

      Genes Cells. 11(8)

      Pages: 871-882

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.2006

    • Author(s)
      Ogata H, Kobayashi T, Chinen T, Takaki H, Yoshimura A, et al.
    • Journal Title

      Gastroenterology. 131(1)

      Pages: 179-193

    • Related Report
      2006 Annual Research Report
  • [Journal Article] IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice.2006

    • Author(s)
      Hanada T, Kobayashi T, Chinen T, Saeki K, Yoshimura A, et al.
    • Journal Title

      J Exp Med. 203(6)

      Pages: 1391-1397

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors.2006

    • Author(s)
      Yoshida T, Hisamoto T, Akiba J, Yoshimura A, Sata M, et al.
    • Journal Title

      Oncogene. 25(45)

      Pages: 6056-6066

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-betal production.2006

    • Author(s)
      Ogata H, Chinen T, Yoshida T, Yoshimura A, et al.
    • Journal Title

      Oncogene. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Suppressor of Cytokine Signaling-1 Regulates Inflammatory Bowel Disease in Which Both IFNgamma and IL-4 Are Involved.2006

    • Author(s)
      Chinen T, Kobayashi T, Ogata H, Yoshimura A, et al.
    • Journal Title

      Gastroenterology. 130(2)

      Pages: 373-388

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice.2006

    • Author(s)
      Inagaki-Ohara K, Sasaki A, Matsuzaki G, Yoshimura A, et al.
    • Journal Title

      Gut. 55(2)

      Pages: 212-219

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1.2005

    • Author(s)
      Nonami A, Taketomi T, Kimura A, Yoshimura A, et al.
    • Journal Title

      Genes Cells. 10(9)

      Pages: 887-895

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia.2005

    • Author(s)
      Taketomi T, Yoshiga D, Taniguchi K, Yoshimura A, et al.
    • Journal Title

      Nat Neurosci. 8(7)

      Pages: 855-857

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Induction of hyper Th1 cell-type immune responses by dendritic cells lacking the suppressor of cytokine signaling-1 gene.2005

    • Author(s)
      Hanada T, Tanaka K, Yoshimura A, et al.
    • Journal Title

      J Immunol. 174(7)

      Pages: 4325-4332

    • Related Report
      2005 Annual Research Report
  • [Presentation] SOCS is a molecular link between inflammation and cancer development. International symposium of infection-associated cancers2010

    • Author(s)
      Akihiko Yoshimura
    • Organizer
      Conference Hall of Hokkaido University in Sapporo
    • Place of Presentation
      Hokkaido, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] Role of SOCS1 in innate and adaptive immune tolerance2010

    • Author(s)
      Akihiko Yoshimura
    • Organizer
      World Immune Regulation Meeting IV
    • Place of Presentation
      Davos Switzerland
    • Related Report
      2009 Final Research Report
  • [Presentation] sponsored by Aegean ConferencesAldeamar Knossos Royal Village in Hersonissos2009

    • Author(s)
      Akihiko Yoshimura
    • Organizer
      Molecular basis for immune suppression by TGFb/Smad2/3 5th Leukocyte Signal Transduction Workshop
    • Place of Presentation
      Crete, Greece
    • Related Report
      2009 Final Research Report
  • [Presentation] SOCS1 and SOCS3 are Critical Regulators of Cytokine Signaling; Implication for Helper T Cell Differentiation and Tumor Development.2007

    • Author(s)
      Akihiko Yoshimura
    • Organizer
      Implication for Helper T Cell Differentiation and Tumor Development
    • Place of Presentation
      KEYSTONE SYMPOSIA on Molecular and Cellular Biology Keystone USA
    • Related Report
      2009 Final Research Report
  • [Presentation] SOCS1 is a link between inflammation and inflammation-mediated carcinogenesis.2007

    • Author(s)
      Akihiko Yoshimura
    • Organizer
      5th International Aachen Symposium on Cytokine Signalling
    • Place of Presentation
      Aachen Germany
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.new.immunoreg.jp/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.immunoreg.jp/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2018-03-28  

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