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Interaction of cancer cells with basement membrane proteins

Research Project

Project/Area Number 17014077
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionYokohama City University

Principal Investigator

MIYAZAKI Kaoru  Yokohama City University, 大学院・生命ナノシステム科学研究科, 教授 (70112068)

Co-Investigator(Kenkyū-buntansha) HIGASHI Shouichi  横浜市立大学, 大学院・生命ナノシステム科学研究科, 准教授 (10275076)
Co-Investigator(Renkei-kenkyūsha) OGAWA Takashi  横浜市立大学, 大学院・生命ナノシステム科学研究科, 特任助教 (80405018)
Project Period (FY) 2005 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥46,800,000 (Direct Cost: ¥46,800,000)
Fiscal Year 2009: ¥9,100,000 (Direct Cost: ¥9,100,000)
Fiscal Year 2008: ¥9,100,000 (Direct Cost: ¥9,100,000)
Fiscal Year 2007: ¥10,100,000 (Direct Cost: ¥10,100,000)
Fiscal Year 2006: ¥10,100,000 (Direct Cost: ¥10,100,000)
Fiscal Year 2005: ¥8,400,000 (Direct Cost: ¥8,400,000)
Keywordsがん転移 / 基底膜 / 浸潤 / ラミニン / MMP / がん浸潤 / 転移 / 細胞接着分子 / 上皮-間葉変換(EMT) / 細胞外マトリックス / がん / 浸潤・転移 / 腫瘍増殖 / プロテアーゼ / 阻害剤 / マトリライシン / 細胞移動 / ラミニン5 / マトリプターゼ / 細胞接着
Research Abstract

Tumor microenvironments play important roles in tumor progression. The present study demonstrated that the cell adhesion protein laminin-332 (Lm332 ; α3β3γ2) in the basement membrane was converted to a soluble factor capable of strongly promoting tumor cell migration by a proteolytic cleavage of its γ2 chain (Lmγ2). We previously showed that Lmγ2 is solely overexpressed when carcinoma cells invade into stroma. Here, we found that the Lmγ2 expression was induced by TGF-β or some other factors and promoted invasive growth of tumor cells in vivo. Furthermore, we found a novel vascular laminin, laminin-3B11, that was down-regulated in tumor vasculature. The matrix metalloproteinase matrilysin (MMP7) is frequently overexpressed in many types of human cancer and involved in tumor progression and metastasis. Our results suggested that MMP7 might enhance tumor metastasis by binding to cholesterol sulfate of cell membrane and then cleaving cell surface proteins and Lm332. Lmγ2 and MMP7 seem to be good targets for anti-cancer treatments.

Report

(6 results)
  • 2010 Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (132 results)

All 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article (86 results) (of which Peer Reviewed: 56 results) Presentation (36 results) Book (4 results) Remarks (3 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Down-regulation of a newly identified laminin, laminin-3B11, in vascular basement membranes of invasive human breast cancers.2011

    • Author(s)
      Mori, T., Kariya, Y., Komiya, T., Higashi, S., Miyagi, Y., Sekiguchi, K., Miyazaki, K.
    • Journal Title

      Cancer Sci. 102

      Pages: 1095-1100

    • NAID

      10029293987

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of a newly identified laminin, laminin-3B11, in vascular basement membranes of invasive human breast cancers.2011

    • Author(s)
      Mori, T., Miyazaki, K., et al.
    • Journal Title

      Cancer Sci.

      Volume: 102 Pages: 1095-1100

    • NAID

      10029293987

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laminin-3B11, a novel vascular type laminin capable of inducing prominent lamellipodial protrusions in microvascular endothelial cells.2010

    • Author(s)
      Mori, T., Ono, K., Kariya, Y., Ogawa, T., Higashi, S., Miyazaki, K.
    • Journal Title

      J.Biol.Chem. 285

      Pages: 35068-35078

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Production of active MMP7 in E.Coli and its application for metalloproteinase inhibitors screening.2010

    • Author(s)
      Katsuno, H., Shirakawa, R., Miyazaki, K., Ozeki, Y., Yasumitsu, H.
    • Journal Title

      Protein Peptide Lett. 17

      Pages: 568-572

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cholesterol sulfate alters substrate preference of matrix metalloproteinase-7 and promotes degradations of pericellular laminin-332 and fibronectin.2010

    • Author(s)
      Yamamoto, K., Miyazaki, K., Higashi, S.
    • Journal Title

      J.Biol.Chem. 285

      Pages: 28862-28873

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of laminin gamma2 chain monomer enhances invasive growth of human carcinoma cells in vivo.2010

    • Author(s)
      Tsubota, Y., Ogawa, T., Oyanagi, J., Nagashima, Y., Miyazaki, K.
    • Journal Title

      Int.J.Cancer 127

      Pages: 2031-2041

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Production of active MMP7 in E.Coli and its application for metalloproteinase inhibitors screening.2010

    • Author(s)
      Katsuno, H., Miyazaki, K., et al.
    • Journal Title

      Protein Peptide Lett.

      Volume: 17 Pages: 568-572

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of laminin gamma2 chain monomer enhances invasive growth of human carcinoma cells in vivo.2010

    • Author(s)
      Tsubota, Y., Miyazaki, K., et al.
    • Journal Title

      Int.J.Cancer

      Volume: 127 Pages: 2031-2041

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cholesterol sulfate alters substrate preference of matrix metalloprotein ase-7 and promotes degradations of pericellular laminin-332 and fibronectin.2010

    • Author(s)
      Yamamoto, K., Miyazaki, K., et al.
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 28862-28873

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laminin-3B11, a novel vascular type laminin capable of inducing prominent lamellipodial protrusions in microvascular endothelial cells.2010

    • Author(s)
      Mori, T., Miyazaki, K., et al.
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 35068-35078

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New marker proteins of the horny layer for evaluating the skin condition of patients with atopic dermatitis.2009

    • Author(s)
      Yamane, Y., Moriyama, K., Yasuda, C., Miyata, S., Aihara, M., Ikezawa, Z., Miyazaki, K.
    • Journal Title

      Int.Arch.Allergy Immunol. 150

      Pages: 89-101

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Matrilysin (MMP-7) cleaves C-type lectin domain family 3 member A (CLEC3A) on tumor cell surface and modulates its cell adhesion activity.2009

    • Author(s)
      Tsunezumi, J., Higashi, S., Miyazaki, K.
    • Journal Title

      J.Cell.Biochem. 106

      Pages: 693-702

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] New horny layer marker proteins for evaluating skin condition in atopic dermatitis.2009

    • Author(s)
      Yamane, Y., Miyazaki, K., et al.
    • Journal Title

      Int.Arch.Allergy Immunol.

      Volume: 150 Pages: 89-101

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Matrilysin (MMP-7) cleaves C-type lectin domain family 3 member A (CLEC3A) on tumor cell surface and modulates its cell adhesion activity.2009

    • Author(s)
      Tsunezumi, J., Miyazaki, K., et al.
    • Journal Title

      J.Cell.Biochem.

      Volume: 106 Pages: 693-702

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New marker proteins of the horny layer for evaluating the skin condition of patients with atopic dermatitis2009

    • Author(s)
      Yamane, Y., Moriyama, K., Yasuda, C., Miyata, S., Aihara, M., Ikezawa, Z., Miyazaki, K
    • Journal Title

      Arch. Allergy Immunol 150

      Pages: 89-101

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Matrilysin (MMP-7) cleaves C-type lectin domain family 3 member A (CLEC3A) on tumor cell surface and modulates its cell adhesion activity2009

    • Author(s)
      Tsunezumi, J., Higashi, H., Miyazaki, K
    • Journal Title

      J. Cell. Biochem 106

      Pages: 693-702

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Idenitification of amino acid residues of matrix metalloproteinase-2 essential for its selective inhibition by beta-amyloid precursor protein-derived inhibitor.2008

    • Author(s)
      Higashi, S., Miyazaki, K.
    • Journal Title

      J.Biol.Chem. 283

      Pages: 10068-10078

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Localization of laminin alpha3B chain in vascular and epithelial basement membranes of normal human tissues and its down-regulation in skin cancers.2008

    • Author(s)
      Kariya Y, Mori T, Yasuda C, Watanabe N, Kaneko Y, Nakashima Y, Ogawa T, Miyazaki K.
    • Journal Title

      J.Mol.Histol. 39

      Pages: 435-446

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Matrilysin (matrix metallo- protease-7) cleaves membrane-bound annexin II and enhances binding of tissue-type plasminogen activator to cancer cell surfaces.2008

    • Author(s)
      Tsunezumi J, Yamamoto K, Higashi S, Miyazaki K.
    • Journal Title

      FEBS J. 275

      Pages: 4810-4823

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of amino acid residues of matrix metalloproteinase-7 essential for binding to cholesterol sulfate.2008

    • Author(s)
      Higashi, S., Oeda, M., Yamamoto, K., Miyazaki, K.
    • Journal Title

      J.Biol.Chem. 283

      Pages: 35735-35744

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of amino acid residues of matrix metalloproteinase-2 essential for its selective inhibition by beta-amyloid precursor protein-derived inhibitor2008

    • Author(s)
      Higashi, S. and Miyazaki, K
    • Journal Title

      J Biol Chem 283

      Pages: 10068-10078

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization of laminin alpha3B chain in vascular and epithelial basement membranes of normal human tissues and its down-regulation in skin cancers2008

    • Author(s)
      Kariya Y, Mori T, Yasuda C, Watanabe N, Kaneko Y, Nakashima Y, Ogawa T, Miyazaki K
    • Journal Title

      J Mol Histol 39

      Pages: 435-446

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Matrilysin (matrix metalloprotease-7) cleaves membrane-bound annexin II and enhances binding of tissue-type plasminogen activator to cancer cell surfaces2008

    • Author(s)
      Tsunezumi J, Yamamoto K, Higashi S, Miyazaki K
    • Journal Title

      FEBS J 275

      Pages: 4810-4823

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of amino acid residues of matrix metalloproteinase-7 essential for binding to cholesterol sulfate2008

    • Author(s)
      Higashi, S., Oeda, M., Yamamoto, K. and Miyazaki, K
    • Journal Title

      J Biol Chem 838

      Pages: 35735-35744

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 癌の基底膜浸潤におけるEMT-細胞外マトリックス分子の作用2008

    • Author(s)
      小川崇、宮崎香
    • Journal Title

      細胞工学 27

      Pages: 348-352

    • Related Report
      2008 Annual Research Report
  • [Journal Article] タンパク質研究のおもしろさ2008

    • Author(s)
      宮崎香
    • Journal Title

      Kihara Memorial Foundation News Letter 25

      Pages: 5-7

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Identification of amino acid residues of matrix metallopro-teinase-2 essential for its selective inhibition by beta-amyloid precursor protein-derived inhibitor.2008

    • Author(s)
      Higashi, S. Miyazaki, K.
    • Journal Title

      J Biol Chem. 283

      Pages: 10068-10078

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The β3 chain short arm of laminin-332 (laminin-5) induces matrix assembly and cell adhesion activity of laminin-511 (laminin-10).2007

    • Author(s)
      Nakashima, Y., Kariya, Y., Miyazaki, K.
    • Journal Title

      J.Cell.Biochem. 100

      Pages: 545-556

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The short arm of laminin.2 chain of laminin-5 (laminin-332) binds syndecan-1 and regulates cellular adhesion and migration by suppressing phosphorylation of integrin.4 chain.2007

    • Author(s)
      Ogawa, T., Tsubota, Y., Hashimoto, J., Miyazaki, K.
    • Journal Title

      Mol.Biol.Cell 18

      Pages: 1621-1633

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Strong suppression of tumor growth by insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1)/TAF/mac25.2007

    • Author(s)
      Sato, Y., Chen, Z., Miyazaki, K.
    • Journal Title

      Cancer Sci. 98

      Pages: 1055-1063

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fatima Pedrosa Domellof, F.P. Laminins in keratoconus, bullous keratopathy, normal and scarred human corneas. Histochem.2007

    • Author(s)
      Bystrom, B., Virtanen, I., Rousselle, P., Miyazaki, K., Linden, C.
    • Journal Title

      Cell Biol. 127

      Pages: 657-667

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel function of syndecan-2, suppression of MMP-2 activation, which causes suppression of metastasis.2007

    • Author(s)
      Munesue S., Yoshitomi, Y., Kusano, Y., Koyama, Y., Nishiyama, A., Nakanishi, H., Miyazaki, K., Ishimaru, T., Miyaura, S., Okayama, M., Oguri, K.
    • Journal Title

      J.Biol.Chem. 282

      Pages: 28164-28174

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma.2007

    • Author(s)
      Kato, Y., Ozawa, S., Tsukuda, M., Kubota, E., Miyazaki, K., St-Pierre, Y., Hata, R.
    • Journal Title

      FEBS J. 274

      Pages: 3171-3183

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The β3 chain short arm of laminin-332(laminin-5)inducesmatrix assembly and cell adhesion activity of laminin-511(laminin-10).2007

    • Author(s)
      Nakashima, Y., Miyazaki, K., et. al.
    • Journal Title

      J. Cell. Biochem. 100

      Pages: 545-556

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The short arm of laminin gamma2 chain of laminin-5(laminin-332)binds syndecan-1 and regulates cellular adhesion and migration by suppressing phosphorylation of integrin beta4 chain.2007

    • Author(s)
      Ogawa, T., Miyazaki, K., et. al.
    • Journal Title

      Mol. Biol. Cell 18

      Pages: 1621-1633

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strong suppression of tumor growth by insulin-like growth factor binding protein-related protein 1(IGFBP-rP1)/TAF/mac25.2007

    • Author(s)
      Sato, Y., Miyazaki, K., et. al.
    • Journal Title

      Cancer Sci. 98

      Pages: 1055-1063

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laminins in keratoconus, bullous keratopathy, normal and scarred human corneas.2007

    • Author(s)
      Bystrom, B., Miyazaki, K., et. al.
    • Journal Title

      Histochem Cell Biol. 127

      Pages: 657-667

    • Related Report
      2007 Annual Research Report
  • [Journal Article] A novel function of syndecan-2, suppression of MMP-2 activa-tion, which causes suppression of metastasis.2007

    • Author(s)
      Munesue S., Miyazaki, K., et. al.
    • Journal Title

      J Biol Chem. 282

      Pages: 28164-281674

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The alpha3 chain short arm of laminin-332 (laminin-5) induces matrix assembly and cell adhesion activity of laminin-511 (laminin 10).2007

    • Author(s)
      Nakashima, Y., Miyazaki, K.et al.
    • Journal Title

      J. Cell. Biochem. 100

      Pages: 545-556

    • Related Report
      2006 Annual Research Report
  • [Journal Article] N-acetylglucosaminyltransferase III antagonizes the effect of N-acetylglucosaminyltransferase V on alpha 3beta 1 integrin-mediated cell migration.2007

    • Author(s)
      Zhao, Y, Miyazaki, K.et al.
    • Journal Title

      J Biol Chem (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Deletion of core fucosylation on alpha3betal integrin down-regualtes its function.2007

    • Author(s)
      Zhao, Y., Miyazaki, K.et al.
    • Journal Title

      J Biol Chem. (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The short arm of laminin gamma2 chain of laminin-5 (laminin-332) binds syndecan-1 and regulates cellular adhesion and migration by suppressing phosphorylation of integrin beta4 chain.2007

    • Author(s)
      Ogawa, T., Miyazaki, K.et al.
    • Journal Title

      Mol. Biol. Cell (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Strong suppression of tumor growth by insulin-like growth factor binding protein-related protein 1(IGFBP-rPI)/TAF/mac25.2007

    • Author(s)
      Sato, Y., Miyazaki.K.et al.
    • Journal Title

      Cancer Sci. (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Laminins in keratoconus, bullous keratopathy normal and scarred human corneas.2007

    • Author(s)
      S Bystrom B., Miyazaki.K.et al.
    • Journal Title

      Histochem Cell Biol. (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Plasma membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signaling.2006

    • Author(s)
      Kato, K., Shiga, K., Yamaguchi, K., Hata, K., Kobayashi, T., Miyazaki, K., Saijo, S., Miyagi, T.
    • Journal Title

      Biochem.J. 394

      Pages: 647-656

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Laminin-5 : Unique biological activity and role in tumor growth and invasion.2006

    • Author(s)
      Miyazaki, K.
    • Journal Title

      Cancer Sci. 97

      Pages: 91-98

    • Related Report
      2010 Final Research Report 2006 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced expression of laminin-5 in corneal epithelial cells under high glucose condition.2006

    • Author(s)
      Lu W, Ebihara N, Miyazaki K., Murakami A.
    • Journal Title

      Cornea. 25

      Pages: 61-67

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related rrotein-12006

    • Author(s)
      Ahmed, S., Jin, X., Yagi, M., Yasuda, C., Sato, Y., Higashi, S., Lin, C-Y., Dickson, R.B., Miyazaki, K.
    • Journal Title

      IGFBP-rP1/angiomodulin/mac25.FEBS J. 273

      Pages: 615-627

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Binding of active matrilysin to cell surface cholesterol sulfate is essential for its membrane-associated proteolytic action and induction of homotypic cell adhesion.2006

    • Author(s)
      Yamamoto , K., Higashi, S., Kioi, M., Tsunezumi, J., Honke, K., Miyazaki, K.
    • Journal Title

      J.Biol.Chem. 281

      Pages: 9170-9180

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Insulin-like growth factor-1 induces migration and expression of laminin-5 in cultured human corneal epithelial cells.2006

    • Author(s)
      Lee, H. K., Lee, J. H., Kim, M., Kariya, Y., Miyazaki, K., Kim, E. K.
    • Journal Title

      Invest.Ophthalmol.Vis.Sci. 47

      Pages: 873-882

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of proliferation and chondrogenic differentiation of human mesenchymal stem cells by laminin-5 (laminin-332).2006

    • Author(s)
      Hashimoto, J., Kariya, Y., Miyazaki, K.
    • Journal Title

      Stem Cells 24

      Pages: 2346-2354

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Matriptase activates stromelysin (MMP-3) and promotes tumor growth and angiogenesis.2006

    • Author(s)
      Jin, X, J., Yagi, M., Akiyama, N., Hirosaki, T., Higashi, S., Lin, C-Y., Dickson, R.B., Kitamura, H., Miyazaki, K.
    • Journal Title

      Cancer Sci. 97

      Pages: 1327-1334

    • NAID

      10020387781

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-acetylglucosaminyltransferase III antagonizes the effect of N-acetylglucosaminyltransferase V on alpha 3beta 1 integrin-mediated cell migration.J.2006

    • Author(s)
      Zhao, Y., Nakagawa, T., Itoh, S., Inamori, K., Isaji T, Kariya, Y., Kondo, A., Miyoshi, E., Miyazaki, K., Kawasaki, N., Taniguchi, N., Gu, J.
    • Journal Title

      Biol.Chem. 281

      Pages: 32122-32130

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of core fucosylation on alpha3beta1 integrin down-regualtes its function. J.2006

    • Author(s)
      Zhao, Y., Itoh, S., Wang, X., Isaji, T., Miyoshi, E., Kariya Y, Miyazaki, K., Kawasaki, N., Taniguchi, N., Gu J.
    • Journal Title

      Biol.Chem. 281

      Pages: 38343-38350

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signaling.2006

    • Author(s)
      Kato, K., Miyazaki, K.et al.
    • Journal Title

      Biochem.J. 394

      Pages: 647-656

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Binding of active matrilysin to cell surface cholesterol sulfate is essential for its membrane-associated proteolytic action and induction of homotypic cell adhesion.2006

    • Author(s)
      Yamamoto, K., Miyazaki, K.et al.
    • Journal Title

      J.Biol.Chem. 281

      Pages: 9170-9180

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Regulation of proliferation and chondrogenic differentiation of human mesenchymal stem cells by laminin-5 (laminin-332).2006

    • Author(s)
      Hashimoto, J., Miyazaki, K.et al.
    • Journal Title

      Stem Cells 24

      Pages: 2346-2354

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Matriptase activates stromelysin (MMP-3) and promotes tumor growth and angiogenesis.2006

    • Author(s)
      Jin, X, J., Miyazaki, K.et al.
    • Journal Title

      Cancer Sci. 97

      Pages: 1327-1334

    • NAID

      10020387781

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Murakami A. Reduced expression of laminin-5 in corneal epithelial cells under high glucose condition.2006

    • Author(s)
      Lu, W., Miyazaki, K
    • Journal Title

      Cornea. 25

      Pages: 61-67

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Insulin-like growth factor-1 induces migration and expression of laminin-5 in cultured human corneal epithelial cells.2006

    • Author(s)
      Lee, H.K., Miyazaki, K.
    • Journal Title

      Invest.Ophthalmol Vis.Sci. 47

      Pages: 873-882

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Production of soluble matriptase by human cancer cell lines and cell surface activation of its zymogen by trypsin.2005

    • Author(s)
      Jin, X., Hirosaki, T., Lin, C-Y, Dickson, R. B., Higashi, S., Kitamura, H., Miyazaki, K.
    • Journal Title

      J.Cell.Biochem. 95

      Pages: 632-647

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of biological activity and matrix assembly of laminin-5 by COOH-terminal, LG4-5 domain of alfa3 chain.2005

    • Author(s)
      Tsubota, Y., Yasuda, C., Kariya, Y., Ogawa, T., Hirosaki, T., Mizushima, H., Miyazaki, K.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 14370-14377

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of matrix metalloproteinase-9 expression by extracellular pH in mouse metastatic melanoma cells.2005

    • Author(s)
      Kato, Y., Lambert, C. A., Colige, A. C., Mineur, P., Noel, A., Frankenne, F., Foidart, J-M., Baba, M., Hata, R., Miyazaki, K., Tsukuda, M.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 10938-10944

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ly6 family member C4.4A binds laminins 1 and 5, associates with galectin-3 and supports cell migration.2005

    • Author(s)
      Paret, C., Bourouba, M., Beer, A., Miyazaki, K., Schnolzer, M., Fiedler, S., Zoller, M.
    • Journal Title

      Int.J.Cancer 115

      Pages: 724-733

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nephrotic syndrome and aberrant expression of laminin isoforms in glomerular basement membranes in an infant with Herlitz junctional epidermolysis bullosa2005

    • Author(s)
      Hata, D., Miyazaki, M., Seto, S., Kadota, E., Muso, E., Takasu, K., Nakano, A., Tamai, K., Uitto, J., Nagata, M., Moriyama, K., Miyazaki, K.
    • Journal Title

      Pediatrics 116

      Pages: 601-607

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of proteins released by pancreatic cancer cells by multidimensional protein identification technology : a strategy for identification of novel cancer markers.2005

    • Author(s)
      Mauri, P., Scarpa, A., Nascimbeni, A. C., Benazzi, L., Parmagnani, E., Mafficini, A., Peruta, M. D., Bassi, C., Miyazaki, K., Sorio, C.
    • Journal Title

      FASEB J. 19

      Pages: 1125-1127

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Laminin-5 suppresses chondrogenic differentiation of murine teratocarcinoma cell line ATDC5.2005

    • Author(s)
      Hashimoto, J., Ogawa, T., Tsubota, Y., Miyazaki, K.
    • Journal Title

      Exp.Cell.Res. 310

      Pages: 256-269

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of cell adhesion and type VII collagen binding by beta3 chain short arm of laminin-5: effect of its proteolytic cleavage.2005

    • Author(s)
      Nakashima, Y., Kariya, Y., Yasuda, C., Miyazaki, K.
    • Journal Title

      J.Biochem. 138

      Pages: 539-552

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Uncoordinated production of Laminin-5 chains in airways epithelium of allergic asthmatics. Respir.2005

    • Author(s)
      Amin, K., Janson, C., Seveus, L., Miyazaki, K., Virtanen, I., Venge, P.
    • Journal Title

      Res. 6

      Pages: 110-110

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] P.D.A simplified laminin nomenclature.2005

    • Author(s)
      Aumailley, M., Bruckner-Tuderman, L., Carter, W. G., Deutzmann, R., Edgar, D., Ekblom, P., Engel, J., Engvall, E., Hohenester, E., Jones, J. C., Kleinman, H. K., Marinkovich, M. P., Martin, G. R., Mayer, U., Meneguzzi, G., Miner, J. H., Miyazaki, K., Patarroyo, M., Paulsson, M., Quaranta, V., Sanes, J. R., Sasaki,T., Sekiguchi, K., Sorokin, L. M., Talts, J. F., Tryggvason, K., Uitto, J., Virtanen, I., von der Mark, K., Wewer, U. M., Yamada, Y., Yurchenco
    • Journal Title

      Matrix Biol. 24

      Pages: 326-332

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential expression of laminin isoforms in ovarian epithelial carcinomas suggesting different origin and providing tools for differential diagnosis.2005

    • Author(s)
      Maatta, M., Butzow, R., Luostarinen, J., Petajaniemi, N., Pihlajaniemi, T., Salo, S., Miyazaki, K., Autio-Harmainen, H., Virtanen I.
    • Journal Title

      J.Histochem.Cytochem. 53

      Pages: 1293-1300

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Production of soluble matriptase by human cancer cell lines and cell surface activation of its zymogen by trypsin.2005

    • Author(s)
      Jin X., Miyazaki, K.et al.
    • Journal Title

      J.Cell.Biochem. 95

      Pages: 632-647

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Regulation of biological activity and matrix assembly of laminin-5 by COOH-terminal, LG4-5 domain of alfa3 chain.2005

    • Author(s)
      Tsubota, Y., Miyazaki, K.et al.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 14370-14377

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Regulation of matrix metalloproteinase-9 expression by extracellular pH in mouse metastatic melanoma cells.2005

    • Author(s)
      Kato, Y., Miyazaki, K.et al.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 10938-10944

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Ly6 family member C4.4A binds laminins 1 and 5, associates with galectin-3 and supports cell migration.2005

    • Author(s)
      Paret, C., Miyazaki, K.et al.
    • Journal Title

      Int.J.Cancer 115

      Pages: 724-733

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Nephrotic syndrome and aberrant expression of laminin isoforms in glomerular basement membranes in an infant with Herlitz junctional epidermolysis bullosa,2005

    • Author(s)
      Hata, D., Miyazaki, K.et al.
    • Journal Title

      Pediatrics 116

      Pages: 601-607

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Identification of proteins released by pancreatic cancer cells by multidimensional protein identification technology : a strategy for identification of novel cancer markers.2005

    • Author(s)
      Mauri, P., Miyazaki, K.et al.
    • Journal Title

      FASEB J. 19

      Pages: 1125-1127

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Laminin-5 suppresses chondrogenic differentiation of murine teratocarcinoma cell line ATDC5.2005

    • Author(s)
      Hashimoto, J., Miyazaki, K.et al.
    • Journal Title

      Exp.Cell.Res. 310

      Pages: 256-269

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Regulation of cell adhesion and type VII collagen binding by β3 chain short arm of laminin-5: effect of its proteolytic cleavage.2005

    • Author(s)
      Nakashima, Y., Miyazaki, K.et al.
    • Journal Title

      J.Biochem. 138

      Pages: 539-552

    • NAID

      10017348087

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Uncoordinated production of Laminin-5 chains in airways epithelium of allergic asthmatics.2005

    • Author(s)
      Amin, K., Miyazaki, K.et al.
    • Journal Title

      Respiratory Research 6

      Pages: 110-110

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A simplified laminin nomenclature.2005

    • Author(s)
      Aumailley, M., Miyazaki, K.et al.
    • Journal Title

      Matrix Biol. 24

      Pages: 326-332

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Differential expression of laminin isoforms in ovarian epithelial carcinomas suggesting different origin and providing tools for differential diagnosis.2005

    • Author(s)
      Maatta, M., Miyazaki, K.et al.
    • Journal Title

      J Histochem.Cytochem. 53

      Pages: 1293-1300

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Plasma membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin-and fibronectin-derived signaling.2005

    • Author(s)
      Kato, K., Miyazaki, K.et al.
    • Journal Title

      Biochem.J. 394

      Pages: 647-656

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Unique biological activity and role in tumor growth and invasion.2005

    • Author(s)
      Miyazaki, K.
    • Journal Title

      Cancer Sci. 394

      Pages: 91-98

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related rrotein-1 (IGFBP-rP1/angiomodulin/mac25.2005

    • Author(s)
      Ahmed, S., Miyazaki, K.
    • Journal Title

      FEBS J. 273

      Pages: 615-627

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Binding of active matrilysin to cell surface cholesterol sulfate is essential for its membrane-associated proteolytic action and induction of homotypic cell adhesion.

    • Author(s)
      Yamamoto, K., Miyazaki, K.
    • Journal Title

      J.Biol.Chem. (in press)

    • Related Report
      2005 Annual Research Report
  • [Presentation] がんの浸潤・転移を調節する微小環境因子-特に細胞外マトリックス分子とプロテアーゼについて2010

    • Author(s)
      宮崎香
    • Organizer
      数理医学研究会
    • Place of Presentation
      大阪大学(大阪)
    • Year and Date
      2010-12-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] In vitroがん浸潤モデルにおけるラミニン332(ラミニン5)の侵潤促進作用2010

    • Author(s)
      宮崎香
    • Organizer
      第19回日本がん転移学会学術集会・総会
    • Place of Presentation
      金沢市文化ホール(石川)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Gene expression signatures at acidic extracellular pH in metastatic melanoma cells.2010

    • Author(s)
      Yasumasa Kato, Kaoru Miyazaki, et al.
    • Organizer
      Joint Metastasis Research Society-AACR Conference on Metastasis and the Tumor Microenvironment
    • Place of Presentation
      Philadelphia (U.S.A.)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecular design of a highly selective and strong inhibitor against MMP-2.2010

    • Author(s)
      Shouichi Higashi, Kaoru Miyazaki, et al.
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場他(大阪)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification and proper ties of novel vascular laminin, laminin-3B11, that lacks in tumor vasculatures.2010

    • Author(s)
      Mori, T.Miyazaki, K., et al.
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場他(大阪)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Tumor-suppressive effect of IGFBP-related protein 1 (IGFBP-rP1) and its interaction with tumor stroma.2010

    • Author(s)
      Momoko Furuya, Kaoru Miyazaki, et al.
    • Organizer
      第33回分子生物学会/第83回日本生化学会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫>
    • Related Report
      2009 Annual Research Report
  • [Presentation] Interaction of Tumor Invasion Marker Laminin γ2 Chain with Vascular Endothelial Celts.2010

    • Author(s)
      Hiroki Sato, Kaoru Miyazaki, et al.
    • Organizer
      第33回分子生物学会/第83回日本生化学会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫>
    • Related Report
      2009 Annual Research Report
  • [Presentation] Purification of human natural laminin-511 using new monoclonal antibody and its application to culture of human mesenchymal stem cells.2010

    • Author(s)
      Toshihide Yanagawa, Kaoru Miyazaki, et al.
    • Organizer
      第33回分子生物学会/第83回日本生化学会合同
    • Place of Presentation
      神戸ポートアイランド(兵庫>
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cholesterol sulfate alters substrate preference of MMP-7 and promotes degradation of selective pericellular proteins.2010

    • Author(s)
      Shouichi Higashi, Kaoru Miyazaki, et al.
    • Organizer
      第33回分子生物学会/第83回日本生化学会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫>
    • Related Report
      2009 Annual Research Report
  • [Presentation] Induction of IGFBP-related protein 1 (IGFBP-rP1) in blood vessels of breast cancer and its mechanism.2010

    • Author(s)
      Marii Ise, Kaoru Miyazaki, et al.
    • Organizer
      第33回分子生物学会/第83回日本生化学会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫>
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒトiPS細胞フィーダーフリー培養系~臨床応用を目指した培養系における組換えヒトLaminin-5の有用性~2009

    • Author(s)
      山田宗弘、宮崎香, 他
    • Organizer
      日本分子生物学会春季シンポジウム
    • Place of Presentation
      シーガイア ワールドコンベンションセンター・サミット(宮崎)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Expression of laminina α3B chain in vascular and epithelial basement membranes and its possible functions.2009

    • Author(s)
      Taizo Mori, Kaoru Miyazaki, et al.
    • Organizer
      Yokosuka Science Festa 2009 8^<th> Pan-pacitic connective Tissue Societies Symposium.
    • Place of Presentation
      湘南国際村センター(神奈川)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Insulin-like growth factor binding protein-related protein 1 (1rP1/TAF) synergistically modulates tumor cell adhesion with laminin-332 (laminin-5).2009

    • Author(s)
      Eriko Komiya, Kaoru Miyazaki, Et al.
    • Organizer
      Yokosuka Science Festa 2009 8^<th> Pan-pacific connective Tissue Societies Symposium.
    • Place of Presentation
      湘南国際村センター(神奈川)
    • Related Report
      2009 Annual Research Report
  • [Presentation] がん浸潤マーカー分子ラミニンγ2鎖の機能2009

    • Author(s)
      宮崎香、小川崇
    • Organizer
      第18回日本がん転移学会学術集会・総会
    • Place of Presentation
      旭川グランドホテル(北海道)
    • Related Report
      2009 Annual Research Report
  • [Presentation] がん細胞の基底膜浸潤とEMT2009

    • Author(s)
      宮崎香
    • Organizer
      第68回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2009 Annual Research Report
  • [Presentation] がん細胞におけるラミニンγ2鎖の発現と上皮-間葉変換(EMT)の調節機構2009

    • Author(s)
      小柳潤、宮崎香, 他
    • Organizer
      第68回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2009 Annual Research Report
  • [Presentation] IGFBP-rP1/TAFとラミニン332のがん細胞に対する強調的な促進作用2009

    • Author(s)
      古宮栄利子、宮崎香, 他
    • Organizer
      第68回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2009 Annual Research Report
  • [Presentation] がんの基底膜浸潤におけるラミニンγ2鎖の発現と上皮-間葉変換(EMT)2009

    • Author(s)
      小川崇、宮崎香, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(兵庫>
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラミニン332(ラミニン5)のマトリックスプロテアーゼ誘導能とがんの浸潤性増殖2009

    • Author(s)
      佐藤拓輝、宮崎香, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(兵庫>
    • Related Report
      2009 Annual Research Report
  • [Presentation] In vitroがん浸潤モデルを用いたラミニン332(ラミニン5)の浸潤促進作用の解析2009

    • Author(s)
      小島奈子、宮崎香, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(兵庫>
    • Related Report
      2009 Annual Research Report
  • [Presentation] マトリプターゼ(MT-SP1)によるCTGF(IGFBP-rP2)の切断と腫瘍増殖促進作用2009

    • Author(s)
      寺田翔、宮崎香, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(兵庫>
    • Related Report
      2009 Annual Research Report
  • [Presentation] マトリックスメタプロテアーゼ-2(MMP-1)に対し、高い特異性を持つインヒビタータンパク質の設計2009

    • Author(s)
      廣瀬智一、宮崎香, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(兵庫>
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒトiPS細胞フィーダーフリー培養系~臨床応用を目指した培養系における組換えヒトLaminin-5の有用性~2009

    • Author(s)
      山田宗弘、宮崎香, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(兵庫>
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラミニン5および関連分子を利用した幹細胞培養技術の開発2008

    • Author(s)
      宮崎香
    • Organizer
      イノベーションジャパン2008
    • Place of Presentation
      東京
    • Year and Date
      2008-09-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞外マトリックス分子による腫瘍増殖の調節2008

    • Author(s)
      宮崎香
    • Organizer
      文部科学省がん特定領域研究シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-07-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒトがん細胞におけるラミニン5(ラミニン332)構成鎖の常発現と腫瘍増殖におけるその意義2008

    • Author(s)
      小川崇、宮崎香
    • Organizer
      第17回日本がん転移学会学術集会・総会
    • Place of Presentation
      鹿児島
    • Related Report
      2008 Annual Research Report
  • [Presentation] マトリライシンによるがん細胞表層アネキシンHの切断と組織プラスミノーゲン活性因子の膜への結合2008

    • Author(s)
      常住淳、宮崎香
    • Organizer
      第17回日本がん転移学会学術集会・総会
    • Place of Presentation
      鹿児島
    • Related Report
      2008 Annual Research Report
  • [Presentation] APP由来インヒビターによる選択的活性阻害に重要なMMP-2分子内のアミノ酸残基の同定2008

    • Author(s)
      東昌市、宮崎香
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラミニンY2鎖の癌の悪性増殖やEMTのおける役割2008

    • Author(s)
      小川崇、宮崎香
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] 酸性細胞外pHによるマトリックス・メタプロテアーゼ・9発現誘導におけるRhoの役割2008

    • Author(s)
      加藤靖正、西村行生、佃守、宮崎香、畑隆一郎
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] 癌の悪性形質を支えるMMP-2およびMMP-7の細胞表層での活性発現機序とそれを応用した高特異性阻害剤の開発2008

    • Author(s)
      東昌市、山本和博、宮崎香
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] 癌の基底膜浸潤におけるラミニンY2鎖の発現と上皮-間葉変換(EMT)2008

    • Author(s)
      小川崇、清水翔太、宮崎香
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] Matriptaseによる腫瘍増殖機構の解析一IGFBPsの切断の意義について2008

    • Author(s)
      迫田明子、山本和博、寺田翔、秋山渚、東昌市、宮崎香
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規ラミニンアイソフォームラミニン3B11(ラミニン6B)の発現と機能解析2008

    • Author(s)
      森泰三、小川崇、小野孝太、吉村祐太、苅谷慶喜、宮崎香
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] Distinct roles of NF-K13 subunits in matrix metalloproteinase-9 expression induced by acidic extracellular pH2008

    • Author(s)
      Yasumasa Kato, Shigeyuki Oza, Eiro Kubota, Mamoru Tsukuda, Kaoru Miyazaki, Yves St-Pierre, Ryu-Icbiro Hata
    • Organizer
      Metastasis Research Society-Amer. Asociation for Cancer Res. Joint Conference on Metastasis
    • Place of Presentation
      Vancouver
    • Related Report
      2008 Annual Research Report
  • [Presentation] Possible Biomarkers that Identify Degree of Skin Senescence2008

    • Author(s)
      Chic Yasuda, Satoshi Miyata, Tatsuya Kon, Nakaba Kayanuma, Takayo Ueda, Kohsuke Hayamizu, Hironori Tomi and Kaoru Miyazaki
    • Organizer
      25^<th> IFSCC Congress
    • Place of Presentation
      Barcelona
    • Related Report
      2008 Annual Research Report
  • [Book] 上皮-間葉変換と癌の悪性増殖-細胞外マトリックス分子の役割。「実験医学」4月号Vol.21,No.152006

    • Author(s)
      宮崎香
    • Publisher
      羊土社
    • Related Report
      2005 Annual Research Report
  • [Book] 細胞外マトリックス分子と細胞接着。「タンパク質科学-構造・物性・機能」2005

    • Author(s)
      小川崇, 宮崎香(分担)
    • Publisher
      化学同人
    • Related Report
      2005 Annual Research Report
  • [Book] タンパク質研究なるほど(戸田年総, 平野久, 中村和行編)2005

    • Author(s)
      宮崎香(分担)
    • Total Pages
      6
    • Publisher
      羊土社
    • Related Report
      2005 Annual Research Report
  • [Book] 細胞外マトリックス分子と癌の悪性増殖。「肝転移のすべて」(門田守人, 松浦成昭/編)2005

    • Author(s)
      宮崎香(分担)
    • Publisher
      永井書店
    • Related Report
      2005 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://miyazaki.sci.yokohama-cu.ac.jp/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://miyazaki.sci.yokohama-cu.ac.jp/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://miyazaki.sci.yokohama-cu.ac.jp/

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] ラミニン6B(ラミニン3B11)蛋白質2007

    • Inventor(s)
      宮崎香
    • Industrial Property Rights Holder
      公立大学法人横浜市立大学
    • Filing Date
      2007-02-08
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] ラミニン6B(ラミニン3B11)蛋白質2007

    • Inventor(s)
      宮崎 香
    • Industrial Property Rights Holder
      横浜市立大学
    • Filing Date
      2007-02-08
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] ラミニン5を利用した間葉系幹細胞の培養技術2005

    • Inventor(s)
      宮崎香, 橋本絢子, 苅谷慶喜
    • Industrial Property Rights Holder
      公立大学法人横浜市立大学,財団法人木原記念横浜生命科学振興財団
    • Filing Date
      2005-08-16
    • Related Report
      2010 Final Research Report

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Published: 2005-04-01   Modified: 2019-01-10  

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