Mechanisms regulating cell adhesion activities in tumor progression

• Project/Area Number: 17014083
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka Bioscience Institute
• Principal Investigator: SABE Hisataka Osaka Bioscience Institute, 大学院・医学研究科, 教授 (40187282)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥69,900,000 (Direct Cost: ¥69,900,000); Fiscal Year 2009: ¥13,900,000 (Direct Cost: ¥13,900,000); Fiscal Year 2008: ¥13,900,000 (Direct Cost: ¥13,900,000); Fiscal Year 2007: ¥13,900,000 (Direct Cost: ¥13,900,000); Fiscal Year 2006: ¥13,900,000 (Direct Cost: ¥13,900,000); Fiscal Year 2005: ¥14,300,000 (Direct Cost: ¥14,300,000)
• Keywords: 癌 / 浸潤 / 転移 / 細胞接着 / E-カドヘリン / インテグリン / Arf6 / シグナル伝達 / 乳癌 / 浸潤転移 / GBP100 / AMAP1 / インテグリンβ1 / PRKD2 / カドへリン / 癌浸潤 / E-cadherin / 血管新生 / GEP100 / VE-cadherin / EphA / integrin β1 / 上皮細胞接着 / Git1 / Nck / カドヘリン / 細胞運動

Research Abstract

Most malignant human tumors are epithelial cell origin. The basic fear of such tumors are based on their invasion and metastasis. Activation of integrins and inactivation of E-cadherin are hallmark characteristics for such invasive and metastatic properties. Here our purpose is to understanding the underlying molecular mechanisms for integrin activation and E-cadherin inactivation in the malignant development of tumor cells.

Research Products

• [Journal Article] Zyxin mediates actin fiber reorganization nepithelial-mesenchymal transition and contributes to endocardial morphogenesis. (2009)
  • Author(s): Mori M., Nakagami H., Koibuchi N., Miura K., Takami Y., Koriyama H., Hayashi H., Sabe H., Mochizuki N., Morishita R., Kaneda Y.
  • Journal Title: Mol Biol Cell. 20 Pages: 3115-3124
  • Peer Reviewed
• [Journal Article] EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts. (2009)
  • Author(s): Miura K., Nam J.M., Kojima C., Mochizuki N., Sabe H.
  • Journal Title: Mol Biol Cell. 20 Pages: 1949-1959
  • Peer Reviewed
• [Journal Article] The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis. (2009)
  • Author(s): Sabe H., Hashimoto S., Morishige M., Ogawa E., Hashimoto A., Nam J.M., Miura K., Yano H., Onodera Y.
  • Journal Title: Traffic 10 Pages: 982-993
  • Peer Reviewed
• [Journal Article] Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis (2009)
  • Author(s): Mori M
  • Journal Title: Molecular Biology of the cell 20 Pages: 3115-3124
  • Peer Reviewed
• [Journal Article] EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts (2009)
  • Author(s): Miura K
  • Journal Title: Molecular Biology of the cell 20 Pages: 1949-1959
  • Peer Reviewed
• [Journal Article] The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis (2009)
  • Author(s): Sabe H
  • Journal Title: Traffic 10 Pages: 982-993
  • Peer Reviewed
• [Journal Article] EphA2 Engages Gitl to Suppress Arf6 Activity Modulating Epit helial Cell-Cell Contacts (2009)
  • Author(s): Koichi Miura
  • Journal Title: Molecular Biology of the Cell 20 Pages: 1949-1959
  • Peer Reviewed
• [Journal Article] EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition (2009)
  • Author(s): Mariko Hirano
  • Journal Title: Molecular Biology of the Cell 182 Pages: 1949-1959
  • Peer Reviewed
• [Journal Article] The EGFR-GEP100-Arf6-AMAP1 Signaling Pathway Specific to Breast Cancer Invasion and Metastasis (2009)
  • Author(s): Hisataka Sabe
  • Journal Title: Traffic 10
  • Peer Reviewed
• [Journal Article] IRES-mediated translational control of AMAP1 expression during differentiation of monocyte U937 cells. (2008)
  • Author(s): Miyata M., Raven JF., Baltzis D., Koromilas AE., Sabe H.
  • Journal Title: Cell Cycle. 7 Pages: 3273-3281
  • Peer Reviewed
• [Journal Article] EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during pithelial-mesenchymal transition. (2008)
  • Author(s): Hirano M., Hashimoto S., Yonemura S., Sabe H., Aizawa S.
  • Journal Title: J Cell Biol. 182 Pages: 1217-1230
  • Peer Reviewed
• [Journal Article] Clathrin dependent endocytosis of E-cadherin is regulated by the Arf6GAP isoform SMAP1. (2008)
  • Author(s): Kon S., Tanabe K., Watanabe T., Sabe H., Satake M.
  • Journal Title: Exp Cell Res. 314 Pages: 1415-1428
  • Peer Reviewed
• [Journal Article] Dynamic rearrangement of surface proteins is essential for cytokinesis. (2008)
  • Author(s): Bauer T., Motosugi N., Miura K., Sabe H., Hiiragi T.
  • Journal Title: Genesis 46 Pages: 152-162
  • Peer Reviewed
• [Journal Article] Fbx8 makes Arf6 refractory to function via ubiquitination. (2008)
  • Author(s): Yano H., Kobayashi I., Onodera Y., Luton F., Franco M., Mazaki Y., Hashimoto S., Iwai K., Ronai Z., Sabe H.
  • Journal Title: Mol Biol Cell. 19 Pages: 822-832
  • Peer Reviewed
• [Journal Article] GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion. (2008)
  • Author(s): Morishige M., Hashimoto S., Ogawa E., Toda Y., Kotani H., Hirose M., Wei S., Hashimoto A., Yamada A., Yano H., Mazaki Y., Kodama H., Nio Y., Manabe T., Wada H., Kobayashi H., Sabe H.
  • Journal Title: Nat Cell Biol. 10 Pages: 85-92
  • Peer Reviewed
• [Journal Article] The EGFR-GEP100-Arf6 pathway in breast cancer: Full invasiveness is not from the inside. (2008)
  • Author(s): Sabe H., Hashimoto S., Morishige M., Hashimoto A., Ogawa E.
  • Journal Title: Cell Adh Migr. 2 Pages: 71-73
  • Peer Reviewed
• [Journal Article] GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion. (2008)
  • Author(s): Masaki Morishige
  • Journal Title: Nature Cell Biology 10 Pages: 85-92
  • Peer Reviewed
• [Journal Article] Fbx8 Makes Arf6 Refractory to Function via Ubiquitination (2008)
  • Author(s): Hajime Yano
  • Journal Title: Molecular Biology of the Cell 19 Pages: 822-832
  • Peer Reviewed
• [Journal Article] IRES-mediated translationa control of AMAP1 expression during differentiation of monocyte U937 cells (2008)
  • Author(s): Mariko Miyata
  • Journal Title: Cell Cycle 7 Pages: 162-170
  • Peer Reviewed
• [Journal Article] The EGFR-GEP100-Arf6 pathway in breast cancer:Full invasive ness is not from the inside (2008)
  • Author(s): Hisataka Sabe
  • Journal Title: Cell adhesion & migration 2 Pages: 71-73
  • Peer Reviewed
• [Journal Article] GEP 100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion. (2008)
  • Author(s): M. Morishige, S. Hashimoto, E. Ogawa, Y. Toda, H. Kotani, M. Hirose, S. Wei, A. Hashimoto, A. Yamada, H. Yano, Y. Mazaki, H. Kodama, Y. Nio, T. Manabe, H. Wada, H. Kobayashi & H. Sabe.
  • Journal Title: Nat. Cell Biol. 10 Pages: 85-92
  • Peer Reviewed
• [Journal Article] Fbox8 makes Arf6 refractory tofunction via ubiquitination. (2008)
  • Author(s): H. Yano, I. Kobayashi, S. Hashimoto, F. Luton, M. Franco, K. Iwai, Z. Ronai & H. Sabe.
  • Journal Title: Mol. Biol. Cell 19 Pages: 822-832
  • Peer Reviewed
• [Journal Article] Dynamic rearrangement of surface proteins is essential for cytokinesis. (2008)
  • Author(s): T. Bauer, N. Motosugi, K. Miura, H. Sabe & T. Hiiragi.
  • Journal Title: Genesis 46 Pages: 152-62
  • Peer Reviewed
• [Journal Article] CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery. (2007)
  • Author(s): Nam JM., Onodera Y., Mazaki Y., Miyoshi H., Hashimoto S., Sabe H.
  • Journal Title: EMBO J. 26 Pages: 647-656
  • Peer Reviewed
• [Journal Article] CIN85, a Cbl-interacting multiabaptor protein, is a component of AMAP1-mediated breast cancer invasion machinery. (2007)
  • Author(s): J. Nam, Y. Onodera, Y. Mazaki, H. Miyoshi, S.Hashimoto & H. Sabe
  • Journal Title: EMBO J. 26 Pages: 647-656
  • Peer Reviewed
• [Journal Article] CIN85, a cb1-interacting multiadaptor protein,is a component of AMAP1-mediated breast cancer invasion machinery. (2007)
  • Author(s): J.-M.Nam, Y.Onodera, Y.Mazaki, H.Miyoshi, S.Hashimoto, H.sabe
  • Journal Title: EMBO J. 26 Pages: 647-656
• [Journal Article] Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2. (2006)
  • Author(s): Mazaki Y., Hashimoto S., Tsujimura T., Morishige M., Hashimoto A., Aritake K., Yamada A., Nam JM., Kiyonari H., Nakao K., Sabe H.
  • Journal Title: Nat Immunol 7 Pages: 724-731
  • Peer Reviewed
• [Journal Article] Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis. (2006)
  • Author(s): Hashimoto S., Hirose M., Hashimoto A., Morishige M., Yamada A., Hosaka H., Akagi K., Ogawa E., Oneyama C., Agatsuma T., Okada M., Kobayashi H., Wada H., Nakano H., Ikegami T., Nakagawa A., Sabe H.
  • Journal Title: Proc Natl Acad Sci U S A. 103 Pages: 7036-7041
  • Peer Reviewed
• [Journal Article] ArfGAP family proteins in cell adhesion, migration and tumor invasion. (2006)
  • Author(s): Sabe H., Onodera Y., Mazaki Y., Hashimoto S.
  • Journal Title: Curr Opin Cell Biol. 18 Pages: 558-564
  • Peer Reviewed
• [Journal Article] Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis (2006)
  • Author(s): S.Hashimoto, M.Hirose, A.Hashimoto, M.Morishige, A.Yamada, H.Hosaka, K.Akagi, E.Ogawa, C.Oneyama, Agatsuma, T, M.Okada, H.Kobayashi, H.Wada, H.Nakano, T.Ikegami, A.Nakaeawa, H.Sabe
  • Journal Title: Proc Natl Acad Sci U S A. 103・17 Pages: 7036-7041
• [Journal Article] ArfGAP family proteins in cell adhesion, migration and tumor invasion (2006)
  • Author(s): H.Sabe, Y.Onodera, Y.Mazaki, S.Hashimoto
  • Journal Title: Curr. Opin. Cell Biol. 18 Pages: 558-564
• [Journal Article] Assays and properties of the ArfGAPs, AMAP1 and AMAP2, in Arf6 function. (2005)
  • Author(s): Hashimoto S., Hashimoto A., Yamada A., Onodera Y., Sabe H.
  • Journal Title: Methods Enzymol. 404 Pages: 216-231
  • Peer Reviewed
• [Journal Article] Interaction of paxillin with poly(A)-binding protein 1 and its role in focal adhesion turnover and cell migration. (2005)
  • Author(s): Woods A.J., Kantidakis T., Sabe H., Critchley D.R., Norman JC.
  • Journal Title: Mol Cell Biol. 25 Pages: 3763-3773
  • Peer Reviewed
• [Journal Article] Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities. (2005)
  • Author(s): Onodera Y., Hashimoto S., Hashimoto A., Morishige M., Mazaki Y., Yamada A., Ogawa E., Adachi M., Sakurai T., Manabe T., Wada H., Matsuura N., Sabe H.
  • Journal Title: EMBO J. 24 Pages: 963-973
  • Peer Reviewed
• [Journal Article] Expression of AMAP1,an ArfGAP, provides novel targets to inhibit breast cancer invasive activities. (2005)
  • Author(s): Onodera, Y., Hashimoto, N., Hashimoto, A., Morishige, M., Mazaki, Y., Yamada, A., Ogawa, E., Adachi, M., Sakurai, T., Manabe, T., Wada, H., Matsuura, N., Sabe, H.
  • Journal Title: EMBO J. 24・5 Pages: 963-973
• [Journal Article] Interaction of paxillin with poly(A)-binding protein 1 and its role in focal adhesion turnover and cell migration. (2005)
  • Author(s): Woods, A.J., Kantidakis, T., Sabe, H., Critchley, D.R., Norman, J.C.
  • Journal Title: Mol. Cell Biol. 25・9 Pages: 3763-3773
• [Journal Article] Assays and properties of ArfGAPs, AMAP1 and AMAP2,in Arf6 function. Methods Enzymol. (2005)
  • Author(s): Hashimoto, S., Hashimoto, A., Yamada, A., Onodera, Y., Sabe, H.
  • Journal Title: Methods Enzymol. 404 Pages: 216-231
• [Presentation] Integrin activation and E-cadherin inactivation by the Arf6 pathway specific to breast cancer invasion and metastasis. (2010)
  • Author(s): Sabe H
  • Organizer: 第6回OOTR年次学会
  • Place of Presentation: 京都
  • Year and Date: 2010-02-25
• [Presentation] Integrin activation and E-cadherin inactivation by the Arf6 pathway specific to breast cancer invasion and metastasis (2010)
  • Author(s): Sabe H
  • Organizer: 第6回OOTR年次学会
  • Place of Presentation: ウェスティン都ホテル京都(京都市)
  • Year and Date: 2010-02-25
• [Presentation] Both GBF1 and PI3-kinaseγ are essential for Arf1 activation necessary for neutrophil directional migration (2009)
  • Author(s): Masaki Y
  • Organizer: 第39回 日本免疫学会学術集会
  • Place of Presentation: ウェスティン都ホテル京都(京都市)
  • Year and Date: 2009-12-02
• [Presentation] 腫瘍血管における透過性亢進に関与する分子輸送のメカニズム及び病態の解明 (2009)
  • Author(s): Hashimoto A
  • Organizer: 細胞内ロジスティックス斑会議
  • Place of Presentation: 万座ビーチリゾート会議場(恩納村)
  • Year and Date: 2009-11-11
• [Presentation] メンブレントラフィックと癌浸潤形質獲得機序 (2009)
  • Author(s): Sabe H
  • Organizer: 第82回 日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-21
• [Presentation] EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts (2009)
  • Author(s): Miura M
  • Organizer: 第82回 日本生化学会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2009-10-21
• [Presentation] メンブレントラフィックと癌浸潤形質獲得機序 (2009)
  • Author(s): Sabe H
  • Organizer: 第82回 日本生化学会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2009-10-21
• [Presentation] 微小環境の変化に連動した癌の浸潤形質獲得の分子機序 (2009)
  • Author(s): Hashimoto S
  • Organizer: 特別学術講演会
  • Place of Presentation: 北海道大学薬学部臨床薬学講義室(札幌市)
  • Year and Date: 2009-09-25
• [Presentation] Integrin activation and E-cadherin inactivation by the Arf6 pathway specific to breast cancer invasion and metastasis. (2009)
  • Author(s): Sabe H
  • Organizer: 2009 FEBS workshop
  • Place of Presentation: Seefeld
  • Year and Date: 2009-09-06
• [Presentation] Integrin activation and E-cadherin inactivation by the Arf6 pathway specific to breast cancer invasion and metastasis (2009)
  • Author(s): Sabe H
  • Organizer: 2009 FEBS workshop
  • Place of Presentation: Hotel Veronika(ミュンヘン)
  • Year and Date: 2009-09-06
• [Presentation] 癌の浸潤形質獲得機序:その組織特異性についての考察 (2009)
  • Author(s): Sabe H
  • Organizer: 生化学会支部例会
  • Place of Presentation: 旭川医科大学(旭川市)
  • Year and Date: 2009-07-17
• [Presentation] 乳がん浸潤形質獲得の分子機序 (2009)
  • Author(s): Hashimoto S
  • Organizer: 平成21年度大学院「先端医療トピックス」
  • Place of Presentation: 神戸大学医学部B講義室(神戸市)
  • Year and Date: 2009-06-12
• [Presentation] EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts (2009)
  • Author(s): Miura M
  • Organizer: 第61回日本細胞生物学会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2009-06-02
• [Presentation] Roles of GBF1 in neutrophil chemotaxis (2009)
  • Author(s): Masaki Y
  • Organizer: 第61回日本細胞生物学会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2009-06-02
• [Presentation] 乳がんの浸潤性獲得機序:微小環境を考える (2009)
  • Author(s): Hisataka Sabe
  • Organizer: がん特定領域5領域合同シンポジウム
  • Place of Presentation: 学術総合センター一橋記念講堂
  • Year and Date: 2009-02-02
• [Presentation] 乳癌の浸潤転移に特異的EGFR-GEP100-Arf6-AMAP1経路 (2008)
  • Author(s): Hisataka Sabe
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2008-12-12
• [Presentation] Arf6-AMAP1 pathway in invasion of lung cancer and malignant mesothelioma cell lines. (2008)
  • Author(s): Menju T
  • Organizer: 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
  • Place of Presentation: Geneva Palexpo, Geneva, Switzerland
  • Year and Date: 2008-10-22
• [Presentation] Common usage of the GEP100-Arf6-AMAP1 pathway in tumor invation, angiogenesis and vascular permeability. (2008)
  • Author(s): Hashimoto A
  • Organizer: 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
  • Place of Presentation: Geneva Palexpo, Geneva, Switzerland
  • Year and Date: 2008-10-22
• [Presentation] The EGFR-GEP100-Arf6 Pathway in breast cancer invasion and metastasis. (2008)
  • Author(s): Hashimoto S
  • Organizer: 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
  • Place of Presentation: Geneva Palexpo, Geneva, Switzerland
  • Year and Date: 2008-10-22
• [Presentation] The ECFR-GEP100-Arf6 pathway in breast cancer:full invasiveness is not from the inside (2008)
  • Author(s): Hisataka Sabe
  • Organizer: 第2回日本癌学会・アメリカ癌学会合同カンファレンス
  • Place of Presentation: 兵庫県立淡路夢舞台国際会議場
  • Year and Date: 2008-07-15
• [Presentation] Arf6 constitutes a central pathway involved in breast cancer cell invasion and metastasis (2007)
  • Author(s): H. Sabe
  • Organizer: The 4th annual conference of the Organisation for Oncology and Translational Research
  • Place of Presentation: イタリア
  • Year and Date: 2007-11-09
• [Presentation] Fbx8 makes Arf6 refractory to function via ubiquitination. (2007)
  • Author(s): Yano H
  • Organizer: FASEB Summer Research Conferences, II Ciocco
  • Place of Presentation: Tuscany, Italy
  • Year and Date: 2007-06-26
• [Presentation] Essential role of Arf6/AMAP1 signaling pathway in tumor angiogenesis. (2007)
  • Author(s): Hashimoto A
  • Organizer: FASEB Summer Research Conferences and Jacques Monod "Arf Family GTPases" II Ciocco
  • Place of Presentation: Italy
  • Year and Date: 2007-06-24
• [Presentation] GEP100 links epidermal growth factor receptor signaling to Arf6 activation to induce breast cancer invasion. (2007)
  • Author(s): Hashimoto S
  • Organizer: FASEB Summer Research Conferences and Jacques Monod "Arf Family GTPases" II Ciocco
  • Place of Presentation: Italy
• [Presentation] Arf6 constitutes a signaling pathway involved in the invasive phenotypes of primary tumors of the human breast. (2007)
  • Author(s): Sabe H
  • Organizer: FASEB Summer Research Conferences, II Ciocco
  • Place of Presentation: Tuscany, Italy
• [Presentation] The roles of AMAP1 for integrin trafficking in breast cancer invasion. (2007)
  • Author(s): Onodera Y
  • Organizer: Keystone Symposia, Molecular Target for Cancer / Mouse Models of Cancer Discovery
• [Presentation] CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery. (2007)
  • Author(s): Nam JM
  • Organizer: Keystone Symposia
  • Place of Presentation: Whistler, Canada
• [Presentation] Comprehensive analysis for the acquisition of invasiveness in mammary epithelial cells. (2006)
  • Author(s): Hashimoto S
  • Organizer: The 46th annual meeting of the American Society for Cell Biology
  • Place of Presentation: San Diego, CA
  • Year and Date: 2006-12-12
• [Presentation] Neutrophil directional sensing and superoxide production Linked by GIT2 (2006)
  • Author(s): Masaki Y
  • Organizer: The 46th annual meeting of the American Society for Cell Biology
  • Place of Presentation: San Diego, CA
  • Year and Date: 2006-12-11
• [Presentation] How invasive Phenotypes Arise in Primary Tumors of Human Breast (2006)
  • Author(s): Sabe H
  • Organizer: Burnham institute for Medical Research
  • Place of Presentation: CA, USA
  • Year and Date: 2006-12-11
• [Presentation] Cancer Cell Invation:How the invative phenotypes arises in Breast Tumors (2006)
  • Author(s): Sabe H
  • Organizer: Beatson Institute Worksho
  • Place of Presentation: Glasgow, UK
• [Presentation] Reglation of cancer cell mobility (2005)
  • Author(s): Sabe H
  • Organizer: Montebello Conference 2005
  • Place of Presentation: Olso, Norway
• [Book] 蛋白質・核酸・酸素:細胞骨格と接着(第51巻第6号編集) (2006)
  • Author(s): 貝渕弘三、稲垣昌樹、佐邊壽孝
  • Publisher: 共立出版
• [Book] 発生分化再生研究2005 実験医学増刊『上皮細胞における接着分子機能の動的制御』 (2005)
  • Author(s): 三浦浩一, 佐邊壽孝
  • Publisher: 羊土社
• [Remarks]
  • URL: http://www.obi.or.jp/japanese/introduction/set_introduction.html
• [Remarks]
  • URL: http://www.obi.or.jp/japanese/introduction/set_biology.html
• [Patent(Industrial Property Rights)] 血管新生ならびに癌細胞のmesenchymal型およびamoeboid型浸潤を阻害するための薬剤 (2007)
  • Inventor(s): 佐邊壽孝、橋本あり、橋本茂
  • Industrial Property Rights Holder: 佐邊壽孝、橋本あり、橋本茂
  • Acquisition Date: 2007-03-28
• [Patent(Industrial Property Rights)] 血管新生ならびに癌細胞のmesenchymal型およびamoeboid型浸潤を阻害するための薬剤 (2007)
  • Inventor(s): 佐邊壽孝, 橋本茂, 橋本あり
  • Industrial Property Rights Holder: (財)大阪バイオサイエンス研究所
  • Filing Date: 2007-03-28
• [Patent(Industrial Property Rights)] 非典型的なプロリンリッチ配列結合阻害剤 (2006)
  • Inventor(s): 佐邊壽孝、橋本茂、中野洋文、我妻勉
  • Industrial Property Rights Holder: 佐邊壽孝、橋本茂、中野洋文、我妻勉
  • Acquisition Date: 2006-09-28
• [Patent(Industrial Property Rights)] 血管新生ならびに癌細胞のmesenchymal型およびamoeboid型浸潤を阻害するための薬剤 (2006)
  • Inventor(s): 佐邊壽孝、橋本あり、橋本茂
  • Industrial Property Rights Holder: 佐邊壽孝、橋本あり、橋本茂
  • Acquisition Date: 2006-09-28
• [Patent(Industrial Property Rights)] 非典型的なプロリンリッチ配列結合阻害剤 (2006)
  • Inventor(s): 佐邊壽孝, 橋本茂, 中野洋文, 我妻勉
  • Industrial Property Rights Holder: (財)大阪バイオサイエンス研究所協和発酵工業(株)
  • Filing Date: 2006-09-28
• [Patent(Industrial Property Rights)] ヒトがん細胞の浸潤および転移を阻害するペプチド、それをコードするポリヌクレオチドおよびそれらを含有する薬剤 (2005)
  • Inventor(s): 佐邊 壽孝, 橋本 茂
  • Industrial Property Rights Holder: (財)大阪バイオサイエンス研究所
  • Filing Date: 2005-09-14
• [Patent(Industrial Property Rights)] 非典型的なプロリンリッチ配列結合阻害剤 (2005)
  • Inventor(s): 佐邊 壽孝, 橋本 茂, 中野 洋文, 我妻 勉
  • Industrial Property Rights Holder: (財)大阪バイオサイエンス研究所
  • Filing Date: 2005-09-29
• [Patent(Industrial Property Rights)] ヒトがん細胞の浸潤活性を阻害するオリゴリボヌクレオチド (2005)
  • Inventor(s): 佐邊 壽孝, 橋本 茂, 古林 秀則, 森重 真毅
  • Industrial Property Rights Holder: (財)大阪バイオサイエンス研究所
  • Filing Date: 2005-09-30