| Project/Area Number |
17015003
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tohoku University |
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Principal Investigator |
HORII Akira Tohoku University, 大学院・医学系研究科, 教授 (40249983)
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| Co-Investigator(Kenkyū-buntansha) |
SUNAMURA Makoto 東北大学, 大学院・医学系研究科, 非常勤講師 (10201584)
YAEGASHI Nobuo 東北大学, 大学院・医学系研究科, 教授 (00241597)
EGAWA Shinichi 東北大学, 大学院・医学系研究科, 准教授 (00270679)
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| Co-Investigator(Renkei-kenkyūsha) |
SUNAMURA Makoto 東北大学, 大学院・医学系研究科, 非常勤講師 (10201584)
YAEGASHI Nobuo 東北大学, 大学院・医学系研究科, 教授 (00241597)
EGAWA Shinichi 東北大学, 大学院・医学系研究科, 准教授 (00270679)
|
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| Project Period (FY) |
2005 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥43,400,000 (Direct Cost: ¥43,400,000)
Fiscal Year 2009: ¥8,100,000 (Direct Cost: ¥8,100,000)
Fiscal Year 2008: ¥8,100,000 (Direct Cost: ¥8,100,000)
Fiscal Year 2007: ¥9,100,000 (Direct Cost: ¥9,100,000)
Fiscal Year 2006: ¥9,100,000 (Direct Cost: ¥9,100,000)
Fiscal Year 2005: ¥9,000,000 (Direct Cost: ¥9,000,000)
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| Keywords | 膵癌 / 婦人科癌 / 個別化医療 / RNAi / epigenetic / がん遺伝子 / がん抑制遺伝子 / がん / ゲノム / 発現制御 / メチル化 / 抗がん剤耐性 / 病理学 / 卵巣癌 / DUSP6 / AURKA / FBXW7 / ETS2 / MAPK / siRNA / マイクロアレイ / Wnt |
|---|
| Research Abstract |
Overexpression of the AURKA and S100A4 genes and expressional suppression of the DUSP6 gene functions as the drivers of pancreatic carcinogenesis. In addition, knockdown of AURKA caused synergistic chemosensitivity with taxane. Restoration of DUSP6 caused suppression of AURKA via suppression of ETS-2. Further, expressional link of PRDM2 and VASH1 with S100A4 was found. Both MAPK and PI3K cascades are keys in endometrial carcinogenesis and regulation of these cascade are potentially useful for clinical managements.
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