Development of cancer diagnostics based on genomic information

• Project/Area Number: 17015008
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: ABURATANI Hiroyuki The University of Tokyo, 先端科学技術研究センター, 教授 (10202657)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥116,700,000 (Direct Cost: ¥116,700,000); Fiscal Year 2009: ¥23,400,000 (Direct Cost: ¥23,400,000); Fiscal Year 2008: ¥23,400,000 (Direct Cost: ¥23,400,000); Fiscal Year 2007: ¥23,400,000 (Direct Cost: ¥23,400,000); Fiscal Year 2006: ¥23,400,000 (Direct Cost: ¥23,400,000); Fiscal Year 2005: ¥23,100,000 (Direct Cost: ¥23,100,000)
• Keywords: ゲノム / がん / 遺伝子 / マイクロアレイ / エピゲノム / DNAメチル化 / 染色体欠失 / がん転移 / 発現プロファイル / 染色体コピー数 / 発現データベース / バイオマーカー / がん診断 / メチル化 / モノクロナル抗体

Research Abstract

Integrated analysis of gene expression, genomic copy number and DNA methylation profiles has enabled stratification of cancer patients and will be crucial in applying personalized treatment.

Research Products

• [Journal Article] Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma. (2010)
  • Author(s): Deng YB, Nagae G, Midorikawa Y, Yagi K, Tsutsumi S, Yamamoto S, Hasegawa K, Kokudo N, Aburatani H, Kaneda A.
  • Journal Title: Cancer Sci. (Epub ahead of print)
  • NAID: 10026593919
• [Journal Article] Identification of chromosomal aberrations of metastatic potential in colorectal carcinoma. (2010)
  • Author(s): Yamamoto S, Midorikawa Y, Morikawa T, Nishimura Y, Sakamoto H, Ishikawa S, Akagi K, Aburatani H.
  • Journal Title: Genes Chromosomes Cancer. 49(5) Pages: 487-96
• [Journal Article] Genome-wide single nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in PI3-kinase pathway. (2010)
  • Author(s): Murayama-Hosokawa S, Oda K, Nakagawa S, Ishikawa S, Yamamoto S, Shoji K, Ikeda Y, Uehara Y, Fukayama M, McCormick F, Yano T, Taketani Y, Aburatani H.
  • Journal Title: Oncogene 29(13) Pages: 1897-908
• [Journal Article] Three DNA Methylation Epigenotypes in Human Colorectal Cancer. (2010)
  • Author(s): Yagi K, Akagi K, Hayashi H, Nagae G, Tsuji S, Isagawa T, Midorikawa Y, Nishimura Y, Sakamoto H, Seto Y, Aburatani H, Kaneda A.
  • Journal Title: Clin Cancer Res. 16(1) Pages: 21-33
• [Journal Article] Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma (2010)
  • Author(s): Deng YB
  • Journal Title: Cancer Science 101(in press)
  • Peer Reviewed
• [Journal Article] Identification of chromosomal aberrations of metastatic potential in colorectal carcinoma (2010)
  • Author(s): Yamamoto S
  • Journal Title: Genes Chromosomes and Cancer 49 Pages: 487-496
  • Peer Reviewed
• [Journal Article] Three DNA Methylation Epigenotypes in Human Colorectal Cancer (2010)
  • Author(s): Yagi K
  • Journal Title: Clinical Cancer Research 16 Pages: 21-33
  • Peer Reviewed
• [Journal Article] Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells (2010)
  • Author(s): Murohashi M
  • Journal Title: British Journal of Cancer 102 Pages: 206-212
  • Peer Reviewed
• [Journal Article] The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas. (2009)
  • Author(s): Shoji K, Oda K, Nakagawa S, Hosokawa S, Nagae G, Uehara Y, Sone K, Miyamoto Y, Hiraike H, Hiraike-Wada O, Nei T, Kawana K, Kuramoto H, Aburatani H, Yano T, Taketani Y.
  • Journal Title: Br J Cancer. 101(1) Pages: 145-8
• [Journal Article] Glypican-3 expression in clear cell adenocarcinoma of the ovary., Chauhan SC, Vannatta K, Ebeling MC, Vinayek N, Watanabe A, Pandey KK, Bell MC, Koch MD, Aburatani H, Lio Y, Jaggi M. Expression and functions of transmembrane mucin MUC13 in ovarian cancer. (2009)
  • Author(s): Maeda D, Ota S, Takazawa Y, Aburatani H, Nakagawa S, Yano T, Taketani Y, Kodama T, Fukayama M.
  • Journal Title: Mod Pathol., Cancer Res. 22(6),69(3)
• [Journal Article] Allelic imbalances and homozygous deletion on 8p23. 2 for stepwise progression of hepatocarcinogenesis. (2009)
  • Author(s): Midorikawa Y, Yamamoto S, Tsuji S, Kamimura N, Ishikawa S, Igarashi H, Makuuchi M, Kokudo N, Sugimura H, *Aburatani H.
  • Journal Title: Hepatology. 49(2) Pages: 513-22
• [Journal Article] Anti-glypican 3 antibodies cause ADCC against human hepatocellular carcinoma cells. (2009)
  • Author(s): Nakano K, Orita T, Nezu J, Yoshino T, Ohizumi I, Sugimoto M, Furugaki K, Kinoshita Y, Ishiguro T, Hamakubo T, Kodama T, Aburatani H, Yamada-Okabe H, Tsuchiya M.
  • Journal Title: Biochem Biophys Res Commun. 378(2) Pages: 279-84
• [Journal Article] Genome-wide single nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in PI3-kinase pathway (2009)
  • Author(s): Murayama-Hosokawa S
  • Journal Title: Oncogene 29 Pages: 1897-1908
  • Peer Reviewed
• [Journal Article] Identification of Cystatin SN as a novel tumor marker for colorectal cancer (2009)
  • Author(s): Yoneda K
  • Journal Title: Int J Oncol. 35 Pages: 33-40
  • Peer Reviewed
• [Journal Article] The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas (2009)
  • Author(s): Shoji K
  • Journal Title: British Journal of Cancer 101 Pages: 145-148
  • Peer Reviewed
• [Journal Article] Diffuse-Type Gastric Carcinoma : Progression, Angiogenesis, and Transforming Growth Factor{beta}Signaling (2009)
  • Author(s): Komuro A
  • Journal Title: J Natl Cancer Inst. 101 Pages: 592-604
  • Peer Reviewed
• [Journal Article] Glypican-3 expression in clear cell adenocarcinoma of the ovary (2009)
  • Author(s): Maeda D
  • Journal Title: Modern Pathology 22 Pages: 824-832
  • Peer Reviewed
• [Journal Article] Glypican 3-expressing gastric carcinoma : Distinct subgroup unifying hepatoid, clear-cell, and alpha-fetoprotein-producing gastric carcinomas (2009)
  • Author(s): Ushiku T
  • Journal Title: Cancer Science (掲載確定)(In press)
  • Peer Reviewed
• [Journal Article] Allelic imbalances and homozygous deletion on 8p23.2 for stepwise progression of hepatocarcinogenesis (2009)
  • Author(s): Midorikawa Y
  • Journal Title: Hepatology 49 Pages: 513-522
  • Peer Reviewed
• [Journal Article] Expression and functions of transmembrane mucin MUC13 in ovarian cancer (2009)
  • Author(s): Chauhan SC
  • Journal Title: Cancer Research 69 Pages: 765-774
  • Peer Reviewed
• [Journal Article] Anti-glypican 3 antibodies cause ADCC against human hepatocellular carcinoma cells (2009)
  • Author(s): Nakano K
  • Journal Title: Biochem Biophys Res Commun. 378 Pages: 279-284
  • Peer Reviewed
• [Journal Article] Anti-glypican 3 antibody as a potential antitumor agent for human liver cancer. (2008)
  • Author(s): Ishiguro T, Sugimoto M, Kinoshita Y, Miyazaki Y, Nakano K, Tsunoda H, Sugo I, Ohizumi I, Aburatani H, Hamakubo T, Kodama T, Tsuchiya M, Yamada-Okabe H.
  • Journal Title: ancer Res. 68(23) Pages: 9832-8
• [Journal Article] The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. (2008)
  • Author(s): Hiratsuka S, Watanabe A, Sakurai Y, Akashi-Takamura S, Ishibashi S, Miyake K, Shibuya M, Akira S, Aburatani H, Maru Y.
  • Journal Title: Nat Cell Biol. 10(11) Pages: 1349-55
• [Journal Article] Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF. (2008)
  • Author(s): Torisu Y, Watanabe A, Nonaka A, Midorikawa Y, Makuuchi M, Shimamura T, Sugimura H, Niida A, Akiyama T, Iwanari H, Kodama T, Zeniya M, *Aburatani H.
  • Journal Title: Cancer Sci. 99(6) Pages: 1139-46
• [Journal Article] Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines. (2008)
  • Author(s): Nakamura Y, Matsubara D, Goto A, Ota S, Sachiko O, Ishikawa S, Aburatani H, Miyazawa K, Fukayama M, Niki T.
  • Journal Title: Cancer Sci. 99(1) Pages: 14-22
  • NAID: 10024000720
• [Journal Article] Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF (2008)
  • Author(s): Torisu Y
  • Journal Title: Cancer Science 99 Pages: 1139-1146
  • Peer Reviewed
• [Journal Article] Anti-glypican 3 antibody as a potential antitumor agent for human liver cancer (2008)
  • Author(s): Ishiguro T
  • Journal Title: Cancer Research 68 Pages: 9832-9888
  • Peer Reviewed
• [Journal Article] The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes apre-metastatic phase (2008)
  • Author(s): Hiratsuka S
  • Journal Title: Nat Cell Biol 10 Pages: 1349-1355
  • Peer Reviewed
• [Journal Article] Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF (2008)
  • Author(s): Torisu Y
  • Journal Title: Cancer Sci (In press)
  • Peer Reviewed
• [Journal Article] AKR1B 10 in usual interstitial pneumonia: Expression in squamousmetaplasia in association with smoking and lung cancer (2008)
  • Author(s): Li CP
  • Journal Title: Pathol Res Pract (In press)(掲載確定)
  • Peer Reviewed
• [Journal Article] Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines (2008)
  • Author(s): Nakamura Y
  • Journal Title: Cancer Sci. 99 Pages: 14-22
  • Peer Reviewed
• [Journal Article] Identification of toll-like receptor 3 as a potential therapeutic target in clear cell renal cell carcinoma. (2007)
  • Author(s): Morikawa T, Sugiyama A, Kume H, Ota S, Kashima T, Tomita K, Kitamura T, Kodama T, Fukayama M, Aburatani H.
  • Journal Title: Clin Cancer Res. 13(19) Pages: 5703-9
• [Journal Article] High-density oligonucleotide array with sub-kilobase resolution reveals breakpoint information of submicroscopic deletions in nevoid basal cell carcinoma syndrome. (2007)
  • Author(s): Fujii K, Ishikawa S, Uchikawa H, Komura D, Shapero MH, Shen F, Hung J, Arai H, Tanaka Y, Sasaki K, Kohno Y, Yamada M, Jones KW, Aburatani H, Miyashita T.
  • Journal Title: Hum Genet. 122(5) Pages: 459-66
• [Journal Article] Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. (2007)
  • Author(s): Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara SI, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, Ishikawa Y, Aburatani H, Niki T, Sohara Y, Sugiyama Y, Mano H.
  • Journal Title: Nature. 448(7153) Pages: 561-6
• [Journal Article] Identification of novel androgen response genes in prostate cancer cells by coupling chromatin immunoprecipitation and genomic microarray analysis. (2007)
  • Author(s): Takayama K, Kaneshiro K, Tsutsumi S, Horie-Inoue K, Ikeda K, Urano T, Ijichi N, Ouchi Y, Shirahige K, Aburatani H, Inoue S.
  • Journal Title: Oncogene. 26(30) Pages: 4453-63
• [Journal Article] Identification of toll-like receptor 3 as a potential therapeutic target in clear cell renal cell carcinoma (2007)
  • Author(s): Morikawa T
  • Journal Title: Clin Cancer Res. 13 Pages: 5703-9
  • Peer Reviewed
• [Journal Article] Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer (2007)
  • Author(s): Soda M
  • Journal Title: Nature 448 Pages: 561-6
  • Peer Reviewed
• [Journal Article] High-density oligonucleotide array with sub-kilobase resolution reveals breakpoint information of submicroscopic deletions in nevoid basal cell carcinoma syndrome (2007)
  • Author(s): Fujii K
  • Journal Title: Hum Genet 122 Pages: 459-66
  • Peer Reviewed
• [Journal Article] Identification of novel androgen response genes in prostate cancer cells by coupling chromatin immunoprecipitation and genomic microarray analysis (2007)
  • Author(s): Takayama K
  • Journal Title: Oncogene 26 Pages: 4453-63
  • Peer Reviewed
• [Journal Article] Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. (2006)
  • Author(s): Hiratsuka S, Watanabe A, Aburatani H, Maru Y.
  • Journal Title: Nat Cell Biol. 8(12) Pages: 1369-75
• [Journal Article] Hepatocellular oncofetal protein, glypican 3 is a sensitive marker for alpha-fetoprotein-producing gastric carcinoma. (2006)
  • Author(s): Hishinuma M, Ohashi KI, Yamauchi N, Kashima T, Uozaki H, Ota S, Kodama T, Aburatani H, Fukayama M.
  • Journal Title: Histopathology. 49(5) Pages: 479-86
• [Journal Article] Oncofetal protein glypican-3 in testicular germ-cell tumor. (2006)
  • Author(s): Ota S, Hishinuma M, Yamauchi N, Goto A, Morikawa T, Fujimura T, Kitamura T, Kodama T, Aburatani H, Fukayama M.
  • Journal Title: Virchows Arch. 449(3) Pages: 308-14
• [Journal Article] Copy number variation: New insights in genome diversity. (2006)
  • Author(s): Freeman JL, Perry GH, Feuk L, Redon R, McCarroll SA, Altshuler DM, Aburatani H, Jones KW, Tyler-Smith C, Hurles ME, Carter NP, Scherer SW, Lee C.
  • Journal Title: Genome Res. 16(8) Pages: 949-61
• [Journal Article] Noise Reduction from genotyping microarrays using probe level information. (2006)
  • Author(s): Komura D, Nishimura K, Ishikawa S, Panda B, Huang J, Nakamura H, Ihara S, Hirose M, Jones KW, Aburatani H.
  • Journal Title: In Silico Biol. 6(1-2) Pages: 79-92
• [Journal Article] Molecular karyotyping of human hepatocellular carcinoma using single-nucleotide polymorphism arrays. (2006)
  • Author(s): Midorikawa Y, Yamamoto S, Ishikawa S, Kamimura N, Igarashi H, Sugimura H, Makuuchi M, Aburatani H.
  • Journal Title: Oncogene. 25(40) Pages: 5581-90
• [Journal Article] Identification of ROBO1 as a Novel Hepatocellular Carcinoma Antigen and a Potential Therapeutic and Diagnostic Target. (2006)
  • Author(s): Ito H, Funahashi S, Yamauchi N, Shibahara J, Midorikawa Y, Kawai S, Kinoshita Y, Watanabe A, Hippo Y, Ohtomo T, Iwanari H, Nakajima A, Makuuchi M, Fukayama M, Hirata Y, Hamakubo T, Kodama T, Tsuchiya M, Aburatani H.
  • Journal Title: Clin Cancer Res. 12(11) Pages: 3257-64
• [Journal Article] A new melanoma antigen Fatty Acid-binding protein 7, involved in proliferation and invasion, is a potential target for immunotherapy and molecular target therapy. (2006)
  • Author(s): Goto Y, Matsuzaki Y, Kurihara S, Shimizu A, Okada T, Yamamoto K, Murata H, Takata M, Aburatani H, Hoon DS, Saida T, Kawakami Y.
  • Journal Title: Cancer Res. 66(8) Pages: 4443-9
• [Journal Article] Hepatocellular carcinoma in Txnip-deficient mice. (2006)
  • Author(s): Sheth SS, Bodnar JS, Ghazalpour A, Thipphavong CK, Tsutsumi S, Tward AD, Demant P, Kodama T, Aburatani H, Lusis AJ.
  • Journal Title: Oncogene. 25(25) Pages: 3528-36
• [Journal Article] CARAT: A novel method for allelic detection of DNA copy number changes using high density oligonucleotide arrays. (2006)
  • Author(s): Huang J, Wei W, Chen J, Zhang J, Liu G, Di X, Mei R, Ishikawa S, Aburatani H, Jones KW, Shapero MH.
  • Journal Title: BMC Bioinformatics. 7(1) Pages: 83-83
• [Journal Article] Chromosomal Numerical Abnormality Profiles of Gastrointestinal Stromal Tumors. (2006)
  • Author(s): Yamashita K, Igarashi H, Kitayama Y, Ozawa T, Kiyose S, Konno H, Kazui T, Ishikawa S, Aburatani H, Tanioka F, Suzuki M, Sugimura H.
  • Journal Title: Jpn J Clin Oncol. 36(2) Pages: 85-92
• [Journal Article] Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer. (2006)
  • Author(s): Tanaka T, Jiang S, Hotta H, Takano K, Iwanari H, Sumi K, Daigo K, Ohashi R, Sugai M, Ikegame C, Umezu H, Hirayama Y, Midorikawa Y, Hippo Y, Watanabe A, Uchiyama Y, Hasegawa G, Reid P, Aburatani H, Hamakubo T, Sakai J, Naito M, Kodama T.
  • Journal Title: J Pathol. 208(5) Pages: 662-672
• [Journal Article] Elevated expression and potential roles of human Sp5, a member of Sp transcription factor family, in human cancers. (2006)
  • Author(s): Chen Y, Guo Y, Ge X, Itoh H, Watanabe A, Fujiwara T, Kodama T, Aburatani H.
  • Journal Title: Biochem Biophys Res Commun. 340(3) Pages: 758-66
• [Journal Article] Topological and functional discovery in a gene coexpression meta-network of gastric cancer. (2006)
  • Author(s): Aggarwal A, Li Guo D, Hoshida Y, Tsan Yuen S, Chu KM, So S, Boussioutas A, Chen X, Bowtell D, Aburatani H, Leung SY, Tan P.
  • Journal Title: Cancer Res. 66(1) Pages: 232-41
• [Journal Article] Molecular karyotyping of human hepatocellular carcinoma using single-nucleotide polymorphism arrays. (2006)
  • Author(s): Midorikawa Y, et al.
  • Journal Title: Oncogene (印刷中)
• [Journal Article] CARAT : A novel method for allelic detection of DNA copy number changes using high density oligonucleotide arrays. (2006)
  • Author(s): Hwang J, et al.
  • Journal Title: BMC Bioinformatics 7(1) Pages: 83-83
• [Journal Article] Chromosomal Numerical Abnormality Profiles of Gastrointestinal Stromal Tumors. (2006)
  • Author(s): Yamashita K, et al.
  • Journal Title: Jpn J Clin Oncol 36(2) Pages: 85-92
• [Journal Article] Dysregulated expression of p1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer. (2006)
  • Author(s): Tanaka T, et al.
  • Journal Title: J Pathol 208(5) Pages: 662-672
• [Journal Article] Elevated expression and potential roles of human Sp5, a member of Sp"transcription factor family, in human cancers. (2006)
  • Author(s): Chen Y, et al.
  • Journal Title: Biochem Biophys Res Commun 340(3) Pages: 758-766
• [Journal Article] Topological and functional discovery in a gene coexpression meta-network of gastric cancer. (2006)
  • Author(s): Aggarwal A, et al.
  • Journal Title: Cancer Res. 66(1) Pages: 232-241
• [Journal Article] Lipocalin-type prostaglandin D synthase as a melanocyte marker regulated by MITF. (2006)
  • Author(s): Takeda K. et al.
  • Journal Title: Biochem Biophys Res Commun 339(4) Pages: 1098-1106
• [Journal Article] Hepatocyte-specific deletion of the keapl gene activates Nrf2 and confers potent resistance against acute drug toxicity. (2006)
  • Author(s): Okawa H, et al.
  • Journal Title: Biochem Biophys Res Commun 339(1) Pages: 79-88
• [Journal Article] Differential expression of S100A2 and S100A4 in lung adenocarcinomas: Clinicopathological significance, relationship to p53 and identification of their target genes. (2005)
  • Author(s): Matsubara D, Niki T, Ishikawa S, Goto A, Ohara E, Yokomizo T, Heizmann CW, Aburatani H, Moriyama S, Moriyama H, Nishimura Y, Funata N, Fukayama M.
  • Journal Title: Cancer Sci. 96(12) Pages: 844-57
  • NAID: 10017103994
• [Journal Article] Two subclasses of lung squamous cell carcinoma with different gene expression profiles and prognosis identified by hierarchical clustering and non-negative matrix factorization. (2005)
  • Author(s): Inamura K, Fujiwara T, Hoshida Y, Isagawa T, Jones MH, Virtanen C, Shimane M, Satoh Y, Okumura S, Nakagawa K, Tsuchiya E, Ishikawa S, Aburatani H, Nomura H, Ishikawa Y.
  • Journal Title: Oncogene. 24(47) Pages: 7105-13
• [Journal Article] Allelic dosage analysis with genotyping microarrays. (2005)
  • Author(s): Ishikawa S, Komura D, Tsuji S, Nishimura K, Yamamoto S, Panda B, Huang J, Fukayama M, Jones KW, Aburatani H.
  • Journal Title: Biochem Biophys Res Commun. 333(4) Pages: 1309-1314
• [Journal Article] Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells. (2005)
  • Author(s): Yokoyama K, Higashi H, Ishikawa S, Fujii Y, Kondo S, Kato H, Azuma T, Wada A, Hirayama T, Aburatani H, Hatakeyama M.
  • Journal Title: Proc Natl Acad Sci U S A. 102(27) Pages: 9661-6
• [Journal Article] Interpreting expression profiles of cancers by genome-wide survey of breadth-of-expression in normal tissues. (2005)
  • Author(s): Ge X, Yamamoto S, Tsutsumi S, Midorikawa Y, Ihara S, Wang SM, Aburatani H.
  • Journal Title: Genomics 86(2) Pages: 127-141
• [Journal Article] The Glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma. (2005)
  • Author(s): Yamauchi N, Watanabe A, Hishinuma M, Ohashi KI, Midorikawa Y, Morishita Y, Niki T, Shibahara J, Mori M, Makuuchi M, Hippo Y, Kodama T, Iwanari H, Aburatani H, Fukayama M.
  • Journal Title: Modern Pathology 18(12) Pages: 1591-8
• [Journal Article] Overexpression of MUC13 is associated with intestinal-type gastric cancer. (2005)
  • Author(s): Shimamura T, Ito H, Shibahara J, Watanabe A, Hippo Y, Taniguchi H, Chen Y, Kashima T, Ohtomo T, Tanioka F, Iwanari H, Kodama T, Kazui T, Sugimura H, Fukayama M, Aburatani H.
  • Journal Title: Cancer Sci. 96(5) Pages: 265-73
• [Journal Article] Paired-like homeoprotein ESXR1 acts as a sequence-specific transcriptional repressor of the human K-ras gene. (2005)
  • Author(s): Yanagihara M, Ishikawa S, Naito M, Nakajima J, Aburatani H, Hatakeyama M.
  • Journal Title: Oncogene 24(38) Pages: 5878-87
• [Journal Article] Differential expression of S100A2 and S100A4 in lung adenocarcinomas : Clinicopathological significance, relationship to p53 and identification of their target genes. (2005)
  • Author(s): Matsubara D, et al.
  • Journal Title: Cancer Sci. 96(12) Pages: 844-857
• [Journal Article] The mammalian homolog of the Drosophila discs large tumor suppressor protein up-regulates expression of the ELR(+) CXC chemokine Scyb5. (2005)
  • Author(s): Aiba T, et al.
  • Journal Title: Biochem Biophys Res Commun 337(1) Pages: 191-194
• [Journal Article] Two subclasses of lung squamous cell carcinoma with different gene expression profiles and prognosis identified by hierarchical clustering and non-negative matrix factorization. (2005)
  • Author(s): Inamura K, et al.
  • Journal Title: Oncogene 24(47) Pages: 7105-7113
• [Journal Article] Allelic dosage analysis with genotyping microarrays. (2005)
  • Author(s): Ishikawa S, et al.
  • Journal Title: Biochem Biophys Res Commun 333(4) Pages: 1309-1314
• [Journal Article] Functional antagonism between Heicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells. (2005)
  • Author(s): Yokoyama K, et al.
  • Journal Title: Proc Natl Acad Sci USA 102(27) Pages: 9661-9666
• [Journal Article] Fine mapping of radiation susceptibility and gene expression analysis of LEC congenic rat lines. (2005)
  • Author(s): Tsuji AB, et al.
  • Journal Title: Genomics 86(3) Pages: 271-219
• [Journal Article] Interpreting expression profiles in cancers by genome-wide survey of breadth-of-expression in normal tissues. (2005)
  • Author(s): Ge X, et al.
  • Journal Title: Genomics 86(2) Pages: 127-141
• [Journal Article] The Glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma. (2005)
  • Author(s): Yamauchi N, et al.
  • Journal Title: Modern Pathology 18(12) Pages: 1591-1598
• [Journal Article] Overexpression of MUC13 is associated with intestinal-type gastric cancer. (2005)
  • Author(s): Shimamura T, et al.
  • Journal Title: Cancer Sci 96(5) Pages: 265-273
• [Journal Article] Paired-like homeoprotein ESXR1 acts as a sequence-specific transcriptional repressor of the human K-ras gene. (2005)
  • Author(s): Yanagihara M, et al.
  • Journal Title: Oncogene 24(38) Pages: 5878-5887
• [Presentation] Cancer exome (2009)
  • Author(s): 油谷浩幸
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: Yokohama
  • Year and Date: 2009-12-10
• [Presentation] Personalized medicine in cancer (2009)
  • Author(s): 油谷浩幸
  • Organizer: 20th Asia Pacific Cancer Conference
  • Place of Presentation: Tsukuba
  • Year and Date: 2009-11-12
• [Presentation] Epigenetic dynamics (2009)
  • Author(s): 油谷浩幸
  • Organizer: 2009 International Conference on Genomics-Human and Beyond
  • Place of Presentation: Shenzhen, China
  • Year and Date: 2009-11-04
• [Presentation] Genomic medicine (2009)
  • Author(s): 油谷浩幸
  • Organizer: 第19回日本医療薬学会
  • Place of Presentation: Nagasaki
  • Year and Date: 2009-10-25
• [Presentation] Cancer epigenomics (2009)
  • Author(s): 油谷浩幸
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: Yokohama
  • Year and Date: 2009-10-03
• [Presentation] Integrated analysis of genomic and epigenomic alterations in liver cancer (2009)
  • Author(s): 油谷浩幸
  • Organizer: Cold Spring Harbor meeting on Personal genomes
  • Place of Presentation: Cold Spring Harbor, USA
  • Year and Date: 2009-09-15
• [Presentation] Epigenomic profiling of cancer. (2009)
  • Organizer: Epigenetics in Development and Diseases Conference : 4th Asian Epigenomics Meeting
  • Place of Presentation: Singapore
  • Year and Date: 2009-08-25
• [Presentation] Integrated analysis of genetic and epigenetic alterations in cancer (2009)
  • Author(s): 油谷浩幸
  • Organizer: 8th International Workshop on Advanced Genomics
  • Place of Presentation: Tokyo
  • Year and Date: 2009-06-18
• [Presentation] Integrated analysis of genetic and epigenetic alterations in liver cancer (2009)
  • Author(s): 油谷浩幸
  • Organizer: 3rd International Kobe Liver Symposium
  • Place of Presentation: Kobe
  • Year and Date: 2009-06-06
• [Presentation] Integrated analysis of genetic and epigenetic alterations in liver cancer (2009)
  • Author(s): 油谷浩幸
  • Organizer: Gordon Research Conference : Cancer Genetics & Epigenetics
  • Place of Presentation: Ventura, CA USA
  • Year and Date: 2009-01-30
• [Presentation] Cancer genome, epigenome. (2009)
  • Organizer: HGM2007 Workshop : Cancer Genomics
  • Place of Presentation: Montreal
• [Presentation] Integrated analysis of genomic, epigenomic alterations in liver cancer. (2009)
  • Organizer: Personal genomes
  • Place of Presentation: Cold Spring Harbor
• [Presentation] Epigenetic dynamics. (2009)
  • Organizer: 2009 International Conference on Genomics -Human and Beyond
  • Place of Presentation: henzhen, China
• [Presentation] がんの統合的ゲノム解析-ゲノムからエピゲノムへ- (2008)
  • Author(s): 油谷浩幸
  • Organizer: 日本分子生物学会第8回春季シンポジウム
  • Place of Presentation: 札幌
  • Year and Date: 2008-05-26
• [Presentation] Epigenomic profiling : Global DNA methylation profiles in differentiation from ES cells. (2008)
  • Organizer: 7th Human Genome Organization (HUGO)-Pacific meeting
  • Place of Presentation: Cebu
  • Year and Date: 2008-04-02
• [Presentation] Genomic strategy for personalized cancer treatment (2008)
  • Author(s): 油谷浩幸
  • Organizer: The 6th Annual Meeting of Japanese Society of Medical Oncology
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-21
• [Presentation] Regulatory genomics : allelic variaion in transcriptional variation. (2008)
  • Organizer: JST-ETH Zurich workshop on Medical Research
  • Place of Presentation: Zurich
• [Presentation] Genomic and epigenomic profiling in cancer (2007)
  • Author(s): 油谷浩幸
  • Organizer: AACR Centennial Conference
  • Place of Presentation: Singapore
  • Year and Date: 2007-11-06
• [Presentation] Epigenomic profiling in cancer: genome-wide detection of DNA methylation (2007)
  • Author(s): 油谷浩幸
  • Organizer: 日本血液学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-11
• [Presentation] エピゲノム解析 (2007)
  • Organizer: 第66回日本癌学会総会シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-05
• [Presentation] エピゲノム解析 (2007)
  • Author(s): 油谷浩幸
  • Organizer: 第66回日本癌学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-05
• [Presentation] Cancer genome and epigenome (2007)
  • Author(s): 油谷浩幸
  • Organizer: HGM2007
  • Place of Presentation: Montreal
  • Year and Date: 2007-05-23
• [Presentation] Copy number variation in human genome. (2007)
  • Organizer: AACR Annual Meeting 2007 Method Workshop‘Interpreting Chromosomal Copy Number Aberrations'
  • Place of Presentation: Los Angeles
  • Year and Date: 2007-04-14
• [Presentation] Copy number variation in human genome (2007)
  • Author(s): 油谷浩幸
  • Organizer: AACR Annual Meeting 2007
  • Place of Presentation: Los Angeles, USA
  • Year and Date: 2007-04-14
• [Presentation] Genomic, epigenomic profiling in cancer. (2007)
  • Organizer: AACR Centennial Conference Concurrent session : Systems Medicine
  • Place of Presentation: Singapore
• [Presentation] アレイを用いた網羅的エピゲノム解析 (2006)
  • Organizer: 第65回日本癌学会学術総会シンポジウム「ゲノミクス・プロテオミクスによる大規模解析とその臨床応用」
  • Place of Presentation: 横浜
  • Year and Date: 2006-09-30
• [Presentation] Glypican-3 as a novel diagnostic, therapeutic target for hepatocellular carcinoma. (2006)
  • Organizer: Gordon Research Conference (Proteoglycans)
  • Place of Presentation: 米国
  • Year and Date: 2006-07-14
• [Book] がん研究のいま3 がんの診断と治療 (2005)
  • Author(s): 中村祐輔
  • Total Pages: 236
  • Publisher: 東京大学出版会
• [Remarks]
  • URL: http://www.genome.rcast.u-tokyo.ac.jp/
• [Remarks]
  • URL: http://www.genome.rcast.u-tokyo.ac.jp/
• [Remarks]
  • URL: http://www.genome.rcast.u-tokyo.ac.jp/
• [Patent(Industrial Property Rights)] 抗●●●抗体を用いた癌の診断と治療 (2008)
  • Inventor(s): 油谷浩幸、西村邦裕、堤修一、作本裕史、川合重人
  • Industrial Property Rights Holder: 東京大学ほか
  • Industrial Property Number: 2008-004423
  • Filing Date: 2008-11-01
• [Patent(Industrial Property Rights)] 抗Desmoglein3抗体を用いる癌の診断および治療 (2007)
  • Inventor(s): 川合重人、中野清孝、伊藤浩孝、油谷浩幸、石川俊平
  • Industrial Property Rights Holder: 東京大学、未来創薬研究所
  • Industrial Property Number: 2007-019108
  • Filing Date: 2007-01-30
• [Patent(Industrial Property Rights)] 遺伝子コピーの解析方法及び装置 (2005)
  • Inventor(s): 油谷浩幸、石川俊平、西村邦裕、河村大輔
  • Industrial Property Rights Holder: 国立大学法人東京大学
  • Filing Date: 2005-09-07
• [Patent(Industrial Property Rights)] 遺伝子コピーの解析方法及び装置 (2005)
  • Inventor(s): 油谷 浩幸, 石川 俊平, 西村 邦裕, 河村 大輔
  • Industrial Property Rights Holder: 国立大学法人東京大学
  • Filing Date: 2005-09-07
• [Patent(Industrial Property Rights)] 肝炎重篤化のモニター薬 (2005)
  • Inventor(s): 中島 淳, 油谷 浩幸, 岩成 宏子, 大口 正夫, 佐藤 広一
  • Industrial Property Rights Holder: ペルセウスプロテオミクス
  • Filing Date: 2005-10-03
• [Patent(Industrial Property Rights)] 大腸癌および/または大腸ポリープの診断ならびに術後経過観察おび再発のモニター薬 (2005)
  • Inventor(s): 油谷 浩幸, 島村 隆浩, 渡邊 清高, 浅野 岳晴, 大西 真, 浜窪 隆雄, 杉山 暁, 細見 直樹, 岩成 宏子, 石井 敬介
  • Industrial Property Rights Holder: ペルセウス, 国立大学法人東京大学
  • Filing Date: 2005-12-14