Development of new diagnostic and therapeutic approaches based on information of the human genome

• Project/Area Number: 17015009
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: FURUKAWA Yoichi The University of Tokyo, 医科学研究所, 教授 (20272560)
• Co-Investigator(Kenkyū-buntansha): HAMAMOTO Ryuji 東京大学, 医科学研究所, 助教 (80321800)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥43,200,000 (Direct Cost: ¥43,200,000); Fiscal Year 2009: ¥8,300,000 (Direct Cost: ¥8,300,000); Fiscal Year 2008: ¥8,300,000 (Direct Cost: ¥8,300,000); Fiscal Year 2007: ¥8,800,000 (Direct Cost: ¥8,800,000); Fiscal Year 2006: ¥8,800,000 (Direct Cost: ¥8,800,000); Fiscal Year 2005: ¥9,000,000 (Direct Cost: ¥9,000,000)
• Keywords: ゲノム / 癌 / マイクロアレイ / 診断 / 治療

Research Abstract

Genome-wide gene expression profile analyses of human colorectal, hepatocellular, and gastric carcinomas have identified candidate genes for targeted cancer therapies against these tumors. Through the functional analyses of these genes, we have elucidated a part of mechanism(s) underlying these tumors, and obtained useful information for the development of the therapeutic approaches.

Research Products

• [Journal Article] C20orf20 (MRG-binding protein) as a potential therapeutic target for colorectal cancer. (2010)
  • Author(s): Yamaguchi K, Sakai M, Shimokawa T, Yamada Y, Nakamura Y, Furukawa Y.
  • Journal Title: Br. J. Cancer 102 Pages: 325-31
• [Journal Article] C20orf20(MRG-binding protein)as a potential therapeutic target for colorectal cancer (2010)
  • Author(s): Yamaguchi K, Sakai M, Shimokawa T, Yamada Y, Nakamura Y, Furukawa Y
  • Journal Title: Br.J.Cancer 102 Pages: 325-331
  • Peer Reviewed
• [Journal Article] Deficiency of GMD leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling (2009)
  • Author(s): Moriwaki K, Noda K, Furukawa Y, Ohshima K, Uchiyama A, Nakagawa T, Taniguchi N, Daigo Y, Nakamura Y, Hayashi N, Miyoshi E.
  • Journal Title: Gastroenterology 137 Pages: 188-198
• [Journal Article] XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway (2009)
  • Author(s): Tanikawa C, Furukawa Y, Yoshida N, Arakawa H, Nakamura Y, Matsuda K
  • Journal Title: Oncogene 28 Pages: 3081-3092
  • Peer Reviewed
• [Journal Article] Determination of splice-site mutations in Lynch syndrome(hereditary non-polyposis colorectal cancer)patients using functional splicing assay (2009)
  • Author(s): Naruse H, Ikawa N, Yamaguchi K, Nakamura Y, Arai M, Ishioka C, Sugano K.Tamura K.Tomita N.Matsubara N
  • Journal Title: Fam Cancer 8 Pages: 509-517
  • Peer Reviewed
• [Journal Article] Deficiency of GMD leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling (2009)
  • Author(s): Moriwaki K, Noda K, Furukawa Y, Ohshima K, Uchiyama A, Nakagawa T, Taniguchi N, Daigo Y, Nakamura Y, Hayashi N, Miyoshi E
  • Journal Title: Gastroenterology 137 Pages: 188-198
  • Peer Reviewed
• [Journal Article] Enhanced expression of RAD51AP1 is involved in the growth of intrahepatic choloangiocarcinoma cells. (2008)
  • Author(s): Obama K, Satoh S, Hamamoto R, Sakai Y, Nakamura Y, Furukawa Y.
  • Journal Title: Clinical Cancer Research 14(5) Pages: 1333-1339
• [Journal Article] Enhanced expression of RAD51AP1 is involved in the growth of intrahepatic choloangiocarcinoma cells (2008)
  • Author(s): Obama K, Satoh S, Hamamoto R, Sakai Y, Nakamura Y, Furukawa Y
  • Journal Title: Clin. Cancer Res 14 Pages: 1333-1339
  • Peer Reviewed
• [Journal Article] Enhanced methyltransferase activity of SMYD3 by the cleavage of its N-terminal region in human cancer cells (2008)
  • Author(s): Silva FP, Hamamoto R, Kunizaki M, Tsuge M, Nakamura Y, Furukawa Y
  • Journal Title: Oncogene 27 Pages: 2686-2692
  • Peer Reviewed
• [Journal Article] CDC2O, a potential cancer therapeutic target, is negatively regulated by p53 (2008)
  • Author(s): Kidokoro T, Tanikawa C, Furukawa Y, Katagiri T, Nakamura Y, Matsuda K
  • Journal Title: Oncogene 27 Pages: 1562-1571
  • Peer Reviewed
• [Journal Article] CDC20, a potential cancer therapeutic target, is negatively regulated by p53 (2008)
  • Author(s): Kidokoro, T., et. al.
  • Journal Title: Oncogene 27 Pages: 1562-1571
  • Peer Reviewed
• [Journal Article] Enhanced methyltransferase activity of SMYD3 by the cleavage of its N-terminal region in human cancer cells (2008)
  • Author(s): Silva, F. P., et. al.
  • Journal Title: Oncogene 27 Pages: 2686-2692
  • Peer Reviewed
• [Journal Article] The lysine 831 of VEGFR1 is a novel target of methylation by SMYD3. (2007)
  • Author(s): Kunisaki M, Hamamoto R, Silva FP, Yamaguchi K, Nagayasu T, Shibuya M, Nakamura Y, Furukawa Y.
  • Journal Title: Cancer Res 67(22) Pages: 10759-10765
• [Journal Article] The lysine 831 of VEGFR1 is a novel target of methylation by SMYD3 (2007)
  • Author(s): Kunisaki, M., et. al.
  • Journal Title: Cancer Research 67 Pages: 10759-10765
  • Peer Reviewed
• [Journal Article] Enhanced expression of RAD51AP1 is involved in the growth of intrahepatic choloangiocarcinoma cells (2007)
  • Author(s): Obama, K., et. al.
  • Journal Title: Clinical Cancer Research 14 Pages: 1333-1339
  • Peer Reviewed
• [Journal Article] Comparison of gene expression profiles between opisthorchis viverrini and non-opisthorchis viverrini associated human intrahepatic cholangiocarcinoma. (2006)
  • Author(s): Jinawath N, Chamgramol Y, Furukawa Y, Obama K, Tsunoda T, Sripa B, Pairojkul C, Nakamura Y.
  • Journal Title: Hepatology 44(4) Pages: 1025-1038
• [Journal Article] Enhanced SMYD3 expression is essential for the growth of breast cancer cells. (2006)
  • Author(s): Hamamoto, R., et al.
  • Journal Title: Cancer Science 97 Pages: 113-118
  • NAID: 10020388459
• [Journal Article] TIPUH1 encodes a novel KRAB zinc-finger protein highly expressed in human hepatocellular carcinomas. (2006)
  • Author(s): Silva, FP., et al.
  • Journal Title: Oncogene 25 Pages: 5063-5070
• [Journal Article] Identification of secernin 1 as a novel immunotherapy target for gastric cancer using the expression profiles of cDNA microarray. (2006)
  • Author(s): Suda, T., et al.
  • Journal Title: Cancer Science 97 Pages: 411-419
• [Journal Article] A gene encoding a family with sequence similarity 84, member A (FAM84A) enhanced migration of human colon cancer cells. (2006)
  • Author(s): Kobayashi, T., et al.
  • Journal Title: International Journal of Oncology 29 Pages: 341-347
• [Journal Article] Identification of TOMM34, which shows elevated expression in the mojority of human colon cancers, as a novel drug target. (2006)
  • Author(s): Shimokawa, T., et al.
  • Journal Title: International Journal of Oncology 29 Pages: 381-386
• [Journal Article] Comparison of gene expression profiles between opisthorchis viverrini and non-opisthorchis viverrini associated human intrahepatic cholangiocarcinoma. (2006)
  • Author(s): Jinawath, N., et al.
  • Journal Title: Hepatology 44 Pages: 1025-1038
• [Journal Article] Enhanced RASGEF1A expression is involved in the growth and migration of intrahepatic cholangiocarcinoma. (2006)
  • Author(s): Ura, K.et al.
  • Journal Title: Clinical Cancer Research 12 Pages: 6611-6616
• [Journal Article] VNTR Polymorphism of E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers. (2005)
  • Author(s): Tsuge M, Hamamoto R, Silva FP, Ohnishi Y, Chayama K, Kamatani N, Furukawa Y, Nakamura Y.
  • Journal Title: Nature Genet 37(10) Pages: 1104-1107
• [Journal Article] Identification of SP5 as a downstream gene of the beta-catenin/Tcf pathway and its enhanced expression in human colon cancer (2005)
  • Author(s): Takahashi, M et al.
  • Journal Title: International Journal of Oncology vol.27 Pages: 1483-1487
• [Journal Article] VNTR Polymorphism of E2F-1 binding element in the 5'flanking region of SMYD3 is a risk factor for human cancers. (2005)
  • Author(s): Tsuge, M. et al.
  • Journal Title: Nature Genetics vol.37(10) Pages: 1104-1107
• [Journal Article] Genome-wide analysis of gene expression in human intrahepatic cholangiocarcinoma (2005)
  • Author(s): Obama, K. et al.
  • Journal Title: Hepatology vol.41 Pages: 1339-1348
• [Journal Article] Identification of Immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas (2005)
  • Author(s): Watanabe, T. et al.
  • Journal Title: Cancer Science vol.96(8) Pages: 498-506
• [Journal Article] Elevated expression of C10orf3(Chromosome 10 open reading frame 3) is involved in the growth of human colon tumor (2005)
  • Author(s): Sakai, M. et al.
  • Journal Title: Oncogene vol.19 Pages: 1-7
• [Journal Article] Overexpression of peptidyl-prolyl isomerase-like 1 is associated with the growth of colon cancer cells (2005)
  • Author(s): Obama, K. et al.
  • Journal Title: Clinical Cancer Research vol.12(1) Pages: 70-76
• [Presentation] Ghenome-wide expression analysis identified MRG-binding protein (MRGBP) as a gene involved in colorectal carcinogenesis (2010)
  • Organizer: The 8th Joint Conference of AACR and JCA
  • Place of Presentation: Hawaii
  • Year and Date: 2010-02-08
• [Presentation] Ghenome-wide expression analysis identified MRG-binding protein(MRGBP)as a gene involved in colorectal carcinogenesis (2010)
  • Author(s): 古川洋一
  • Organizer: The 8th Joint Conference of AACR and JCA
  • Place of Presentation: アメリカ・ハワイ
  • Year and Date: 2010-02-07
• [Presentation] Application of global expression analyses of colon cancer for the clinics (2009)
  • Organizer: 第68回日本癌学会総会、シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] Application of global expression analyses of colon cancer for the clinics (2009)
  • Author(s): 古川洋一
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: 日本・横浜
  • Year and Date: 2009-10-03
• [Presentation] Clinical and genetic characteristics of Japanese HNPCC (2009)
  • Author(s): Yoichi Furukawa, Teruhiko Yoshida, Yusuke Nakamura, Yoshihiro Moriya
  • Organizer: The 3rd Meeting of International Society for Gastrointestinal Hereditary Tumours
  • Place of Presentation: ドイツ・デュッセルドルフ
  • Year and Date: 2009-06-25
• [Presentation] 日本のHNPCCの臨床遺伝学的特徴 (2008)
  • Author(s): 古川洋一
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] The lysine 831 of VEGFR1 is a novel target of methylation by SMYD3 histone methyltransferase (2007)
  • Organizer: The 14th. East Asia Joint Symposium
  • Place of Presentation: 東京
  • Year and Date: 2007-11-14
• [Presentation] RB1 is a novel target for methylation by SMYD3 histone methyltransferase (2007)
  • Author(s): 古川 洋一
  • Organizer: 第66回日本癌学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-05
• [Presentation] A repeat polymorphism of E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers (2006)
  • Organizer: The 97th Annual meeting of American Association for Cancer Research
  • Place of Presentation: Washiington DC
  • Year and Date: 2006-04-03
• [Book] Molecular Mechanisms Underlying Colorectal Carcinogenesis(Tumor Budding in Colorectal Cancer, Horizons in Cancer Research volume 8, Chapter III) (2006)
  • Author(s): Tetsuichiro Muto, Hidetaka Mochizuki, Tadahiko Masaki, Yoichi Furukawa, 他
  • Publisher: Nova Publishers
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/furukawa/index.html
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/furukawa/index.html
• [Patent(Industrial Property Rights)] BREAST CANCER RELATED GENE ZNFN3A1 (2006)
  • Inventor(s): 中村 祐輔, 古川 洋一, 中鶴 修一
  • Industrial Property Rights Holder: 東京大学, オンコセラピー・サイエンス株式会社
  • Filing Date: 2006-02-13
• [Patent(Industrial Property Rights)] BREAST CANCER RELATED GENE ZNFN3A1 (2006)
  • Inventor(s): 中村 祐輔, 古川 洋一, 中鶴 修一
  • Industrial Property Rights Holder: 東京大学, オンコセラピー・サイエンス株式会社
  • Filing Date: 2006-02-09
• [Patent(Industrial Property Rights)] Colon cancer related gene TOM34 (2005)
  • Inventor(s): 中村祐輔、古川洋一、角田卓也、田原秀晃、松島敏志
  • Industrial Property Rights Holder: オンコセラピーサイエンス社
  • Filing Date: 2005-07-27
• [Patent(Industrial Property Rights)] CXADRL1またはGCUD1タンパク質を発現する胃癌または結腸直腸癌の治療のためのペプチドワクチン (2005)
  • Inventor(s): 中村祐輔、古川洋一、角田卓也、田原秀晃、松島敏志
  • Industrial Property Rights Holder: オンコセラピーサイエンス社
  • Industrial Property Number: 2005-211289
  • Filing Date: 2005-07-21
• [Patent(Industrial Property Rights)] METHODS OF MODULATING SMYD3 FOR TREATMENT OF CANCER (2005)
  • Inventor(s): 中村祐輔、古川洋一、中鶴修一、浜本隆二
  • Industrial Property Rights Holder: オンコセラピーサイエンス社
  • Filing Date: 2005-07-01
• [Patent(Industrial Property Rights)] Cancer related gene RASGEF1A (2005)
  • Inventor(s): 中村祐輔、古川洋一、中鶴修一
  • Industrial Property Rights Holder: オンコセラピーサイエンス社
  • Filing Date: 2005-07-28
• [Patent(Industrial Property Rights)] POLYMORPHISMS OFE2F-1 BINDING ELEMENT ANDMETHODS OF DETERMINING CANCER SUSCEPTIBILITY (2005)
  • Inventor(s): 中村 祐, 古川 洋一, 中鶴 修一
  • Industrial Property Rights Holder: 国立大学法人東京大学, オンコセラピー・サイエンス株式会社
  • Filing Date: 2005-05-12
• [Patent(Industrial Property Rights)] METHODS OF MODULATING SMYD3 FOR TREATMENT OF CANCER (2005)
  • Inventor(s): 中村 祐輔, 古川 洋一, 浜本 降二, 中鶴 修一
  • Industrial Property Rights Holder: 国立大学法人東京大学, オンコセラピー・サイエンス株式会社
  • Filing Date: 2005-07-01
• [Patent(Industrial Property Rights)] Cancer related gene RASGEF1A (2005)
  • Inventor(s): 中村 祐輔, 古川 洋一, 中鶴 修一
  • Industrial Property Rights Holder: 東京大学, オンコセラピー・サイエンス株式会社
  • Filing Date: 2005-07-28
• [Patent(Industrial Property Rights)] Colorectal cancer related gene NSE1 (2005)
  • Inventor(s): 中村 祐輔, 古川 洋一, 中鶴 修一
  • Industrial Property Rights Holder: 東京大学, オンコセラピー・サイエンス株式会社
  • Filing Date: 2005-07-29
• [Patent(Industrial Property Rights)] INTERACTION OF COLON CANCER RELATED GENE C200RF20 WITH p120 (2005)
  • Inventor(s): 中村 祐輔, 古川 洋一, 中鶴 修一
  • Industrial Property Rights Holder: 東京大学, オンコセラピー・サイエンス株式会社
  • Filing Date: 2005-08-09