| Project/Area Number |
17015012
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
INAZAWA Johji Tokyo Medical and Dental University, 難治疾患研究所, 教授 (30193551)
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| Co-Investigator(Kenkyū-buntansha) |
IMOTO Issei 東京医科歯科大学, 難治疾患研究所, 教授 (30258610)
KOZAKI Kenichi 東京医科歯科大学, 硬組織疾患ゲノムセンター, 特任准教授 (50270715)
横井 左奈 東京医科歯科大学, 難治疾患研究所, 助手 (30372452)
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| Project Period (FY) |
2005 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥116,500,000 (Direct Cost: ¥116,500,000)
Fiscal Year 2009: ¥23,200,000 (Direct Cost: ¥23,200,000)
Fiscal Year 2008: ¥23,400,000 (Direct Cost: ¥23,400,000)
Fiscal Year 2007: ¥23,400,000 (Direct Cost: ¥23,400,000)
Fiscal Year 2006: ¥23,400,000 (Direct Cost: ¥23,400,000)
Fiscal Year 2005: ¥23,100,000 (Direct Cost: ¥23,100,000)
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| Keywords | がん / ゲノム / エピゲノム / マイクロアレイ / がん遺伝子 / がん抑制遺伝子 / マイクロRNA / CGH / 個性診断 / 分子標的治療 / CGHアレイ / DNAメチル化 / GhIP法 / BAMCA法 / アレイCGH / ChIP法 |
|---|
| Research Abstract |
Innovative techniques for detection of genomic and epigenomic aberrations underlying the pathogenesis have been developed and using those techniques numerous cancer-related genes have been successfully identified during the course of the research program. In particular, we identified 10 candidate oncogenes including DUSP26 and SMYD2 up-regulated due to gene amplification, and 10 candidate tumor suppressor genes including DBC1 and PCDH17. Furthermore four tumor-suppressor microRNAs, miR-13 and miR-193a, or miR-124 and miR-203, epigenetically silenced, were successfully identified in oral cancer or hepatocellular carcinoma, respectively.
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