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Biomarkers related to carcinogenesis and surrogate markers for cancer prevention

Research Project

Project/Area Number 17015020
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNagoya University

Principal Investigator

HAMAJIMA Nobuyuki  Nagoya University, 大学院・医学系研究科, 教授 (30172969)

Co-Investigator(Kenkyū-buntansha) EGUCHI Hidetaka  埼玉医科大学, 医学部, 准教授 (00260232)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥141,000,000 (Direct Cost: ¥141,000,000)
Fiscal Year 2009: ¥25,900,000 (Direct Cost: ¥25,900,000)
Fiscal Year 2008: ¥26,100,000 (Direct Cost: ¥26,100,000)
Fiscal Year 2007: ¥29,000,000 (Direct Cost: ¥29,000,000)
Fiscal Year 2006: ¥29,000,000 (Direct Cost: ¥29,000,000)
Fiscal Year 2005: ¥31,000,000 (Direct Cost: ¥31,000,000)
Keywords生活習慣 / 遺伝子多型 / ピロリ菌感染 / 慢性萎縮性胃炎 / 葉酸 / 尿酸 / 腫瘍マーカーCA19-9 / ACE / SLC22A12 / ABCG2 / TLR2 / uPA / NOS3 / IL-8 / 血清p53抗体 / CA19-9 / Lewis / TLR4 / FGFR2 / 遺伝子環境交互作用 / ピロリ菌 / 胃粘膜萎縮 / TNF-α / MCP1 / ODC / PTPN11 / Gab1 / ecNOS
Research Abstract

Biomarkers associated with carcinogenesis could be used as surrogate markers for the evaluation of cancer prevention. This study examined the associations of markers related to carcinogenesis and cancer diagnosis with lifestyle and genotypes. The following associations were observed; 1) a PTPN11 polymorphism with chronic atrophic gastritis, 2) MTHFR C609T with serum folate, 3) genotypes of ecNOS, SLC22A12 and ABCG2 with serum urate, 4) ACE I/D with ACE activity, 5) genotypes of Le and Se with serum CA19-9, and 6) IL-8 T-251 with serum IL-8.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (94 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (50 results) (of which Peer Reviewed: 34 results) Presentation (44 results)

  • [Journal Article] Association between circulating IL-8 levels, IL-8 T-251A genotypes and Helicobacter pylori infection2010

    • Author(s)
      Naito M, Eguchi H, Goto Y, Kondo T, Nishio K, Ishida Y, Kawai S, Okada R, Hishida A, Wakai K, Hamajima N.
    • Journal Title

      Epidemiol Infect 138

      Pages: 512-518

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between circulating IL-8 levels, IL-8 T-251A genotypes and Helicobacter pylori infection2010

    • Author(s)
      Naito M, et al.
    • Journal Title

      Epidemiol Infect VOL.138

      Pages: 512-518

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common defects of ABCG2, a high-capacity urate exporter, cause gout: a functional-based genetic analysis in a Japanese population2009

    • Author(s)
      Matsuo H, Takada T, Ichida K, Nakamura T, Nakayama A, Ikebuchi Y, Ito K, Kusanagi Y, Chiba T, Tadokoro S, Takada Y, Oikawa Y, Inoue H, Suzuki K, Okada R, Nishiyama J, Domoto H, Watanabe S, Fujita M, Morimoto Y, Naito M, Nishio K, Hishida A, Wakai K, Asai Y, Niwa K, Kamakura K, Nonoyama S, Sakurai Y, Hosoya T, Kanai Y, Suzuki K, Hamajima N, Shinomiya N.
    • Journal Title

      Science Translational Med 1(5-8)

      Pages: 41-48

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significant association between methylenetetrahydrofolate reductase (MTHFR) 677T allele and hyperuricemia among adult Japanese subjects2009

    • Author(s)
      Itou S, Goto Y, Suzuki K, Kawai S, Naito M, Ito Y, Hamajima N.
    • Journal Title

      Nutr Res 29

      Pages: 710-715

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] RUNX3 polymorphisms, Helicobacter pylori seropositivity, and risk of gastric atrophy and cancer in Japanese2009

    • Author(s)
      Hishida A, Matsuo K, Goto Y, Mitsuda Y, Naito M, Wakai K, Tajima K, Hamajima N.
    • Journal Title

      J Gastroenterol 44

      Pages: 1165-1171

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor 4 +3725 G/C polymorphism, Helicobacter pylori seropositivity, and the risk of gastric atrophy and gastric cancer in Japanese2009

    • Author(s)
      Hishida A, Matsuo K, Goto Y, Mitsuda Y, Hiraki A, Naito M, Wakai K, Tajima K, Hamajima N.
    • Journal Title

      Helicobacter 14

      Pages: 47-53

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between interleukin-1B C-31T polymorphism and obesity in Japanese2009

    • Author(s)
      Suzuki K, et al.
    • Journal Title

      J Epidemiol VOL.19

      Pages: 131-135

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Applicability of allele/genotype frequency from documented controls for case-control studies on genotypes among Japanese : MTHFR C677T as an example2009

    • Author(s)
      Iida K, et al.
    • Journal Title

      Asian Pac J Cancer Prev VOL.10

      Pages: 231-236

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Smoking cessation, alcohol intake and the risk of metabolic syndrome in Japanese : a cohort study at one health checkup institution2009

    • Author(s)
      Hishikda A, et al.
    • Journal Title

      BMC Public Health VOL.9

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Associations of a PTPN11 G/A polymorphism at intron 3 with Helcobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese2009

    • Author(s)
      Hishida A, et al.
    • Journal Title

      BMC Gastroenterol VOL.9

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-8 T-251A polymorphism was associated with positive anti-p53 antibodies in Uzbekistan population2009

    • Author(s)
      Okada R, et al.
    • Journal Title

      Nagoya J Med Sci VOL.71

      Pages: 151-156

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common defects of ABCG2, a high-capacity urate exporter, cause gout : a functional-based genetic analysis in a Japanese population2009

    • Author(s)
      Matsuo H, et al.
    • Journal Title

      Science Transl Med VOL.1

      Pages: 41-48

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RUNX3 polymorphisms, Helicobacter pylori seropositivity, and risk of gastric atrophy and cancer in Japanese2009

    • Author(s)
      Hishikda A, et al.
    • Journal Title

      J Gastroenterol VOL.44

      Pages: 1165-1171

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significant association between methylenetetrahydrofolate reductase (MTHFR) 677T allele and hyperuricemia among adult Japanese subjects2009

    • Author(s)
      Itou S, et al.
    • Journal Title

      Nutr Res VOL.29

      Pages: 710-715

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor 4 + 3725 G/C polymorphism, Helicobacterpylori seropositivity, and the risk of gastric atrophy and gastric cancer in Japanese2009

    • Author(s)
      Hishida A, et.al.
    • Journal Title

      Helicobacter 14

      Pages: 47-53

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Smoking and serum CA19-9 levels according to Lewis and Secretor genotypes2008

    • Author(s)
      Kawai S, Suzuki K, Nishio K, Ishida Y, Okada R, Goto Y, Naito M, Wakai K, Ito Y, Hamajima N.
    • Journal Title

      Int J Cancer 123

      Pages: 2880-2884

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significant association between Helicobacter pylori infection and C-ractive protein2008

    • Author(s)
      Ishida Y, Suzuki K, Taki K, Niwa T, Kurotsuchi S,, o H, Iwase A, Nishio K, Wakai K, Ito Y, Hamajima N.
    • Journal Title

      Int J Med Sci 5

      Pages: 224-229

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum folate and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism adjusted for folate intake2008

    • Author(s)
      Nishio K, Goto Y, Kondo T, Ito S, Ishida Y, Kawai S, Naito M, Wakai K, Hamajima N.
    • Journal Title

      J Epidemiol 18

      Pages: 125-131

    • NAID

      10024796267

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum folate and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism adjusted for folate intake2008

    • Author(s)
      Nishio K, et.al.
    • Journal Title

      J Epidemiol 18

      Pages: 125-131

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of Epstein-Barr virus antibody titers with a human IL-10 promoter polymorphism in Japanese women2008

    • Author(s)
      Yasui Y, et.al.
    • Journal Title

      BMC J Autoimmune Di(電子出版3月4日) 5

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A PTPN 11 polymorphism modifies the smoking-cholesterol association in a Japanese population2008

    • Author(s)
      Okada R, et.al.
    • Journal Title

      Mol Med Rep 1

      Pages: 595-598

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significant association between Helicobacter pyloriinfection and C-ractive protein2008

    • Author(s)
      Ishida Y, et.al.
    • Journal Title

      Int J Med Sci 5

      Pages: 224-229

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between a PTPN 11 polymorphism and gastricatrophy - opposite in Uzbekistan to that in Japan2008

    • Author(s)
      Hamajima N, et.al.
    • Journal Title

      Asian Pac J Cancer Prev 9

      Pages: 217-220

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Smoking and serum CA19-9 levels according to Lewis and Secretor genotypes2008

    • Author(s)
      Kawai S, et.al.
    • Journal Title

      Int J Cancer 123

      Pages: 2880-2884

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RET/PTC rearrangements preferentially occurred in papillary thyroid cancer among atomic bomb survivors exposed to high radiation dose2008

    • Author(s)
      Hamatani K, et.al.
    • Journal Title

      Cancer Res 68

      Pages: 7176-7182

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sixty years of follow-up of Hiroshima and Nagasaki survivors : current progress in molecular epidemiology studies2008

    • Author(s)
      Nakachi K, et.al.
    • Journal Title

      Mutat Res 659

      Pages: 109-117

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of a polymorphism in the ornithine decarboxylase gene with whole blood polyamine concentrations in a non-smoking healthy population2008

    • Author(s)
      Kondo T, et. al.
    • Journal Title

      J Health Sci (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum folate and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism adjusted for folate intake2008

    • Author(s)
      Nishio K, et. al.
    • Journal Title

      J Epidemiol (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese2007

    • Author(s)
      Itou S, Goto Y, Kondo T, Nishio K, Kawai S, Ishida Y, Naito M, Hamajima N.
    • Journal Title

      Int J Med Sci 4

      Pages: 98-104

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Grb2-associated Binder 1 polymophism was associated with the risk of Helicobacter pylori infection and gastric atrophy2007

    • Author(s)
      Goto Y, et. al.
    • Journal Title

      Int J Med Sci 4

      Pages: 1-6

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] No association between Helicobacter pylori seropositivity and ornithine decarboxylase (ODC) A317G polymorphism, and no modification by NAD (P) H:quinone oxidoreductase 1 (NQO1) C609T2007

    • Author(s)
      Goto Y, et. al.
    • Journal Title

      Nagoya J Med Sc 69

      Pages: 17-22

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese2007

    • Author(s)
      Itou S, et. al.
    • Journal Title

      Int J Med Sci 4

      Pages: 98-104

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Associations between serum C-reactive protein (CRP) levels and polymorphisms of CRP, interleukin 1B, and tumor necrosis factor A genes among Japanese health checkup examinees2007

    • Author(s)
      Kikuchi M, et. al.
    • Journal Title

      Asian Pac J Cancer Prev 8

      Pages: 87-92

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between serum pepsinogens and polymorphism of PTPN11 encoding SHP-2 among Helicobacter pylori seropositive Japanese2006

    • Author(s)
      Goto Y,, o T, Yamamoto K, Tamakoshi A, El-Omar E, Goto H, Hamajima N.
    • Journal Title

      Int J Cancer 118

      Pages: 203-208

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between serum pepsinogens and polymorphism of PTPN11 encoding SHP-2 among Helicobacter pylori seropositive Japanese2006

    • Author(s)
      Goto Y
    • Journal Title

      Int J Cancer 118

      Pages: 203-208

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Significant association between PTPN11 polymorphism and gastric atrophy among Japanese Brazilians2006

    • Author(s)
      Kawai S
    • Journal Title

      Gastric Cancer 9

      Pages: 277-283

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Inducible nitric oxide synthase (iNUS) polymorphism is associated with the increased risk of differentiated type gastric cancer in Japanese population2006

    • Author(s)
      Goto Y
    • Journal Title

      World J Gastroenterol 12

      Pages: 6361-6365

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The Grb2-associated Binder 1 polymophism was associated with the risk of Helicobacter pylori infection and gastric atrophy2006

    • Author(s)
      Goto Y
    • Journal Title

      Int J Med Sci 4

      Pages: 1-6

    • Related Report
      2006 Annual Research Report
  • [Journal Article] No association of an SDHC gene polymorphism with gastric cancer2006

    • Author(s)
      Goto Y
    • Journal Title

      Asian Pac J Cancer Prev 7

      Pages: 525-528

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A population-based follow-up study on mortality from cancer or cardiovascular disease and serum carotinoids, retinol and tocopherols in Japanese inhabitants2006

    • Author(s)
      Ito Y
    • Journal Title

      Asian Pac J Cancer Prev 7

      Pages: 533-546

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Association between serum pepsinogens and polymorphism of PTPN11 encoding SHP-2 among Helicobacter pylri seropositive Japanese2006

    • Author(s)
      Goto Y
    • Journal Title

      Int J Cancer 118

      Pages: 203-208

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Association between Helicobacter pylori seropositivity and NAD(P)H :quinone exidoreductase 1(NQO1)C609T polymorphism observed for outpatients and health checkup examinees2005

    • Author(s)
      Goto Y
    • Journal Title

      Gastric Cancer 8

      Pages: 12-17

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Interleukin-2 gene polymorphisms associated with increased risk of gastric atrophy from Helicobacter pylon infection2005

    • Author(s)
      Togawa S
    • Journal Title

      Helicobacter 10

      Pages: 172-178

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Association of XRCC1 Arg399Gin and OGG1 Ser326Cys polymorphisms with the risk of cervical cancer in Japanese subjects2005

    • Author(s)
      Niwa Y
    • Journal Title

      Gynecol Oncol 99(1)

      Pages: 43-49

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Polymorphism of dihydropyrimidine dehydrogenease(DPYD) Cys29Arg and risk of sex malignancies in Japaneses2005

    • Author(s)
      Tanaka D
    • Journal Title

      Nagoya J Med Sci 67

      Pages: 117-124

    • Related Report
      2005 Annual Research Report
  • [Journal Article] No association of EGF gene polymorphism with gastric cancer2005

    • Author(s)
      Goto Y
    • Journal Title

      Cancer Epidemiol Biomarkers Prev 14

      Pages: 2454-2456

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The ACE gene polymorphism is associalted with the incidence of gastric cancer among H.pylori seropositive subjects with atrophic gastritis2005

    • Author(s)
      Goto Y
    • Journal Title

      Asian Pac J Cancer Prev 6

      Pages: 464-467

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan2005

    • Author(s)
      Kuraoka K
    • Journal Title

      Oncol Rep 14(2)

      Pages: 465-470

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Associations of TNF-A-1031TT and -857TT genotypes with Helicobacter pylon seropositivity and gastric atrophy among Japanese Brazilians

    • Author(s)
      Atsuta Y
    • Journal Title

      Int J Clin Oncol (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Helicobacter pylori cagA polymorphism in patients with duodenal ulcer and gastric cancer in young Japanese : Detection form paraffin-embedded materials

    • Author(s)
      Ueda H
    • Journal Title

      Digestion (in press)

    • Related Report
      2005 Annual Research Report
  • [Presentation] Genetic traits for H. pylori persistent infection, atrophic gastritis, and gastric carcinogenesis2010

    • Author(s)
      Hamajima N.
    • Organizer
      8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association. Cancer Genomics, Epigenetics, and the Development of Novel Therapeutics
    • Place of Presentation
      Hawaii
    • Year and Date
      2010-02-07
    • Related Report
      2009 Final Research Report
  • [Presentation] Genetic traits for H.pylori persistent infection, atrophic gastritis, and gastric carcinogenesis2010

    • Author(s)
      Hamajima N
    • Organizer
      8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association. Cancer Genomics, Epigenetics, and the Development of Novel Therapeutics
    • Place of Presentation
      Hilton Waikoloa Village (Waikoloa, Hawaii
    • Year and Date
      2010-02-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Alternative grouping method of CYP2D6 genotypes for clinical use2010

    • Author(s)
      Kawai S, et al.
    • Organizer
      The Joint Scientific Meeting of the International Epidemiological Association Western Pacific Region and the Japan Epidemiological Association
    • Place of Presentation
      埼玉県立大学(越谷)
    • Year and Date
      2010-01-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Serum CA125 levels among Japanese Brazilians2010

    • Author(s)
      Hamajima N, et al.
    • Organizer
      The Joint Scientific Meeting of the International Epidemiological Association Western Pacific Region and the Japan Epidemiological Association
    • Place of Presentation
      埼玉県立大学(越谷)
    • Year and Date
      2010-01-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Associations of leisure time physical activities with the prostate-specific antigen concentration I Japanese men2010

    • Author(s)
      Naito M, et al.
    • Organizer
      The Joint Scientific Meeting of the International Epidemiological Association Western Pacific Region and the Japan Epidemiological Association
    • Place of Presentation
      埼玉県立大学(越谷)
    • Year and Date
      2010-01-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Association of MDR1 polymorphism with Helicobacter pylori seropositivity, gastric atrophy, and gastric cancer in Japanese2010

    • Author(s)
      Tomita K, et al.
    • Organizer
      The Joint Scientific Meeting of the International Epidemiological Association Western Pacific Region and the Japan Epidemiological Association
    • Place of Presentation
      埼玉県立大学(越谷)
    • Year and Date
      2010-01-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Smoking behavior and risk of Helicobacter pylori infection, gastric atrophy and gastric cancer in Japanese2010

    • Author(s)
      Hishida A, et al.
    • Organizer
      The Joint Scientific Meeting of the International Epidemiological Association Western Pacific Region and the Japan Epidemiological Association
    • Place of Presentation
      埼玉県立大学(越谷)
    • Year and Date
      2010-01-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Angiotensin-converting enzyme (ACE) insertion/deletion polymorphism and blood levels of angiotensin II and ACE activity2010

    • Author(s)
      Wakai K, et al.
    • Organizer
      The Joint Scientific Meeting of the International Epidemiological Association Western Pacific Region and the Japan Epidemiological Association
    • Place of Presentation
      埼玉県立大学(越谷)
    • Year and Date
      2010-01-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Frequency of the SLC22A12 W258X polymorphism among those with low serum uric acid2010

    • Author(s)
      Kuriki S, et al.
    • Organizer
      The Joint Scientific Meeting of the International Epidemiological Association Western Pacific Region and the Japan Epidemiological Association
    • Place of Presentation
      埼玉県立大学(越谷)
    • Year and Date
      2010-01-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] γGTPと炎症関連生体指標遺伝子多型との関連2009

    • Author(s)
      浜島信之, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 健康な日本人成人における血清γGTP値と喫煙および肥満との関連2009

    • Author(s)
      川合紗世, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 日本人男性における内皮型一酸化窒素合成酵素遺伝子多型(ecNOS)と高尿酸血症との関連について2009

    • Author(s)
      森田えみ, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] FGFR2遺伝子多型と脂肪代謝の関連2009

    • Author(s)
      冨田耕太郎, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 日本人におけるRUNX3遺伝子多型とピロリ菌感染、胃粘膜萎縮、胃がん発生リスク2009

    • Author(s)
      菱田朝陽, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 北海道八雲町における健康診断受診者のSLC22A12 W258Xと血清尿酸値2009

    • Author(s)
      栗木砂家加, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 癌特異的不死化関連遺伝子GTSE1: 膵癌の新たな分子標的候補2009

    • Author(s)
      江口英孝, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 日本人男性における糖尿病およびBMIと前立腺特異抗原との関連2009

    • Author(s)
      内藤真理子, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 名古屋市住民におけるIL-8 T-251A遺伝子多型と抗p53抗体との関連2009

    • Author(s)
      岡田理恵子, 他
    • Organizer
      がん予防大会2009愛知
    • Place of Presentation
      愛知県がんセンター(名古屋)
    • Year and Date
      2009-06-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] ゲノム多型性はバイオマーカーとなりうるか?2009

    • Author(s)
      浜島信之
    • Organizer
      第7回日本臨床腫瘍学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-20
    • Related Report
      2009 Final Research Report
  • [Presentation] 日本人におけるTLR4+3725G/C遺伝子多型と胃がん・胃粘膜萎縮発生リスク2009

    • Author(s)
      菱田朝陽, 他
    • Organizer
      第19回日本疫学会学術総会
    • Place of Presentation
      金沢
    • Related Report
      2008 Annual Research Report
  • [Presentation] Lewis, seoretor遺伝子多型を考慮したウズベク人における喫煙と飲酒が血清CA19-9値に及ぼす影響2009

    • Author(s)
      川合紗世, 他
    • Organizer
      第19回日本疫学会学術総会
    • Place of Presentation
      金沢
    • Related Report
      2008 Annual Research Report
  • [Presentation] F6FR2遺伝子多型と胃がん発生リスク2009

    • Author(s)
      冨田耕太郎, 他
    • Organizer
      第19回日本疫学会学術総会
    • Place of Presentation
      金沢
    • Related Report
      2008 Annual Research Report
  • [Presentation] 日本人Helicobacter pylori感染者における胃粘膜委縮の発生とODC G317A遺伝子多型ならびに血漿TNFαレベルとの関連2008

    • Author(s)
      江口英孝, 他
    • Organizer
      第6回RCGMフロンティア国際シンポジウム
    • Place of Presentation
      埼玉
    • Year and Date
      2008-10-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] CYPC19遺伝子を用いたピロリ菌除菌自由診療 : 第4報除菌率2008

    • Author(s)
      浜島信之, 他
    • Organizer
      第54回東海公衆衛生学会学術大会
    • Place of Presentation
      静岡
    • Year and Date
      2008-07-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 日本人におけるPTPN11イントロン3G/A遺伝子多型と胃粘膜萎縮発症リスクに関する検討2008

    • Author(s)
      菱田朝陽, 他
    • Organizer
      がん予防大会2008福岡
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] PTPN11 intron 3G/A遺伝子多型(rs2301756)アレル頻度の民族間差2008

    • Author(s)
      川合紗世, 他
    • Organizer
      がん予防大会2008福岡
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] Alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 polymorphisms in Uzbekistan2008

    • Author(s)
      Naito M, et.al.
    • Organizer
      がん予防大会2008福岡
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] PTPN11多型と胃粘膜萎縮 : レビュー2008

    • Author(s)
      浜島信之, 他
    • Organizer
      第14回日本ヘリコバクター学会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] H-pylori seropositivity and IL-6 C-634G genotype among Japanese Brazilians2008

    • Author(s)
      Hamajima N, et.al.
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] AICDA 7888 C/T polymorphism and risk of gastric cancer and gastric atrophy in Japanese2008

    • Author(s)
      Hishida A, et.al.
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] The IL-6 C-634G genotype and H. pylori seropositivity among Japanese health checkup examinees2008

    • Author(s)
      Naito M, et.al.
    • Organizer
      The IL-6 C-634 G genotype and H. pylori seropositivity among Japanese health checkup examinees
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] IL-8 T-251A polymorphism was associated with serum anti-p53 antibody in Uzbekistan population2008

    • Author(s)
      Okada R, et.al.
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] 膵癌細胞株における不死化関連遺伝子の役割2008

    • Author(s)
      Eguchi H, et.al.
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] ODC G317A遺伝子多型と血漿TNF-αレベルはHelicobacter pylori感染者における胃粘膜萎縮の発生と関連する2008

    • Author(s)
      江口英孝, 他
    • Organizer
      第18回日本疫学会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] PTPN11 genotypeとHelicobacter pylori感染および胃粘膜萎縮との関連2008

    • Author(s)
      西尾和子, 他
    • Organizer
      第18回日本疫学会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] ELISA法を用いたIL-1B C-31T,IL-1RN VNTR遺伝子多型と血中IL-1β、IL-6レベルとの関連についての検討2008

    • Author(s)
      菱田朝陽, 他
    • Organizer
      第18回日本疫学会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] Genetic traits for H. pylori persistent infection, atrophic gastritis, and gastric carcinogenesis2007

    • Author(s)
      Hamajima N.
    • Organizer
      7th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association. In the Forefront of Basic and Translational Cancer Research
    • Place of Presentation
      Hawaii
    • Year and Date
      2007-01-22
    • Related Report
      2009 Final Research Report
  • [Presentation] Goto Y. PTPN11 genotype: a genetic trait of H. pylori related gastric cancer at the step of atrophy development2007

    • Author(s)
      Hamajima N, Goto Y.
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Inducible nitric oxide synthase (iNOS)遺伝子多型の分化型胃癌のリスクとの関連2007

    • Author(s)
      後藤康幸, 他
    • Organizer
      第13回日本ヘリコバクター学会
    • Place of Presentation
      大津
    • Related Report
      2007 Annual Research Report
  • [Presentation] The associations between H. pylori infection and plasma IL-8 and MCP-1 levels2007

    • Author(s)
      Naito M, et. al.
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Helicobacter pylori infection and serum C reactive protein (CRP)2007

    • Author(s)
      Ishida Y, et. al.
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] PTPN11 genotype: a genetic trait of H. pylori related gastric cancer at the step of atrophy development2007

    • Author(s)
      Hamajima N, et. al.
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Smoking and Serum CA19-9 levels according to Lewis and Secretor genotypes2007

    • Author(s)
      Kawai S, et. al.
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Genetic traits for gastric strophy among Helicobacter pylori infected individuals2006

    • Author(s)
      Hamajima N.
    • Organizer
      The 5rd Sino-Japan Joint Conference for Cancer Research
    • Place of Presentation
      Shanghai
    • Related Report
      2009 Final Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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