| Project/Area Number |
17015023
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
TOGUCHIDA Junya Kyoto University, 再生医科学研究所, 教授 (40273502)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Takashi 京都大学, 医学研究科, 教授 (10201675)
NAKAYAMA Tomitaka 京都大学, 医学研究科, 講師 (80335273)
MATSUMINE Akihiko 三重大学, 医学部附属病院, 講師 (00335118)
KUSUZAKI Katsuyuki 三重大学, 医学部附属病院, 准教授 (30177993)
MURATA Hiroaki 京都府立医科大学, 医学研究科, 助手 (90360031)
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| Project Period (FY) |
2005 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥73,600,000 (Direct Cost: ¥73,600,000)
Fiscal Year 2009: ¥13,800,000 (Direct Cost: ¥13,800,000)
Fiscal Year 2008: ¥13,800,000 (Direct Cost: ¥13,800,000)
Fiscal Year 2007: ¥15,400,000 (Direct Cost: ¥15,400,000)
Fiscal Year 2006: ¥15,400,000 (Direct Cost: ¥15,400,000)
Fiscal Year 2005: ¥15,200,000 (Direct Cost: ¥15,200,000)
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| Keywords | 肉腫 / 遺伝子発現 / 遺伝子診断 / 予後診断 / 分子標的治療 |
|---|
| Research Abstract |
Spindle cell sarcoma is a subtype of bone and soft tissue sarcomas, for which definite diagnoses are difficult in some cases, and no effective drugs are available. We have performed genome-wide expression profiling of spindle cell sarcomas, and found that spindle cell sarcomas were classified based on gene expression profiles, which was different from pathological classification. We also found that anti-FZD10 antibody, inhibitor of FGF receptors, and retinoic acid are candidates for molecular target therapy for synovial sarcoma. Finally, we found a novel molecule, of which the expression was closely associated with prognosis of spindle cell sarcomas irrespective with pathological diagnoses.
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