Development of individualized diagnosis for cancer of digestive organ
Project/Area Number |
17015042
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Keio University |
Principal Investigator |
SAKAMOTO Michiie Keio University, 医学部, 教授 (40221270)
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Project Period (FY) |
2005 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥66,700,000 (Direct Cost: ¥66,700,000)
Fiscal Year 2009: ¥13,300,000 (Direct Cost: ¥13,300,000)
Fiscal Year 2008: ¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2007: ¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2006: ¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2005: ¥13,200,000 (Direct Cost: ¥13,200,000)
|
Keywords | 多段階発がん / 早期肝細胞がん / 浸潤性膵管がん / 神経浸潤 / 移植モデル / 遺伝子発現プロファイル / プロテオーム / 浸潤 / synuclein-Y / Schwann細胞 / 予後因子 / 悪性度 / CD74 |
Research Abstract |
We found that cyclase-associated protein 2 (CAP2) is up-regulated in early HCC and is further up-regulated in progressed HCC. Another homologue CAP1 was overexpressed in pancreatic cancer and was involved in cancer cell motility and poor prognosis. We established a novel perineural invasion model and distinguished high- and low- perineural invasion group in pancreatic cancer. Gene expression analysis revealed CD74 as a possible molecule involved in perineural invasion. Proteomic analysis revealed synuclein-γ is closely involved in perineural invasion and distant metastasis and is a prognostic factor in pancreatic cancer.
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Report
(6 results)
Research Products
(47 results)
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[Journal Article] Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility.2009
Author(s)
Yamazaki K, Takamura M, Masugi Y, Mori T, Du W, Hibi T, Hiraoka N, Ohta T, Ohki M, Hirohashi S, Sakamoto M
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Journal Title
Lab Invest 89(4)
Pages: 425-432
Related Report
Peer Reviewed
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[Journal Article] Synuclein-gamma is closely involved in perineural invasion and distant metastasis in mouse models and is a novel prognostic factor in pancreatic cancer.2009
Author(s)
Hibi T, Mori T, Fukuma M, Yamazaki K, Hashiguchi A, Yamada T, Tanabe M, Aiura K, Kawakami T, Ogiwara A, Kosuge T, Kitajima M, Kitagawa Y, Sakamoto M
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Journal Title
Clin Cancer Res 15(8)
Pages: 2864-2871
Related Report
Peer Reviewed
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[Journal Article] Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility.2009
Author(s)
Yamazaki K, Takamura M, Masugi Y, Mori T, Du W, Hibi T, Hiraoka N, Ohta T, Ohki M, Hirohashi S, Sakamoto M.
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Journal Title
Lab Invest. 89(4)
Pages: 425-432
Related Report
Peer Reviewed
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[Journal Article] Intraductal carcinoma component as a favorable prognostic factor in biliary tract carcinoma.2009
Author(s)
Ojima H, Kanai Y, Iwasaki M, Hiraoka N, Shimada K, Sano T, Sakamoto Y, Esaki M, Kosuge T, Sakamoto M, Hirohashi S.
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Journal Title
Cancer Sci. 100(1)
Pages: 62-70
NAID
Related Report
Peer Reviewed
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[Journal Article] Synuclein-gamma is closely involved in perineural invasion and distant metastasis in mouse models and is a novel prognostic factor in pancreatic cancer.2009
Author(s)
Hibi T, Mori T, Fukuma M, Yamazaki K, Hashiguchi A, Yamada T, Tanabe M, Aiura K, Kawakami T, Ogiwara A, Kosuge T, Kitajima M, Kitagawa Y, Sakamoto M.
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Journal Title
Clin Cancer Res 15(8)
Pages: 2864-2871
Related Report
Peer Reviewed
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[Journal Article] Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility2009
Author(s)
Yamazaki K, Takamura M, Masugi Y, Mori T, Du W, Hibi T, Hiraoka N, Ohta T, Ohki M, Hirohashi S, Sakamoto M
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Synuclein-y is closely involved in perineural invasion and distant metastasis in mouse models and is a novel prognostic factor in pancreatic cancer2009
Author(s)
Hibi T, Mori T, Fukuma M, Yamazaki K, Hashiguchi A, Yamada T, Tanabe M, Aiura K, Kawakami T, Ogiwara A, Kosuge T, Kitajima M, Kitagawa Y. Sakamoto M
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Journal Title
Clin Cancer Res (in press)
Related Report
Peer Reviewed
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[Journal Article] Histopathological features and prognostic significance of the micropapillary pattern in lung adenocarcinoma.2008
Author(s)
Kamiya K, Hayashi Y, Douguchi J, Hashiguchi A, Yamada T, Izumi Y, Watanabe M, Kawamura M, Horinouchi H, Shimada N, Kobayashi K, Sakamoto M
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Journal Title
Mod Pathol 21
Pages: 992-1001
Related Report
Peer Reviewed
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[Journal Article] Histopathological features and prognostic significance of the micropapillary pattern in lung adenocarcinoma2008
Author(s)
Kamiya K, Hayashi Y, Douguchi J, Hashiguchi A, Yamada T, Izumi Y, Watanabe M, Kawamura M, Horinouchi H, Shimada N, Kobayashi K, Sakamoto M
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Journal Title
Mod Pathol 21
Pages: 992-1001
Related Report
Peer Reviewed
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[Journal Article] Genome-wide array-based comparative genomic hybridizationanalysis of pancreatic adenocarcinoma: Identification of genti indicators that predict patient outcome.2007
Author(s)
Loukopoulos P, Shibata T, Katoh H, Kokubu A, Saka moto M, Yamazaki K, Kosuge T, Kanai Y, Hosoda F, Imoto I, Ohki M, Inazawa J, Hirohashi S
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Journal Title
Cancer Sci 98
Pages: 392-400
Related Report
Peer Reviewed
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[Journal Article] Establishment of Perineural Invasion Models and Analysis of Gene Expression Revealed an Invariant Chain (CD74) as a Possible Molecule involved in Perineural Invasion in Pancreatic Cancer.2006
Author(s)
Koide N, Yamada T, Shibata R, Mori T, Fukuma M, Yamazaki K, Aiura K, Shimazu M, Hirohashi S, Nimura Y, Sakamoto M
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Journal Title
Clin Cancer Res 12(8)
Pages: 2419-2426
Related Report
Peer Reviewed
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[Journal Article] Establishment of Perineural Invasion Models and Analysis of Gene Expression Revealed an Invariant Chain (CD74) as a Possible Molecule involved in Perineural Invasion in Pancreatic Cancer2006
Author(s)
Koide N, Yamada T, Shibata R, Mori T, Fukuma M, Yamazaki K, Aiura K, Shimazu M, Hirohashi S, Nimura Y, Sakamoto M
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Journal Title
Clin Cancer Res 12(8)
Pages: 2419-2426
Related Report
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[Journal Article] Proposal of histological criteria for intraepithelial atypical/ proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma : Preliminary report based on interobserver agreement.2005
Author(s)
Yoh Z, Aishima S, Ajioka Y, Haratake J, Kage M, Kondo F, Nimura Y, Sakamoto M, Sasaki M, Shimamatsu K, Wakasa K, Young N.P, Ming F.C, Atomi Y, Nakanuma Y
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Journal Title
Pathol Int 55
Pages: 180-188
NAID
Related Report
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[Journal Article] Establishment of Perineural Invasion Models and Analysis of Gene Expression Revealed an Invariant Chain (CD74) as a Possible Molecule involved in Perineural Invasion in Pancreatic Cancer
Author(s)
Koide N, Yamada T, Shibata R, Mori T, Fukuma M, Yamazaki K, Aiura K, Shimazu M, Hirohashi S, Nimura Y, Sakamoto M.
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Journal Title
Clin Cancer Res (in press)(印刷中)
Related Report
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