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Long term follow up study and prevention of ATL occurrence among HTLV-1 carriers : a nationwide cohort study

Research Project

Project/Area Number 17015047
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

山口 一成  National Institute of Infectious Diseases, 血液・安全性研究部, 客員研究員 (20128325)

Co-Investigator(Kenkyū-buntansha) 渡辺 俊樹 (渡邉 俊樹)  東京大学, 大学院・新領域科学研究所 (30182934)
緒方 正男  大分大学, 医学部 (10332892)
魚住 公治  鹿児島大学, 大学院・医歯学総合研究科 (90253864)
岩永 正子  活水女子大 (00372772)
内丸 薫  東京大学, 医科学研究所 (60251203)
上平 憲  長崎大学 (80108290)
岡山 昭彦  宮崎大学, 医学部 (70204047)
高 起良  大阪市立大学, 大学院 (10315997)
日野 茂男  鳥取大学, 医学部, 教授 (70012763)
田口 博國  高知大学, 医学部, 教授 (20033350)
菊池 博  大分大学, 医学部附属病院, 講師 (30128425)
米村 雄士  熊本大学, 医学部附属病院, 講師 (60301371)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥91,800,000 (Direct Cost: ¥91,800,000)
Fiscal Year 2009: ¥17,800,000 (Direct Cost: ¥17,800,000)
Fiscal Year 2008: ¥18,000,000 (Direct Cost: ¥18,000,000)
Fiscal Year 2007: ¥18,000,000 (Direct Cost: ¥18,000,000)
Fiscal Year 2006: ¥18,000,000 (Direct Cost: ¥18,000,000)
Fiscal Year 2005: ¥20,000,000 (Direct Cost: ¥20,000,000)
KeywordsHTLV-1 / ATL / JSPFAD / キャリア / 長期追跡 / ATL高危険群 / コホート研究 / ATL発症高危険群 / HTLV-1関連疾患 / HTLV-1キャリア / Nutlin / HTLV-1と疾患 / HTLV-I / HTLV-Iキャリア / 造血細胞移植
Research Abstract

There are still 1.0 million HTLV-1 carriers in Japan. Definitive risk factors for ATL development from carrier status remain unclear. To investigate viral- and host-specific determinants of the development of ATL among HTLV-1 carriers. A nationwide cohort study for HTLV-1 carriers named the Joint Study on Predisposing Factors of ATL Development (JSPFAD) comprising of 41 institutions. Participants were HTLV-1 carriers who provided written informed consent. HTLV-1 proviral load (VL) and sIL-2R were measured annually. Demographic characteristics and clinical data were also collected annually. We evaluated 1218 HTLV-1 carriers (426 males and 792 females) who were enrolled during 2002-2008. VL at enrollment was significantly higher in males than females (median, 2.10 vs 1.39 copies/100PBMC), in those aged 40-49 and 50-59 yrs than that of those aged &lt ; 40 yrs (P=0.02 and 0.007, respectively), and in those with a family history of ATL than those without the history (median, 2.32 vs 1.33 copies/100PBMC) (P=0.005). During follow-up as of September 2009, 14 participants progressed to overt ATL. Their baseline VL was high (range, 4. 17-28.58 copies/100PBMC). None developed ATL among those with a baseline VL lower than &lt ; 4 copies/100PBMC. Multivariate Cox analyses indicated that not only a higher VL but also advanced age, family history of ATL, and first opportunity for HTLV-1 testing during treatment for other diseases were independent risk factors for progression of ATL from carrier status

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report

Research Products

(64 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (59 results) (of which Peer Reviewed: 16 results) Book (2 results) Remarks (3 results)

  • [Journal Article] CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells.2010

    • Author(s)
      Masuda M, Ohta T, Maruyama T, Ito A, Hayashi T, Tsukasaki K, Kamihira S, Yamaoka S, Hoshino H, Yoshida T, Watanabe T, Stanbridge E-J, Murakami Y.
    • Journal Title

      J Biol Chem 285

      Pages: 15511-15522

    • Related Report
      2009 Final Research Report
  • [Journal Article] Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan.2010

    • Author(s)
      Iwanaga M, Watanabe T, Utsunomiya A, Okayama A, Uchimaru K, Koh Ki-R, Ogata M, Kikuchi H, Sagara Y, Uozumi K, Mochizuki M, Tsukasaki K, Saburi Y, Yamamura M, Tanaka J, Moriuchi Y, Hino S, Kamihira S, Yamaguchi K.
    • Journal Title

      Blood (prepublished online)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma.2010

    • Author(s)
      Yamamoto K, Utsunomiya A, Tsukasaki K, Uike N, Uozumi K, Yamaguchi K, Hanada S, Tamura K, Nakamura S, Inagaki H, Ohshima K, Kiyoi H, Ishida T, Matsushima K, Akinaga S, Ogura M, Tomonaga M, Ueda R.
    • Journal Title

      J Clin Oncol 28:9

      Pages: 1591-1598

    • Related Report
      2009 Final Research Report
  • [Journal Article] High human T cell leukemia virus type-1(HTLV-1) provirus load in patients with HTLV-1 carriers complicated with HTLV-1-unrelated disorders.2010

    • Author(s)
      Sasaki D, Doi Y, Hasegawa H, Yanagihara K, Tsukasaki K, Iwanaga M, Yamada Y, Watanabe T, Kamihira S.
    • Journal Title

      Virol J 7:81

    • Related Report
      2009 Final Research Report
  • [Journal Article] Long-term study of indolent adult T-cell leukemia-lymphoma.2010

    • Author(s)
      Takasaki Y, Iwanaga M, Imaizumi Y, Tawara M, Joh T, Kohno T, Yamada Y, Kamihira S, Ikeda S, Miyazaki Y, Tomonaga M, Tsukasaki K.
    • Journal Title

      Blood 115(22)

      Pages: 4337-43

    • Related Report
      2009 Final Research Report
  • [Journal Article] Trends in HTLV-1 prevalence and incidence of adult T-cell leukemia/lymphoma in Nagasaki, Japan.2010

    • Author(s)
      Koga Y, Iwanaga M, Soda M, Inokuchi N, Sasaki D, Hasegawa H, Yanagihara K, Yamaguchi K, Kamihira S, Yamada Y.
    • Journal Title

      J Med Virol 82(4)

      Pages: 668-74

    • Related Report
      2009 Final Research Report
  • [Journal Article] Defective human T-lymphotropic virus type 1 provirus in asymptomatic carriers.2010

    • Author(s)
      Takenouchi H, Umeki K, Sasaki D, Yamamoto I, Nomura H, Takajo I, Ueno S, Umekita K, Kamihira S, Morishita K, Okayama A.
    • Journal Title

      Int J Cance

    • Related Report
      2009 Final Research Report
  • [Journal Article] Downregulation of CDKN1A in adult T-cell leukemia/lymphoma despite overexpression of CDKN1A in human T-lymphotropic virus type 1-infected cell lines.2010

    • Author(s)
      Watanabe M, Nakahata S, Hamasaki M, Saito Y, Kawano Y, Hidaka T, Yamashita K, Umeki K, Taki T, Taniwaki M, Okayama A, Morishita K.
    • Journal Title

      J Virol 84(14)

      Pages: 6966-77

    • Related Report
      2009 Final Research Report
  • [Journal Article] Multiple integrations of human T-lymphotropic virus type 1 proviruses in the engrafted cells from the asymptomatic carriers in NOD/SCID/gammacnull mice.2010

    • Author(s)
      Yamamoto I, Takajo I, Umeki K, Morishita K, Hatakeyama K, Kataoka H, Nomura H, Okayama A.
    • Journal Title

      Intervirology 53(4)

      Pages: 229-39

    • Related Report
      2009 Final Research Report
  • [Journal Article] Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma.2010

    • Author(s)
      Yamamoto K, Utsunomiya A, T sukasaki K, Uike N, Uozumi K, Yamaguchi K, Hanada S, Tamura K, Nakamura S, Inagaki H, Ohshima K, Kiyoi H, Ishida T, Matsushima K, Akinaga S, Ogura M, Tomonaga M, Ueda R.
    • Journal Title

      Journal of Clinical Oncology 28

      Pages: 1591-1598

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers : a nationwide prospective study in Japan.2010

    • Author(s)
      Iwanaga M, Watanabe T, Utsunomiya A, Okayama A, Uchimaru K, Koh KR, Ogata M, Kikuchi H, Sagara Y, Uozumi K, Mochizuki M, Tsukasaki K, Saburi Y, Yamamura M, Tanaka J, Moriuchi Y, Hino S, Kamihira S, Yamaguchi K
    • Journal Title

      Blood 23

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trends in HTLV-1 prevalence and incidence of adult T-cell leukemia/lymphoma in Nagasaki, Japan.2010

    • Author(s)
      Koga Y, Iwanaga M, Soda M, Inokuchi N, Sasaki D, Hasegawa H, Yanagihara K, Yamaguchi K, Kamihira S, Yamada Y
    • Journal Title

      Joumal of Medical Virology 82

      Pages: 668-674

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defective human T-lymphotripic virus type 1 provirus in asymptomatic carriers.2010

    • Author(s)
      Takenouchi H, Umeki K, Sasaki D, Yamamoto I, Nomura H, Takajo I, Ueno S, Umekita K, Kamihira S, Morishita K, Okayama A.
    • Journal Title

      International Journal of Cancer

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of CDKN1A in adult T cell leukemia/lymphoma despite overexpression of CDKN1A in HTLV-1-infected cell lines.2010

    • Author(s)
      Watanabe M, Nakahata S, Hamasaki M, Saito Y, Kawano Y, Hidaka T, Yamashita K, Umeki K, Taki T, Taniwaki M, Okayama A, Mori shita K
    • Journal Title

      J Virol

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of cancer stem cells in a Tax-transgenic (Tax-Tg) mouse model of adult T- cell leukemia / lymphoma (ATL).2009

    • Author(s)
      Yamazaki J, Mizukami T, Takizawa K, Kuramitsu M, Momose H, Masumi A, Ami Y, Hasegawa H, Hall WW, Tsujimoto H, Hamaguchi I, Yamaguchi K.
    • Journal Title

      Blood 114(13)

      Pages: 2709-20

    • Related Report
      2009 Final Research Report
  • [Journal Article] Definition, prognostic factors, treatment and response criteria of adult T-cell leukemia-lymphoma: a proposal from an International Consensus Meeting.2009

    • Author(s)
      Tsukasaki K, Hermine O, Bazarbachi A, Ratner L, Ramos JC, Harrington W, O'Mahony D, Janik JE, Bittencourt AL, Taylor GP, Yamaguchi K, Utsunomiya A, Tobinai K, Watanabe T.
    • Journal Title

      J Clin Oncol 27

      Pages: 453-459

    • Related Report
      2009 Final Research Report
  • [Journal Article] Trends in the seroprevalence of HTLV-1 in Japanese blood donors in Nagasaki Prefecture2009

    • Author(s)
      Iwanaga M, Chiyoda S, Kusaba E, Kamihira S.
    • Journal Title

      Int J Hematol 90(2)

      Pages: 186-90

    • Related Report
      2009 Final Research Report
  • [Journal Article] Impaired Tax-specific T-cell responses with insufficient control of HTLV-1 in a subgroup of individuals at asymptomatic and smoldering stages.2009

    • Author(s)
      Shimizu Y, Takamori A, Utsunomiya A, Kurimura M, Yamano Y, Hishizawa M, Hasegawa A, Kondo F, Kurihara K, Harashima N, Watanabe T, Okamura J, Masuda T, Kannagi M.
    • Journal Title

      Cancer Sci 100

      Pages: 481-489

    • NAID

      10025143429

    • Related Report
      2009 Final Research Report
  • [Journal Article] Inhibition of the SDF-1{alpha}-CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice.2009

    • Author(s)
      Kawaguchi A, Orba Y, Kimura T, Iha H, Ogata M, Tsuji T, Ainai A, Sata T, Okamoto T, Hall WW, Sawa H, Hasegawa H.
    • Journal Title

      Blood 114

      Pages: 2961-2968

    • Related Report
      2009 Final Research Report
  • [Journal Article] Population differences in immune marker profiles associated with human T-lymphotropic virus type I infection in Japan and Jamaica.2009

    • Author(s)
      Birmann MB, Breen CE, Stuver S, Cranston B, Martinez-Maza O, Falk IK, Okayama A, Hanchard B, Mueller N, Hisada M.
    • Journal Title

      Int J Cancer 124

      Pages: 614-621

    • Related Report
      2009 Final Research Report
  • [Journal Article] Proviral loads and clonal expansion of HTLV-1 infected cells following vertical transmission: A 10-year follow-up of children in Jamaica.2009

    • Author(s)
      Umeki K, Hisada M, Maloney ME, Hanchard B, Okayama A.
    • Journal Title

      Intervirology 52

      Pages: 115-122

    • Related Report
      2009 Final Research Report
  • [Journal Article] Identification of cancer stem cells in a Tax-transgenic (Tax-Tg) mouse model of adult T- cell leukemia / lymphoma (ATL).2009

    • Author(s)
      Yamazaki J, Mizukami T, Takizawa K, Kuramitsu M, Momose H, Masumi A, Ami Y, Hasegawa H, Hall WW, Tsujimoto H, Hamaguchi I, Yamaguchi K
    • Journal Title

      Blood 114

      Pages: 2709-20

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Definition, prognostic factors, treatment and response criteria of adult T-cell leukemia-lymphoma : A proposal from an international consensus meeting.2009

    • Author(s)
      Tsukasaki K, Hermine O, Bozorbachi A, Ratner L, Ramos J, Harrington W, O'Mahony D, Janik J, Bittencourt A, Taylor G, Yamaguchi K, Utsunomiya A, Tobinai K, Watanabe T
    • Journal Title

      Journal of Clinical Oncology 27

      Pages: 453-459

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients.2009

    • Author(s)
      Kozako T., Yoshimitsu M., Fujiwara H., Masamoto I., Horai S., White Y., Akimoto M., Suzuki S., Matsushita K., Uozumi K., Tei C., Arima N.
    • Journal Title

      Leukemia 23

      Pages: 375-382

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Population differences in immune marker profiles associated with human T-lymphotropic virus type I infection in Japan and Jamaica.2009

    • Author(s)
      Birmann BM, Breen EC, Stuver S, Cranston B, Martinez-Maza O, Falk KI, Okayama A, Hanchard B, Mueller N, Hisada M.
    • Journal Title

      Int J Cancer 124

      Pages: 614-21

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpressed NF-kB inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells.2008

    • Author(s)
      Saitoh Y, Yamamoto N, Dewan MDZ, Sugimoto H, Martinez VJ, Iwasaki Y, Matsu-bara K, Qi X, Saitoh T, Imoto I, Inazawa J, Utsunomiya A, Watanabe T, MasudaT, Yamamoto N, Yamaoka S.
    • Journal Title

      Blood 111

      Pages: 5118-5129

    • Related Report
      2009 Final Research Report
  • [Journal Article] Factors predisposing to HTLV-1 infection in residents of the greater Tokyo area.2008

    • Author(s)
      Uchimaru K, Nakamura Y, Tojo A, Watanabe T, Yamaguchi K.
    • Journal Title

      Int J Hematol 88

      Pages: 565-570

    • NAID

      10023971392

    • Related Report
      2009 Final Research Report
  • [Journal Article] Down-regulation of TCF8 is involved in the leukemogenesis of adult T-cell leukemia/lymphoma.2008

    • Author(s)
      Hidaka T, Nakahara S, Hatakeyama K, Hamasaki M, Yamashita K, Kohno T, Arai Y, Taki T, Nishida K, Okayama A, Asada Y, Yamaguchi R, Tsubouchi H, Yokota J, Taniwaki M, Higashi Y, Morishita K.
    • Journal Title

      Blood 112

      Pages: 383-393

    • Related Report
      2009 Final Research Report
  • [Journal Article] Activation of complement system in adult T-cell leukemia (ATL) occurs mainly through lectin pathway: A serum proteomic approach using mass spectrometry.2008

    • Author(s)
      Ishida Y, Yamashita K, Sasaki H, Takajou I, Kubuki Y, Morishita K, Tsubouchi H, Okayama A.
    • Journal Title

      Cancer Lett 271

      Pages: 167-177

    • Related Report
      2009 Final Research Report
  • [Journal Article] Foxp3 expression on normal and leukemic CD4+CD25+ T cells implicated in human T-cell leukemia virus type-1 is inconsistent with Treg cells.2008

    • Author(s)
      Abe M, Uchihashi K, Kazuto T, Osaka A, Yanagihara K, Tsukasaki K, Hasegawa H, Yamada Y, Kamihira S.
    • Journal Title

      Eur J Haematol 81(3)

      Pages: 209-17

    • NAID

      120006982421

    • Related Report
      2009 Final Research Report
  • [Journal Article] Characteristic expression of HTLV-1 basic zipper factor (HBZ) transcripts in HTLV-1 provirus-positive cells.2008

    • Author(s)
      Usui T, Yanagihara K, Tsukasaki K, Murata K, Hasegawa H, Yamada Y, Kamihira S.
    • Journal Title

      Retrovirology 22;5:34

    • NAID

      120006981409

    • Related Report
      2009 Final Research Report
  • [Journal Article] Factors predisposing to HTLV-1 infection in residents of the greater Tokyo area2008

    • Author(s)
      Uchimaru K, Nakamura Y, Tojo A, Watanabe T, Yamaguchi K.
    • Journal Title

      Int J Hematol 88

      Pages: 565-570

    • NAID

      10023971392

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of complement system in adult T-cell leukemia (ATL) occurs mainly through lectin pathway : a serum proteomic approach usingmass spectrometry.2008

    • Author(s)
      Ishida Y, Yamashita K, Sasaki H, Takajou I, Kubuki Y, Morishita K, Tsubouchi H, Okayama A.
    • Journal Title

      Cancer Lett. 271

      Pages: 167-77

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Smouldering adult T-cell leukaemia/lymphoma : a follow-up study in Kyushu.2008

    • Author(s)
      Ishitsuka K., Ikeda S., Utsunomiya A., Saburi Y., Uozumi K., Tsukasaki K., Etou K., Muta K., Ohno Y., Kinoshita K., Tamura K.
    • Journal Title

      Br J Haematol. 143

      Pages: 442-444

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Population differences in immune marker profiles associated with human T-lymphotropic virus type I infection in Japan and Jamaica.2008

    • Author(s)
      Birmann BM, Breen EC, Stuver S, Cranston B, Martinez-Maza O, Falk KI, Okayama A. Hanchard B, Mueller N, Hisada M
    • Journal Title

      Int J Cancer. 124

      Pages: 614-21

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of TCF8 is involved in the leukemogenesis of adult T-cell leukemia/lymphoma.2008

    • Author(s)
      Hidaka T, Nakahata S, Hatakeyama K, Hamasaki M, Yamashita K, Kohno T, Arai Y, Taki T, Nishida K, Okayama A. Asada Y, Yamaguchi R, Tsubouchi H, Yokota J, Taniwaki M, Higashi Y, Morishita K.
    • Journal Title

      Blood 112

      Pages: 383-93

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adhesion-dependent growth of primary adult T cell leukemia cells with down-regulation of HTLV-I p40Tax protein : a novel in vitro model of the growth of acute ATL cells.2008

    • Author(s)
      Nagai K, Jinnai I, Hata T, Usui T, Sasaki D, Tsukasaki K, Sugahara K, Hishikawa Y, Yamada Y, Tanaka Y, Koji T, Mano H, Kamihira S. Tomonaga M
    • Journal Title

      Int J Hematol. 88(5)

      Pages: 551-64

    • NAID

      10023971331

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autocrine and/or paracrine growth of aggressive ATLL cells caused by HGF and c-Met.2008

    • Author(s)
      Onimaru Y, Tsukasaki K, Murata K, Imaizumi Y, Choi YL, Hasegawa H, Sugahara K, Yamada Y, Hayashi T, Nakashima M, Taguchi T, Mano H, Kamihira S. Tomonaga M
    • Journal Title

      Int J Oncol. 33(4)

      Pages: 697-703

    • NAID

      120006983903

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpressed NF-κB inducing kinase contributes to the tumorigenesis of adult T-cell leukemi a and Hodgkin Reed-Stemberg cells2008

    • Author(s)
      Saitoh Y, Yamamoto N, Dewan MDZ, Sugimoto H, Martinez VJ, Iwasaki Y, Matsubara K, Qi X, Saitoh T, Imoto I, Inazawa J, U tsunomiya A, Watanabe T, Masuda T, Yamamoto N, Yamaoka S.
    • Journal Title

      Blood

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Engraftment of peripheral blood mononuclear cells from human T-lymphotropic virus type 1 carriers in NOD/SCID/gammac(null)(NOD) mice.2007

    • Author(s)
      Takajo I, Umeki K, Morishita K, Yamamoto I, Kubuki Y, Hatakeyama K, Kataoka H, Okayama A.
    • Journal Title

      Int J Cancer 121(10)

      Pages: 2205-11

    • Related Report
      2009 Final Research Report
  • [Journal Article] Dehydroxymethylepoxyquinomicin (DHMEQ) therapy reduces tumor formation in mice inoculated with Tax-deficient adult T-cell leukemia-derived cell lines.2007

    • Author(s)
      Ohsugi T, Kumasaka T, Okada S, Ishida T, Yamaguchi K, Horie R, Watanabe T, Umezawa K.
    • Journal Title

      Cancer Lett 257

      Pages: 206-215

    • Related Report
      2009 Final Research Report
  • [Journal Article] Impact of visceral involvements and blood cell count abnormalities on survival in adult T-cell leukemia/lymphoma (ATLL).2007

    • Author(s)
      Takasaki Y, Iwanaga M, Tsukasaki K, Kusano M, Sugahara K, Yamada Y, Kamihira S, Ikeda S, Tomonaga M.
    • Journal Title

      Leuk Res 31(6)

      Pages: 751-7

    • Related Report
      2009 Final Research Report
  • [Journal Article] VCAP-AMP-VECP versus biweekly CHOP for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study2007

    • Author(s)
      Tsukasaki K, Utsunomiya A, Fukuda H, Fukushima T, Takatsuka Y, Ikede S, Masuda M, Nagashi H, Ueda R, Tamura K, Sano M, Momita S, Yamaguchi K, Kawano F, Hanada S, Tobinai K, Shimoyama M, Hotta T, Tomonaga M, LSG Group
    • Journal Title

      J Clin Oncol 25(34)

      Pages: 5458-64

    • Related Report
      2009 Final Research Report
  • [Journal Article] A novel natural compound,a cycloanthranilylproline derivative (Fuligocandin B),sensitizes leukemia cells to apoptosis induced by tumornecrosis factor related apoptosis-inducing ligand(TRAIL)through 15-deoxy-Delta 12,14 prostaglandin J2 production2007

    • Author(s)
      Hasegawa H, Yamada Y, Komiyama K, Hayashi M, Ishibashi M, Sunazuka T, Izuhara T, Sugahara K, Tsuruda K, Masuda M, Takasu N, Tsukasaki K, Tomonaga M, Kamibira S.
    • Journal Title

      Blood 110

      Pages: 1664-1674

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Impact of visceral involvements and blood cell countabnormalities on survival in adult T-cell leukemia/lymphoma(ATLL)2007

    • Author(s)
      Takasaki Y, Iwanaga M, Tsukasaki K, Kusano M, Sugahara K, Yamada Y, Kamihira S, Ikeda S, Tomonaga M
    • Journal Title

      Leuk Res 31

      Pages: 751-757

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Clinical manifbstations of human T lymphotropicvirus type I-infected patients with systemic lupus erythematosus2007

    • Author(s)
      Akimoto M., Matsushita K., Suruga Y., Aoki N., Ozaki A., Uozumi K., Teic., Arima N
    • Journal Title

      J.Rheumatol 34

      Pages: 1841-1848

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Engraftment of peripheral blood mononuclear cells from human T-lymphotropic virus type 1 carriers in NOD/SC ID/gammac(null)(NOG)mice2007

    • Author(s)
      Takajo I, Kazumi Umeki K, Morishita K, Yamamoto I, Kubuki Y, Hatakeyama K, Kataoka, OkayamaA.:
    • Journal Title

      Int J Cancer 121

      Pages: 2205-2211

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Dehydroxymethylepoxyquinomicin(DHMEQ)therapy reduces tumor fomation inmice inoculated with Tax-deficient aduit T-cell leukemia derived cell lines2007

    • Author(s)
      Ohsugi T, Kumasaka T, Okada S, Ishida T, Yamaguchi K, Horie R, Watanabe T, Umezawa K
    • Journal Title

      Cancer Letters 257

      Pages: 206-215

    • Related Report
      2007 Annual Research Report
  • [Journal Article] A novel alternative splicing isoform of human T-cell leukemia virus type 1 bZIP factor (HBZ-SI) targets distinct subnuclear localization.2006

    • Author(s)
      Murata K, Hayashibara T, Sugahara K, Uemura A, Yamaguchi T, arasawa H, Hasegawa H, Tsuruda K, Okazaki T, Koji T, Miyanishi T, Yamada Y, Kamihira S
    • Journal Title

      J Virol. 80

      Pages: 2495-2505

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Dihydrof lavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells.2006

    • Author(s)
      Hasegawa H, Yamada Y, Komiyama K, Hayashi M, Ishibashi M, Yoshida T, Sakai T, Koyano T, Kam TS, Murata K, Sugahara K, Tsuruda K, Akamatsu N, Tsukasaki K, Masuda M, Takasu N, Kamihira S
    • Journal Title

      Blood. 107

      Pages: 679-688

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Human herpesvirus 6 DNA in plasma after allogeneic stem cell transplantation : Incidence and clinical significance.2006

    • Author(s)
      Ogata M, Kikuchi H, Satou T, Kawano R, Ikewaki J, Kohno K, Kashima K, Ohtsuka E, Kadota J
    • Journal Title

      J.Infect.Dis. 193

      Pages: 68-79

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Adult T-cell leukemia developme nt from a human T-cell leukemia virus type I carrier after a living-donor liver transplantation.2006

    • Author(s)
      Kawano N, Shimoda K, Ishikawa F, Taketomi A, Yoshizumi T, Shimoda S, Yoshida S, Uozumi K, Suzuki S, Maehara Y, Harada M
    • Journal Title

      Transplantation 82

      Pages: 840-843

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Blocking NF-kappaB as a potential strategy to treat adult T-cell leukemia/lymphoma.2006

    • Author(s)
      Horie R, Watanabe T, Umezawa K
    • Journal Title

      Drug News Perspect 19

      Pages: 201-209

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir.2006

    • Author(s)
      Dewan MZ, Uchihara JN, Terashima K, Honda M, Sara T, Ito M, Fujii N, Uozumi K, Tsukasaki K, Tomonaga M, Kubuki Y, Okayama A, Toi M, Mori N, Yamamoto N
    • Journal Title

      Blood 107

      Pages: 716-724

    • Related Report
      2005 Annual Research Report
  • [Journal Article] In vitro and in vivo antitumor activity of the NF-kB inhibitor DHMEQ in the human T-cell leukemia virus type I transformed cell line, HUT-102.2006

    • Author(s)
      Ohsugi T, Kumasaka T, Ishida A, Ishida T, Horie R, Watanabe T, Umezawa K, Yamaguchi K
    • Journal Title

      Leuk Res 30

      Pages: 90-97

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Human herpesvirus 6 DNA in plasma after allogeneic stem cell transplantation : Incidence and clinical significance.2006

    • Author(s)
      Ogata M, Kikuchi H, Satou T, Kawano R, Ikewaki J, Kohno K, Kashima K, Ohtsuka E, Kadota J
    • Journal Title

      J Infect Dis 193

      Pages: 68-79

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-kappaB, as a strategy for chemoprevention and therapy of adult T-cell leukemia.2005

    • Author(s)
      Watanabe M, Ohsugi T, Shoda M, Ishida T, Aizawa S, Maruyama-Nagai M, Utsunomiya A, Koga S, Yamada Y, Kamihira S, Okayama A, Kikuchi H, Uozumi K, Yamaguchi K, Horie R, Higashihara M, Umezawa K, Watanabe T
    • Journal Title

      Blood 106

      Pages: 2462-2471

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The Clonal Expansion of Human T Lymphotropic Virus Type 1-Infected T Cells: A Comparison between Seroconverters and Long-Term Carriers.2005

    • Author(s)
      Tanaka G, Okayama A, Watanabe T, Aizawa S, Stuver S, Mueller N, Hsieh CC, Tsubouchi H
    • Journal Title

      J Infect Dis 191

      Pages: 1140-1147

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Impact of p53 aberration on the progression of Adult T-cell Leukemia/Lymphoma.2005

    • Author(s)
      Tawara M, Hogerzeil SJ, Yamada Y, Soda H, Takasaki Y, Hasegawa H, Murata K, Ikeda S, Imaizumi Y, Sugahara K, Tsuruda K, Tsukasaki K, Tomonaga M, Hirakata Y, Kamihara S
    • Journal Title

      Cancer Lett

    • Related Report
      2005 Annual Research Report
  • [Book] HTLV-1と疾患2007

    • Author(s)
      渡辺俊樹、上平憲、山口一成(編集)
    • Total Pages
      263
    • Publisher
      文光堂
    • Related Report
      2009 Final Research Report
  • [Book] HTLV-1と疾患2007

    • Author(s)
      渡邊 俊樹, 上平 憲, 山口一成
    • Publisher
      文光堂
    • Related Report
      2006 Annual Research Report
  • [Remarks] (JSPFADホームページ)

    • URL

      http://www.htlv1.org/

    • Related Report
      2009 Final Research Report
  • [Remarks] (JSPFADホームページ)

    • URL

      http://www.htlv1.org/

    • Related Report
      2009 Annual Research Report
  • [Remarks] JSPFADホームページ

    • URL

      http://www.htlvl.org/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2005-03-31   Modified: 2018-03-28  

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