| Project/Area Number |
17015049
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
|---|
Principal Investigator |
TSUGANE Shoichiro National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 予防研究部, 部長 (40179982)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IWASAKI Motoki 国立がんセンター(研究所及び東病院臨床開発センター), 予防研究部, 室長 (60392338)
OTANI Tetsuya 国立がんセンター(研究所及び東病院臨床開発センター), 予防研究部, 研究員 (70392339)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HAMADA Gerson Shigueaki Nikkei Disease Prevention Center, Director
|
|---|
| Project Period (FY) |
2005 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥48,200,000 (Direct Cost: ¥48,200,000)
Fiscal Year 2009: ¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 2008: ¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 2007: ¥10,100,000 (Direct Cost: ¥10,100,000)
Fiscal Year 2006: ¥10,100,000 (Direct Cost: ¥10,100,000)
Fiscal Year 2005: ¥10,000,000 (Direct Cost: ¥10,000,000)
|
|---|
| Keywords | ブラジル日系移民 / がん / 乳がん / 大腸腺腫 / 症例対照研究 / 断面研究 / 環境要因 / 遺伝的素因 |
|---|
| Research Abstract |
We have conducted epidemiological studies such as cross-sectional and case-control study among Japanese Brazilians living in Sao Paulo. In case-control studies for breast cancer, we analyzed data from in three populations : Japanese living in Japan, Japanese Brazilians living in Sao Paulo, and non-Japanese Brazilians living in Sao Paulo. We found an inverse association between isoflavone intake and breast cancer risk, and stratified analysis suggested that polymorphisms in the estrogen receptor beta, 17β-HSD1 and SHBG genes may modify the association between isoflavone intake and breast cancer risk. We found no overall association between folate, vitamin B6, and vitamin B12 intake and the risk of breast cancer. In a cross-sectional study of colorectal adenoma among Japanese Brazilians living in Sao Paulo, Brazil, participants have been recruited in two hospitals and we completed a survey from 719 participates at the end of March, 2010.
|
