Molecular mechanisms of lymphomagenesis

• Project/Area Number: 17015050
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: SETO Masao Aichi Cancer Center Research Institute, 遺伝子医療研究部, 副所長兼部長 (80154665)
• Co-Investigator(Kenkyū-buntansha): 都筑 忍 (都築 忍) 愛知県がんセンター(研究所), 遺伝子医療研究部, 室長 (00342965)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥84,700,000 (Direct Cost: ¥84,700,000); Fiscal Year 2009: ¥16,900,000 (Direct Cost: ¥16,900,000); Fiscal Year 2008: ¥17,000,000 (Direct Cost: ¥17,000,000); Fiscal Year 2007: ¥17,000,000 (Direct Cost: ¥17,000,000); Fiscal Year 2006: ¥17,000,000 (Direct Cost: ¥17,000,000); Fiscal Year 2005: ¥16,800,000 (Direct Cost: ¥16,800,000)
• Keywords: マントル細胞リンパ腫 / びまん性大細胞型B細胞リンパ腫 / MALTリンパ腫 / NK / T白血病・リンパ / MALT1 / API2-MALT1 / BIM / TNFAIP3 / アレイCGH / ゲノム異常 / 6q欠失 / AP12-MALT / CD40ligand / B細胞 / 長期培養 / BIM遺伝子 / NOXA / BCL2 / DLBCL / MCL / T白血病・リンパ腫 / CCND3 / BYSL / c-REL / BCL11A

Research Abstract

悪性リンパ腫のうち、MALTリンパ腫、マントル細胞リンパ腫、びまん性大細胞型B細胞リンパ腫、T/NK細胞性リンパ腫の病因と病態に関して、アレイCGHにより、ゲノム異常を解析し、各疾患単位にとく著的なゲノム異常が存在することを明らかにした。ATLLのリンパ腫型とPTCL-Uの一部であるゲノム異常陽性群が臨床病態上、区別できないことを見出したことは、今後の疾患単位を考える上できわめて重要な発見である。

Research Products

• [Journal Article] Cutaneous type adult T-cell leukemia/lymphoma is a characteristic subtype and includes erythema/papule and nodule/tumor subgroups. (2010)
  • Author(s): Miyata, T., Yonekura, K. Seto, M., 他3名, Last Author
  • Journal Title: Int J Cancer 126 Pages: 1521-1528
• [Journal Article] Cutaneous type adult T cell leukemia/lymphoma is a characteristic subtype and includes erythema/papule and nodule/tumor subgroups. (2010)
  • Author(s): Miyata, T
  • Journal Title: Int J Cancer 126 Pages: 1521-1528
  • Peer Reviewed
• [Journal Article] MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta. (2010)
  • Author(s): Tsukamoto, Y
  • Journal Title: Cancer Res. 70 Pages: 2339-2349
  • Peer Reviewed
• [Journal Article] Diversity of genome profiles in malignant lymphoma. (2010)
  • Author(s): Seto, M
  • Journal Title: Cancer Science (in press)
  • NAID: 10026588848
  • Peer Reviewed
• [Journal Article] Genomic profiling of gastric carcinoma in situ and adenomas by array-based comparative genomic hybridization. (2010)
  • Author(s): Uchida, M.
  • Journal Title: Journal of Pathology (in press)
  • Peer Reviewed
• [Journal Article] Favorable consolidative effect of high-dose melphalan and total-body irradiation followed by autologous peripheral blood stem cell (2009)
  • Author(s): Kato, H., Taji, H., Seto, M., 他8名, 9番目
  • Journal Title: Clin Lymphoma Myeloma 9 Pages: 443-118
• [Journal Article] TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas. (2009)
  • Author(s): Honma, K, Tsuzuki, S. Seto, M., 他4名, Last Author
  • Journal Title: Blood 114 Pages: 2467-2475
• [Journal Article] The potential of copy number gains and losses, detected by array-based comparative genomic hybridization, for computational differential diagnosis of B-cell lymphomas and genetic regions involved in lymphomagenesis (2009)
  • Author(s): Takeuchi, I., Tagawa, H. Seto, M., 他4名, Last Author
  • Journal Title: Haematologica 94 Pages: 61-69
• [Journal Article] Array CGH analysis of PTCL-U reveals a distinct subgroup with genetic alterations similar to lymphoma-type ATLL. (2009)
  • Author(s): Nakagawa, M., Nakagawa-Oshiro, A. Seto, M., 他6名, Last Author
  • Journal Title: Clin Cancer Res. 15 Pages: 30-38
• [Journal Article] Array CGH analysis of PTCL-U reveals a distinct subgroup with genetic alterations similar to lymphoma-type ATLL. (2009)
  • Author(s): Nakagawa, M.
  • Journal Title: Clin Cancer Res. 15 Pages: 30-38
  • Peer Reviewed
• [Journal Article] The potential of copy number gains and losses, detected by array-based comparative genomic hybridization, for computational differential diagnosis of B-cell lymphomas and genetic regions involved in lymphomagenesis. (2009)
  • Author(s): Takeuchi, I.
  • Journal Title: Haematologica 94 Pages: 61-69
  • Peer Reviewed
• [Journal Article] Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma. (2009)
  • Author(s): Lee, S-Y.
  • Journal Title: Cancer Science 100 Pages: 920-926
  • Peer Reviewed
• [Journal Article] TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas. (2009)
  • Author(s): Honma, K
  • Journal Title: Blood 114 Pages: 2467-2475
  • Peer Reviewed
• [Journal Article] Array CGH analysis of PTCL-U reveals a distinct subgroup with genetic alterations similar to lymphoma-type ATLL. (2009)
  • Author(s): Nkagawa, M.
  • Journal Title: Clin Cancer Res. 15 Pages: 30-38
  • Peer Reviewed
• [Journal Article] Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma. (2009)
  • Author(s): Lee, S-Y.
  • Journal Title: Cancer Science (in press)
  • Peer Reviewed
• [Journal Article] BCL6 gene amplification/3q27 gain is associated with unique clinicopathological characteristics among follicular lymphoma without BCL2 gene translocation. (2008)
  • Author(s): Karube, K., Ying, G., Seto, M., 他11名, 13番目
  • Journal Title: Mod Pathol. 21 Pages: 973-978
• [Journal Article] Clinical features and prognosis of gastric MALT lymphoma with special reference to responsiveness to H. pylori eradication and API2-MALT1 status. (2008)
  • Author(s): Nakamura, T., Seto, M., Tajika, M., 他4名, 2番目
  • Journal Title: Am J Gastroenterol 103 Pages: 62-70
• [Journal Article] TNFAIP3 is the target gene of chromosome band 6q23. 3-q24. 1 loss in cular. Adnexal marginal zone B cell lymphoma. (2008)
  • Author(s): Honma, K., Tsuzuki, S., Nakagawa, M., Seto, M., 他6名, Last Author
  • Journal Title: Genes Chrom. Cancer 47 Pages: 1-7
• [Journal Article] TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in cular. Adnexal marginal zone B cell lymphoma. (2008)
  • Author(s): Honma, K.
  • Journal Title: Genes Chrom. Cancer 47 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Clinical features and prognosis of gastric MALT lymphoma with special reference to resposiveness to H. pylori eradication T1 status. (2008)
  • Author(s): Nakamura, T.
  • Journal Title: Am J Gastroenterol 103 Pages: 62-70
  • Peer Reviewed
• [Journal Article] BCL6 gene amplification/3q27 gain is associated with unique clinicopathological characteristics among follicular lymphoma without BCL2 gene translocation. (2008)
  • Author(s): Karube, K
  • Journal Title: Mod Pathol 21 Pages: 973-978
  • Peer Reviewed
• [Journal Article] Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer. (2008)
  • Author(s): Tsukamoto, Y.
  • Journal Title: J Pathol., 216 Pages: 471-482
  • Peer Reviewed
• [Journal Article] Genome-wide microRNA expression profiling in renal cell carcinoma: significant downregulation of miR-141 and miR-200c. (2008)
  • Author(s): Nakada, C.
  • Journal Title: J Pathol. 216 Pages: 418-427
  • Peer Reviewed
• [Journal Article] TNFAIP3 is the target gene of chromosome band 6q23.3・q24.1 loss in cnlar.Adnegal marginal zone B cell lymphoma. (2008)
  • Author(s): Honma, K.
  • Journal Title: Genes Chrom.Cancer 47 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Clinical features and prognosis of gastric MALT Iymphoma with specialreference to responsiveness to H, pylori eradication and API2-MALTI status. (2008)
  • Author(s): Nakamura, T.
  • Journal Title: Am J Gastroenterol 103 Pages: 62-70
  • Peer Reviewed
• [Journal Article] Trisomy 3 is a specific genomic aberration of t(14;18) negative follicular lymphoma. (2007)
  • Author(s): Tagawa, H., Karube, K., Seto, M., 他6名, Last Author
  • Journal Title: Leukemia 21 Pages: 2549-2551
• [Journal Article] Synergistic action of the microRNA-17 polycistron and Myc in aggressive cancer development. (2007)
  • Author(s): Tagawa, H., Karube, K., Tsuzuki, S., Ohshima, K., Seto, M.
  • Journal Title: Cancer Sci. 98 Pages: 1482-1490
  • NAID: 10019999091
• [Journal Article] Genome-wide array-based comparative genomic hybridization of ocular marginal zone B cell lymphoma (2007)
  • Author(s): Kim, W-S., Honma, K., Seto, M., 他5名, 7番目
  • Journal Title: Genes Chromosomes and Cancer 46 Pages: 776-783
• [Journal Article] Chromosomal imbalances are associated with outcome of Helicobacter pylori eradication in t(11;18)(q21;q21) negative gastric malt lymphomas. (2007)
  • Author(s): Fukuhara, N., Nakamura, T., Seto, M., 他6名, Last Author
  • Journal Title: Genes Chromosomes and Cancer 46 Pages: 784-790
• [Journal Article] Isoform-Specific Potentiation of Stem and Progenitor Cell Engraftment by AML1/RUNX1. (2007)
  • Author(s): Tsuzuki, S., Hong, D., Gupta, R., Matsuo, K., Seto, M., Enver, T.
  • Journal Title: PLoS Med. 4
• [Journal Article] Genetic abnormalities involved in t(12;21) TEL-AML1 acute lymphoblastic leukemia: Analysis by means of array-based comparative genomic hybridization. (2007)
  • Author(s): Tsuzuki, S., Karnan, S., Seto, M., 他9名, Last Author
  • Journal Title: Cancer Sci. 98 Pages: 698-706
• [Journal Article] CD10(-)MUM1(+) follicular lymphoma lacks BCL2 translocation and shows characteristic biological and clinical features. (2007)
  • Author(s): Karube, K., Guo, Y., Seto, M., 他14名, 16番目
  • Journal Title: Blood 109 Pages: 3076-3079
• [Journal Article] CD10(-)MLTMI(+)follicular lymphoma lacks BCL2 translocation and shows characteristic biological and clinical features. (2007)
  • Author(s): Karube, K.
  • Journal Title: Blood 109 Pages: 3076-3079
  • Peer Reviewed
• [Journal Article] Genetic abnormalities involved in t(12;21)TEL-AM-L1 acute lymphoblastic leukemia:Analysis by means of array-based comparative genomic hybridization. (2007)
  • Author(s): Tsuzuki, S
  • Journal Title: Cancer Sci. 98 Pages: 698-706
  • Peer Reviewed
• [Journal Article] Genomic profiling of malignant pleural mesothehoma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN ampificaation on 1p32.:,2007. (2007)
  • Author(s): Taniguchi, T.
  • Journal Title: Cancer Sci. 98 Pages: 438-446
  • Peer Reviewed
• [Journal Article] Isoform- Specific Potentiation of Stem and Progellitor Cell Engraftment by AMLl1RUNX1. (2007)
  • Author(s): Tsuzuki, S.
  • Journal Title: PLoS Med. 4
  • Peer Reviewed
• [Journal Article] Chromosomal imbalances are associated with outcome of Helicobacter pylori eradication in t(11;18)(g21;g21)negative gastric malt lymphomas. (2007)
  • Author(s): Fukuhara, N
  • Journal Title: Genes Chromosomes and Cancer 46 Pages: 784-790
  • Peer Reviewed
• [Journal Article] Genome-wide array-based comparative genomic hybridization of pcularmarginal zone b cell lymphoma:comparison with pulmonary and nodalmarginal zone b cell lymphoma. (2007)
  • Author(s): Kim, W・S.
  • Journal Title: Genes Chromosomes and Cancer 46 Pages: 776-783
  • Peer Reviewed
• [Journal Article] API2-MALTl chimeric transcript-positive gastroduodenal MALT lymphoma with subsequent development of adenocarcinoma as a collision tumour over a clinical course of 7 years. (2007)
  • Author(s): Isaka, T.
  • Journal Title: Histopathology 51 Pages: 119-123
  • Peer Reviewed
• [Journal Article] Synergistic action of the microRNA-17 polycistron and Myc in aggressive capcer development . (2007)
  • Author(s): Tagawa, H.
  • Journal Title: Cancer Sci. 98 Pages: 1482-1490
  • Peer Reviewed
• [Journal Article] Trisomy 3 is a specific genomic aberration of t(14;18)negativee follicularlymphoma. (2007)
  • Author(s): Tagawa, H.
  • Journal Title: Leukemia 21 Pages: 2549-2551
  • Peer Reviewed
• [Journal Article] Yoshim.oto,T. High-resolution analysis of DNA copy number alterations and gene egpression in renal clear cell carrcinoma.:,2007. (2007)
  • Author(s): Yoshimoto, T.
  • Journal Title: J Pathol. 213 Pages: 392-401
  • Peer Reviewed
• [Journal Article] Expression profiling analysis of the CD5(+) diffuse large B-cell lymphoma subgroup: Development of a CD5 signature. (2006)
  • Author(s): Suguro, M., Tagawa, H., Seto, M., 他6名, Last Author
  • Journal Title: Cancer Sci. 97 Pages: 868-874
  • NAID: 10018767404
• [Journal Article] Characterization of target genes at the 2p15-16 amplicon in diffuse large B-cell lymphoma. (2006)
  • Author(s): Fukuhara, N., Tagawa, H., Seto, M., 他7名, Last Author
  • Journal Title: Cancer Sci. 97 Pages: 499-504
  • NAID: 10018176261
• [Journal Article] Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia (2006)
  • Author(s): Oshiro, A., Tagawa, H., Seto, M., 他9名, Last Author
  • Journal Title: Blood 107 Pages: 4500-4507
• [Journal Article] Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia. (2006)
  • Author(s): Karnan, S., Tsuzuki, S., Seto, M., 他4名, 6番目
  • Journal Title: Genes Chrom. Cancer 45 Pages: 420-425
• [Journal Article] Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia. (2006)
  • Author(s): Karnan, S.
  • Journal Title: Genes Chrom. Cancer 45 Pages: 420-425
• [Journal Article] Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia/lymphoma. (2006)
  • Author(s): Oshiro, A.
  • Journal Title: Blood 107 Pages: 4500-4507
• [Journal Article] Characterization of target genes at 2pl5-16 amplicon in diffuse large B cell lymphoma. (2006)
  • Author(s): Fukuhara, N.
  • Journal Title: Cancer Science 97 Pages: 499-504
• [Journal Article] Expression profiling analysis of the CD5(+) diffuse large B-cell lymphoma subgroup : Development of a CD5 signature. (2006)
  • Author(s): Suguro, M.
  • Journal Title: Cancer Sci. 97 Pages: 868-874
• [Journal Article] Molecular pathogenesis of MALT lymphoma : two signaling pathways underlying the antiapoptotic effect of API2-MALT1 fusion protein. (2006)
  • Author(s): Nakagawa, M.
  • Journal Title: Leukemia 20 Pages: 929-936
• [Journal Article] CD10(-)MUM1(+) follicular lymphoma lacks BCL2 translocation and shows characteristic biological and clinical features. (2006)
  • Author(s): Karube, K.
  • Journal Title: Blood (in press)
• [Journal Article] Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia. (2006)
  • Author(s): Karnan, S.
  • Journal Title: Genes Chrom.Cancer 45 Pages: 420-425
• [Journal Article] Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia/lymphoma. (2006)
  • Author(s): Oshiro, A.
  • Journal Title: Blood in press
• [Journal Article] Characterization of target genes at 2p15-16 amplicon in diffuse large B cell lymphoma. (2006)
  • Author(s): Fukuhara, N.
  • Journal Title: Cancer Science in press
• [Journal Article] Identification of CCND3 and BYSL as Candidate Targets (2005)
  • Author(s): Kasugai, Y., Tagawa, H., Seto, M., 他4名, Last Author
  • Journal Title: Clin. Cancer Res. 11 Pages: 8265-8272
• [Journal Article] MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10. (2005)
  • Author(s): Nakagawa, M., Hosokawa, Y., Seto, M., 他5名, Last Author
  • Journal Title: Blood 106 Pages: 4210-4216
• [Journal Article] A microRNA cluster as a target of genomic amplification in malignant lymphoma. (2005)
  • Author(s): Tagawa, H., Seto, M.
  • Journal Title: Leukemia 19 Pages: 2013-2016
• [Journal Article] Genome-wide array-based comparative genomic hybridization of Natural killer cell lymphoma/leukemia (2005)
  • Author(s): Nakashima, Y., Tagawa, H., Seto, M., 他8名, Last Author
  • Journal Title: Genes Chrom. Cancer 44 Pages: 247-255
• [Journal Article] Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell lymphoma. (2005)
  • Author(s): Tagawa, H., Suguro, M., Seto, M., 他7名, Last Author
  • Journal Title: Blood 106 Pages: 1770-1777
• [Journal Article] Genome-wide array-based CGH for mantle cell lymphoma: Identification of homozygous deletions of the proapoptotic gene (2005)
  • Author(s): Tagawa, H., Karnan, S., Seto, M., 他6名, Last Author
  • Journal Title: BIM. Oncogene 24 Pages: 1348-1358
• [Journal Article] Genome-wide array-based CGH for mantle cell lymphoma : Identification of homozygous deletions of the proapoptotic gene BIM. (2005)
  • Author(s): Tagawa, H.
  • Journal Title: Oncogene 24 Pages: 1348-1358
• [Journal Article] Differential expression of cytokines, chemokines and their receptors in follicular lymphoma and reactive follicular hyperplasia : Assessment by complementary DNA microarray. (2005)
  • Author(s): Fujii, A.
  • Journal Title: Oncol.Rep. 13 Pages: 819-824
• [Journal Article] Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell lymphoma. (2005)
  • Author(s): Tagawa, H.
  • Journal Title: Blood 106 Pages: 1770-1777
• [Journal Article] API2-MALT1 fusion protein induces transcriptional activation of the API2 gene through NF-kappaB binding elements : evidence for a positive feed-back loop pathway resulting in unremitting NF-kappaB activation. (2005)
  • Author(s): Hosokawa, Y.
  • Journal Title: Biochem.Biophys.Res.Commun. 334 Pages: 51-60
• [Journal Article] Genome-wide array-based comparative genomic hybridization of Natural killer cell lymphoma/leukemia : Different genomic alteration patterns of aggressive NK-cell leukemia and extranodal NK/T lymphoma, Nasal type. (2005)
  • Author(s): Nakashima, Y.
  • Journal Title: Genes Chrom.Cancer 44 Pages: 247-255
• [Journal Article] A microRNA cluster as a target of genomic amplification in malignant lymphoma. (2005)
  • Author(s): Tagawa, H.
  • Journal Title: Leukemia(Correspondence) 19 Pages: 2013-2016
• [Journal Article] BMI-1 Is Highly Expressed in MO-Subtype Acute Myeloid Leukemia. (2005)
  • Author(s): Sawa, M.
  • Journal Title: Int.J.Hematol. 82 Pages: 42-47
• [Journal Article] MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10. (2005)
  • Author(s): Nakagawa, M.
  • Journal Title: Blood 106 Pages: 4210-4216
• [Journal Article] Identification of CCND3 and BYSL as Candidate Targets for the 6p21 Amplification in Diffuse Large B-Cell Lymphoma. (2005)
  • Author(s): Kasugai, Y.
  • Journal Title: Clin.Cancer Res. 11 Pages: 8265-8272
• [Journal Article] Clinical impact and predisposing factors of delayed-onset neutropenia after autologous
  • Author(s): Kato, H., Yamamoto, K., Seto, M., 他6名, 7番目
  • Journal Title: Ann Oncol. (in press)
• [Presentation] アレイCGHにより明らかになった急性型ATLの多クローン性. (2009)
  • Author(s): 海野啓
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-10-03
• [Presentation] 急性型成人T細胞性白血病/リンパ腫症例はリンパ腫型に特徴的な遺伝子発現プロファイルを用いると複数のグループに分類できる. (2009)
  • Author(s): 中川雅夫
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-10-02
• [Presentation] NK/T細胞性腫瘍の遺伝子発現プロファイル.()[ポスター(示説)] (2009)
  • Author(s): 加留部謙之輔
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-10-02
• [Presentation] 悪性リンパ腫におけるTNFAIP3/A20. (2009)
  • Author(s): 本間圭一郎
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-10-02
• [Presentation] 急性リンパ性白血病の前白血病期におけるTEL-AML1の役割. (2009)
  • Author(s): 都築忍
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-10-01
• [Presentation] Cytotoxic molecule (CM)-positive classical Hodgkin lymphoma (2009)
  • Author(s): Asano, N., Tamaru, J., Seto, M., 他7名, 9番目
  • Organizer: 第51回米国血液学会総会
  • Place of Presentation: 米国
• [Presentation] Distinct genome profiles of acute and lymphoma type ATLL (2009)
  • Author(s): Nakagawa, M, Umino, A., Seto, M., 他5名, Last Author
  • Organizer: 14th International Conference on Human Retrovirology
  • Place of Presentation: ブラジル
• [Presentation] Distinct genome profiles of acute and lymphoma type ATLL : an indication for two subtypes in acute type ATLL. (2009)
  • Author(s): Masao Nakagawa
  • Organizer: 14th International Conference on Human Retrovirology
  • Place of Presentation: ブラジルサルバトール
• [Presentation] :悪性リンパ腫発症の分子機構.(シンポジウム) (2008)
  • Author(s): 瀬戸加大
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-30
• [Presentation] 急性型成人T細胞性自血病/リンパ腫症例の一部はリンパ腫型と同一のゲノム異常領域を持つ.(ワークショップ) (2008)
  • Author(s): 中川雅夫
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] 胃癌にむけるmiRNAの網羅的発現解析.(ポスター) (2008)
  • Author(s): 中田知里
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] NK/T細胞性腫瘍の遺伝子発現プロファイル.(ワークショップ) (2008)
  • Author(s): 加留部謙之輔
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] TEL-AML1自血病におけるTEL欠失の作用.(ポスター) (2008)
  • Author(s): 都築忍
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] リンパ腫発生進展におけるA20の機能解析.(ポスター) (2008)
  • Author(s): 本間圭一郎
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] 胃癌におけるゲノムコピー数異常と遺伝子発現異常の統合解析.(ポスター) (2008)
  • Author(s): 塚本善之
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] A Part of Acute-type ATLL Cases Has Genomic Imbalance in Common With Lymphoma-type ATLL.(ポスター(示説)) (2008)
  • Author(s): Nakagawa, M.
  • Organizer: 第50回米国血液学会総会
  • Place of Presentation: 米国サンフランシスコ
• [Presentation] Ocular adnexal marginal zone B cell lymphoma has characteristic deletion of TNFAIP3,suppressor of NF-□B.(B6) (2008)
  • Author(s): Honma, K.
  • Organizer: Keystone Symposia NF-kappaB
  • Place of Presentation: (米国)[ポスター(示説)]
• [Presentation] 胃MALTリンパ腫のH.pylori除菌反応とゲノム異常. (2007)
  • Author(s): 福原 規子
  • Organizer: 第47回日本網内系学会総会
  • Place of Presentation: (淡路)[ポスター]
• [Presentation] 胃MALTリンパ腫の病態とゲノム異常. (2007)
  • Author(s): 中村 常哉
  • Organizer: 第13回日本ヘリコバクター学会総会
  • Place of Presentation: (滋賀)[シンポジゥム]
• [Presentation] Functional analysis of the t(12; 21) -associated TEL-AML1 fusion gene. (2007)
  • Author(s): Tsuzula, S
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: (横浜)[ポスター(示説)]
• [Presentation] Comparison of PTCL-U and lymphoma-type ATLL in terms of genomicmbalance by using array CGH analysis. (2007)
  • Author(s): 中川 雅夫
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: (横浜)[口演]
• [Presentation] Analysis of advanced gastric carcinoma with array・based co皿parative genomic hybridization. (2007)
  • Author(s): Uchida, T.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: (横浜)[ポスター(示説)]
• [Presentation] High-resolution analysis of DNA copy number alterations and the geneexpression in renal clear cell carcinoma. (2007)
  • Author(s): Matsuura, K
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: (横浜)[ポスター(示説)]
• [Presentation] Kaman S.,Tagawa,H.,Masao Seto:Ocular adnexal marginal zone B cell lymphoma showed distinct genomicprofile. (2007)
  • Author(s): Honma, K
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: (横浜)[ボスタr(示説)]
• [Presentation] Activating mutations and copy number gains of Notch2 in diffuse large B-cell lymphoma (2007)
  • Author(s): Lee, S-Y.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: (横浜)[ワ「クショップ]
• [Presentation] 濾胞性リンパ腫の臨床病態・分子病態. (2007)
  • Author(s): 加留 部, 謙之 輔
  • Organizer: 第69回日本血液学会総会・第49回目本臨床血液学会総会
  • Place of Presentation: (横浜)[シンポジウム]
• [Presentation] HUVECおよびIL-2依存性ATL腫瘍細胞株の樹立.Growth of ATLL cells byHUVEC and IL-2: (2007)
  • Author(s): 鏡味 良豊
  • Organizer: 第69回日本血液学会総会・第49回日本臨床血液学会総会
  • Place of Presentation: (横浜)[シンポジウム]
• [Presentation] アレイCGH解析によるPTCL-U再分類の可能性. (2007)
  • Author(s): 中川 雅夫
  • Organizer: 第69回日本血液学会総会・第49回日本臨床血液学会総会
  • Place of Presentation: (横浜)[ポスター]
• [Presentation] Array CGH analysis for PTCL-U revealed a distinct subgroup with pathological and clonial relevance. (2007)
  • Author(s): Nakagawa, M
  • Organizer: 第49回米国血液学会総会
  • Place of Presentation: (米国)[誌上発表]
• [Presentation] Ocular adnexal margimal zone B cell lymphoma has characteristic deleti.on at chromosome band 6q23.3-24.1whose target is TNFAIP3. (2007)
  • Author(s): Hoonma, K
  • Organizer: 第49回米国血液学会総会
  • Place of Presentation: (米国)[ポスター(示説)]
• [Remarks]
  • URL: http://www.pref.aichi.jp/cancer-center/200/255/mokuji/04-idenshi_iryou/p1/04-p1.html
• [Remarks] 研究開発支援総合ディレクトリ(Read)
  • URL: http://read.jst.go.jp/
• [Remarks] 研究開発支援総合ディレクトリ(Read)
  • URL: http://read.jst.go.jp/
• [Remarks] 研究開発支援総合ディレクトリ(ReaD)
  • URL: http://read.jst.go.jp/
• [Patent(Industrial Property Rights)] リンパ腫の病型および予後診断方法 (2008)
  • Inventor(s): 瀬戸加大(愛知県がんセンター)、田川博之(愛知県がんセンター)、吉田安子(日本ガイシ)、吉良茂樹(日本ガイシ)
  • Industrial Property Rights Holder: 愛知県、日本ガイシ(株)
  • Filing Date: 2008-10-30
• [Patent(Industrial Property Rights)] リンパ腫の病型および予後診断方法 (2008)
  • Inventor(s): 瀬戸加大、田川博之、吉田安子、吉良茂樹、
  • Industrial Property Rights Holder: 瀬戸加大、田川博之、吉田安子、吉良茂樹、
  • Filing Date: 2008-10-30
  • Overseas
• [Patent(Industrial Property Rights)] びまん性大細胞方型B細胞リンパ腫の病型の診断方法及び予後診断の方法 (2006)
  • Inventor(s): 瀬戸加大(愛知県がんセンター)、田川博之(愛知県がんセンター)、吉田安子(日本ガイシ(株))、吉良茂樹(日本ガイシ(株))
  • Industrial Property Rights Holder: 愛知県、日本ガイシ(株)
  • Filing Date: 2006-04-19
• [Patent(Industrial Property Rights)] 生物体のタイプを判別するためのマーカーの選択方法及び選択されたマーカーの利用 (2006)
  • Inventor(s): 瀬戸加大(愛知県がんセンター)、竹内一郎(三重大学)、吉田安子(日本ガイシ)、吉良茂樹(日本ガイシ)、田川博之(愛知県がんセンター)
  • Industrial Property Rights Holder: 愛知県、三重大学、日本ガイシ(株)
  • Industrial Property Number: 2006-229798
  • Filing Date: 2006-08-25
• [Patent(Industrial Property Rights)] びまん性大細胞方型B細胞リンパ腫の病型の診断方法及び予後診断の方法 (2006)
  • Inventor(s): 瀬戸加大 他3名
  • Industrial Property Rights Holder: 愛知県, 日本ガイシ
  • Filing Date: 2006-04-19
• [Patent(Industrial Property Rights)] 生物体のタイプを判別するためのマーカーの選択方法及び選択されたマーカーの利用 (2006)
  • Inventor(s): 瀬戸加大 他4名
  • Industrial Property Rights Holder: 愛知県, 日本ガイシ, 三重大学
  • Filing Date: 2006-08-25
• [Patent(Industrial Property Rights)] 悪性リンパ腫の診断及び予後診断の方法 (2005)
  • Inventor(s): 瀬戸加大(愛知県がんセンター)、田川博之(愛知県がんセンター)、吉田安子(日本ガイシ(株))、吉良茂樹(日本ガイシ(株))、吉良茂樹(日本ガイシ(株))
  • Industrial Property Rights Holder: 愛知県、日本ガイシ(株)
  • Filing Date: 2005-12-05
• [Patent(Industrial Property Rights)] Method for prognosis B-cell lymphoma (2005)
  • Inventor(s): 瀬戸加大 他3名
  • Industrial Property Rights Holder: 愛知県,日本ガイシ
  • Filing Date: 2005-04-19
• [Patent(Industrial Property Rights)] 悪性リンパ腫の診断及び予後診断の方法 (2005)
  • Inventor(s): 瀬戸加大 他3名
  • Industrial Property Rights Holder: 愛知県,日本ガイシ
  • Filing Date: 2005-12-05
• [Patent(Industrial Property Rights)] 遺伝子検出方法、及びDNAマイクロアレイ (2005)
  • Inventor(s): 瀬戸加大 他3名
  • Industrial Property Rights Holder: 愛知県,日本ガイシ
  • Filing Date: 2005-09-12