NKT cell-based immunotherapy for cancer

• Project/Area Number: 17016010
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Chiba University
• Principal Investigator: NAKAYAMA Toshinori Chiba University, 大学院・医学研究院, 教授 (50237468)
• Co-Investigator(Kenkyū-buntansha): KIMURA Motoko 千葉大学, 大学院・医学研究院, 助手 (00345018)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥46,200,000 (Direct Cost: ¥46,200,000); Fiscal Year 2009: ¥9,300,000 (Direct Cost: ¥9,300,000); Fiscal Year 2008: ¥9,300,000 (Direct Cost: ¥9,300,000); Fiscal Year 2007: ¥9,300,000 (Direct Cost: ¥9,300,000); Fiscal Year 2006: ¥9,300,000 (Direct Cost: ¥9,300,000); Fiscal Year 2005: ¥9,000,000 (Direct Cost: ¥9,000,000)
• Keywords: 免疫学 / 発生・分化 / 癌 / トランスレーショナルリサーチ / 糖鎖 / 免疫 / 糖類

Research Abstract

To evaluate the safety, immune responses and antitumor responses after the administration of α-Galactosylceramide (αGalCer; KRN7000)-pulsed APCs, a phase I-II study in patients with non-small cell lung cancer (NSCLC) was carried out. αGalCer-pulsed APCs (1x10 9/m2) were intravenously administered four times to 17 cases. The estimated median survival time (MST) of the 17 cases was 18.6 months. Ten patients who displayed increased IFN-g producing cells (≥2 fold) showed prolonged MST (31.9 months) as compared to poor-responder patients (n=7, 9.7 months). The administration of αGalCer-pulsed APCs was well tolerated and was accompanied by the successful induction of NKT cell-dependent immune responses. These results are encouraging and warrant further evaluation for survival benefit of this immunotherapy.

Research Products

• [Journal Article] Organization of immunological memory by bone marrow stroma. (2010)
  • Author(s): Tokoyoda, K., Hauser A.E., Nakayama, T., Radbruch, A.
  • Journal Title: N a t. R e v. I m m u n o l. 10 Pages: 193-200
  • Peer Reviewed
• [Journal Article] Color-coded real-time cellular imaging of T lymphocyte accumulation and focus formation in mouse asthma model. (2010)
  • Author(s): Hasegawa, A., Hayashi, K., Kishimoto, H., Yang, M., Tofukuji, S., Suzuki, K., Nakajima, H., Hoffman, R.M., Shirai, M., Nakayama, T.
  • Journal Title: J Allergy Clin. I m m u n o l. 125
  • Peer Reviewed
• [Journal Article] Protective roles of B and T lymphocyte attenuator in NKT cell-mediated experimental hepatitis (2010)
  • Author(s): Iwata, A.
  • Journal Title: J.Immunol. 184 Pages: 127-133
  • Peer Reviewed
• [Journal Article] Color-coded real-time cellular imaging of T lymphocyte accumulation and focus formation in mouse asthma model (2010)
  • Author(s): Hasegawa, A.
  • Journal Title: J Allergy Clin.Immunol 125
  • Peer Reviewed
• [Journal Article] Organization of immunological memory by bone marrow stroma (2010)
  • Author(s): Tokoyoda, K.
  • Journal Title: Nat.Rev.Immunol. 10 Pages: 193-200
  • Peer Reviewed
• [Journal Article] CD69 controls the pathogenesis of allergic airway inflammation. (2009)
  • Author(s): Miki, H.T., Hasegawa, A., Iwamura, C., Shinoda, K., Tofukuji, S., Watanabe, Y., Hosokawa, H., Motohashi, S., Hashimoto, K., Shirai, M., Yamashita, M., Nakayama, T.
  • Journal Title: J. Immunol. 183 Pages: 8203-8215
  • Peer Reviewed
• [Journal Article] The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3. (2009)
  • Author(s): Kohu, K., Ohmori, H., Wong, W.F., Onda, D., Wakoh, T., Kon, S., Yamashita, M., Nakayama, T., Kubo, M., Satake, M.
  • Journal Title: J. Immunol. 183 Pages: 7817-7824
  • Peer Reviewed
• [Journal Article] Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice. (2009)
  • Author(s): Kitajima, M., Iwamura, C., Miki, H.T., Shinoda, K., Endo, Y., Watanabe, Y., Shinnakasu, R., Hosokawa, H., Hashimoto, K., Motohashi, S., Koseki, H., Ohara, O., Yamashita, M., Nakayama, T.
  • Journal Title: J. Immunol. 183 Pages: 5388-5396
  • Peer Reviewed
• [Journal Article] Combination therapy of in vitro-expanded natural killer T cells and α-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma. (2009)
  • Author(s): Kunii, N., Horiguchi, S., Motohashi, S., Yamamoto, H., Ueno, N., Yamamoto, S., Sakurai, D., Taniguchi, M., Nakayama, T., Okamoto, Y.
  • Journal Title: C a n c e r S c i. 100 Pages: 1092-1098
  • NAID: 10025146740
  • Peer Reviewed
• [Journal Article] Critical role of the Polycomb and Trithorax complexes in the maintenance of CD4 T cell memory. (2009)
  • Author(s): Nakayama, T., Yamashita, M.
  • Journal Title: S e m i n. I m m u n o l. 21 Pages: 78-83
  • Peer Reviewed
• [Journal Article] Natural killer T cell-mediated immunotherapy for malignant diseases. (2009)
  • Author(s): Motohashi, S., Nakayama, T.
  • Journal Title: F r o n t i e r s i n B i o s c i e n c e S1 Pages: 108-116
  • Peer Reviewed
• [Journal Article] Invariant natural killer T cell -based immunotherapy for cancer. (2009)
  • Author(s): Motohashi, S., Nakayama, T.
  • Journal Title: I m m u n o t h e r a p y 1 Pages: 73-82
  • Peer Reviewed
• [Journal Article] A phase I-II study of α-Galactosylceramide-pulsed IL-2/GM-CSF-cultured peripheral blood mononuclear cells in patients with advanced and recurrent non -small cell lung cancer. (2009)
  • Author(s): Motohashi, S., Nagato, K., Kunii, N., Yamamoto, H., Yamasaki, K., Okita, K., Hanaoka, H., Shimizu, N., Suzuki, M., Yoshino, I., Taniguchi, M., Fujisawa, T., Nakayama, T.
  • Journal Title: J. Immunol. 182 Pages: 2492-2501
  • Peer Reviewed
• [Journal Article] Natural killer T cell-mediated immunotherapy for malignant diseases (2009)
  • Author(s): Motohashi, S.
  • Journal Title: Frontiers in Bioscience S1 Pages: 108-116
  • Peer Reviewed
• [Journal Article] Critical role of the Polycomb and Trithorax complexes in the maintenance of CD4 T cell memory (2009)
  • Author(s): Nakayama, T.
  • Journal Title: Semin.Immunol. 21 Pages: 78-83
  • Peer Reviewed
• [Journal Article] Combination therapy of in vitro-expanded natural killer T cells and α-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma (2009)
  • Author(s): Kunii, N.
  • Journal Title: Cancer Sci. 100 Pages: 11092-1098
  • Peer Reviewed
• [Journal Article] Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice (2009)
  • Author(s): Kitajima, M.
  • Journal Title: J.Immunol. 183 Pages: 5388-5396
  • Peer Reviewed
• [Journal Article] Bmi1 regulates memory Th cell survival via repression of the Noxa gene (2009)
  • Author(s): Yamashita, M.
  • Journal Title: Proceedings of the 2^<nd> European Congress of Immunology Pages: 157-159
  • Peer Reviewed
• [Journal Article] The Runx3 transcription factor augments T_h1 and down-modulates T_h2 phenotypes by interacting with and attenuating GATA3 (2009)
  • Author(s): Kohu, K.
  • Journal Title: J.Immunol. 183 Pages: 7817-7824
  • Peer Reviewed
• [Journal Article] CD69 controls the pathogenesis of allergic airway inflammation (2009)
  • Author(s): Miki, H.T.
  • Journal Title: J.Immunol. 183 Pages: 8203-8215
  • Peer Reviewed
• [Journal Article] A novel subset of mouse NKT cells bearing the IL -17 receptor B responds to IL -25 and contributes to airway hyperreactivity. (2008)
  • Author(s): Terashima, A., Watarai, H., Inoue, S., Sekine, E., Nakagawa, R., Hase, K., Iwamura, C., Nakajima, H., Nakayama, T., Taniguchi, M.
  • Journal Title: J. E x p. M e d. 205 Pages: 2727-2733
  • Peer Reviewed
• [Journal Article] Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation. (2008)
  • Author(s): Shinnakasu, R., Yamashita, M., Kuwahara, M., Hosokawa, H., Hasegawa, A., Motohashi, S., Nakayama, T.
  • Journal Title: J. Biol. Chem. 283 Pages: 28216-28225
  • Peer Reviewed
• [Journal Article] Repressor of GATA regulates TH2-driven allergic airway inflammation and airway hyperresponsiveness. (2008)
  • Author(s): Hirahara, K., Yamashita, M., Iwamura, C., Shinoda, K., Hasegawa, A., Yoshizawa, H., Koseki, H., Gejyo, F., Nakayama, T.
  • Journal Title: J. Allergy C l i n. Immunol. 122
  • Peer Reviewed
• [Journal Article] Development and characterization of IL-21-producing CD4+ T cells. (2008)
  • Author(s): Suto, A., Kashiwakuma, D., Kagami, S., Hirose, K., Watanabe, N., Yokote, K., Saito, Y., Nakayama, T., Grusby, J.M., Iwamoto, I., Nakajima, H.
  • Journal Title: J. Exp. M e d. 205 Pages: 1369-1379
  • Peer Reviewed
• [Journal Article] Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172. (2008)
  • Author(s): Ito, T., Hasegawa, A., Hosokawa, H., Yamashita, M., Motohashi, S., Naka, T., Okamoto, Y., Fujita, Y., Ishii, Y., Taniguchi, M., Yano, I., Nakayama, T.
  • Journal Title: I n t. I m m u n o l. 20 Pages: 849-860
  • Peer Reviewed
• [Journal Article] Initiation and maintenance of Th2 cell identity. Truncated title: Regulation of Th2 responses. (2008)
  • Author(s): Nakayama, T., Yamashita, M.
  • Journal Title: C u r r. O p i n. I m m u n o l. 20 Pages: 265-271
  • Peer Reviewed
• [Journal Article] Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. (2008)
  • Author(s): Yamashita, M., Kuwahara, M., Suzuki, A., Hirahara, K., Shinnakasu, R., Hosokawa, H., Hasegawa, A., Motohashi, S., Iwama, A., Nakayama, T.
  • Journal Title: J. Exp. Med. 205 Pages: 1109-1120
  • Peer Reviewed
• [Journal Article] Clinical applications of natural killer T cell-based immunotherapy for cancer. (2008)
  • Author(s): Motohashi, S., Nakayama, T.
  • Journal Title: C a n c e r S c i. 99 Pages: 638-645
  • NAID: 10024004283
  • Peer Reviewed
• [Journal Article] Induction of natural killer cell-dependent antitumor immunity by the Autographa californica multiple nuclear polyhedrosis virus. (2008)
  • Author(s): Kitajima, M., Abe, T., Miyano, K.N., Taniguchi, M., Nakayama, T., Takaku, H.
  • Journal Title: M o l. Ther. 16 Pages: 261-268
  • Peer Reviewed
• [Journal Article] Phase I study of α- galactosylceramide-pulsed antigen presenting cells administration to the nasal submucosa in unresectable or recurrent head and neck cancer. (2008)
  • Author(s): Uchida, T., Horiguchi, S., Tanaka, Y., Yamamoto, H., Kunii, N., Motohashi, S., Taniguchi, M., Nakayama, T., Okamoto, Y.
  • Journal Title: C a n c e r I m m u n o l. Immunother. 57 Pages: 337-345
  • Peer Reviewed
• [Journal Article] A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway. hyperreactivity. (2008)
  • Author(s): Terashima, A.
  • Journal Title: J. Exp. Med. 205 Pages: 2727-2733
  • Peer Reviewed
• [Journal Article] Gfi1-mediated stabilization of GATA3 protein is required for Th2 Cell differentiation (2008)
  • Author(s): Shinnakasu, R.
  • Journal Title: J. BioL Chem. 283 Pages: 28216-28225
  • Peer Reviewed
• [Journal Article] Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type2 cell (2008)
  • Author(s): Hossain, M. B.
  • Journal Title: Immunology 125 Pages: 377-386
  • Peer Reviewed
• [Journal Article] Repressor of GATA regulates TH2-driven allergic airway inflammationand airway hyperresponsiveness (2008)
  • Author(s): Hirahara, K.
  • Journal Title: J. Allergy Cliri. Immunol. 122 Pages: 512-520
  • Peer Reviewed
• [Journal Article] Development and characterization of IL-21-producing CD4^+ T cells (2008)
  • Author(s): Suto, A.
  • Journal Title: J. Exp. Med. 205 Pages: 1369-1379
  • Peer Reviewed
• [Journal Article] Human T_h1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172 (2008)
  • Author(s): Ito, T.
  • Journal Title: Mt. Immunol. 20 Pages: 849-860
  • Peer Reviewed
• [Journal Article] Initiation and maintenance of Th2 cell identity. Truncated title : Regulation of Th2 responses (2008)
  • Author(s): Nakayama, T
  • Journal Title: Curr. Opin. Immunol. 20 : 20 Pages: 265-271
  • Peer Reviewed
• [Journal Article] Role of Vα14^+ NKT cells in the development of hepatitis B virus specific CTL : Activation of Vα14^+ NKT cells Promotes the breakageof CTL tolerance (2008)
  • Author(s): Ito, H.
  • Journal Title: Int. Immunot 20 Pages: 869-879
  • Peer Reviewed
• [Journal Article] Brnil regulates memory CD4 T cell survival via repression of the Noxa gene (2008)
  • Author(s): Yamashita, M.
  • Journal Title: J. EXD. Med. 205 Pages: 1109-1120
  • Peer Reviewed
• [Journal Article] Clinical applications of natural killer T cell-based immunotherapy for cancer (2008)
  • Author(s): Motohashi, S.
  • Journal Title: Cancer Sci. 99 Pages: 638-645
  • Peer Reviewed
• [Journal Article] Induction of natural killer cell-dependent antitumor immunity by the Autogranha californica multiple nuclear polyhedrosis virus (2008)
  • Author(s): Kitajima, M.
  • Journal Title: Mol. Ther. 16 Pages: 261-268
  • Peer Reviewed
• [Journal Article] Phase I study of α-galactosylceramide-pulsed antigen presenting cells administration to the nasal submucosa in unresectable or recurrent head and neck cancer (2008)
  • Author(s): Uchida, T.
  • Journal Title: Cancer Immunol. Immunother. 57 Pages: 337-345
  • Peer Reviewed
• [Journal Article] Induction of natural killer cell-dependent antitumor immunity by the Autographa californica multiple nuclear polyhedrosis virus. (2008)
  • Author(s): Kitajima, M.
  • Journal Title: Mol. Ther. 16 Pages: 261-268
  • Peer Reviewed
• [Journal Article] Phase I study of a-galactosylceramide-pulsed antigen presenting cells administration to the nasal submucosa in unresectable or recurrent head and neck cancer. (2008)
  • Author(s): Uchida, T.
  • Journal Title: Cancer Immunol. Immunother. 57 Pages: 337-345
  • Peer Reviewed
• [Journal Article] Immune mechanisms of allergic airway diseases: Regulation by transcription factors. (2007)
  • Author(s): Yamashita, M., Onodera, A., Nakayama, T.
  • Journal Title: C r i t. Rev. Immunol. 27 Pages: 539-546
  • Peer Reviewed
• [Journal Article] Schnurri-2 controls memory Th1 and Th2 cell numbers in vivo. (2007)
  • Author(s): Kimura, Y.M., Iwamura, C., Suzuki, A., Miki, T., Hasegawa, A., Sugaya, K., Yamashita, M., Ishii, S., Nakayama, T.
  • Journal Title: J. I m m u n o l. 178 Pages: 4926-4936
  • NAID: 40016084081
  • Peer Reviewed
• [Journal Article] Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells. (2007)
  • Author(s): Kaneko, T., Hosokawa, H., Yamashita, M., Wang, C.R., Hasegawa, A., Kimura, Y.M., Kitajima, M., Kimura, F., Miyazaki, M., Nakayama, T.
  • Journal Title: M o l. I m m u n o l. 44 Pages: 2249-2256
  • Peer Reviewed
• [Journal Article] Immune mechanisms of allergic airway diseases: Regulation by transcription factors. (2007)
  • Author(s): Yamashita, M.
  • Journal Title: Crit. Rev. lmmunol. 27 Pages: 539-546
  • Peer Reviewed
• [Journal Article] Schnurri-2 controls the generation of memory Th1 and Th2 cells. (2007)
  • Author(s): Kimura, Y. M.
  • Journal Title: 13th International congress of Immunology. Pages: 475-479
• [Journal Article] Detection of natural killer T cells in the sinus mucosa from asthmatics with chronic sinusitis. (2007)
  • Author(s): Yamamoto, H.
  • Journal Title: Allergy 62 Pages: 1451-1455
  • Peer Reviewed
• [Journal Article] T cell lineage determination precedes the initiation of TCRb gene rearrangement. (2007)
  • Author(s): Masuda. K.
  • Journal Title: J. Immunol. 179 Pages: 3699-3706
  • Peer Reviewed
• [Journal Article] Schnurri-2 regulates T_h2-dependent airway inflammation and airway hyper responsiveness. (2007)
  • Author(s): Iwamura, C.
  • Journal Title: Int. Immunol. 19 Pages: 755-762
  • Peer Reviewed
• [Journal Article] Schunurri-2 controls memory Th1 and Th2 cell number in vivo. (2007)
  • Author(s): Kimura, Y
  • Journal Title: J. Immunol. 178 Pages: 4926-4936
  • Peer Reviewed
• [Journal Article] Role of a-galactosylceramide-activated Va14 natural killer T cells in the regulation of allergic diseases. (2007)
  • Author(s): Iwamura, C.
  • Journal Title: Allergology International 56 Pages: 1-6
  • Peer Reviewed
• [Journal Article] Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells. (2007)
  • Author(s): Kaneko, T.
  • Journal Title: Mol. Immunol. 44 Pages: 2249-2256
  • Peer Reviewed
• [Journal Article] IL-21-induced Be cell apoptosis mediated by natural killer T cells suppresses IgE responses. (2006)
  • Author(s): Harada, M., Magara, K.K., Watarai, H., Nagata, Y., Ishii, Y., Kojo, S., Horiguchi, S., Okamoto, Y., Nakayama, T., Suzuki, N., Yeh, W.C., Akira, S., Kitamura, H., Ohara, O., Seino, K., Taniguchi, M.
  • Journal Title: J. E x p. M e d. 203 Pages: 2929-2937
  • Peer Reviewed
• [Journal Article] Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3. (2006)
  • Author(s): Hosokawa, H., Kimura, Y.M., Shinnakasu, R., Suzuki, A., Miki, T., Koseki, H., van Lohuizen, M., Yamashita, M., Nakayama, T.
  • Journal Title: J. Immunol. 177 Pages: 7656-7664
  • Peer Reviewed
• [Journal Article] Critical YxKxHxxxRP motif in the C-terminal region of GATA3 for its DNA binding and function. (2006)
  • Author(s): Shinnakasu, R., Yamashita, M., Shinoda, K., Endo, Y., Hosokawa, H., Hasegawa, A., Ikemizu, S., Nakayama, T.
  • Journal Title: J. I m m u n o l. 177 Pages: 5801-5810
  • Peer Reviewed
• [Journal Article] A phase I study of in vitro expanded natural killer T cells in patients with advanced and recurrent non-small cell lung cancer. (2006)
  • Author(s): Motohashi, S., Ishikawa, A., Ishikawa, E., Otsuji, M., Iizasa, T., Hanaoka, H., Shimizu, N., Horiguchi, S., Okamoto, Y., Fujii, S., Taniguchi, M., Fujisawa, T., Nakayama, T.
  • Journal Title: C l i n. C a n. R e s. 12 Pages: 6079-6086
  • Peer Reviewed
• [Journal Article] Crucial role of MLL for the maintenance of memory T helper type 2 cell responses. (2006)
  • Author(s): Yamashita, M., Hirahara, K., Shinnakasu, R., Hosokawa, H., Norikane, S., Kimura, Y.M., Hasegawa, A., Nakayama, T.
  • Journal Title: I m m u n i t y 24 Pages: 611-622
  • Peer Reviewed
• [Journal Article] Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice. (2006)
  • Author(s): Hasegawa, A., Miki, T., Hosokawa, H., Hossain, M.B., Shimizu, C., Hashimoto, K., Kimura, Y.M., Yamashita, M., Nakayama, T.
  • Journal Title: J. Immunol. 176 Pages: 2546-2554
  • Peer Reviewed
• [Journal Article] Regulation of allergic airway inflammation through Toll -like receptor 4-mediated modification of mast cell function. (2006)
  • Author(s): Nigo, I.Y., Yamashita, M., Hirahara, K., Shinnakasu, R., Inami, M., Kimura, M., Hasegawa, A., Kohno, Y., Nakayama, T.
  • Journal Title: P r o c. N a t l. A c a d. S c i. U S A 103 Pages: 2286-2291
  • NAID: 40015396097
  • Peer Reviewed
• [Journal Article] Natural killer T-cells participate in rejection of islet allografts in the liver of mice. (2006)
  • Author(s): Toyofuku, A.
  • Journal Title: Diabetes 55・1 Pages: 34-39
• [Journal Article] Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice. (2006)
  • Author(s): Hasegawa, A.
  • Journal Title: J. Immunol. 176・4 Pages: 2546-2554
• [Journal Article] Crucial role of MLL for the maintenance of memory T helper type 2 cell responses. (2006)
  • Author(s): Yamashita, M
  • Journal Title: Immunity 24・5 Pages: 611-622
• [Journal Article] A phase I study of in vitro expanded natural killer T cells in patients with advanced and recurrent non-small cell lung cancer. (2006)
  • Author(s): Motohashi, S.
  • Journal Title: Clin. Can. Res. 12・20 Pages: 6079-6086
• [Journal Article] Critical YxKxHxxxRP motif in the C-terminal region of GATA3 for its DNA binding and function. (2006)
  • Author(s): Shinnakasu, R.
  • Journal Title: J. Immunol. 177・9 Pages: 5801-5810
• [Journal Article] NKT cells play a limited role in the neutrophilic inflammatory responses and host defense to pulmonary infection with Pseudomonas aeruginosa. (2006)
  • Author(s): Kinjo, T.
  • Journal Title: Microbes and Infection 8・12-13 Pages: 2679-2685
• [Journal Article] Regulation of Th2 development by Polycomb group gene bmi-1 through the stabilization of GATA3. (2006)
  • Author(s): Hosokawa, H.
  • Journal Title: J. Immunol. 177・12 Pages: 7656-7664
• [Journal Article] IL-21-induced Bε cell apoptosis mediated by natural killer T cells suppresses IgE responses. (2006)
  • Author(s): Harada, M.
  • Journal Title: J. Exp. Med. 203・13 Pages: 2929-2937
• [Journal Article] Regulation of allergic airway inflammation through Toll-like recepter 4-mediated modification of mast function (2006)
  • Author(s): Nigo, I.Y.
  • Journal Title: Proc.Natl.Acad.Sci.USA 103(7) Pages: 2286-2291
• [Journal Article] Natural Killer T-cells Participate in Regection of Islet Allografts in the Liver of Mice (2006)
  • Author(s): Toyofuku, A.
  • Journal Title: Diabetes 55(1) Pages: 34-39
• [Journal Article] Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice. (2006)
  • Author(s): Hasegawa, A
  • Journal Title: J.Immunol. 17・4 Pages: 2546-2554
• [Journal Article] Accelerated chemically-induced tumor development mediated by CD4+ CD25+ regulatory T cells in wild-type hosts. (2005)
  • Author(s): Nishikawa, H., Kato, T., Tawara, I., Takemitsu, T., Saito, K., Wang, L., Ikarashi, Y., Wakasugi, H., Nakayama, T., Taniguchi, M., Kuribayashi, K., Old, L.J., Shiku, H.
  • Journal Title: P r o c. N a t l. A c a d. S c i. U S A 102 Pages: 9253-9257
  • Peer Reviewed
• [Journal Article] Differentiation of NK1 and NK2 cells. (2005)
  • Author(s): Kimura, Y.M., Nakayama, T.
  • Journal Title: C r i t. R e v. I m m. 25 Pages: 361-374
  • Peer Reviewed
• [Journal Article] Induction of regulatory properties in dendritic cells by Vα14 NKT cells. (2005)
  • Author(s): Kojo, S., Seino, K., Harada, M., Watarai, H., Wakao, H., Uchida, T., Nakayama, T., Taniguchi, M.
  • Journal Title: J. Immunol. 175 Pages: 3648-3655
  • Peer Reviewed
• [Journal Article] Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway. (2005)
  • Author(s): Yamashita, M., Shinnakasu, R., Asou, H., Kimura, M., Hasegawa, A., Hashimoto, K., Hatano, N., Ogata, M., Nakayama, T.
  • Journal Title: J. B i o l. C h e m. 280 Pages: 29409-29419
  • Peer Reviewed
• [Journal Article] Dendritic cell maturation by CD11c - T cells and Vα24+ natural killer T -cell activation byα-Galactosylceramide. (2005)
  • Author(s): Ishikawa, E., Motohashi, S., Ishikawa, A., Ito, T., Uchida, T., Kaneko, T., Tanaka, Y., Horiguchi, S., Okamoto, Y., Fujisawa, T., Tsuboi, K., Taniguchi, M., Matsumura, A., Nakayama, T.
  • Journal Title: I n t. J. C a n c e r 117 Pages: 265-273
  • Peer Reviewed
• [Journal Article] Dramatic changes in surface expression during the maturation of human dendritic cells. (2005)
  • Author(s): Watarai, H.
  • Journal Title: Proteomics 5・15 Pages: 4001-4011
• [Journal Article] Hematopoietic stem cell and marrow stromal cell for spinal cord injury in mice. (2005)
  • Author(s): Koda, M
  • Journal Title: Neuroreport 16・16 Pages: 1763-1767
• [Journal Article] Accelerated chemically-induced tumor development mediated by CD4^+ CD25^+ regulatory T cells in wild-type hosts. (2005)
  • Author(s): Nishikawa, H.
  • Journal Title: Proc.Natl.Acad.Sci.USA 102・26 Pages: 9253-9257
• [Journal Article] Differentiation of NK1 and NK2 cells. (2005)
  • Author(s): Kimura, Y.M.
  • Journal Title: Crit.Rev.Imun. 25・5 Pages: 361-374
• [Journal Article] Induction of regulatory properties in dendritic cells by Vα14 NKT cells. (2005)
  • Author(s): Kojo, S.
  • Journal Title: J.Immunol. 175・6 Pages: 3648-3655
• [Journal Article] Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway. (2005)
  • Author(s): Yamashita, M
  • Journal Title: J.Biol.Chem. 280・33 Pages: 29409-29419
• [Journal Article] Dendritic cell maturation by CD11c^- T cells and Vα24^+ NKT cell activation by α-Galactosylceramide. (2005)
  • Author(s): Ishikawa, E.
  • Journal Title: Int.J.Cancer 117・2 Pages: 265-273
• [Journal Article] Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration. (2005)
  • Author(s): Miyamoto, T.
  • Journal Title: Int.Immunol 17・6 Pages: 759-768
• [Journal Article] Adjuvant activity mediated by iNKT cells.
  • Author(s): Fujii, S., Motohashi, S., Shimizu, K., Nakayama, T., Yoshiga, Y., Taniguchi, M.
  • Journal Title: S e m i n. I m m u n o l. (in press)
  • Peer Reviewed
• [Journal Article] Adjuvant activity mediated by iNKT cells
  • Author(s): Fujii, S.
  • Journal Title: Semin.Immunol. (in press)
  • Peer Reviewed
• [Journal Article] Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung
  • Author(s): Suzuki, A.
  • Journal Title: J.Immunol. (in press)
  • Peer Reviewed
• [Journal Article] Phosphate activated glutaminase(GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
  • Author(s): Ishii, Y.
  • Journal Title: Proc.Natl.Acad.Sci.USA (in press)
  • Peer Reviewed
• [Journal Article] Combination therapy of in vitro expanded natural killer T cells and α-galactosylceramide-pulsed antigen presenting cells in patients with recurrent head and neck carcinoma.
  • Author(s): Kunii, N.
  • Journal Title: Cancer Sci. (in press)
  • Peer Reviewed
• [Journal Article] A phase I-II study of α-Galactosylceramide(KRN7000)-pulsed IL-2/GM-CSF-cultured peripheral blood mononuclear cells in patients with advanced and recurrent non-small cell 1ung cancer.
  • Author(s): Motohashi, S.
  • Journal Title: J.Immunol (in press)
  • Peer Reviewed
• [Journal Article] Invariant natural killer T cell-based immunotherapy for cancer
  • Author(s): Motohashi, S.
  • Journal Title: Immunotherapy (in press)
  • Peer Reviewed
• [Journal Article] Natural killer T cell-mediated immunotherapy for malignant diseases
  • Author(s): Motohashi, S.
  • Journal Title: Frontiers in Bioscience (in press)
  • Peer Reviewed
• [Journal Article] Bmil regulates memory CD4 T cell survival via repression of the Noxa gene.
  • Author(s): Yamashita, M.
  • Journal Title: J. Exp. Med. (In press)
  • Peer Reviewed
• [Journal Article] Clinical applications of natural killer T cell-based immunotherapy for cancer.
  • Author(s): Motohashi, S.
  • Journal Title: Cancer Sci. (In press)
  • Peer Reviewed
• [Presentation] Regulation of GATA3-induced immune responses by the transcription factor Sox4 (2009)
  • Author(s): 山下政克
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-12
• [Presentation] CD4 T細胞の機能分化と維持のメカニズム (2009)
  • Author(s): 中山俊憲
  • Organizer: 第39回日本免疫学会総会・学術集会レビュ-ト-ク
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-04
• [Presentation] 腸炎の発症におけるCD69分子の役割/Crucial role for CD69 in the pathogenesis of experimental colitis (2009)
  • Author(s): 長谷川明洋
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-04
• [Presentation] Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice (2009)
  • Author(s): 岩村千秋
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-04
• [Presentation] Suppression of BBN-induced bladder carcinoma by R8-liposomal BCG-CWS in rats (2009)
  • Author(s): 小濱秀泰
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-04
• [Presentation] Regulation of GATA3-induced immune responses by the transcription factor Sox4 (2009)
  • Author(s): 山下政克
  • Organizer: 第39回日本免疫学会総会・学術集会(シンポジウム)
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-04
• [Presentation] Essential role of HSP90α in antigen cross-presentation by dendritic cells(DC) (2009)
  • Author(s): Ichiyanagi, T.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] Professional memory CD4 T lymphocytes preferentially reside and rest in the bone marrow (2009)
  • Author(s): Tokoyoda, K.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] Sox4 regulates GATA3-induced Th2 cell differentiation and Th2-dependent inflammatory responses (2009)
  • Author(s): Kuwahara, M.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] Transcription factor MLL regulates IL-4 mediated anti-tumor response by tumor specific memory Th2 cells (2009)
  • Author(s): Hosokawa, H.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] The involvement of Sec8 molecule, a subunit of exocyst complex which supports vesicle trafficking, for activation process of B cell (2009)
  • Author(s): 田口純
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] The function of CD69 molecules on dendritic cells to induce IL-17 producing cells (2009)
  • Author(s): Sawada, K.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] Phase II study of ex vivo expanded natural killer T cells and α-GalactosylCeramide-pulsed antigen presenting cells administration before salvage operation in patients with recurrent head and neck carccinoma (2009)
  • Author(s): Yamasaki, K
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] A set of genes whose expression is associated with the IFN-γ response/survival undergoing NKT cell-based immunotherapy (2009)
  • Author(s): 本橋新一郎
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] 食事誘導性肥満におけるNKT細胞の役割/Diet-induced obesity is suppressed in CD1d-deficient but not in invariant NKT cell-deficient mice (2009)
  • Author(s): Satoh, M.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] Enhanced development of atherosclerosis in[β2m^<-/->-> Ldlr^<-/->]irradiaton bone-marrow chimeras-possible involvement of innate T cell other than CD1d-restricted NKT cell (2009)
  • Author(s): Ogura, H.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] Role of neutrophils and myeloperoxidase in lung injury induced by influenza A/H1N1(PR-8)infection in mice (2009)
  • Author(s): Tomizawa, K.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] Early phase of diffuse alveolar damage induced by TNFα, IL-6 prior to VILI in mice (2009)
  • Author(s): 志賀由佳
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] ApolipoproteinA-II protects from ConcanavalinA-induced hepatitis through the inhibition of CD4 T cell activation (2009)
  • Author(s): 山下潤二
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] ヒト免疫疾患におけるメモリ-T細胞の役割:新展開 (2009)
  • Author(s): 中山俊憲
  • Organizer: 第37回日本臨床免疫学会総会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-11-13
• [Presentation] ヒト免疫疾患におけるメモリ-T細胞の役割:新展開 (2009)
  • Author(s): 中山俊憲
  • Organizer: 第37回日本臨床免疫学会総会(シンポジウム)
  • Place of Presentation: 東京
  • Year and Date: 2009-11-13
• [Presentation] Transcription factor MLL regulates IL-4 mediated anti-tumor response by tumor specific memory Th2 cells (2009)
  • Author(s): Ito, T.
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] Phase II study of activated NKT cells and αGalcer-pulsed DCs before surgery in patients with head and neck cancer (2009)
  • Author(s): Yamasaki, K.
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] A set of genes whose expression is associated with the IFN-gresponse/survival undergoing NKT cell-based immunotherapy (2009)
  • Author(s): 本橋新一郎
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] Intravesical and intravenous administration of R8 encapsulated BCG CWS suppresses BBN-induced rat urinary carcinoma (2009)
  • Author(s): Akaza, H
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] iNKT cell based immunotherapy for cancer. (2009)
  • Author(s): Nakayama, T.
  • Organizer: Japanese-German Cancer Workshop
  • Place of Presentation: Hamburg, Germany
  • Year and Date: 2009-09-18
• [Presentation] iNKT cell based immunotherapy for cancer (2009)
  • Author(s): 中山俊憲
  • Organizer: Japanese-German Cancer Workshop
  • Place of Presentation: Hamburg, Germany
  • Year and Date: 2009-09-18
• [Presentation] Professional memory CD4 T lymphocytes reside and rest in the bone marrow (2009)
  • Author(s): Tokoyoda. K.
  • Organizer: The2nd European Journal of Immunology 2009
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2009-09-16
• [Presentation] Bmi1 regulates memory Th2 cell survival via repression of the noxa gene (2009)
  • Author(s): 中山俊憲
  • Organizer: The2nd European Journal of Immunology 2009
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2009-09-15
• [Presentation] 抗原提示細胞にみられる分泌小胞輸送分子Sec8と抗原ペプチドの動態 (2009)
  • Author(s): 櫻本昌輝
  • Organizer: 第18回日本バイオイメージング学会学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2009-09-04
• [Presentation] B細胞のプラズマ細胞化とその分化マーカー分子のイメージング解析 (2009)
  • Author(s): 松長修
  • Organizer: 第18回日本バイオイメージング学会学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2009-09-04
• [Presentation] 喘息肺へのTリンパ球細胞浸潤のイメージ (2009)
  • Author(s): 長谷川明洋
  • Organizer: 第18回日本バイオイメージング学会学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2009-09-04
• [Presentation] Development of new immunotherapy for cancer: iNKT cell-based immunotherapy. (2009)
  • Author(s): Nakayama, T.
  • Organizer: Thailand Research Expo 2009
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2009-08-29
• [Presentation] Development of new immunotherapy for cancer : iNKT cell-based immunotherapy (2009)
  • Author(s): 中山俊憲
  • Organizer: Thailand Research Expo 2009
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2009-08-29
• [Presentation] CD4陽性T細胞の機能分化:機能獲得と維持のメカニズム (2009)
  • Author(s): 中山俊憲
  • Organizer: 第21回日本比較免疫学会学術集会
  • Place of Presentation: 藤沢
  • Year and Date: 2009-08-04
• [Presentation] 免疫・アレルギ-疾患克服のためのトランスレーショナルリサーチ (2009)
  • Author(s): 中山俊憲
  • Organizer: 平成21年度第1回ちばバイオテクノロジーセミナー
  • Place of Presentation: 千葉
  • Year and Date: 2009-07-13
• [Presentation] NKT cell immunotherapy for lung cancer (2009)
  • Author(s): 本橋新一郎
  • Organizer: 第13回日本がん免疫学会総会
  • Place of Presentation: 北九州
  • Year and Date: 2009-06-25
• [Presentation] Professional memory CD4^+ T lymphocytes reside and rest in the bone marrow (2009)
  • Author(s): Tokoyoda, K.
  • Organizer: The 5^<th> International Workshop of Kyoto T Cell Conference 2009
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-06-04
• [Presentation] Regulation of memory Th cell survival and function by the polycomb and trithorax group gene products. The 5^<th> International Workshop of Kyoto T Cell Conference 2009, June 1-4, Kyoto, Japan (2009)
  • Author(s): 中山俊憲
  • Organizer: T The 5^<th> International Workshop of Kyoto T Cell Conference 2009
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-06-04
• [Presentation] 次世代型"がん"治療免疫治療の最前線 (2009)
  • Author(s): 中山俊憲
  • Organizer: 日本試薬協会講演会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-01
• [Presentation] ROG, repressor of GATA, regulates Th2-driven allergic airway inflammation and airway hyperresponsiveness. (2009)
  • Author(s): Nakayama, T.
  • Organizer: 96th Annual Meeting the American Association of Immunologists Immunology 2009
  • Place of Presentation: Seattle
  • Year and Date: 2009-05-09
• [Presentation] ROG, repressor of GATA, regulates Th2-driven allergic airway inflammation and airway hyperresponsiveness (2009)
  • Author(s): 中山俊憲
  • Organizer: 96th Annual Meeting the American Association of Immunologists Immunology 2009
  • Place of Presentation: Seattle
  • Year and Date: 2009-05-09
• [Presentation] 免疫システム、その統御による免疫治療の開発研究 (2009)
  • Author(s): 中山俊憲
  • Organizer: 第9回Cardiovascular Frontier Conference (CFC)
  • Place of Presentation: 東京
  • Year and Date: 2009-04-04
• [Presentation] 免疫システム、その統御による免疫治療の開発研究 (2009)
  • Author(s): 中山俊憲
  • Organizer: 第9回 Cardiovascular Frontier Conference(CFC)
  • Place of Presentation: 東京
  • Year and Date: 2009-04-04
• [Presentation] CD4T細胞の機能分化と維持のメカニズム (2009)
  • Author(s): 中山俊憲
  • Organizer: 第39回日本免疫学会総会・学術集会(レビュートーク)
  • Place of Presentation: 大阪
• [Presentation] BMI1 REGULATES MEMORY CD4 TCELL SURVIVAL VIA REPRESSION OF THE NOXA GENE (2009)
  • Author(s): Nakayama, T.
  • Organizer: Keystone Symposia 2009
  • Place of Presentation: Colorado, USA
• [Presentation] Initiation and maintenance of Th2 cell identity: Regulation by Polycomb and Trithorax group molecules. (2008)
  • Author(s): Nakayama, T.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] Combination therapy of In vitro expanded natural killer T cells and αGalactosyl Ceramide pulsed APCs in patients with recurrent head and neck carcinoma. (2008)
  • Author(s): Nakayama, T.
  • Organizer: The Second International Cell Therapy Conference Present a nd Future of Cell Therapy
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-11-20
• [Presentation] 細菌・アレルギー・癌と戦う免疫細胞を見る (2008)
  • Author(s): 中山俊憲
  • Organizer: 第17回日本バイオイメージング学会学術講演会公開講座
  • Place of Presentation: 千葉
  • Year and Date: 2008-10-31
• [Presentation] A Phase I/II study of αGalCer-pulsed dendritic cells in patients with advanced or recurrent non-small cell lung cancer (2008)
  • Author(s): 中山俊憲
  • Organizer: 日本臨床免疫学会総会シンポジウム
  • Place of Presentation: 新宿
  • Year and Date: 2008-10-17
• [Presentation] メモリーTh1/Th2細胞の形成と維持機構 (2008)
  • Author(s): 中山俊憲
  • Organizer: 第44回日本移植学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2008-09-20
• [Presentation] 免疫システム<、その統御による免疫治療の開発研究 (2008)
  • Author(s): 中山俊憲
  • Organizer: 第84回千葉医学会学術大会
  • Place of Presentation: 千葉
  • Year and Date: 2008-09-05
• [Presentation] Regulation of memory Th2 cell survival and function by the Polycomb group and Trithorax group gene products. (2008)
  • Author(s): Nakayama, T.
  • Organizer: Immunochemistry & Immunobiology, Magdalen College
  • Place of Presentation: Oxford, UK
  • Year and Date: 2008-08-20
• [Presentation] NKT細胞免疫系を利用した癌の免疫細胞治療 (2008)
  • Author(s): 中山俊憲
  • Organizer: 第4回北海道癌免疫制御研究会
  • Place of Presentation: 札幌
  • Year and Date: 2008-06-07
• [Presentation] Bmi1 regulates memory Th2 cell survival via repression of the Noxa gene. (2008)
  • Author(s): Nakayama, T.
  • Organizer: Experimental Biology 2008, San Diego Convention Center
  • Place of Presentation: San Diego, USA
  • Year and Date: 2008-04-06
• [Presentation] Initiation and maintenance of Th2 cell identity: Regulation by Polycomb and Trithorax group molecules. (2008)
  • Author(s): Nakayama, T.
  • Organizer: Allergy Symposium Program La Jolla Institute for Allergy and Immunology (LIAI)
  • Place of Presentation: USA
  • Year and Date: 2008-04-04
• [Presentation] Initiation and maintenance of Th2 cell identity: Regulation by Polycomb and Trithorax group molecules. (2008)
  • Author(s): Nakayama, T.
  • Organizer: Karp Family Research Laboratories, One Blackfan Circle, 10th Floor Conference Room
  • Place of Presentation: Boston, USA
  • Year and Date: 2008-03-03
• [Presentation] Initiation an d maintenance of Th2 cell identity: Regulation by Polycomb and Trithorax group molecules. (2008)
  • Author(s): Nakayama, T.
  • Organizer: National Jewish Medical and Research Center, University of Colorado at Denver and Health Sciences Center
  • Place of Presentation: Denver, USA
  • Year and Date: 2008-02-22
• [Presentation] Natural Killer T cell-based immunotherapy for lung cancer. (2008)
  • Author(s): 本橋新一郎
  • Organizer: 窮12回基盤的癌免疫研究会総会
  • Place of Presentation: 新宿
• [Presentation] In vitroにおけるIVIg治療の作用機序解析と判定法の確立/Modulation of endothelial cell function by intravenous immunoglohulin in vitro (2008)
  • Author(s): 常賀
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] 喘息発症に関与するIL-17RB陽性NKT細胞のサブセット/Anovel subset of mouse iNKT cell bearing IL-17 receptor B responslble fbr the development of asthma (2008)
  • Author(s): Terashima, A.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Crucial role for CD69 in the pathogenesis of Th2-deriven allergic airway inflammation (2008)
  • Author(s): Iwamura, C.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] 乳酸菌を用いたアレルギー性鼻炎抑制効果の検討/Effect of Lactic acid Bacteria on the develoment of Allergic rhinitis during the Japanese cedar pollen season (2008)
  • Author(s): 稲嶺絢子
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Gfi1はGATA3蛋白質の安定化を介してTh2細胞分化を制御する/Gfil-mediated stabilization of GArA3 protein is required fbr Th2 cell diflbrentiation (2008)
  • Author(s): Shinnakasu, R.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Lymphoid enhancer factof 1(LEF 1)はGATA3に会合しその機能を調節ずる/Lymphoid enhancer factor interacts with GATA3 and controls its function in T helper type 2 cells (2008)
  • Author(s): 細川裕之
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Polycomb group protein Ring1B regulates Th2-dependent airway inflammation through the control of Th2 cell differentiation and anontosis (2008)
  • Author(s): Suzuki, A.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] BCG Tokyo-172から分離精製したLAMILM分子によるHuman Th1分化誘導機構Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mcobacterium bovis BCGToko-172 (2008)
  • Author(s): Ito,T.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] NKT細胞におけるBTLAの役割/Role of BTL A expressed on natural killer(NK)T Cells in inmune regulation (2008)
  • Author(s): 岩田有史
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] ARDS病態モテルの肺組織変化に連動するサイトカイ,ンストームの意義/The pathological findings of Lung involvOd in cytoklne storm from an animal model of ARDS (2008)
  • Author(s): 鄒軍
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] 樹状細胞に発現するCD69分子のIL-17A産生細胞への影響/The funnction of CD69 molecule on dendritic cell to induce IL-17A producinf cells (2008)
  • Author(s): 澤田景子
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] BmilはNoxa遺伝子の発現抑制を介してメモリーTh細胞の生存を制御する/Rmilregulates memory CD4 T cell survivial valvia renression of the Noxa gene (2008)
  • Author(s): Yamashita, M.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] ヒト化マウスにおけるヒトB細胞機能と原発性免疫不全症モデルへの応用/Development of fUnctional human B cells in NODISCID/IL2rgKO mice and the application of xenotransplant model in studying human primary immunodeficiency (2008)
  • Author(s): Doi. T
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Activation of tumor infiltrating Va24 NKT cells aiterpreoperative a -Galactosylceramide-pulsed dendritic celitreatment (2008)
  • Author(s): Nagato, K.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] 分泌小胞輸送複合体exocyst complexのサブニットであるSec8分臓の脾臓B細胞の分化過程における機能の解析/The involvement of Sec8 molecule ; a subunit of exocyst complex, which supPorts vesicles transportation, for activating Process of B cell (2008)
  • Author(s): 田口純
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] 再発頭頸部癌患者に対する活性化NKT細胞とα-GalCerパルス樹状細胞を用いた第I/II相臨床研究/Combination therapy of actiyated NKT cells and α-GalCer pulsed DCs in patients with recurrent head and neck (2008)
  • Author(s): Kunii,N.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] The function of the exocyst complex member, Sec8 molecules in the antigen presenting cells (2008)
  • Author(s): Sakuramoto, M.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Crucial role for CD69 in the pathogenesis of colitis induced by dextran sulphate sodium (2008)
  • Author(s): Hasegawa, A.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Reduction of CD3+B220+CD69+cell population by treatment with 15-deoxyspergualin in SCG/Kj mice (2008)
  • Author(s): Kusunoki, R.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Secretion of neutrophil chemotactic factors from glomerular endothelial cells byanti-mvelonernxiclase antihody (2008)
  • Author(s): Nagao, T.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Gfi1はGATA3蛋白質の安定化を介してTh2細胞分化を制御する (2008)
  • Author(s): 山下政克
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] 抗原提示細胞におけるExocyst複合体のサブユニットSec8分子の機能解析 (2008)
  • Author(s): 山本紘士
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] Schnurri-2 regulates Th2-dependent airway inflammation and airway hyperresponsiveness. (2008)
  • Author(s): Iwamura, C.
  • Organizer: Keystone Symposia 2008
  • Place of Presentation: Colorado, USA
• [Presentation] Combination therapy of In vitro expanded natural killer T cells and a-galactosylceramide-pulsed antigen presenting cells in patients with b-recurrent head and neck carcinoma. (2008)
  • Author(s): Nakayama, T.
  • Organizer: Keystone Symposia 2008
  • Place of Presentation: Colorado, USA
• [Presentation] 免疫細胞療法 (2007)
  • Author(s): 中山俊憲
  • Organizer: トランスレ-ショナルリサ-チLesson & Lectureシリ-ズ
  • Place of Presentation: 東京
  • Year and Date: 2007-10-17
• [Presentation] Regulation of the generation and maintenance of memory Th1/Th2 cells. (2007)
  • Author(s): Nakayama, T.
  • Organizer: 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Year and Date: 2007-10-04
• [Presentation] NKT細胞免疫療法の開発研究と肺がんにおける治療 (2007)
  • Author(s): 中山俊憲
  • Organizer: 第23回東日本癌免疫療法研究会
  • Place of Presentation: 甲府
  • Year and Date: 2007-09-08
• [Presentation] Schnurri-2 regulates the generation of effector and memory Th1/Th2 cells. (2007)
  • Author(s): Nakayama, T.
  • Organizer: California Institute of Technology
  • Place of Presentation: Denver, CO, USA
  • Year and Date: 2007-05-22
• [Presentation] Schnurri -2 controls memory Th1 and Th2 cell numbers in vivo. (2007)
  • Author(s): Nakayama, T.
  • Organizer: Immunology 2007
  • Place of Presentation: Miami Beach, FL, USA
  • Year and Date: 2007-05-21
• [Presentation] Schnurri-2 regulates the generation of effector and memory Th1/Th2 cells. (2007)
  • Author(s): Nakayama, T.
  • Organizer: California Institute of Technology
  • Place of Presentation: Pasadena, CA, USA
  • Year and Date: 2007-05-17
• [Presentation] Schnurri-2 regulates the generation of effector and memory Th1/Th2 cells. (2007)
  • Author(s): Nakayama, T.
  • Organizer: NCI, NIH
  • Place of Presentation: Bethesda, MD, USA
  • Year and Date: 2007-04-30
• [Presentation] Crucial role of MLL for the maintenance of memory Th2 cell identity. (2007)
  • Author(s): Nakayama, T.
  • Organizer: Immunology Seminar Series, University of Chicago
  • Place of Presentation: USA
  • Year and Date: 2007-04-23
• [Presentation] Schnurri-2 regulates the generation of effector and memory Th1/Th2 cells. (2007)
  • Author(s): Nak ayama, T.
  • Organizer: Benaroya Research Institute
  • Place of Presentation: USA
  • Year and Date: 2007-03-12
• [Presentation] Schnurri -2 regulates the generation of effector and memory Th1/Th2 cells. (2007)
  • Author(s): Nakayama, T.
  • Organizer: La Jolla Institute for Allergy and Immunology
  • Place of Presentation: La Jolla, USA
  • Year and Date: 2007-03-08
• [Presentation] Innate immunity activation in mouse dendritic cells infected by Bacurovirus. (2007)
  • Author(s): Hashimoto, K.
  • Organizer: Immunology 2007
  • Place of Presentation: Miami beach, FL, USA
• [Presentation] A phase I/II study of aGalCer-pulsed dendritic cells in patients with advanced or recurrent non-small cell lung cancer. (2007)
  • Author(s): Motohashi, S.
  • Organizer: 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜
• [Presentation] 原発性肺癌に対するNKT細胞免疫療法 (2007)
  • Author(s): Motohashi, S.
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 品川
• [Presentation] Bmi1はNoxa遺伝子の発現抑制を介してメモリーTh細胞の生存を維持する (2007)
  • Author(s): 山下政克
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 品川
• [Presentation] Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3. (2007)
  • Author(s): Hosokawa, H.
  • Organizer: Chromatin Structure & Function
  • Place of Presentation: Antigua
• [Presentation] Bmi1はNoxa遺伝子の発現調節を介してメモリーCD4 T細胞の生存を制御する (2007)
  • Author(s): 山下政克
  • Organizer: 第30回日本分子生物学会年会第80回日本生化学学会大会 合同大会 BMB2007
  • Place of Presentation: 横浜
• [Presentation] NKT細胞免疫系をタ-ゲットにしたがんの免疫細胞療法 (2006)
  • Author(s): 中山俊憲
  • Organizer: 癌領域におけるトランスレ-ションリサ-チセミナ-
  • Place of Presentation: 山口
  • Year and Date: 2006-11-22
• [Presentation] Visualization of lymphocyte migration in the asthmatic lung. (2006)
  • Author(s): Nakayama, T.
  • Organizer: The International Symposia for Bioimaging
  • Place of Presentation: Kyoto
  • Year and Date: 2006-10-30
• [Presentation] Chromatin remodeling of the Th2 cytokine gene loci. (2005)
  • Author(s): Nakayama, T.
  • Organizer: Cellular & Molecular Immunology FIMSA 2005
  • Place of Presentation: Hangzhou China
• [Book] Memory Th1/Th2 cell generation controlled by schnurri-2. M e m o r y T - C e l l s (edited by Maurizio Zanetti) (2009)
  • Author(s): Nakayama, T., Kimura, Y.M.
• [Book] 分子細胞生物学辞典第2版 (2008)
  • Author(s): 中山俊憲
  • Total Pages: 1184
  • Publisher: 東京化学同人
• [Book] The Innate Immune System : Strategies for Disease Control (International Congress Series 1285) (2005)
  • Author(s): Nakayama, T.
  • Total Pages: 216
  • Publisher: Elsevier, UK
• [Remarks]
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