| Project/Area Number |
17016012
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Japanese Foundation For Cancer Research (2006-2009)
The University of Tokyo (2005) |
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Principal Investigator |
TOMIDA Akihiro (2008-2009) Japanese Foundation For Cancer Research, 癌化学療法センター ゲノム研究部, 部長 (40251483)
鶴尾 隆 (2005-2007) Japanese Foundation For Cancer Research, 癌化学療法センター, 所長 (00012667)
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| Co-Investigator(Kenkyū-buntansha) |
HAGA Naomi 財団法人癌研究会, 癌化学療法センターゲノム研究部, 研究員 (40376645)
RYOUHEI Katayama 財団法人癌研究会, 癌化学療法センター基礎研究部, 研究員 (60435542)
MASHIMA Tetsuo 財団法人癌研究会, 癌化学療法センター分子生物治療研究部, 研究員 (30311228)
冨田 章弘 (財)癌研究会, 癌化学療法センターゲノム研究部, 部長 (40251483)
|
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAMOTO Hiroshi 中外製薬鎌倉研究所, 創薬研究第二部
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| Project Period (FY) |
2005 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥132,200,000 (Direct Cost: ¥132,200,000)
Fiscal Year 2009: ¥22,000,000 (Direct Cost: ¥22,000,000)
Fiscal Year 2008: ¥22,000,000 (Direct Cost: ¥22,000,000)
Fiscal Year 2007: ¥30,500,000 (Direct Cost: ¥30,500,000)
Fiscal Year 2006: ¥30,500,000 (Direct Cost: ¥30,500,000)
Fiscal Year 2005: ¥27,200,000 (Direct Cost: ¥27,200,000)
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| Keywords | 癌 / シグナル伝達 / ゲノム / 医療・福祉 / 薬学 / シゲナル伝達 |
|---|
| Research Abstract |
We studied molecular mechanisms of various types of drug resistance, such as apoptosis resistance, tumor microenvironment-associated drug resistance, PDK1-Akt-related cell survival signaling pathways, and telomere-mediated cell maintenance. We succeeded to identify new molecular targets and to discover compounds that inhibit such molecular targets. By evaluating the antitumor effect of such compounds, we accumulated fundamental information to develop new molecular-targeted therapy that controls drug resistance features of tumor cells.
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