| Project/Area Number |
17016016
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MAEDA Shin (2008-2009) The University of Tokyo, 医学部附属病院, 特任講師 (40415956)
小俣 政男 (2005-2007) The University of Tokyo, 医学部附属病院, 教授 (90125914)
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| Co-Investigator(Kenkyū-buntansha) |
ENOMOTO Nobuyuki 山梨大学, 大学院・医学工学総合研究部, 教授 (20251530)
SASAKI Shigeru 札幌医科大学, 医学部, 講師 (10305229)
KANAI Fumihiko 東京大学, 医学部附属病院, 特任准教授 (70334399)
TATEISHI Keisuke 東京大学, 医学部附属病院, 助手 (20396948)
TANAKA Yasuo 東京大学, 医学部附属病院, 寄附講座教員 (40422290)
吉田 晴彦 東京大学, 医学部附属病院, 講師 (60240305)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥71,500,000 (Direct Cost: ¥71,500,000)
Fiscal Year 2009: ¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2008: ¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2007: ¥14,900,000 (Direct Cost: ¥14,900,000)
Fiscal Year 2006: ¥14,900,000 (Direct Cost: ¥14,900,000)
Fiscal Year 2005: ¥14,900,000 (Direct Cost: ¥14,900,000)
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| Keywords | 癌 / 遺伝子 / ゲノム / 炎症 / プロテオミクス / 臨床 / プロオミクス / 生体マーカー / 肝癌 |
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| Research Abstract |
This project has attempted to find out new biological markers relating to hepato-cellular carcinoma (HCC) and develop new treatment protocol against HCC. To analyze many clinical samples, some experimental systems including Genechip, Protein array, and Mass spectrometry were applied to the assay, and the data was comprehensively analyzed. As the achievements in this period, we found that 1) The tumor incidence rate is related to the serum concentration of IL-6 in women, 2) Platelet Factor 4(PF4), Angiogenin(ANG), TIMP-1, Serpin E1(PAI-1), VEGF are upregulated and Hip is decreased in HCC, 3) In the serum after the ablation of HCC, proapolipoprotein, α2-HS glycoprotein, apolipoprotein A-IV precursor, PRO1708/PRO2044 are decreased and leucine-rich α2-glycoprotein、α1-antitrypsin are increased, 4) High DCP can be a prognostic factor of PVTT . In addition, 5) We designed and performed the randomized control study about the effect of VitaminK treatment against HCC recurrence.
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