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Polymeric micelle nanocarrier for drug and gene delivery

Research Project

Project/Area Number 17016017
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

KATAOKA Kazunori  The University of Tokyo, 大学院・工学系研究科, 教授 (00130245)

Co-Investigator(Kenkyū-buntansha) YAMASAKI Yuichi  東京大学, 大学院・工学系研究科, 准教授 (00322678)
NISHIYAMA Nobuhiro  東京大学, 大学院・医学系研究科, 准教授 (10372385)
OSADA Kensuke  東京大学, 大学院・工学系研究科, 特任講師 (10396947)
MIYATA Kanjiro  東京大学, 大学院・医学系研究科, 助教 (50436523)
KISHIMURA Akihiro  東京大学, 大学院・工学系研究科, 助教 (70422326)
ISHII Takehiko  東京大学, 大学院・工学系研究科, 特任助教 (80415075)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥46,200,000 (Direct Cost: ¥46,200,000)
Fiscal Year 2009: ¥9,300,000 (Direct Cost: ¥9,300,000)
Fiscal Year 2008: ¥9,300,000 (Direct Cost: ¥9,300,000)
Fiscal Year 2007: ¥9,300,000 (Direct Cost: ¥9,300,000)
Fiscal Year 2006: ¥9,300,000 (Direct Cost: ¥9,300,000)
Fiscal Year 2005: ¥9,000,000 (Direct Cost: ¥9,000,000)
Keywordsドラッグデリバリー / ナノキャリア / 高分子ミセル / がん化学療法 / 遺伝子治療 / siRNA / ナノテクノロジー / がん治療 / 化学療法 / がん標的治療
Research Abstract

To realize the targeting therapy against intractable tumors, we developed functional polymeric micelles integrated with the sensitivity to intracellular low pH conditions and the ability to bind the specific cells for the delivery of antitumor agents, and demonstrated their effectiveness in the in vivo study using tumor-bearing mice. Also, to establish the molecular cancer therapy based on gene delivery, we developed a non-viral gene vector based on polymeric micelles stabilized through the cross-linking cleavable under the intracellular reductive conditions, and succeeded in their application to antiangiogenic cancer therapy.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (151 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (71 results) (of which Peer Reviewed: 58 results) Presentation (56 results) Book (11 results) Remarks (6 results) Patent(Industrial Property Rights) (7 results) (of which Overseas: 1 results)

  • [Journal Article] Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble Flt-12010

    • Author(s)
      M. Oba, Y. Vachutinsky, K. Miyata, M.R. Kano, S. Ikeda, N. Nishiyama, K. Itaka, K. Miyazono, H. Koyama, K. Kataoka
    • Journal Title

      Mol. Pharm 7(2)

      Pages: 501-509

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] pDNA/poly(L-lysine)polyplexes functionalized with a pH-sensitive charge-conversional poly(aspartamide)derivative for controlled gene delivery to human umbilical vein endothelial cells2010

    • Author(s)
      M.Sanjoh, K.Kataoka, et al.
    • Journal Title

      Macromol.Rapid Commun. ((印刷中)掲載確定)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles2010

    • Author(s)
      Y.Vachutinsky, K.Kataoka, et al.
    • Journal Title

      J.Control.Release ((印刷中)掲載確定)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown2010

    • Author(s)
      H.Kim, K.Kataoka, et al.
    • Journal Title

      J.Control.Release ((印刷中)掲載確定)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Enhanced transfection with silica-coated polyplexes loading plasmid DNA2010

    • Author(s)
      K.Miyata, K.Kataoka, et al.
    • Journal Title

      Biomaterials 31

      Pages: 4764-4770

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biodegradable polyamino acid-based polycations as safe and effective gene carrier minimizing cumulative toxicity2010

    • Author(s)
      K.Itaka, K.Kataoka, et al.
    • Journal Title

      Biomaterials 31

      Pages: 3707-3714

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polyplex nanomicelle promotes hydrodynamic gene introduction to skeletal muscle2010

    • Author(s)
      K.Itaka, K.Kataoka, et al.
    • Journal Title

      J.Control.Release 143

      Pages: 112-119

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble Flt-12010

    • Author(s)
      M.Oba, K.Kataoka, et al.
    • Journal Title

      Molecular Pharmaceutics 7

      Pages: 501-509

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] siRNA-based therapy ameliorates glomerulonephritis2010

    • Author(s)
      H.Shimizu, K.Kataoka, et al.
    • Journal Title

      J.Am.Soc.Nephrol. 21

      Pages: 622-633

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient delivery of bioactive antibodies into the cytoplasm of living cells by charge-conversional polyion complex micelles2010

    • Author(s)
      Y.Lee, K.Kataoka, et al.
    • Journal Title

      Angew.Chem.Int.Ed. 49

      Pages: 2552-2555

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Versatile and selective synthesis of "Click Chemistry" compatible heterobifunctional polyethylene glycol)s possessing azide and alkyne functionalities2010

    • Author(s)
      S.Hiki, K.Kataoka, et al.
    • Journal Title

      Bioconjugate Chem. 21

      Pages: 248-254

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous formation of nanosized unilamellar polyion complex vesicles with tunable size and properties2010

    • Author(s)
      Y.Anraku, K.Kataoka, et al.
    • Journal Title

      J.Am.Chem.Soc. 132

      Pages: 1631-1636

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced magnetic resonance imaging of experimental pancreatic tumor in vivo by block-copolymer-coated magnetite nanoparticles with TGF-beta inhibitor2009

    • Author(s)
      M. Kumagai, M.R. Kano, Y. Morishita, M. Ota, Y. Imai, N. Nishiyama, M. Sekino, S. Ueno, K. Miyazono, K. Kataoka
    • Journal Title

      J. Control. Release 140(3)

      Pages: 306-311

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles2009

    • Author(s)
      M. Han, M. Oba, N. Nishiyama, M.R. Kano, S. Kizaka-Kondoh, K. Kataoka
    • Journal Title

      Mol. Ther. 17(8)

      Pages: 1404-1410

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced magnetic resonance imaging of experimental pancreatic tumor in vivo by block-copolymer-coated magnetite nanoparticles combined with TGF-beta inhibitor2009

    • Author(s)
      M.Kumagai, K.Kataoka, et al.
    • Journal Title

      J.Control.Release 140

      Pages: 306-311

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PEGylated calcium phosphate nanocomposites as smart environment-sensitive carriers for siRNA delivery2009

    • Author(s)
      M.Zhang, K.Kataoka, et al.
    • Journal Title

      Adv.Mater. 21

      Pages: 3520-3525

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles2009

    • Author(s)
      M.Han, K.Kataoka, et al.
    • Journal Title

      Mol.Ther. 17

      Pages: 1404-1410

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats2009

    • Author(s)
      M.Harada-Shiba, K.Kataoka, et al.
    • Journal Title

      Molecular Ther. 17

      Pages: 1180-1186

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm2009

    • Author(s)
      Y.Lee, K.Kataoka, et al.
    • Journal Title

      Angew.Chem.Int.Ed. 48

      Pages: 5309-5312

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats2009

    • Author(s)
      M. Harada-Shiba, K. Kataoka, et.al.
    • Journal Title

      Molecular Ther. (印刷中)(掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm2009

    • Author(s)
      Y. Lee, K. Kataoka, et.al.
    • Journal Title

      Angew. Chem. Int. Ed. (印刷中)(掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Environment-responsive block copolymer micelles with a disulfidecross-linked core for enhanced siRNA delivery2009

    • Author(s)
      S. Matsumoto, K. Kataoka, et.al.
    • Journal Title

      Biomacromolecules 10

      Pages: 119-127

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced photodynamic cancer treatment by supramolecular nanocarriers charged with dendrimer phthalocyanine2009

    • Author(s)
      N. Nishiyama, K. Kataoka, et.al.
    • Journal Title

      J. Control. Release 133

      Pages: 245-251

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A photo-activated targeting chemotherapy using glutathione sensitive camptothecin-loaded polymeric micelles2009

    • Author(s)
      H. Cabral, K. Kataoka, et.al.
    • Journal Title

      Pharm. Res. 26

      Pages: 82-92

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polyplexes from poly(aspartamide) bearing 1, 2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity2008

    • Author(s)
      K. Miyata, M. Oba, M. Nakanishi, S. Fukushima, Y. Yamasaki, H. Koyama, N. Nishiyama, K. Kataoka
    • Journal Title

      J. Am. Chem. Soc. 130(48)

      Pages: 16287-16294

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomal escaping, and DNA-condensing functions for systemic gene delivery to pancreatic tumor2008

    • Author(s)
      K. Miyata, M. Oba, M.R. Kano, S. Fukushima, Y. Vachutinsky, M. Han, H. Koyama, K. Miyazono, N. Nishiyama, K. Kataoka
    • Journal Title

      Pharm. Res. 25(12)

      Pages: 2924-2936

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polyplex micelles with cyclic RGD peptide ligands and disulfide cross-links directing to the enhanced transfection via controlled intracellular trafficking2008

    • Author(s)
      M. Oba, K. Aoyagi, K. Miyata, Y. Matsumoto, K. Itaka, N. Nishiyama, Y. Yamasaki, H. Koyama, K. Kataoka
    • Journal Title

      Mol. Pharm. 5(6)

      Pages: 1080-1092

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polyplex micelles with cyclic RGD peptide ligands and disulfide crosslinks directing to the enhanced transfection via controlled intracellular trafficking2008

    • Author(s)
      M. Oba, K. Kataoka, et.al.
    • Journal Title

      Mol. Pharm. 5

      Pages: 1080-1092

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polyplexes from poly (aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplifiedt ransfection and negligible cytotoxicity2008

    • Author(s)
      Miyata, K. Kataoka, et.al.
    • Journal Title

      J. Am. Chem. Soc. 130

      Pages: 16287-16294

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomal escaping, and DNA-condensing functions for systemic gene delivery to pancreatic tumor tissue2008

    • Author(s)
      K. Miyata, K. Kataoka, et.al.
    • Journal Title

      Pharm. Res. 25

      Pages: 2924-2936

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive non-viral gene vectors2008

    • Author(s)
      S. Takae K. Kataoka, et.al.
    • Journal Title

      J. Am. Chem. Soc. 130

      Pages: 6001-6009

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Charge-conversional ternary polyplex with endosome disruption moiety : a new paradaigm for the efficient and safe gene delivery2008

    • Author(s)
      Y. Lee, K. Kataoka, et.al.
    • Journal Title

      Angew. Chem., Int. Ed. 47

      Pages: 5163-5166

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of angiogenesis through stabilization of hypoxia inducible factor-1 by silencing prolyl hydroxylase domain 2 gene2008

    • Author(s)
      S. Wu, K. Kataoka, et.al.
    • Journal Title

      Molecular Ther. 16

      Pages: 1227-1234

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of Angiogenesis through Stabilization of Hypoxia Inducible Factor-1 by Silehcing Proly1 Hydroxylase Domain 2 Gene2008

    • Author(s)
      S, Wu, K. Kataoka, et. al.
    • Journal Title

      Mol. Ther. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive non-viral gene vectors.2008

    • Author(s)
      S.Takae, K. Kataoka, et. al.
    • Journal Title

      J.Am. Chem. Soc. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photodynamic therapy for corneal neovascularization using polymeric micelles encapsulating dendrimer porphyrins2008

    • Author(s)
      K. Sugisaki, K. Kataoka, et. al.
    • Journal Title

      Invest. Ophth. Vis. Sci. 49

      Pages: 894-899

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PEG-based block catiomers possessing DNA anchoring and endosomal escaping functions to form polyplex micelles with improved stability and high transfection efficacy2007

    • Author(s)
      K. Miyata, S. Fukushima, N. Nishiyama, Y. Yamasaki, K. Kataoka
    • Journal Title

      J. Control. Release 122(3)

      Pages: 252-260

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optimization of (1, 2-diamino- cyclohexane)platinum(II)-loaded polymeric micelles directed to improved tumor targeting and enhanced antitumor activity2007

    • Author(s)
      H. Cabral, N. Nishiyama, K. Kataoka
    • Journal Title

      J. Control. Release 121(3)

      Pages: 146-155

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo antitumor activity of the folate-conjugated pH-sensitive polymeric micelle selectively releasing adriamycin in the intracellular acidic compartments2007

    • Author(s)
      Y. Bae, N. Nishiyama, K. Kataoka
    • Journal Title

      Bioconjugate Chem. 18(4)

      Pages: 1131-1139

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling2007

    • Author(s)
      M.R. Kano, Y. Bae, C. Iwata, Y. Morishita, M. Yashiro, M. Oka, T. Fujii, A. Komuro, K. Kiyono, M. Kaminishi, K. Hirakawa, Y. Ouchi, N. Nishiyama, K. Kataoka, K. Miyazono
    • Journal Title

      P. Natl. Acad. Sci. USA. 104(9)

      Pages: 3460-3465

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Study of the quantitative aminolysis reaction of poly(beta-benzy1 L-aspartate)(PBLA)as a platform polymer for functionality matetials2007

    • Author(s)
      K. Nakanishi, K. Kataoka, et. al.
    • Journal Title

      React. Funct. Polym. 67

      Pages: 1361-1372

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles2007

    • Author(s)
      K.Itaka, K. Kataoka, et. al.
    • Journal Title

      Mol. Ther. 15

      Pages: 1655-1662

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A protein nanocarrier from charge-conversion polymer in response to endosomal pH2007

    • Author(s)
      Y.Lee, K. Kataoka, et. al.
    • Journal Title

      J. Am. Chem. Soc. 129

      Pages: 5362-5363

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Iron hydroxide nanoparticles coated with poly(ethylene glycol)-poly(aspartic acid)block copolymer as novel magnetic resonance contrast agents for in vivo cancer imaging2007

    • Author(s)
      M. Kumagai, K. Kataoka, et. al.
    • Journal Title

      Colloids Surf., B Biointerfaces 56

      Pages: 174-181

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene delivery with biocompatible cationic polymer: Pharmacogenomic analysis on cell bioactivity.2007

    • Author(s)
      K. Masago, K. Kataoka, et. al.
    • Journal Title

      Biomaterials 28

      Pages: 5169-5175

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dendrimer Generation Effects on Photodynamic Efficacy of Dendrimer Porphyrins and Dendrimer-Loaded Supramolecular Nanocarrier2007

    • Author(s)
      Y.Li, K. Kataoka, et. al.
    • Journal Title

      Chem. Mater. 19

      Pages: 5557-5562

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] pH-Responsive Multi-PEGylated Dual Cationic Nanoparticles Enable Charge Modulations for Safe Gene Delivery.2007

    • Author(s)
      M.P. Xiong, K. Kataoka, et. al.
    • Journal Title

      Chem MedChem 2

      Pages: 1321-1327

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Growth Inhibition of Hepatic Multicellular Tumor Spheroids by Lactosylated Poly(ethylene glycol)-siRNA Conjugate Formulated in PEGylated Polyplexes.2007

    • Author(s)
      M. Oishi, K. Kataoka, et. al.
    • Journal Title

      ChemMedChem 2

      Pages: 1290-1297

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PEG-based block catiomers possessing DNA anchoring and endosomal escaping functions to form polyplex micelles with improved stability and high transfection effocacy.2007

    • Author(s)
      K. Miyata, K. Kataoka, et. al.
    • Journal Title

      J.Control. Release 122

      Pages: 252-260

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing alphavbeta3 and alphavbeta5 integrins.2007

    • Author(s)
      M. Oba, K. K. Kataoka, et. al.
    • Journal Title

      Bioconjugate Chem. 18

      Pages: 1415-1423

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimization of(1,2-diamino-cyclohexane)platinum(II)-loaded polymeric micelles directed to improved tumor targeting and enhanced antitumor activity.2007

    • Author(s)
      H. Cabral, K. Kataoka, et. al.
    • Journal Title

      J.Control. Release 121

      Pages: 146-155

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transfection Study Using Multicellular Tumor Spheroids for Screening Non-viral Polymeric Cene Vectors with Low Cytotoxicity and High Transfection Efficiencies.2007

    • Author(s)
      M. Han, K. Kataoka, et. al.
    • Journal Title

      Bioconjugate Chem. 121

      Pages: 38-48

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In Vivo Antitumor Activity of the Folate-Conjugated pH-Sensitive Polymeric Micelle Selectively Releasing Adriamycin in the Intracellular Acidic Compartments.2007

    • Author(s)
      Y. Bae, K. Kataoka, et. al.
    • Journal Title

      J.Control. Release 18

      Pages: 1131-1139

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation.2007

    • Author(s)
      D. Akagi, K. Kataoka, et. al.
    • Journal Title

      Gene Ther. 14

      Pages: 1029-1038

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling.2007

    • Author(s)
      M. R. Kano, K. Kataoka, et. al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 104

      Pages: 3460-3465

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of naphthalocyanine dendrimer loaded polyion complex micelle for photodynamic therapy.2007

    • Author(s)
      W. -D. Jang, K. Kataoka, et. al.
    • Journal Title

      Key Eng. Mater. 342-343

      Pages: 465-468

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kataoka, Supramolecular nanocarriers integrated with dendrimers encapsulating photosensitizers for effective photodynamic therapy and photochemical gene delivery.2007

    • Author(s)
      N. Nishiyama, K. Kataoka, et. al.
    • Journal Title

      New J. Chem. 31

      Pages: 1074-1082

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-signaling2007

    • Author(s)
      Kano, MR, Nishiyama, N et al.
    • Journal Title

      Proc. Natl. Acad. Sci., USA 104(9)

      Pages: 3460-3465

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Preparation and characterization of polyion complex micelles with a novel thermosensitive poly(2-isopropyl-2-oxazoline) shell via the complexation of oppositely charged block ionomers2007

    • Author(s)
      Park, J-S, Kataoka, K et al.
    • Journal Title

      Langmuir 23(1)

      Pages: 138-146

    • Related Report
      2006 Annual Research Report
  • [Journal Article] PEGylated gene nanocarriers based on block catiomers bearing ethylenediamine repeating units directed to remarkable enhancement of photochemical transfection2006

    • Author(s)
      Arnida, Kataoka, K et al.
    • Journal Title

      Journal of Controlled Release 115(2)

      Pages: 208-215

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Semipermeable polymer vesicle (PICsome) self-assembled in aqueous medium from a pair of oppositely charged block copolymers : physiologically stable micro-/nanocontainers of water-soluble macromolecules.2006

    • Author(s)
      Koide, A, Kataoka, K et al.
    • Journal Title

      Journal of the American Chemical Society 128 (18)

      Pages: 5988-5989

    • Related Report
      2006 Annual Research Report
  • [Journal Article] pH-responsive three-layered PEGylated polyplex micelle based on a lactosylated ABC triblock copolymer as a targetable and endosome-disruptive nonviral gene vector.2006

    • Author(s)
      Oishi, M, Kataoka, K et al.
    • Journal Title

      Bioconjugate Chemistry 17 (3)

      Pages: 677-688

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Organic-inorganic hybrid-nanocarrier of siRNA constructing through the self-assembly of calcium phosphate and PEG-based block aniomer.2006

    • Author(s)
      Kakizawa, Y, Kataoka, K et al.
    • Journal Title

      Journal of Controlled Release 111 (3)

      Pages: 368-370

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Freeze-dried formulations for in vivo gene delivery of PEGylated polyplex micelle with disulfide crosslinked cores to the liver2006

    • Author(s)
      Miyata, K., Kataoka, K.et al.
    • Journal Title

      Journal of Controlled Release 109(1-3)

      Pages: 15-23

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery.2005

    • Author(s)
      Y. Bae, W. -D. Jang, N. Nishiyama, S. Fukushima, K. Kataoka
    • Journal Title

      Mol. BioSyst. 1(3)

      Pages: 242-250

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer2005

    • Author(s)
      Nishiyama, N., Kataoka, K.et al.
    • Journal Title

      Nature Materials 4(12)

      Pages: 934-941

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery2005

    • Author(s)
      Bae, Y., Kataoka, K.et al.
    • Journal Title

      Molecular Biosystems 1(3)

      Pages: 242-250

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A synthetic block copolymer regulates S1 nuclease fragmentation of supercoiled plasmid DNA2005

    • Author(s)
      Osada, K., Kataoka, K.et al.
    • Journal Title

      Angewandte Chemie, International Edition 44(23)

      Pages: 3544-3548

    • Related Report
      2005 Annual Research Report
  • [Journal Article] PEGylated polyplex micelles from triblock catiomers with spatially ordered layering of condensed pDNA and buffering units for enhanced intracellular gene delivery2005

    • Author(s)
      Fukushima, S., Kataoka, K.et al.
    • Journal Title

      Journal of the American Chemical Society 127(9)

      Pages: 2810-2811

    • Related Report
      2005 Annual Research Report
  • [Journal Article] NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel2005

    • Author(s)
      Hamaguchi, T., Kataoka, K.et al.
    • Journal Title

      British Journal of Cancer 92(7)

      Pages: 1240-1246

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles

    • Author(s)
      Y. Vachutinsky, M. Oba, K. Miyata, S. Hiki, M.R. Kano, N. Nishiyama, H. Koyama, K. Miyazono, K. Kataoka
    • Journal Title

      J. Control. Release (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] 高分子が先導するナノバイオテクノロジー ~ピンポイント診断・治療のための高分子ナノデバイス設計~2009

    • Author(s)
      片岡一則
    • Organizer
      第18回ポリマー材料フォーラム
    • Place of Presentation
      タワーホール船堀、東京
    • Year and Date
      2009-11-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Supramoleuclar Nanodevises for Nucleic Acid Delivery2009

    • Author(s)
      片岡一則
    • Organizer
      Joint Symposium of the 5th Annual Meeting of the Oligonucleotide Therapeutics Society and the 19th Antisense Symposium
    • Place of Presentation
      Centennial Hall, Kyushu University Hospital Campus, Fukuoka, Japan
    • Year and Date
      2009-11-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Supramoleuclar Nanodevices from Block Copolymers for Smart Molecular Therapy2009

    • Author(s)
      片岡一則
    • Organizer
      2nd Aquitane conference on Polymers
    • Place of Presentation
      Palais des Congres, Arcachon, France
    • Year and Date
      2009-10-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Supra-moleuclar Structures as Nanodevices in Gene and Drug Delivery ~Challenges to Smart Molecular Therapy~2009

    • Author(s)
      片岡一則
    • Organizer
      The Norman Bethune International Medical Forum 2009 & 70th Anniversary Celebration for Former Norman Bethune University of Medical Sciences
    • Place of Presentation
      Changchun, China
    • Year and Date
      2009-09-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 健康サスティナブル社会を先導するナノバイオマテリアル ~ピンポイントDDSへの展開~2009

    • Author(s)
      片岡一則
    • Organizer
      第58回高分子討論会
    • Place of Presentation
      熊本大学工学部黒髪地区、熊本
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Supra-molecular Nanocarriers for Gene and Drug Delivery2009

    • Author(s)
      片岡一則
    • Organizer
      2nd Swiss-Japanese Symposium on Bionanotechnology
    • Place of Presentation
      Aigle Castle, Switzerland
    • Year and Date
      2009-09-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Supramoleuclar Nanocarriers for Gene and Drug Delivery ~Challenges to Intracellular Nanomedicine~2009

    • Author(s)
      片岡一則
    • Organizer
      22nd European Conference on Biomaterials
    • Place of Presentation
      Lausanne, Switzerland
    • Year and Date
      2009-09-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Nanotherapeutics through Polymer Chemistry ~Supra-molecular Nanocarriers for Gene and Drug Delivery~2009

    • Author(s)
      片岡一則
    • Organizer
      2nd TERMIS World Congress
    • Place of Presentation
      Lotte Hotel World, Seoul, Korea
    • Year and Date
      2009-08-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Supra-macromoleuclar Nanodevices for Smart Molecular Therapy2009

    • Author(s)
      片岡一則
    • Organizer
      73rd Prague Meeting on Macromolecules
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2009-07-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Nanotherapeutics through Polymer Chemistry : Supra-molecular Nanocarriers for Gene and Drug Delivery2009

    • Author(s)
      片岡一則
    • Organizer
      34th FEBS Congress
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2009-07-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Importance of Nanotechnology in Healthcare in the 21st Century-The Japanese Perspective ~Towards Smart Molecular Therapy~2009

    • Author(s)
      片岡一則
    • Organizer
      2nd ESF/UB European Summer School in Nanomedicine
    • Place of Presentation
      Quinta da Marinha, Cascais, Lisbon, Portugal
    • Year and Date
      2009-06-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Supramoleular Assemblies of Smart Block Copolymers as Nanocarriers for Gene and Drug Delivery2009

    • Author(s)
      片岡一則
    • Organizer
      International Symposium Celebrating the 50th Anniversary of the Journal "Polymer"
    • Place of Presentation
      The Congress Centrum Mainz, Mainz, Germany
    • Year and Date
      2009-06-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Smart Nanocarrier Systems for Targeted Drug and Gene Delivery ~A Future for the Pharmaceutical Industry~2009

    • Author(s)
      片岡一則
    • Organizer
      2nd European Conference for Clinical Nanomedicine
    • Place of Presentation
      Messe Schweiz, Hall l'Entree, Basel, Switzerland
    • Year and Date
      2009-04-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Supramolecular Structures as Carriers in Gene and Drug Delivery ~Challenge to Smart Molecular Therapy~2009

    • Author(s)
      片岡一則
    • Organizer
      Biomaterials Asia 2009
    • Place of Presentation
      Regal Airport Hotel, Hong Kong, China
    • Year and Date
      2009-04-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Block copolymer micelles and vesicles as nanocarriers for gene and drug delivery2009

    • Author(s)
      K. Kataoka
    • Organizer
      The 10th US-Japan symposium on Drug Delivery System
    • Place of Presentation
      Lahaina, Maui, Hawaii, USA
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Supramoleuclar Nanocarriers for Gene and Drug Delivery2009

    • Author(s)
      K. Kataoka
    • Organizer
      1st Annual Conference of the American Society for Nanomedicine
    • Place of Presentation
      Bolger Center, Potomac, Maryland, USA
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 健康サスティナブル社会を先導するナノバイオマテリアル~ピンポイントDDSへの展開~2009

    • Author(s)
      片岡一則
    • Organizer
      第58回高分子討論会
    • Place of Presentation
      熊本大学工学部黒髪地区、熊本県
    • Related Report
      2009 Final Research Report
  • [Presentation] ポリエチレングリコール-ポリアミノ酸ブロック共重合体を基盤とする高分子ミセル型DDSの開発2009

    • Author(s)
      片岡一則
    • Organizer
      第25回日本DDS学会学術集会
    • Place of Presentation
      東京ドームホテル、東京
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Smart Nanocarrier Systems for Targeted Drug and Gene Delivery ~A Future for the Pharmaceutical Industry~2009

    • Author(s)
      K. Kataoka
    • Organizer
      2nd European Conference for Clinical Nanomedicine
    • Place of Presentation
      Messe Schweiz, Hall l'Entree, Basel, Switzerland
    • Related Report
      2009 Final Research Report
  • [Presentation] 高分子ミセル型超分子ナノデバイスによる遺伝子デリバリー2008

    • Author(s)
      片岡一則
    • Organizer
      様々な機能を備えた遺伝子導入技術の最前線inむ神戸〜臨床応用に向けた課題と今後展開〜
    • Place of Presentation
      ニチイ学館神戸ポートアイランドセンター、神戸
    • Year and Date
      2008-12-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] がん治療における高分子ミセル製剤の基礎2008

    • Author(s)
      片岡一則
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場、名古屋市
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 超分子ナノデバイスによる薬物・遺伝子のピンポイントデリバリー2008

    • Author(s)
      片岡一則
    • Organizer
      創剤フォーラム第14回シンポジウム
    • Place of Presentation
      グランドヒル市ヶ谷、東京
    • Year and Date
      2008-10-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Supra-Moleular Nanodevices for Gene and Drug Delivery-Challenge to Smart Molecular Therapy -2008

    • Author(s)
      K. Kataoka
    • Organizer
      NanoDDS '08
    • Place of Presentation
      University of Toronto, Toronto, Canada
    • Year and Date
      2008-10-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Supramoleular Assemblies from Smart Block Copolymers as Nanocarriers for Gene and Drug Delivery2008

    • Author(s)
      K. Kataoka
    • Organizer
      8th France-Japan Drug Delivery Symposium
    • Place of Presentation
      Cannes, France
    • Year and Date
      2008-10-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高分子が先導するナノバイオテクノロジー〜ピンポイント診断・治療のための高分子ナノデバイス設計〜2008

    • Author(s)
      片岡一則
    • Organizer
      第57回高分子討論会
    • Place of Presentation
      東京ビッグサイト、東京
    • Year and Date
      2008-09-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Supramoleular Nanocarriers for Gene and Drug Delivery -Challenges to Intracellular Nanomedicine-2008

    • Author(s)
      K. Kataoka
    • Organizer
      Gordon Research Conference "Biointerface Science"
    • Place of Presentation
      Aussois, France
    • Year and Date
      2008-09-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] NanoBio Integration for Medical Innovation -Supramolecular Nanodevices for Gene and Drug Delivery-2008

    • Author(s)
      K. Kataoka
    • Organizer
      ASMeW International Symposium
    • Place of Presentation
      Waseda University, Tokyo
    • Year and Date
      2008-08-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Supramolecular Nanodevices for Gene and Drug Delivery -Challenge to Smart Molecular Therapy-2008

    • Author(s)
      K. Kataoka
    • Organizer
      8th International Biorelated Polymers Symposium 236th American Chemical Society National Meeting & Exposition
    • Place of Presentation
      Philadelphia, PA, USA
    • Year and Date
      2008-08-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] ナノ治療イノベーションを実現する超分子ナノデバイス設計2008

    • Author(s)
      片岡一則
    • Organizer
      第7回国際バイオフォーラム
    • Place of Presentation
      東京ビッグサイト、東京
    • Year and Date
      2008-07-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Supramolecular assemblies of smart block copolymers as nanocarriers for gene and drug delivery- Challenge to intracellular nanomedicine2008

    • Author(s)
      K. Kataoka
    • Organizer
      The 42nd IUPAC World Polymer Congress (MACRO 2008)
    • Place of Presentation
      Taipei International Convention Center, Taipei
    • Year and Date
      2008-07-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] 超分子ナノデバイスによるDDSイノベーション2008

    • Author(s)
      片岡一則
    • Organizer
      第24回日本DDS学会学術集会
    • Place of Presentation
      六本木アカデミーヒルズ、東京
    • Year and Date
      2008-06-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Supra-Molecular Nanodevices for Gene and Drug Delivery2008

    • Author(s)
      K. Kataoka
    • Organizer
      TERMIS-EU 2008
    • Place of Presentation
      Alfandega Congress Center, Porto, Portugal
    • Year and Date
      2008-06-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Supramolecular Devices as Smart Nanocarriers for Gene and Drug Delivery2008

    • Author(s)
      K. Kataoka
    • Organizer
      CeNS Semina
    • Place of Presentation
      Baeyer Lecture Hall, High-tech Campus, LMU Munich, Germany
    • Year and Date
      2008-06-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] 遺伝子治療実用化に向けた高分子ミセル型ナノデバイスの創製2008

    • Author(s)
      片岡一則
    • Organizer
      日本薬剤学会第23年会
    • Place of Presentation
      札幌コンベンションセンター、札幌市
    • Year and Date
      2008-05-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 遺伝子治療実用化に向けたインテリジェント超分子ナノデバイスの構築2008

    • Author(s)
      片岡一則
    • Organizer
      遺伝子・デリバリー研究会第8回シンポジウム
    • Place of Presentation
      千里ライフサイエンスセンター、豊中市
    • Year and Date
      2008-05-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] ナノバイオ・インテグレーションが拓く未来医療〜高分子ミセル型ナノデバイスによる薬物・遺伝子のピンポイントデリバリー〜2008

    • Author(s)
      片岡一則
    • Organizer
      ナノ学会第6回大会
    • Place of Presentation
      九州大学医学部百年記念講堂、福岡
    • Year and Date
      2008-05-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高分子ミセル型超分子ナノデバイスによる薬物・遺伝子デリバリー2008

    • Author(s)
      片岡一則
    • Organizer
      第6回遺伝子治療シンポジウム
    • Place of Presentation
      千里阪急ホテル,大阪
    • Year and Date
      2008-02-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] ナノメディシンが拓く未来医療:ピンポイント診断・治療の実現を目指して2007

    • Author(s)
      片岡一則
    • Organizer
      第133回日本医学会シンポジウム
    • Place of Presentation
      旧本医師会館大講堂,東京
    • Year and Date
      2007-12-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] ナノバイオテクノロジーと高分子の融合による未来医療の開拓2007

    • Author(s)
      片岡一則
    • Organizer
      第25回医用高分子研究会講座
    • Place of Presentation
      山上会館大会議室
    • Year and Date
      2007-11-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] ナノバイオテクノロジーが拓く未来医療2007

    • Author(s)
      片岡一則
    • Organizer
      第48回日本脈管学会総会
    • Place of Presentation
      松本ホテルブエナビスタ
    • Year and Date
      2007-10-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Novel Supramolecular Nanovector for Non-viral Gene Therapy2007

    • Author(s)
      片岡一則
    • Organizer
      第4回21世紀COE国際シンポジラム
    • Place of Presentation
      ヒルトン名古屋,愛知
    • Year and Date
      2007-10-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] ナノバイオテクノロジーが拓く未来医療2007

    • Author(s)
      片岡一則
    • Organizer
      第7回次世代医療システム産業化フォーラム
    • Place of Presentation
      大阪商工会議所7階国際会議ホール
    • Year and Date
      2007-10-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 超分子ナノデバイスによるDDSイノベーション2007

    • Author(s)
      片岡一則
    • Organizer
      NEDO公開シンポジウム「ダブルターゲティングDDS-次世代DDS型治療システム-」
    • Place of Presentation
      東京女子医大弥生記念講堂
    • Year and Date
      2007-10-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] 高分子ミセル型制がん剤の技術開発と臨床展開2007

    • Author(s)
      片岡一則
    • Organizer
      第69回日本血液学会・第49回日本臨床血液学会(合同総会)
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] ナノ構造デバイスによる標的治療2007

    • Author(s)
      片岡一則
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] 薬物・遺伝子デリバリーと高分子ゲル-ナノバイオインターフェイスに挑む-2007

    • Author(s)
      片岡一則
    • Organizer
      ゲルワークショップ イン 名古屋
    • Place of Presentation
      KKR ホテル名古屋
    • Year and Date
      2007-09-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] ナノバイオテクノロジーが拓く未来医療〜高分子ナノミセルによる薬物・遺伝子のピンポイントデリバリー〜2007

    • Author(s)
      片岡一則
    • Organizer
      第11回Molecular Cardiovascular Conference
    • Place of Presentation
      小樽キロロ,北海道
    • Year and Date
      2007-09-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] Supramolecular nanocarriers assembled from block copolymers for gene and drug delivery2007

    • Author(s)
      Kazunori Kataoka
    • Organizer
      The 234th ACS National Meeting
    • Place of Presentation
      Westin Boston Waterfront, Boston
    • Year and Date
      2007-08-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Engineered supra-macromolecular assemblies as nanocarriers for gene and drug delivery2007

    • Author(s)
      Kazunori Kataoka
    • Organizer
      The 3rd SBE International Conference on Bioengineering and Nanotechnology (ICBN 2007)
    • Place of Presentation
      Biopolis, Singapore
    • Year and Date
      2007-08-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] Multimolecular-Assembly of Smart Block Copolymers as Nanocarriers for Gene and Drug Delivery2007

    • Author(s)
      Kazunori Kataoka
    • Organizer
      GelSympo2007
    • Place of Presentation
      東京大学
    • Year and Date
      2007-08-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Smart polymeric micelles as nanocarriers for gene and drug delivery2007

    • Author(s)
      Kazunori Kataoka
    • Organizer
      International Conference on Materials for Advanced Technologies 2007 (ICMAT2007)
    • Place of Presentation
      SuntecSingapore International Convension and Exibition Center, Singapore
    • Year and Date
      2007-07-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Polymeric-micellar nanodevice for smart gene vector2007

    • Author(s)
      片岡一則
    • Organizer
      第13回日本遺伝子治療学会
    • Place of Presentation
      愛知県がんセンター国際医学交流センター
    • Year and Date
      2007-06-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 遺伝子デリバリーのための超分子ナノデバイス設計2007

    • Author(s)
      片岡一則
    • Organizer
      第23回日本DDS学会
    • Place of Presentation
      ホテル日航熊本,熊本
    • Year and Date
      2007-06-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] Light-induced Gene and Drug Delivery by Supramolecular Nanocarrier2007

    • Author(s)
      Kazunori Kataoka
    • Organizer
      3rd Pharmaceutical Sciences World Congress (PSWC2007)
    • Place of Presentation
      Amsterdam RAI, The Netherlands
    • Year and Date
      2007-04-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] ナノバイオテクノロジーが拓く未来医療:ピンポイント診断・治療のためのナノデバイス設計2007

    • Author(s)
      片岡一則
    • Organizer
      第4回「東京大学の生命科学」シンポジウム
    • Place of Presentation
      安田講堂,東京大学
    • Year and Date
      2007-04-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] ナノバイオテクノロジーが拓く未来医療〜超分子ナノデバイスによるセルセラピー〜2007

    • Author(s)
      片岡一則
    • Organizer
      第27回日本医学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2007-04-08
    • Related Report
      2007 Annual Research Report
  • [Book] 抗がん剤を運ぶシステム:高分子ミセル型DDS、現代化学(464)2009

    • Author(s)
      宮田完二郎、片岡一則
    • Related Report
      2009 Final Research Report
  • [Book] ナノテクノロジーの癌医療への応用 高分子ミセル型抗癌剤の開発、癌と化学療法36(3)2009

    • Author(s)
      西山伸宏、片岡一則
    • Related Report
      2009 Final Research Report
  • [Book] 細胞工学2008

    • Author(s)
      西山伸宏、片岡一則
    • Publisher
      人工ウイルスの実現に向けた高分子ミセル型ベクターの設計
    • Related Report
      2007 Annual Research Report
  • [Book] 血管医学2007

    • Author(s)
      西山伸宏、片岡一則
    • Publisher
      ドラッグデリバリーシステム(DDS)と血管
    • Related Report
      2007 Annual Research Report
  • [Book] 高分子2007

    • Author(s)
      西山伸宏、片岡一則
    • Publisher
      先端医療のためのインテリジェント型高分子ミセルの設計
    • Related Report
      2007 Annual Research Report
  • [Book] レーザー研究2007

    • Author(s)
      西山伸宏、片岡一則
    • Publisher
      デンドリマー光増感剤を利用した部位選択的遺伝子導入
    • Related Report
      2007 Annual Research Report
  • [Book] ゲノム医学2007

    • Author(s)
      西山伸宏、片岡一則
    • Publisher
      分子標的治療薬とDDSの融合とのその可能性
    • Related Report
      2007 Annual Research Report
  • [Book] Mebio Oncology, 松村保広編、メジカルレビュー社2007

    • Author(s)
      西山伸宏、片岡一則
    • Publisher
      高分子ミセルを利用したがん標的治療
    • Related Report
      2007 Annual Research Report
  • [Book] 呼吸と循環2007

    • Author(s)
      西山伸宏、鄭雄一、片岡一則
    • Publisher
      循環器疾患の治療のためのナノDDS
    • Related Report
      2007 Annual Research Report
  • [Book] インテリジェント高分子ミセルからのDDS2006

    • Author(s)
      Younsoo Bae, 片岡一則
    • Publisher
      最新医学(最新医学社)
    • Related Report
      2006 Annual Research Report
  • [Book] 医学のためのナノ工学2006

    • Author(s)
      西山伸宏, 片岡一則
    • Total Pages
      6
    • Publisher
      日本臨床社
    • Related Report
      2005 Annual Research Report
  • [Remarks] 2009年7月NIMS Award 2009 2008年6月Controlled Release Society Founders Award

    • Related Report
      2009 Final Research Report
  • [Remarks] 2009年5月10日日本経済新聞サイエンス:がん患部直接たたけ2007年1月22日読売新聞夕刊偶然の球体患部狙い撃ち

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.bmw.t.u-tokyo.ac.jp/research/research2-1.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.bmw.t.u-tokyo.ac.jp/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.bmw.t.u-tokyo.ac.jp/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.bmw.t.u-tokyo.ac.jp/research/research2-1.html

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] カチオン性のポリ(アミノ酸)およびその使用2009

    • Inventor(s)
      西山伸宏, 片岡一則, 宮田完二郎, 石井武彦, 呉寿栄, キムヒュンジン
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Number
      2009-031799
    • Filing Date
      2009-02-12
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] Size Controlled Micelle of Plutinum Coordination Complex2009

    • Inventor(s)
      片岡一則, 他3名
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2009-07-16
    • Related Report
      2009 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] カチオン性のポリ(アミノ酸)およびその使用2009

    • Inventor(s)
      片岡一則, 他5名
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Number
      2009-031799
    • Filing Date
      2009-02-12
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] ポリエチレングリコールの結合した核酸のコンジュゲートとリン酸カルシウムの有機-無機ハイブリッド型ナノ粒子2007

    • Inventor(s)
      片岡一則他4名
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Number
      2007-280803
    • Filing Date
      2007-10-29
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] tgf-βシグナル阻害剤と抗腫瘍剤の組み合せ使用2006

    • Inventor(s)
      宮園浩平, 狩野光伸, べーユンスー, 西山伸宏, 片岡一則
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Filing Date
      2006-08-30
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] TGF-βシグナル阻害剤と抗腫瘍剤の組み合わせ使用2006

    • Inventor(s)
      西山伸宏, 他4名
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2006-02-01
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] pH応答性高分子ミセルの調整に用いる新規ブロック共合体及びその製造法の提供2005

    • Inventor(s)
      片岡 一則, 他4名
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Number
      2005-035233
    • Filing Date
      2005-04-22
    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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