Cell surface antigenic molecules as targets for immunotherapy

• Project/Area Number: 17016049
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Yamaguchi University
• Principal Investigator: HINODA Yuji Yamaguchi University, 大学院・医学系研究科, 教授 (10165128)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥45,000,000 (Direct Cost: ¥45,000,000); Fiscal Year 2009: ¥9,000,000 (Direct Cost: ¥9,000,000); Fiscal Year 2008: ¥9,000,000 (Direct Cost: ¥9,000,000); Fiscal Year 2007: ¥9,000,000 (Direct Cost: ¥9,000,000); Fiscal Year 2006: ¥9,000,000 (Direct Cost: ¥9,000,000); Fiscal Year 2005: ¥9,000,000 (Direct Cost: ¥9,000,000)
• Keywords: がん / 免疫療法 / 細胞表面抗原分子 / 樹状細胞 / mRNA / Wntシグナル経路 / frizzled-7 / 大腸癌 / Frizzled-7 / si-RNA / 樹状細胞療法 / 細胞プロセシング / rizzled-7 / 大腸癌細胞 / siRNA / 免疫学的モニタリング / 結核菌抗原 / Interferon-γ / 抗体療法 / RHAMM / モノクローナル抗体

Research Abstract

For the purpose of development of the immunotherapy targeting cell surface antigenic molecules, we evaluated dendritic cell therapy using mRNA as antigen and antibody therapy in this study. For dendritic cell therapy, we performed the preclinical studies with several mouse models and then its clinical application in liver, biliary and pancreatic cancer patients. With regard to antibody therapy, we examined the molecules that express in cancer stem cells and found that a receptor molecule, Frizzled-7, is highly expressed in colorectal cancer and could be a potential therapeutic target.

Research Products

• [Journal Article] TWIST1 hyper- methylation is observed frequently in colorectal tumors and its overexpression is associated with (2009)
  • Author(s): Okada T, Suehiro Y, Ueno K, Mitomori S, Kaneko S, Nishioka M, Okayama N, Sakai K, Higaki S, Hazama S, Hirata H, Sakaida I, Oka M, Hinoda Y
  • Journal Title: Genes Chromosomes Cancer 49 Pages: 452-62
  • Peer Reviewed
• [Journal Article] Role of secreted frizzled-related protein 3 in human renal cell carcinoma (2009)
  • Author(s): Hirata H, Hinoda Y, Ueno K, Majid S, Saini S, Dahiya R
  • Journal Title: Cancer Res 70 Pages: 1896-905
  • Peer Reviewed
• [Journal Article] Methylation level of the RASSF1A promoter is an independent prognostic factor for clear-cell renal cell carcinoma (2009)
  • Author(s): Kawai Y, Sakano S, Suehiro Y, Okada T, Korenaga Y, Hara T, Naito K, Matsuyama H, Hinoda Y
  • Journal Title: Ann Oncol (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Phase I study of irinotecan and doxifluridine for metastatic colorectal cancer focusing on the UGT1A1*28 polymorphism (2009)
  • Author(s): Hazama S, Nagashima A, Kondo H, Yoshida S, Shimizu R, Araki A, Yoshino S, Okayama N, Hinoda Y, Oka M
  • Journal Title: Cancer Sci 101 Pages: 722-7
  • NAID: 10026589707
  • Peer Reviewed
• [Journal Article] Vaccine therapy with dendritic cells transfected with Il13ra2 mRNA for glioma in mice (2009)
  • Author(s): Saka M, Amano T, Kajiwara K, Yoshikawa K, Ideguchi M, Nomura S, Fujisawa H, Kato S, Fujii M, Ueno K, Hinoda Y, Suzuki M
  • Journal Title: J Neurosurg (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells (2009)
  • Author(s): Ueno K, Hazama S, Mitomori S, Nishioka M, Suehiro Y, Hirata H, Oka M, Imai K, Dahiya R, Hinoda Y
  • Journal Title: Br J Cancer 101 Pages: 1374-81
  • Peer Reviewed
• [Journal Article] Association of TP53 and MDM2 polymorphisms with survival in bladder cancer patients treated with chemoradiotherapy (2009)
  • Author(s): Shinohara A, Sakano S, Hinoda Y, Nishijima J, Kawai Y, Misumi T, Nagao K, Hara T, Matsuyama H
  • Journal Title: Cancer Sci 100 Pages: 2376-82
  • NAID: 10027198427
  • Peer Reviewed
• [Journal Article] Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways (2009)
  • Author(s): Hirata H, Hinoda Y, Nakajima K, Kawamoto K, Kikuno N, Kawakami K, Yamamura S, Ueno K, Majid S, Saini S, Ishii N, Dahiya R
  • Journal Title: Clin Cancer Res 15 Pages: 5678-87
  • Peer Reviewed
• [Journal Article] Wnt antagonist gene polymorphisms and renal cancer (2009)
  • Author(s): Hirata H, Hinoda Y, Nakajima K, Kikuno N, Yamamura S, Kawakami K, Suehiro Y, Tabatabai ZL, Ishii N, Dahiya R
  • Journal Title: Cancer 115 Pages: 4488-503
  • Peer Reviewed
• [Journal Article] The bcl2 -938CC genotype has poor prognosis and lower survival in renal cancer (2009)
  • Author(s): Hirata H, Hinoda Y, Nakajima K, Kikuno N, Suehiro Y, Tabatabai ZL, Ishii N, Dahiya R
  • Journal Title: J Urol 182 Pages: 721-7
  • Peer Reviewed
• [Journal Article] Bcl2 -938C/A polymorphism carries increased risk of biochemical recurrence after radical prostatectomy (2009)
  • Author(s): Hirata H, Hinoda Y, Kikuno N, Suehiro Y, Shahryari V, Ahmad AE, Tabatabai ZL, Igawa M, Dahiya R
  • Journal Title: J Urol 181 Pages: 1907-12
  • Peer Reviewed
• [Journal Article] TWIST1 hyperlnethylation is observed frequently in colorectal tumors and its overexpression is associated with unfavorable outcomes in patients with colorectal cancer. (2009)
  • Author(s): Okada Toshiyuki
  • Journal Title: Genes Chromosomes Cancer 49 Pages: 452-462
  • Peer Reviewed
• [Journal Article] Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. (2009)
  • Author(s): Ueno Koji
  • Journal Title: Br J Cancer 101 Pages: 1374-1381
  • Peer Reviewed
• [Journal Article] Vaccine therapy with dendritic cells transfected with II13ra2 mRNA for glioma in mice. (2009)
  • Author(s): Saka Makoto
  • Journal Title: J Neurosurg Epub ahead of print
  • Peer Reviewed
• [Journal Article] Frizzled-7 as a potential therapeutic target in colorectal cancer (2008)
  • Author(s): Ueno K, Hiura M, Suehiro Y, Hazama S, Hirata H, Oka M, Imai K, Dahiya R, Hinoda Y
  • Journal Title: Neoplasia 10 Pages: 697-705
  • Peer Reviewed
• [Journal Article] Aneuploidy predicts outcome in patients with endometrial carcinoma and is related to lack of CDH13 hypermethylation (2008)
  • Author(s): Suehiro Y, Okada T, Okada T, Anno K, Okayama N, Ueno K, Hiura M, Nakamura M, Kondo T, Oga A, Kawauchi S, Hirabayashi K, Numa F, Ito T, Saito T, Sasaki K, Hinoda Y
  • Journal Title: Clin Cancer Res 14 Pages: 3354-61
  • Peer Reviewed
• [Journal Article] Epigenetic-Genetic Interactions in the APC/WNT, RAS/RAF, and P53 Pathways in Colorectal Carcinoma (2008)
  • Author(s): Suehiro Y, Wong CW, Chirieac LR, Kondo Y, Shen L, Webb CR, Chan YW, Chan AS, Chan TL, Wu TT, Rashid A, Hamanaka Y, Hinoda Y, Shannon RL, Wang X, Morris J, Issa JP, Yuen ST, Leung SY, Hamilton SR
  • Journal Title: Clin Cancer Res 14 Pages: 2560-9
  • Peer Reviewed
• [Journal Article] changes in aberrant crypt foci and serrated polyps (2008)
  • Author(s): Suehiro Y, Hinoda Y. Genetic, epigenetic
  • Journal Title: Cancer Sci 99 Pages: 1071-6
  • Peer Reviewed
• [Journal Article] Mismatch repair gene MSH3 polymorphism is associated with the risk of sporadic prostate cancer (2008)
  • Author(s): Hirata H, Hinoda Y, Kawamoto K, Kikuno N, Suehiro Y, Okayama N, Tanaka Y, Dahiya R
  • Journal Title: J Urol 179 Pages: 2020-4
  • Peer Reviewed
• [Journal Article] COMT polymorphisms affecting protein expression are risk factors for endometrial cancer (2008)
  • Author(s): Hirata H, Hinoda Y, Okayama N, Suehiro Y, Kawamoto K, Kikuno N, Rabban JT, Chen LM, Dahiya R
  • Journal Title: Mol Carcinog 47 Pages: 768-74
  • Peer Reviewed
• [Journal Article] DNA repair gene polymorphisms may be associated with prognosis of upper urinary tract transitional cell carcinoma (2008)
  • Author(s): Sasaki M, Sakano S, Okayama N, Akao J, Hara T, Kawai Y, Ohmi C, Hinoda Y, Naito K
  • Journal Title: Neoplasia 10 Pages: 255-65
  • Peer Reviewed
• [Journal Article] polymorphisms are risk factors for endometrial cancer susceptibility (2008)
  • Author(s): Hirata H, Hinoda Y, Okayama N, Suehiro Y, Kawamoto K, Kikuno N, Rabban JT, Chen LM, Dahiya R. CYP1A1, SULT1A1, SULT1E1
  • Journal Title: Cancer 112 Pages: 1964-73
  • Peer Reviewed
• [Journal Article] Hyper- methylation status of APC inversely correlates with the presence of submucosal invasion in laterally spreading colorectal tumors (2008)
  • Author(s): Hashimoto K, Shimizu Y, Suehiro Y, Okayama N, Hashimoto S, Okada T, Hiura M, Ueno K, Hazama S, Higaki S, Hamanaka Y, Oka M, Sakaida I, Hinoda Y
  • Journal Title: Mol Carcinog 47 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Adoptive immunotherapy for pancreatic cancer using MUC1 peptide-pulsed dendritic cells and activated T lymphocytes (2008)
  • Author(s): Kondo H, Hazama S, Kawaoka T, Yoshino S, Yoshida S, Tokuno K, Takashima M, Ueno T, Hinoda Y, Oka M
  • Journal Title: Anticancer Res 28 Pages: 379-87
  • Peer Reviewed
• [Journal Article] Frizzled-7 as a potential therapeutic target in colorectal cancer (2008)
  • Author(s): Ueno K, et.al.
  • Journal Title: Neoplasia 10 Pages: 697-705
  • Peer Reviewed
• [Journal Article] Aneuploidy predicts outcome in patients with endometrial carcinoma and is related to lack of CDH 13 hypermethylation (2008)
  • Author(s): Suehiro Y., et.al.
  • Journal Title: Clin Cancer Res 14 Pages: 3354-3361
  • Peer Reviewed
• [Journal Article] Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma (2008)
  • Author(s): Suehiro Y., et.al.
  • Journal Title: Clin Cancer Res 14 Pages: 2560-2569
  • Peer Reviewed
• [Journal Article] A simple immunomonitoring procedure for mRNAloaded dendritic cell therapy (2007)
  • Author(s): Hiura M, Ueno K, Suehiro Y, Hazama S, Oka M, Imai K, Hinoda Y
  • Journal Title: Tumour Biol 28 Pages: 350-7
  • Peer Reviewed
• [Journal Article] CXCL12 G801A polymorphism is a risk factor for sporadic prostate cancer susceptibility (2007)
  • Author(s): Hirata H, Hinoda Y, Kikuno N, Kawamoto K, Dahiya AV, Suehiro Y, Tanaka Y, Dahiya R
  • Journal Title: Clin Cancer Res 13 Pages: 5056-62
  • Peer Reviewed
• [Journal Article] The association of DNA repair gene polymorphisms with the development and progression of renal cell carcinoma (2007)
  • Author(s): Sakano S, Hinoda Y, Okayama N, Kawai Y, Korenaga Y, Eguchi S, Nagao K, Ohmi C, Naito K
  • Journal Title: Ann Oncol 18 Pages: 1817-27
  • Peer Reviewed
• [Journal Article] MDM2 SNP309 polymorphism as risk factor for susceptibility and poor prognosis in renal cell carcinoma (2007)
  • Author(s): Hirata H, Hinoda Y, Kikuno N, Kawamoto K, Suehiro Y, Tanaka Y, Dahiya R
  • Journal Title: Clin Cancer Res 13 Pages: 4123-9
  • Peer Reviewed
• [Journal Article] Polymorphisms of DNA repair genes are risk factors for prostate cancer (2007)
  • Author(s): Hirata H, Hinoda Y, Tanaka Y, Okayama N, Suehiro Y, Kawamoto K, Kikuno N, Majid S, Vejdani K, Dahiya R
  • Journal Title: Eur J Cancer 43 Pages: 231-7
  • Peer Reviewed
• [Journal Article] Association of interleukin-19 gene polymorphisms with age (2007)
  • Author(s): Okayama N, Suehiro Y, Hamanaka Y, Nakamura J, Hinoda Y
  • Journal Title: J Gerontol A Biol Sci Med Sci 62 Pages: 507-11
  • Peer Reviewed
• [Journal Article] Antitumor effects of vaccination with dendritic cells transfected with modified receptor for hyaluronan-mediated motility mRNA in a mouse glioma model (2007)
  • Author(s): Amano T, Kajiwara K, Yoshikawa K, Morioka J, Nomura S, Fujisawa H, Kato S, Fujii M, Fukui M, Hinoda Y, Suzuki M
  • Journal Title: J Neurosurg 106 Pages: 638-45
  • Peer Reviewed
• [Journal Article] A simple immunomonitoring procedure for mRNA-loaded dendritic cell therapy. (2007)
  • Author(s): Hiura M, et. al.
  • Journal Title: Tumor Biol. 28 Pages: 350-357
  • Peer Reviewed
• [Journal Article] Antitumor effects of vaccination with dendritic cells transfected with modified receptor for hyaluronan-mediated motility mRNAin a mouse glioma model. (2007)
  • Author(s): Amamo T, et. al.
  • Journal Title: J Neurosurg. 106 Pages: 638-645
  • Peer Reviewed
• [Journal Article] CXCL12 G801Apolymorphsim is a risk factor for sporadic prostate cancer susceptibility. (2007)
  • Author(s): Hirata H, et. al.
  • Journal Title: Clin.Cancer Res. 13 Pages: 5056-5062
  • Peer Reviewed
• [Journal Article] Anti-tumor effects of vaccination with dendritic cells transfected with modified RHAMM (receptor for hyaluronan-mediated motility) mRNA for mice glioma. (2007)
  • Author(s): Amano et al.
  • Journal Title: Journal of Neurosurgery 106(4) Pages: 638-645
• [Journal Article] Polymorphisms of DNA repair genes are associated with renal cell carcinoma. Biochem (2006)
  • Author(s): Hirata H, Hinoda Y, Matsuyama H, Tanaka Y, Okayama N, Suehiro Y, Zhao H, Urakami S, Kawamoto K, Kawakami T, Igawa M, Naito K, Dahiya R
  • Journal Title: Biophys. Res. Commun 342 Pages: 1058-1062
  • Peer Reviewed
• [Journal Article] Catechol-O- methyltransferase gene polymorphisms in benign prostatic hyperplasia and sporadic prostate cancer (2006)
  • Author(s): Tanaka Y, Sasaki M, Shiina H, Tokizane T, Deguchi M, Hirata H, Hinoda Y, Okayama N, Suehiro Y, Urakami S, Kawakami T, Kaneuchi M, Pookot D, Igawa M, Okuyama A, Ishii N, Dahiya R
  • Journal Title: Cancer Epidemiol. Biomarkers Prev 15 Pages: 238-244
  • Peer Reviewed
• [Journal Article] Interaction of OGG1 Ser326Cys polymorphism with cigarette smoking in head and neck squamous cell carcinoma (2006)
  • Author(s): Hashimoto T, Uchida K, Okayama N, Imate Y, Suehiro Y, Hamanaka Y, Ueyama Y, Yamashita H, Hinoda Y
  • Journal Title: Mol Carcinog 45 Pages: 344-348
  • Peer Reviewed
• [Journal Article] Anti-tumor activity of dendritic cells transfected with mRNA for receptor for hyaluronan-mediated motility is mediated by CD4+ T cells (2006)
  • Author(s): Fukui M, Ueno K, Suehiro Y, Hamanaka Y, Imai K, Hinoda Y
  • Journal Title: Cancer Immunol Immunother 55 Pages: 538-46
  • Peer Reviewed
• [Journal Article] Relation between cytokine promoter gene polymorphism and toxicity of 5-fluorouracil plus cisplatin chemotherapy (2006)
  • Author(s): Sakamoto K, Oka M, Yoshino S, Hazama S, Abe T, Okayama N, Hinoda Y
  • Journal Title: Oncol Rep 16 Pages: 381-387
  • Peer Reviewed
• [Journal Article] Antisense Therapy of MAdCAM-1 for Trinitrobenzenesulfonic Acid-Induced Murine Colitis (2006)
  • Author(s): Goto A, Arimura Y, Shinomura Y, Imai K, Hinoda Y
  • Journal Title: Inflamm. Bowel Dis 12 Pages: 758-765
  • Peer Reviewed
• [Journal Article] Anti-tumor activity of dendritic cells transtected with mRNA for receptor for hyaluronan-mediated motility is mediated by CD4(+)T cells. (2006)
  • Author(s): Fukui et al.
  • Journal Title: Cancer Immunol Immunother 55・5 Pages: 538-546
• [Journal Article] Antisense Therapy of MAdCAM-1 for Trinitrobenzenesulfonic Acid-Induced Murine Colitis. (2006)
  • Author(s): Goto et al.
  • Journal Title: Inflamm. Bowel Dis 12(8) Pages: 758-765
• [Journal Article] Relation between cytokine promoter gene polymorphism and toxicity of 5-fluorouracil plus cisplatin chemotherapy. (2006)
  • Author(s): Sakamoto et al.
  • Journal Title: Oncol. Rep 16(2) Pages: 381-387
• [Journal Article] Anti-tumor effects of vaccination with dendritic cells transfected with modified RHAMM (receptor for hyaluronan-mediated motility) mRNA for mice glioma. (2006)
  • Author(s): Amano et al.
  • Journal Title: Journal of Neurosurgery (In press)
• [Journal Article] Anti-tumor activity of dendritic cells transfected with mRNA for receptor for hyaluronan-mediated motility is mediated by CD4(+) T cells. (2006)
  • Author(s): Fukui et al.
  • Journal Title: Cancer Immunol Immunother 55・5 Pages: 538-546
• [Journal Article] MUC1 peptide vaccination in patients with advanced pancreas or biliary tract cancer (2005)
  • Author(s): Yamamoto K, Ueno T, Kawaoka T, Hazama S, Fukui M, Suehiro Y, Hamanaka Y, Ikematsu Y, Imai K, Oka M, Hinoda Y
  • Journal Title: Anticancer Res 25 Pages: 3575-9
  • Peer Reviewed
• [Journal Article] The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer (2005)
  • Author(s): Akino K, Toyota M, Suzuki H, Mita H, Sasaki Y, Ohe-Toyota M, Issa JP, Hinoda Y, Imai K, Tokino T
  • Journal Title: Gastroenterology 129 Pages: 156-169
  • Peer Reviewed
• [Journal Article] Association of the BCRP C421A polymorphism with nonpapillary renal cell carcinoma (2005)
  • Author(s): Korenaga Y, Naito K, Okayama N, Hirata H, Suehiro Y, Hamanaka Y, Matsuyama H, Hinoda Y
  • Journal Title: Int. J. Cancer 117 Pages: 431-434
  • Peer Reviewed
• [Journal Article] Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts (2005)
  • Author(s): Min Y, Adachi Y, Yamamoto H, Imsumran A, Arimura Y, Endo T, Hinoda Y, Lee CT, Nadaf S, Carbone DP, Imai K
  • Journal Title: Gut 54 Pages: 591-600
  • Peer Reviewed
• [Journal Article] Gene expression profiling of colorectal adenomas and early invasive carcinomas by cDNA array analysis (2005)
  • Author(s): Nosho K, Yamamoto H, Adachi Y, Endo T, Hinoda Y, Imai K
  • Journal Title: Br. J. Cancer 92 Pages: 1193-200
  • Peer Reviewed
• [Journal Article] Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours (2005)
  • Author(s): Murai M, Toyota M, Satoh A, Suzuki H, Akino K, Mita H, Sasaki Y, Ishida T, Shen L, Garcia-Manero G, Issa JP, Hinoda Y, Tokino T, Imai K
  • Journal Title: Br. J. Cancer 92 Pages: 1165-1172
  • Peer Reviewed
• [Journal Article] Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer (2005)
  • Author(s): Murai M, Toyota M, Suzuki H, Satoh A, Sasaki Y, Akino K, Ueno M, Takahashi F, Kusano M, Mita H, Yanagihara K, Endo T, Hinoda Y, Tokino T, Imai K
  • Journal Title: Clin. Cancer Res 11 Pages: 1021-1027
  • Peer Reviewed
• [Journal Article] Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis (2005)
  • Author(s): Nosho K, Yoshida M, Yamamoto H, Taniguchi H, Adachi Y, Mikami M, Hinoda Y, Imai K
  • Journal Title: Carcinogenesis 26 Pages: 892-899
  • Peer Reviewed
• [Journal Article] MUC1 peptide vaccination in patients with advanced pancreas or biliary tract cancer. (2005)
  • Author(s): Yamamoto et al.
  • Journal Title: Anticancer Res 25・5 Pages: 3575-3579
• [Journal Article] Association of interleukin-10 promoter single nucleotide polymorphisms-819 T/C and-592 A/C with aging. (2005)
  • Author(s): Okayama et al.
  • Journal Title: J Gerontol A Biol Sci Med Sci. 60・12 Pages: 1525-1529
• [Presentation] RASSF1A遺伝子プロモーター領域のメチル化レベルは淡明細胞型腎癌患者の独立予後予測因子となる (2009)
  • Author(s): 川井禎久、坂野滋、末広寛、岡田季之、原 智彦、長尾一公、原貴彦、松山豪泰、日野田裕治
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜市
• [Presentation] IL13Rα2(interleukin thirteen receptor alpha2)mRNA導入樹状細胞を用いたグリオーマワクチン療法 (2009)
  • Author(s): 坂真人、梶原浩司、天野貴之、吉川功一、出口誠、上野耕司、日野田裕治、鈴木倫保
  • Organizer: 第13回日本がん免疫学会総会
  • Place of Presentation: 北九州市
• [Presentation] Frizzled-7 as a potential therapeutic target in colorectal cancer (2008)
  • Author(s): Ueno K., et.al.
  • Organizer: 36^<th> Meeting of the International Society of Oncology and BioMarkers
  • Place of Presentation: 東京
  • Year and Date: 2008-10-08
• [Presentation] Frizzled-7 as a Potential Therapeutic Target in Colorectal Cancer (2008)
  • Author(s): Koji Ueno, Sayaka kaneko, Mikiko Nakamura, Yutaka Suehiro, Kohzoh Imai, Yuji Hinoda
  • Organizer: The 36th Meeting of the International Society of Oncologyand BioMarkers
  • Place of Presentation: ISOBM 2008, Tokyo
• [Presentation] Aneuploidy Predicts Outcome in Patients with Endometrial Carcinoma and is Related to Lack of CDH13 Hypermethylation (2008)
  • Author(s): Yutaka Suehiro, Yuji Hinoda
  • Organizer: The 36th Meeting of the International Society of Oncology and BioMarkers
  • Place of Presentation: ISOBM 2008, Tokyo
• [Presentation] Frizzled-7 is a candidate therapeutic target for colorectal cancer (2007)
  • Author(s): 上野耕司ほか
  • Organizer: 日本癌学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2007-10-03
• [Presentation] A simple method for immuno-monitoring mRNA-loaded dendritic cell therapy (2007)
  • Author(s): Mikako Hiura, Koji Ueno, Mikiko Fukui, Yutaka Suehiro, Kohzoh Imai, Yuji Hinoda
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜市
• [Presentation] Frizzled-7 is a candidate therapeutic target for colorectal cancer (2007)
  • Author(s): Koji Ueno, Mikako Hiura, Mikiko Fukui, Yutaka Suehiro, Kohzoh Imai, Yuji Hinoda
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜市
• [Presentation] Hypermethylation status of APC predicts the presence of submucosal invasion in laterally spreading colorectal tumors (2007)
  • Author(s): Yutaka Suehiro, Yuji Hinoda
  • Organizer: American Association for Cancer Research Annual Meeting
  • Place of Presentation: Los Angeles
• [Patent(Industrial Property Rights)] Frizzled-7活性抑制物質 (2009)
  • Inventor(s): 日野田裕治, 他
  • Industrial Property Rights Holder: 日野田裕治, 他
  • Filing Date: 2009-02-12
• [Patent(Industrial Property Rights)] 大腸腫瘍の検出方法 (2009)
  • Inventor(s): 日野田裕治, 他
  • Industrial Property Rights Holder: 日野田裕治, 他
  • Filing Date: 2009-04-03
• [Patent(Industrial Property Rights)] 大腸腫瘍の検出方法 (2009)
  • Inventor(s): 日野田裕治, 他
  • Industrial Property Rights Holder: 日野田裕治, 他
  • Filing Date: 2009-04-03
• [Patent(Industrial Property Rights)] Frizzled-7活性抑制物質 (2009)
  • Inventor(s): 日野田裕治, 他4名
  • Industrial Property Rights Holder: 山口大学
  • Filing Date: 2009-02-12