| Budget Amount *help |
¥43,800,000 (Direct Cost: ¥43,800,000)
Fiscal Year 2009: ¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 2008: ¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 2007: ¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 2006: ¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 2005: ¥9,000,000 (Direct Cost: ¥9,000,000)
|
|---|
| Research Abstract |
Thymidine phosphorylase is an enzyme that has an angiogenic activity. 2-Deoxy-D-ribose, one of the degradation products of thymidine produced by TP also has an angiogenic activity. As well as the inhibitor of TP, 2-deoxy-L-ribose, an stereoisomer of 2-deoxy-D-ribose, suppressed the growth, invasion and metastasis of the TP-expressing tumors. ROS was produced by TP and 2-deoxy-D-ribose, and the ROS activated NFκB. The activated NFκB enhanced the expression of IL-8 and MMPs that are involved in angiogenesis.
|
