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Immunotherapy using humanized monoclonal antibody

Research Project

Project/Area Number 17016060
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionSapporo Medical University

Principal Investigator

IMAI Kohzoh  Sapporo Medical University, 学長 (60117603)

Co-Investigator(Kenkyū-buntansha) ISHIDA Tadao  札幌医科大学, 医学部, 准教授 (20305220)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥138,600,000 (Direct Cost: ¥138,600,000)
Fiscal Year 2009: ¥27,500,000 (Direct Cost: ¥27,500,000)
Fiscal Year 2008: ¥27,500,000 (Direct Cost: ¥27,500,000)
Fiscal Year 2007: ¥27,500,000 (Direct Cost: ¥27,500,000)
Fiscal Year 2006: ¥27,500,000 (Direct Cost: ¥27,500,000)
Fiscal Year 2005: ¥28,600,000 (Direct Cost: ¥28,600,000)
Keywordsヒト抗体 / 免疫療法 / モノクローナル抗体 / ヒト型抗体 / 免疫治療 / モロクローナル抗体
Research Abstract

We have been developed the new monoclonal antibody against FGFR-1, which express on human hepatocellular carcinoma and induced by IFN. When we administrate this antibody and IFN simultaneously, strong anti-cancer effect was observed in vitro and in vivo. Furthermore, we have been developed other monoclonal antibodies aimed at therapy for gastric cancer. These are the humanized bispecific monoclonal antibody targeted tumor antigen×CD3 and the humanized trifunctional bispecific antibody which have the Fc region.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (94 results)

All 2010 2009 2008 2007 2006 2005

All Journal Article (80 results) (of which Peer Reviewed: 55 results) Presentation (11 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.2010

    • Author(s)
      Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa JP, Shinomura Y, Tokino T, Toyota M
    • Journal Title

      Carcinogenesis Vol.31

      Pages: 342-349

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.2010

    • Author(s)
      Suzuki H
    • Journal Title

      Carcinogenesis 31

      Pages: 342-349

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting for insulin-like growth factor-I receptor with short hairpin RNA for human digestive/gastrointestinal cancers.2010

    • Author(s)
      Wang Y
    • Journal Title

      J Gastroenterol 45

      Pages: 159-170

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies.2009

    • Author(s)
      Taniguchi H, Fernandez AF, Setien F, Ropero S, Ballestar E, Villanueva A, Yamamoto H, Imai K, Shinomura Y, Esteller M
    • Journal Title

      Cancer Res Vol.69

      Pages: 8447-8454

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells.2009

    • Author(s)
      Idogawa M, Sasaki Y, Suzuki H, Mita H, Imai K, Shinomura Y, Tokino T
    • Journal Title

      Clin Cancer Res Vol.15

      Pages: 3725-3732

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies.2009

    • Author(s)
      Taniguchi H
    • Journal Title

      Cancer Res 69

      Pages: 8447-8454

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistance in multiple myeloma2009

    • Author(s)
      Nojima M
    • Journal Title

      Clin Cancer Res 15

      Pages: 4356-4364

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers : involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth.2009

    • Author(s)
      Mita H
    • Journal Title

      BMC Cancer 9

      Pages: 1-16

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insulin-like growth factor-I receptor blockade reduces the invasiveness of gastrointestinal cancers via blocking production of matrilysin.2009

    • Author(s)
      Adachi Y
    • Journal Title

      Carcinogenesis 30

      Pages: 1305-1313

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells.2009

    • Author(s)
      Idogawa M
    • Journal Title

      Clin Cancer Res 15

      Pages: 3725-3732

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity.2009

    • Author(s)
      Yabana T
    • Journal Title

      J Pathol 218

      Pages: 350-359

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preventing oxidative stress : a new role for XBP1.2009

    • Author(s)
      Liu Y
    • Journal Title

      Cell Death Differ 16

      Pages: 847-857

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cancer epigenomics : implications of DNA methylation in personalized cancer therapy.2009

    • Author(s)
      Toyota M
    • Journal Title

      Cancer Sci. 100

      Pages: 787-791

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen.2009

    • Author(s)
      Yamaoka S
    • Journal Title

      World J Gastroenterol 15

      Pages: 5579-5585

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of beta3/gamma2 chains of laminin-5 and MMP7 in biliary cancer.2009

    • Author(s)
      Oka T
    • Journal Title

      World J Gastroenterol 15

      Pages: 3865-3873

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p53 family members regulate the expression of the apolipoprotein D gene2009

    • Author(s)
      Sasaki Y
    • Journal Title

      J Biol Chem 284

      Pages: 872-883

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.2008

    • Author(s)
      Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, Tokino T
    • Journal Title

      Cancer Res Vol.68

      Pages: 4123-4132

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer.2008

    • Author(s)
      Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane T, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka H, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T
    • Journal Title

      Carcinogenesis Vol.29

      Pages: 1312-1318

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.2008

    • Author(s)
      Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, Dohi T
    • Journal Title

      Gastroenterology Vol.135

      Pages: 142-151

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics.2008

    • Author(s)
      Imai K, Yamamoto H
    • Journal Title

      Carcinogenesis Vol.29

      Pages: 673-680

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel molecular-targeted therapeutics for the treatment of cancer.2008

    • Author(s)
      Yasui H, Imai K
    • Journal Title

      Anticancer Agents Med Chem Vol.8

      Pages: 470-480

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer2008

    • Author(s)
      Toyota M
    • Journal Title

      Cancer Res 68

      Pages: 4123-4132

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer2008

    • Author(s)
      Suzuki H
    • Journal Title

      Br J Cancer 98

      Pages: 1147-1156

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells2008

    • Author(s)
      Ting AH
    • Journal Title

      Cancer Res 68

      Pages: 2570-2575

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel molecular-targeted therapeutics for the treatment of cancer2008

    • Author(s)
      Yasui H
    • Journal Title

      Anticancer Agents Med Chem 8

      Pages: 470-480

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis2008

    • Author(s)
      Yamamoto E
    • Journal Title

      Cancer Epidemiol Biomarkers Prev 17

      Pages: 2555-2564

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers2008

    • Author(s)
      Oki M
    • Journal Title

      World J Gastroenterol 14

      Pages: 5650-5656

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA methylation and cancer pathways in gastrointestinal tumor2008

    • Author(s)
      Suzuki H
    • Journal Title

      Pharmacogenomics 9

      Pages: 1917-1928

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Over-expression of cysteine proteinase inhibitor cystatin 6 promotes pancreatic cancer growth2008

    • Author(s)
      Hosokawa M
    • Journal Title

      Cancer Sci 99

      Pages: 1626-1632

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models2008

    • Author(s)
      Sasaki Y
    • Journal Title

      Mol Cancer Ther 7

      Pages: 779-787

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas2008

    • Author(s)
      Piao W
    • Journal Title

      Mol Cancer Ther 7

      Pages: 1483-1493

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer2008

    • Author(s)
      Maruyama R
    • Journal Title

      Carcinogenesis 29

      Pages: 1312-1318

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of laterally spreading type and JC virus with methylator phenotype status in colorectal adenoma2008

    • Author(s)
      Nosho K
    • Journal Title

      Hum Pathol 39

      Pages: 767-775

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma2008

    • Author(s)
      Takagi H
    • Journal Title

      J Gastroenterol 43

      Pages: 378-389

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer2008

    • Author(s)
      Kawamura YI
    • Journal Title

      Gastroenterology 135

      Pages: 142-151

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of flotillin-2, a major protein on lipid rafts, as a novel target of p53 family members2008

    • Author(s)
      Sasaki Y
    • Journal Title

      Mol Cancer Res 6

      Pages: 395-406

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma2008

    • Author(s)
      Imai T
    • Journal Title

      Cancer Sci 99

      Pages: 958-966

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carcinogenesis and microsatellite instability:the interrelationship between genetics and epigenetics2008

    • Author(s)
      Imai K
    • Journal Title

      Carcinogenesis 29

      Pages: 673-680

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional silencing of hedgehog-interacting protein by CpG hypermethylation and chromatic structure in human gastrointestinal cancer.2007

    • Author(s)
      Taniguchi H, Yamamoto H, Akutsu N, Nosho K, Adachi Y, Imai K, Shinomura Y
    • Journal Title

      J Pathol Vol.213

      Pages: 131-139

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.2007

    • Author(s)
      Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, Sasaki Y, Mita H, Nishikawa N, Yamaguchi K, Hirata K, Itoh F, Tokino T, Mori M, Imai K, Shinomura Y
    • Journal Title

      Oncogene Vol.26

      Pages: 4699-4713

    • NAID

      130004927598

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer2007

    • Author(s)
      Nojima M.
    • Journal Title

      Oncogene 26

      Pages: 4699-4713

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene amplification and overexpression of PRDM14 in breast cancers2007

    • Author(s)
      Nishikawa N.
    • Journal Title

      Cancer Res 67

      Pages: 9649-9657

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of DICKKOPF family genes in human2007

    • Author(s)
      Sato H.
    • Journal Title

      gastrointestinal tumors 28

      Pages: 2459-2466

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer2007

    • Author(s)
      Akino K.
    • Journal Title

      Cancer Sci 98

      Pages: 88-95

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PRDM5 identified as a target of eqigenetic silencing in colorectal and gastric cancer2007

    • Author(s)
      Watanabe Y.
    • Journal Title

      Clin Cancer Res 13

      Pages: 4786-4794

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single nucleotide polymorphism in the RAD 18 gene and risk of colorectal cancer in the Japanese population2007

    • Author(s)
      Kanzaki H.
    • Journal Title

      Oncol Rep 18

      Pages: 1171-1175

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional silencing of hedgehon-interaction protein by CpGhypermethylation and chromatic structure in human gastrointestinal cancer2007

    • Author(s)
      Taniguchi H.
    • Journal Title

      J Pathol 213

      Pages: 131-139

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential expression of angiogenesis-related genes in human gastric cancers with and those without high-frequency microsatellite instability2007

    • Author(s)
      Miyamoto N.
    • Journal Title

      Cancer Lett 254

      Pages: 42-53

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the immune escape phenotype of human gastric cancers with and without high-frequency microsatellite instability2007

    • Author(s)
      Hirata T.
    • Journal Title

      J Pathol 211

      Pages: 516-523

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic and epigenetic profiling in early colorecetal tumors and prediction of invasive potential in pT1(early invasive)colorectal cancers2007

    • Author(s)
      Nosho K.
    • Journal Title

      Carcinogenesis 28

      Pages: 1364-1370

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insulin-like growth factor-I receptor as a marker for prognosis and a therapeutic target in human esophageal squamous cell carcinoma2007

    • Author(s)
      Imsumran A.
    • Journal Title

      Carcinogenesis 28

      Pages: 947-956

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flat-type colorectal advanced adenomas(laterally spreading tumors)have different genetic and epigenetic alterations from protruded-type advanced adenomas2007

    • Author(s)
      Takahashi T.
    • Journal Title

      Mod Pathol 20

      Pages: 139-147

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene mutation and DNA methylation in non-hereditary colon neoplasms2007

    • Author(s)
      Toyota M.
    • Journal Title

      Nippon Naika Gakkai Zasshi 96

      Pages: 226-230

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Epigenetics in gastroenterological cancer and prospects for translational research2007

    • Author(s)
      Suzuki H.
    • Journal Title

      Nippon Naika Gakkai Zasshi 104

      Pages: 1319-1328

    • Related Report
      2007 Annual Research Report
  • [Journal Article] がん分子標的治療の発展-抗体医薬を中心に-2007

    • Author(s)
      安井 寛
    • Journal Title

      Focus on Oncolog 7

      Pages: 14-15

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Comparing antibody and small-molecule therapies for cancer.2006

    • Author(s)
      Imai K, Takaoka A
    • Journal Title

      Nat Rev Cancer Vol.6

      Pages: 714-727

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.2006

    • Author(s)
      Maruyama R, Aoki F, Toyota M, Sasaki Y, Akashi H, Mita H, Suzuki H, Akino K, Ohe-Toyota M, Maruyama Y, Tatsumi H, Imai K, Shinomura Y, Tokino T
    • Journal Title

      Cancer Res Vol.66

      Pages: 4574-4583

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparing antibody and small-molecule therapies for cancer2006

    • Author(s)
      Imai K
    • Journal Title

      Nat Rev Cancer 6

      Pages: 714-727

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Comparative genome analysis identifies the vitamin D receptor gene as a directtarget of p53-mediated transcriptional activation2006

    • Author(s)
      Maruyama R
    • Journal Title

      Cancer Res. 66

      Pages: 4574-4583

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis2006

    • Author(s)
      Nosho K
    • Journal Title

      Eur J Cancer 42

      Pages: 2374-2381

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Activation of the ribosomal protein L13 gene in human gastrointestinal cancer2006

    • Author(s)
      Kobayashi T
    • Journal Title

      Int J Mol Med 18

      Pages: 161-170

    • Related Report
      2006 Annual Research Report
  • [Journal Article] EPigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines2006

    • Author(s)
      Nishikawa N
    • Journal Title

      Br J Cancer 94

      Pages: 914-921

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Therapeutic implications of the specific inhibition of causative matrix metalloproteinases in experimental colitis induced by dextran sulphate sodium2006

    • Author(s)
      Kobayashi K
    • Journal Title

      J Pathol 209

      Pages: 376-383

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Genetic, epigenetic, and clinicopathologic features of gastric carcinomas with the CpG island methylator phenotype and an association with Epstein-Barr virus.2006

    • Author(s)
      Kusano M
    • Journal Title

      Cancer 106

      Pages: 1467-1479

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Bmf is a possible mediator in histone deacetylase inhibitors FK228 and CBHA-induced apoptosis.2006

    • Author(s)
      Zhang Y
    • Journal Title

      Cell Death Differ 13

      Pages: 129-140

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Tumour matrilysin expression predicts metastatic potential of stage I (pT1) colon and rectal cancers.2005

    • Author(s)
      Kurokawa S, Arimura Y, Yamamoto H, Adachi Y, Endo T, Sato T, Suga T, Hosokawa M, Shinomura Y, Imai K
    • Journal Title

      Gut Vol.54

      Pages: 1751-1758

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers.2005

    • Author(s)
      Taniguchi H
    • Journal Title

      Oncogene 24

      Pages: 7946-7952

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Tumour matrilysin expression predicts metastatic potential of stage (pT1) colon and rectal cancers.2005

    • Author(s)
      Kurokawa S
    • Journal Title

      Gut 54

      Pages: 1751-1758

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts.2005

    • Author(s)
      Min Y
    • Journal Title

      Gut 54

      Pages: 591-600

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Gene expression profiling of colorectal adenomas and early invasive carcinomas by cDNA array analysis.2005

    • Author(s)
      Nosho K
    • Journal Title

      Br J Cancer 922

      Pages: 1193-1200

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The role of T-fimbrin in the response to DNA damage : silencing of T-fimbrin by small interfering RNA sensitizes human liver cancer cells to DNA-damaging agents.2005

    • Author(s)
      Ikeda H
    • Journal Title

      Int J Oncol 27

      Pages: 933-940

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Small Interfering RNA-Induced CHFR Silencing Sensitizes Oral : Squamous Cell Cancer Cells to Microtubule Inhibitors.2005

    • Author(s)
      Ogi K
    • Journal Title

      Cancer Biol Ther 4

      Pages: 773-780

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer.2005

    • Author(s)
      Akino K
    • Journal Title

      Gastroenterology 129

      Pages: 156-169

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours.2005

    • Author(s)
      Murai M
    • Journal Title

      Br J Cancer 92

      Pages: 1165-1172

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Sulindac enhances the proteasome inhibitor bortezomib- mediated oxidative stress and anticancer activity.2005

    • Author(s)
      Minami T
    • Journal Title

      Clin Cancer Res 11

      Pages: 5248-5256

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Adenovirus-mediated gene transfer of caspase-8 sensitizes human adenocarcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand.2005

    • Author(s)
      Yasui H
    • Journal Title

      Int J Oncol 26

      Pages: 537-544

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.2005

    • Author(s)
      Murai M
    • Journal Title

      Clin Cancer Res 11

      Pages: 1021-1027

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mucin expression profile is related to biological and clinical characteristics of intraductal papillary-mucinous tumors of the pancreas.2005

    • Author(s)
      Ito H
    • Journal Title

      Pancreas 30

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis.2005

    • Author(s)
      Nosho K
    • Journal Title

      Carcinogenesis 26

      Pages: 892-899

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Upregulation of BNIP3 by 5-aza-2' -deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death.2005

    • Author(s)
      Abe T
    • Journal Title

      J Gastroenterol 40

      Pages: 504-510

    • Related Report
      2005 Annual Research Report
  • [Presentation] FGFRに対する抗体による肝癌の標的治療2010

    • Author(s)
      石田禎夫
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2009 Final Research Report
  • [Presentation] 消化器がんに対する改造抗体の作成2009

    • Author(s)
      佐々木茂
    • Organizer
      日本DDS学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-03
    • Related Report
      2009 Final Research Report
  • [Presentation] 消化器がんに対する改造抗体の作成2009

    • Author(s)
      佐々木茂
    • Organizer
      日本DDS学会(シンポジウム2)
    • Place of Presentation
      東京都文京区
    • Year and Date
      2009-07-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 消化器がんに対する抗体治療を目指して2009

    • Author(s)
      安井寛
    • Organizer
      日本がん免疫学会総会
    • Place of Presentation
      北九州
    • Year and Date
      2009-06-25
    • Related Report
      2009 Final Research Report
  • [Presentation] 消化器がんに対する抗体治療を目指して2009

    • Author(s)
      安井寛
    • Organizer
      日本がん免疫学会総会(ワークショップ)
    • Place of Presentation
      北九州
    • Year and Date
      2009-06-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Anti-Tumor Efficacy of Anti-FGFR-1 Monoclonal Antibody for Human Hepatoma Cells.2008

    • Author(s)
      Sasaki S
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-10-09
    • Related Report
      2009 Final Research Report
  • [Presentation] Anti-Tumor Efficacy of Anti-FGFR1 Monoclonal Antibody for Human Hepatoma Cells2008

    • Author(s)
      Sasaki S
    • Organizer
      36th Congress of the International Society for Oncodevelopmental Biology and Medicine
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-10-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] FGFR1抗体と二重特異性抗体2008

    • Author(s)
      安井寛
    • Organizer
      第12回基盤的癌免疫研究会総会
    • Place of Presentation
      大宮
    • Year and Date
      2008-07-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] 進行肝細胞癌に対する新規抗体治療2008

    • Author(s)
      佐々木茂
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 進行肝細胞がんに対する抗体治療2007

    • Author(s)
      佐々木 茂
    • Organizer
      第35回日本臨床免疫学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-10-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] 抗原AとCD3に対するbispecific diabodyの抗腫瘍効果2007

    • Author(s)
      安井 寛
    • Organizer
      第35回日本臨床免疫学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-10-19
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 癌治療剤及び癌の治療方法2008

    • Inventor(s)
      今井浩三、佐々木茂、清藤勉
    • Industrial Property Rights Holder
      北海道公立大学法人札幌医科大学、株式会社免疫生物研究所
    • Filing Date
      2008-05-29
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 肝癌治療剤および肝癌の治療法2007

    • Inventor(s)
      今井浩三、佐々木茂、清藤勉
    • Industrial Property Rights Holder
      北海道公立大学法人札幌医科大学、株式会社免疫生物研究所
    • Industrial Property Number
      2007-142308
    • Filing Date
      2007-05-29
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 肝癌治療剤および肝癌の治療法2007

    • Inventor(s)
      肝癌治療剤および肝癌の治療法
    • Industrial Property Rights Holder
      北海道公立大学法人札幌医科大学、株式会社免疫生物研究所
    • Filing Date
      2007-05-29
    • Related Report
      2007 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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