| Project/Area Number |
17016068
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
MITANI Kinuko Dokkyo Medical University, 医学部, 教授 (50251244)
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Ko 獨協医科大学, 医学部, 講師 (60282638)
MAKI Kazuhiro 獨協医科大学, 医学部, 講師 (50337391)
TETSUYA Yamagata 獨協医科大学, 医学部, 准教授 (30424047)
MARIKO Eguchi 獨協医科大学, 医学部, 講師 (40420781)
MINENORI Eguchi 獨協医科大学, 医学部, 講師 (50420782)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥44,600,000 (Direct Cost: ¥44,600,000)
Fiscal Year 2009: ¥8,500,000 (Direct Cost: ¥8,500,000)
Fiscal Year 2008: ¥8,500,000 (Direct Cost: ¥8,500,000)
Fiscal Year 2007: ¥9,300,000 (Direct Cost: ¥9,300,000)
Fiscal Year 2006: ¥9,300,000 (Direct Cost: ¥9,300,000)
Fiscal Year 2005: ¥9,000,000 (Direct Cost: ¥9,000,000)
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| Keywords | 白血病 / 染色体転座 / 転写因子 / RUNX1, RUNX1 / EVI1 / ノックインマウス / ヒストン脱アセチル化酵素阻害剤 / TEL / RUNX1 / DTX2 / アンチセンス / tai-to-tail / レトロウイルス / GFP / ヒストン脱アチヤル化酵素阻害剤 / GATA1 / トランスジェニックマウス / ES / EB / 赤芽球 / IALAS-E / β-major globin / GATAL / ヘモグロビン / アセチル化 / MOZ / 急性巨核芽球性白血病 / ETO / ピストン脱アセチル化酵素阻害剤 / アポトーシス / CDKN1A / アイソフォーム / ドミナント・ネガティブ / ETS / p53 / 骨髄異形成症候群 |
|---|
| Research Abstract |
Generation of chimeric transcription factor is one of major molecular mechanisms in leukemogenesis. In this study, We analyzed functions of a RUNX1 chimera, RUNX1/EVI1, with molecular and gene engineering approaches. Considering that RUNX1 chimera causes leukemia through recruiting histone deacetylase via co-repressor, We also evaluated effects of hlstone deacetylase inhlbitors on leukemic growth induced by RUNX1 chimera.
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