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Development of immunotherapy based on the identification of tumor antigens

Research Project

Project/Area Number 17016070
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKeio University

Principal Investigator

KAWAKAMI Yutaka  Keio University, 医学部, 教授 (50161287)

Co-Investigator(Kenkyū-buntansha) FUJITA Tomonobu  慶應義塾大学, 医学部, 助教 (20199334)
SAKURAI Toshiharu  慶應義塾大学, 医学部, 助教 (20101933)
KUDO Chie  慶應義塾大学, 医学部, 講師 (90424126)
TSUKAMOTO Nobuo  慶應義塾大学, 医学部, 助教 (20407117)
UEDA Ryo  慶應義塾大学, 医学部, 助教 (30317143)
MATSUZAKI Yuriko  慶應義塾大学, 医学部, 助教 (40255435)
TSUKAMOTO Makoto  慶應義塾大学, 医学部, 助教 (50365441)
住本 秀敏  慶應義塾大学, 医学部, 助教 (00306838)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥54,200,000 (Direct Cost: ¥54,200,000)
Fiscal Year 2009: ¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 2008: ¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 2007: ¥8,600,000 (Direct Cost: ¥8,600,000)
Fiscal Year 2006: ¥8,600,000 (Direct Cost: ¥8,600,000)
Fiscal Year 2005: ¥9,000,000 (Direct Cost: ¥9,000,000)
Keywords免疫療法 / 腫瘍抗原 / がん幹細胞 / 上皮間葉転換 / 悪性黒色腫 / 免疫抵抗性 / 免疫抑制 / 樹状細胞 / 制御性T細胞 / 転移 / 網羅的遺伝子解析 / RNA干渉 / HLA遺伝子導入マウス / 免疫回避 / DNAチップ
Research Abstract

Cancer immunotherapy has not been established as a standard cancer therapy. To improve current immunotherapy, in this project we have identified new human tumor antigens, revealed cancer immune responses particularly cancer induced immunosuppression, and evaluated immunological characteristics of cancer stem cells and epithelial-mesenchymal transitioned cancer cells. Newly identified tumor antigens and immune modulation methods may lead to development of new diagnostic and therapeutic methods for cancer.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (136 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (64 results) (of which Peer Reviewed: 40 results) Presentation (61 results) Book (7 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Identification of HLA-A2- and A24-restricted T-cell epitopes derived from SOX6 expressed in glioma stem cells for immunotherapy.2010

    • Author(s)
      Ueda R, Ohkusu-Tsukada K, Fusaki N, Soeda A, Kawase T, Kawakami Y, Toda M
    • Journal Title

      Int J Cancer 126(4)

      Pages: 919-929

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of HLA-A2- and A24-restricted T-cell epitopes derived from SOX6 expressed in glioma stem cells for immunotherapy.2010

    • Author(s)
      Ueda R, et al.
    • Journal Title

      Int J Cancer. 126(4)

      Pages: 919-929

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant Fatty Acid-Binding Protein 7 Gene Expression In Cutaneous Malignant Melanoma.2010

    • Author(s)
      Goto Y, et al.
    • Journal Title

      J Invest Dermatol. 130(1)

      Pages: 221-229

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of cancer stem-like cells from a side population of a humanglioblastoma cell line, SK-MG-1.2010

    • Author(s)
      Fukaya R, et al.
    • Journal Title

      Cancer Letters. 291(2)

      Pages: 150-157

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adjuvant effects of formalin-inactivated HSV through activation of dendritic cells and inactivation of myeloid-derived suppressor cells in cancer immunotherapy.2010

    • Author(s)
      Ohkusu-Tsukada K, et al.
    • Journal Title

      Int J Cancer. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeted inhibition of the p38 MAP kinase of IL-10-secreting CD25- Tregulatory cells in cancer immunotherapy.2010

    • Author(s)
      Ohkusu-Tsukada K, et al.
    • Journal Title

      Eur.J Immunol. 40(4)

      Pages: 1011-1021

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cancer metastasis is accelerated through immunosuppression during EMT of cancer cell.2009

    • Author(s)
      Kudo-Saito C, Shirako H, Takeuchi T, Kawakami Y
    • Journal Title

      Cancer Cell. 16(3)

      Pages: 195-206

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous suppression of MITF and BRAFV600E enhanced inhibition of melanoma cell proliferation.2009

    • Author(s)
      Kido K. Sumimoto H, Asada S, Okada S, Yaguchi T, Kawamura N, Miyagishi M, Saida M, Kawakami Y
    • Journal Title

      Cancer Sci. 100(10)

      Pages: 1863-1869

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impairment of pDC for IFN production by the ligand for immunoglobulin-like transcript 7 (ILT7) expressed on human cancer cells.2009

    • Author(s)
      Tsukamoto N, Okada S, Onami Y, Sasaki Y, Umezawa K, Kawakami Y
    • Journal Title

      Clin Cancer Res. 15(18)

      Pages: 5733-5743

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impairment of pDC for IFN production by the ligand forimmunoglobulin-like transcript 7 (ILT7) expressed on human cancer cells.2009

    • Author(s)
      Tsukamoto N, et al.
    • Journal Title

      Clin Cancer Res. 15(18)

      Pages: 5733-5743

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous suppression of MITF and BRAFV600E enhanced inhibition of melanoma cell proliferation.2009

    • Author(s)
      Kido K, et al.
    • Journal Title

      Cancer Sci. 100(10)

      Pages: 1863-1869

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNA Helicase Encoded by Melanoma Differentiation-Associated Gene 5 Is a Major Autoantigen in Patients With Clinically Amyopathic Dermatomyositis.2009

    • Author(s)
      Sato S, et al.
    • Journal Title

      Arthritis Rheum. 60(7)

      Pages: 2193-2200

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of dendritic-like cells and neural stem/progenitor cells in injured spinal cord by GM-CSF.2009

    • Author(s)
      Hayashi K, et al.
    • Journal Title

      Neurosci Res. 64(1)

      Pages: 96-103

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplantation of dendritic cells promotes functional recovery from spinalcord injury in common marmoset.2009

    • Author(s)
      Yaguchi M, et al.
    • Journal Title

      Neurosci Res. 654

      Pages: 384-392

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial Mesenchymal Transition in Human Ocular Chronic Graft-Versus-Host Disease.2009

    • Author(s)
      Ogawa Y, et al.
    • Journal Title

      Am J Pathol. 175(6)

      Pages: 2372-2381

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Emerging concepts in biomarker discovery.2009

    • Author(s)
      Tahara H., et al.
    • Journal Title

      the US-Japan Workshop on Immunological Molecular Markers in Oncology.J Transl Med. 7

      Pages: 45-45

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The RNA silencing technology applied by lentiviral vectors in oncology2009

    • Author(s)
      Sumimoto H., et.al.
    • Journal Title

      in "Lentivirus Gene Engineering Protocols book the second edition" Humana Press,Totowa, NJ (In press)

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Activation of dendritic-like cells and neural stem/progenitor cells in injured spinal cord by GM-CSF2009

    • Author(s)
      Hayashi K., et.al.
    • Journal Title

      Neuroscience Research (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a WT1 protein-derived peptide, WT1187 as an HLA-A*0206-restricted, WT1-specific CTL epitope2009

    • Author(s)
      Li Zheyu., et.al.
    • Journal Title

      Microbiology and Immunology (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cancer metastasisi is accelerated through immunosuppression during EMT of cancer cell2009

    • Author(s)
      Kudo-Saito C., et.al.
    • Journal Title

      Cancer Cell 16

      Pages: 195-206

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammation and pathogenic fibrosis in human ocular chronic graft versus host disease2008

    • Author(s)
      Ogawa Y., et.al.
    • Journal Title

      Inflammation and Regeneration 28

      Pages: 529-536

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Pilot Study of Human Interferon β Gene Therapy for Patients with Advanced Melanoma by in vivo Transduction Using Cationic Liposomes2008

    • Author(s)
      Matsumoto K., et.al.
    • Journal Title

      Jpn J Clin Oncol 38

      Pages: 849-856

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of Alkali Bum-Induced Corneal Neovascularization by Dendritic Cell Vaccination Targeting VEGF Receptor 22008

    • Author(s)
      Mochimaru H., et.al.
    • Journal Title

      Invest Ophthalmol Vis Sci 49

      Pages: 2172-2177

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional recovery after spinal cord injury in mice through activation ofo microglia and dendritic cells following IL-12 administration2008

    • Author(s)
      Yaguchi M., et.al.
    • Journal Title

      J Neurosci Res 86

      Pages: 1972-1980

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of Immunotherapy for Melanoma Based on the Analysis of Antigen Specific 1 Cells2008

    • Author(s)
      Kawakami Y, et.al.
    • Journal Title

      The Proceedings of 5th International Melanoma Research Congress 2008

      Pages: 111-115

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Induction of protective and therapeutic antitumor immunity by a DNA vaccine with a glioma antigen, SOX62008

    • Author(s)
      Ueda R, et.al.
    • Journal Title

      Int J Cancer 112

      Pages: 2274-2279

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and characterization of dendritic cells from common marmosets for preclinical studies on cell therapy2008

    • Author(s)
      Ohta S., et.al.
    • Journal Title

      Immunology 123

      Pages: 566-574

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dendritic cell based personalized immunotherapy based on cancer antigen research2008

    • Author(s)
      Kawakami Y, et.al.
    • Journal Title

      Frontier in Bioscience 13

      Pages: 1952-1958

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Dendritic ceU based personalized immunotherapy based on cancer antigenresearch.2008

    • Author(s)
      Kawakami y, et al.
    • Journal Title

      Frontier in Bioscience 13

      Pages: 1952-1958

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Isolation and characterization of dendritic cells from common marmosets forpreclinical studies on ceU therapy.2008

    • Author(s)
      Ohta S, et al.
    • Journal Title

      Immunol 123(4)

      Pages: 566-574

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel cancer-testis antigen CRT2 frequently expressed in various cancers using representational differential analysis.2007

    • Author(s)
      Hayashi E, Matsuzaki Y, Kurihara S, Hasegawa G, Fujita T, Yaguchi T, Kageshita T, Sano M, Kawakami Y
    • Journal Title

      Clin Cancer Res. 13(21)

      Pages: 6267-6274

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of individualized immunotherapy based on tha analysis onanti-tumor immune responses to the human tumor antigens identified usingimmunological and genetic methods.2007

    • Author(s)
      Kawakami y, et al.
    • Journal Title

      Gene Therapy

      Pages: 240-248

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Identification of a novel cancer-testis antigen CRT2 frequently expressed invarious cancers using representational differential analysis.2007

    • Author(s)
      Hayashi E, et al.
    • Journal Title

      Clin Cancer Res. 13

      Pages: 6267-6274

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lentiviral Vector-]Mediated RNAi and it's use for Cancer Eesearch.2007

    • Author(s)
      Sumimoto H, et al.
    • Journal Title

      Future Oncology 3

      Pages: 655-664

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification ofo a neuro-specific human gene, KIAA1110, that is a guaninenucleotide exchange factor for ARF1.2007

    • Author(s)
      Hattori y, et al.
    • Journal Title

      Biochem Biophys res Commun 364

      Pages: 737-742

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dendritic cells transduced with autoantigen FCRLA induce cytotoxiclymphocytes and vaccinate against murine B-ceU lymphoma.2007

    • Author(s)
      Inozume T, et al.
    • Journal Title

      J Invest Dermatol 127

      Pages: 2818-2822

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preferential expression and frequent IgG responses of a tumor antigen, SOX5, in glioma patients.2007

    • Author(s)
      Ueda R, Kawakami Y, et al.
    • Journal Title

      Int J Cancer. 120・8

      Pages: 1704-1711

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A novel cancer testis antigen frequently expressed in pancreatic, lung and endometrial cancers.2006

    • Author(s)
      Okada T, Akada M, Fujita T, Iwata T, Goto Y, Kido K, Okada T, Matsuzaki Y, Kobayashi K, Matsuno S, Sunamura M, Kawakami Y
    • Journal Title

      Clin Cancer Res. 12(1)

      Pages: 191-197

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new melanoma antigen FABP7 involved in proliferation and invasion is a potential target for immunotherapy and molecular target therapy.2006

    • Author(s)
      Goto Y, Matsuzaki Y, Kurihara S, Shimizu A, Okada T, Yamamoto K, Murata H, Takata M, Aburatani H, Hoon D, Saida T, Kawakami Y
    • Journal Title

      Cancer Res. 66(8)

      Pages: 4443-4449

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effective inhibition of cell growth and invasion of melanoma by combined suppression of BRAF (V599E) and Skp2 with lentiviral RNAi.2006

    • Author(s)
      Sumimoto H, Hirata K, Yamagata S, Miyoshi H, Miyagishi M, Taira K, Kawakami Y
    • Journal Title

      Int J Cancer 118(2)

      Pages: 472-476

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The BRAF-MAPK signaling pathway is essential for cancer immune evasion in human melanoma cells.2006

    • Author(s)
      Sumimoto H, Imabayashi F, Iwata T, Kawakami Y
    • Journal Title

      J Exp Med 203(7)

      Pages: 1651-1656

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of immunologic tumor regression by intratumoral administration of dendritic cells in combination with cryoablative tumor pretreatment and Bacillus Calmette-Guerin Cell Wall Skeleton Stimulation.2006

    • Author(s)
      Udagawa M, Kudo-Saito C, Hasegawa G, Yano K, Yamamoto A, Sumimoto H, Yaguchi M, Toda M, Azuma I, Iwai T, Kawakami Y
    • Journal Title

      Clin Cancer Res. 12(24)

      Pages: 7465-7475

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The BRAF-MAPK signaling pathway is essential for cancer immune evasion in human melanoma cells.2006

    • Author(s)
      Sumimoto H, Kawakami Y, et al.
    • Journal Title

      J Exp Med 203・7

      Pages: 1651-1656

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Enhancement of immunologic tumor regression by intratumoral administration of dendritic cells in combination with cryoablative tumor pretreatment and Bacillus Calmette-Guerin Cell Wall Skeleton Stimulation.2006

    • Author(s)
      Udagawa M, Kawakami Y, et al.
    • Journal Title

      Clin Cancer Res. 12・24

      Pages: 7465-7475

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effective inhibition of cell growth and invasion of melanoma by combined suppression of BRAF (V599E) and Skp2 with lentiviral RNAi2006

    • Author(s)
      Sumimoto H, Kawakami Y, et al.
    • Journal Title

      Int J Cancer 118・2

      Pages: 472-476

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A novel cancer testis antigen frequently expressed in pancreatic, lung and endometrial cancers2006

    • Author(s)
      Okada T, Kawakami Y, et al.
    • Journal Title

      Clin Cancer Res 12・1

      Pages: 191-197

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Possible involvement of allogeneic antigens recognized by donor-derived CD4+ cytotoxic T cells in selective GVL effects after stem cell transplantation of patients with haematological malignancy2006

    • Author(s)
      Matsushita M, Kawakami Y, et al.
    • Journal Title

      Br J Heamatol 132・1

      Pages: 56-65

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Identification of a antigen, GARC-1, using cytotoxic T lymphocytes induced by HSV cancer vaccine2006

    • Author(s)
      Iizuka Y, Kawakami Y, et al.
    • Journal Title

      Int J Cancer 118・4

      Pages: 942-949

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Systematic identification of human melanoma antigens using serial analysis of gene expression (SAGE).2005

    • Author(s)
      Matsuzaki Y, Hashimoto S, Fujita T, Suzuki T, Sakurai T, Matsushima K, Kawakami Y
    • Journal Title

      J Immunother 28(1)

      Pages: 10-19

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients.2005

    • Author(s)
      Inozume T, Matsuzaki Y, Kurihara S, Fujita T, Yamamoto A, Aburatani H, Shimada S, Kawakami Y
    • Journal Title

      Int J Cancer 114(2)

      Pages: 283-290

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunological detection of altered signaling molecules involved in melanoma development.2005

    • Author(s)
      Kawakami Y, Sumimoto H, Fujita T, Matsuzaki Y
    • Journal Title

      Cancer Metastasis and Rev. 24(2)

      Pages: 357-366

    • Related Report
      2009 Final Research Report
  • [Journal Article] Frequent immune responses to a cancer/testis antigen, CAGE, in patients with microsatellite instability positive endometrial cancer.2005

    • Author(s)
      Iwata T, Fujita T, Hirao N, Matsuzaki Y, Okada T, Mochimaru H, Susumu N, Matsumoto E, Sugano K, Yamashita N, Nozawa S, Kawakami Y
    • Journal Title

      Clin Cancer Res. 11(10)

      Pages: 3949-3957

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis.2005

    • Author(s)
      Okada T, Noji S, Goto Y, Iwata T, Fujita T, Okada T, Matsuzaki Y, Kuwana M, Hirakata M, Horii A, Matsuno S, Sunamura M, Kawakami Y
    • Journal Title

      Int J Cancer 116(6)

      Pages: 925-933

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Systematic identification of human melanoma antigens using serial analysis of gene expression (SAGE)2005

    • Author(s)
      Matsuzaki Y, Kawakami Y, et al.
    • Journal Title

      J.Immunother 28・1

      Pages: 10-19

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients2005

    • Author(s)
      Inozume T, Kawakami Y, et al.
    • Journal Title

      Int.J.Cancer 114・2

      Pages: 283-290

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Genomic alterations in primary cutaneous melanomas detected by metaphase comparative genomic hybridization with laser capture or manual microdissection : 6p gains may predict poor outcome2005

    • Author(s)
      Namiki T, Kawakami Y, et al.
    • Journal Title

      Cancer Genet Cytogenet 157・1

      Pages: 1-11

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Gene therapy for human small cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference2005

    • Author(s)
      Sumimoto H, Kawakami Y, et al.
    • Journal Title

      Gene Therapy 12・1

      Pages: 95-100

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Immunological detection of altered signaling molecules involved in melanoma development2005

    • Author(s)
      Kawakami Y, et al.
    • Journal Title

      Cancer Metastasis and Rev 24・2

      Pages: 357-366

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Frequent immune responses to a cancer/testis antigen, CAGE, in patients with microsatellite instability positive endometrial cancer2005

    • Author(s)
      Iwata T, Kawakami Y, et al.
    • Journal Title

      Clin Cancer Res 11・10

      Pages: 3949-3957

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis2005

    • Author(s)
      Okada T, Kawakami Y, et al.
    • Journal Title

      Int J Cancer 116・6

      Pages: 925-933

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Evaluation of Cytomegalovirus-specific T-cell reconstitution in patients after various allogeneic hematopoietic stem cell transplantation using interferon-γ-enzyme-linked immunospot and HLA tetramer assays with an immunodominant T cell epitope2005

    • Author(s)
      Ohnishi M, Kawakami Y, et al.
    • Journal Title

      Br J Heamatol 131・4

      Pages: 472-479

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Carbonic anhydrase-II is a tumor vessel endothelium-associated antigen targeted by dendritic cell therapy2005

    • Author(s)
      Yoshiura K, Kawakami Y, et al.
    • Journal Title

      Clin Cancer Res 11・22

      Pages: 8201-8207

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Frequent immune response to a melanocyte-specific protein KU-MEL-1 in patients with Vogt-Koyanagi-Harada disease

    • Author(s)
      Ohtani S, Kawakami Y, et al.
    • Journal Title

      Br J Ophthalmol in press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A new melanoma antigen FABP7 involved in proliferation and invasion is a potential target for immunotherapy and molecular target therapy

    • Author(s)
      Goto Y, Kawakami Y, et al.
    • Journal Title

      Cancer Res in press

    • Related Report
      2005 Annual Research Report
  • [Presentation] Improvement of immunetherapy by restoration of immunocompetence through targeting signaling molecules in cancer and immune cells.2010

    • Author(s)
      Kawakami Y
    • Organizer
      8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2010-02-06
    • Related Report
      2009 Final Research Report
  • [Presentation] Improvement of immunotherapy by restoration of immunocompetence through targeting signaling molecules in cancer and immune cells.2010

    • Author(s)
      Yutaka Kawakami.
    • Organizer
      8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
    • Place of Presentation
      Hilton Waikoloa Village Waikoloa, Hawaii, USA.
    • Year and Date
      2010-02-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] MIF acts as a direct regulator of P53 in glioma cells and is a novelmolecular target for glioma cancer stem cells.2009

    • Author(s)
      Fukaya R, et al.
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Generation of human melanocytes from iPS cells in vitro.2009

    • Author(s)
      Ohta S, et al.
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Promotion of cancer metastasis through immuno-suppression and-resistance induced by Snail induced EMT.2009

    • Author(s)
      Kawakami Yutaka.
    • Organizer
      Japanses-German Cancer Workshop
    • Place of Presentation
      Germany
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of cancer immunotherapy through molecular analyses on anti-tumor immune responses.2009

    • Author(s)
      Kawakami Y, et al.
    • Organizer
      Intemational Symposium of novel therapies for unresectable cancers(ISNTUC)
    • Place of Presentation
      Sheraton Dameisha Resort Hotel
    • Year and Date
      2009-08-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Inhibition of a MAPK signal in cancer cells enhanced specificanti-tumor immunity by increased production of chemokines.2009

    • Author(s)
      Iwata-Kajihara T, et al.
    • Organizer
      第15回日本遺伝子治療学会総会
    • Place of Presentation
      大阪大学コンベンションセンター
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] STK24 is a signaling molecule for cancer-induced immunosuppression through IL-10 and TGF-β 1 production.2009

    • Author(s)
      Kawamura N, et al.
    • Organizer
      第15回日本遺伝子治療学会総会
    • Place of Presentation
      大阪大学コンベンションセンター
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] MIF acts as a direct regulator of P53 in the nuclei of glioma cells and is a novel molecular target for the treatment of glioma cancerstem cells.2009

    • Author(s)
      Fukaya R, et al.
    • Organizer
      7th International Society for Stem Cell Research, Annual Meeting
    • Place of Presentation
      Centre Convencions international Barcelona, Carcelona, Spain
    • Year and Date
      2009-07-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Immunoescape of cancer cells expressing an endogenous retrovirus antigen.2009

    • Author(s)
      Kudo-Saito C, et al.
    • Organizer
      100th Annual Meeting of American Association for Cancer Research
    • Place of Presentation
      Denver, (USA)
    • Year and Date
      2009-04-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト悪性黒色腫癌細胞株side populadon分画の癌肝細胞様性質と免疫抵抗性2009

    • Author(s)
      塚本信夫、長谷川豪、永濱康晴、大波陽子、河上裕
    • Organizer
      第8回日本再生医療学会総会
    • Place of Presentation
      国際フォーラム
    • Year and Date
      2009-03-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 癌肝細胞様性質を示すヒト癌細胞株sidepopulatiOn分画の免疫抵抗性機序2008

    • Author(s)
      塚本信夫、長谷川豪、永濱康晴、大波陽子、河上裕
    • Organizer
      第38回日本免疫学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2008-12-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト悪性黒色腫細胞株によるヒト単球由来MDSC様サブセットの誘導2008

    • Author(s)
      山本夏啓、住本秀敏、川村直、梅澤一夫、河上裕
    • Organizer
      第38回日本免疫学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2008-12-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] 癌細胞におけるMAPKシグナル亢進による腫瘍免疫逃避機構の解明2008

    • Author(s)
      谷口智憲、木藤健治、塚本信夫、桜井敏晴、藤田知信、持丸博史、丸山正太郎、里見良輔、井田陽介、住本秀敏、河上裕
    • Organizer
      第38回日本免疫学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2008-12-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Application of tumor cryoablation in the development of cancer immunorherapy2008

    • Author(s)
      Kawakami Y
    • Organizer
      第35回日本低温医学会総会
    • Place of Presentation
      Mori Tower 49F
    • Year and Date
      2008-11-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecular mechanisms for generation ofo immunosuppressive microenviroment by cancer cells2008

    • Author(s)
      Kawakami Y
    • Organizer
      International Society for Biological Therapy of Cancer
    • Place of Presentation
      Westin Gaslamp Quarter Hotel, San Diego CA, USA
    • Year and Date
      2008-11-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Wnt/beta-cateninシグナル亢進による悪性黒色種の免疫逃避機構の解明2008

    • Author(s)
      谷口智憲、木藤健治、塚本信夫、桜井敏晴、持丸博史、丸山正太郎、里見良輔、井田陽介、住本秀敏、河上裕
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 上皮-間葉転換期にある癌細胞が転移能獲得と共に誘導する免疫抑制ならびにその制御2008

    • Author(s)
      工藤千恵、河上裕
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 癌細胞の転移と抗腫瘍免疫回避に密接に関与する内因性レトロウィルス抗原の発現2008

    • Author(s)
      山本隆介、由良昌大、河上裕、工藤千恵
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] siRNAライブラリーを用いた癌免疫回避シグナルの同定2008

    • Author(s)
      川村直、住本秀敏、河上裕
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] MMAIによる細胞増殖とインテグリンを介した細胞接着増強によるヒト悪性黒色腫転移機構2008

    • Author(s)
      藤田知信、松崎ゆり子、宮崎潤一郎、岩田卓、塚本信夫、河上裕
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 培養樹状細胞を用いた免疫療法2008

    • Author(s)
      河上裕、住本秀敏、工藤千恵、塚本信夫、藤田知信、桜井敏晴、谷口智憲、岩田知子、川村直
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Recent Progress of melanoma immunotherapy -Mechanisms for melanoma induced immunosuppressive microenvironment and adoptive T cell Immunotherapy2008

    • Author(s)
      Kawakami Y
    • Organizer
      第60回日本皮膚科学会西部支部学術大会
    • Place of Presentation
      ホテルニューオータニ博多
    • Year and Date
      2008-10-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] シンポジウム2「細胞傷害性T細胞とNKT細胞のTransladonal Research」2008

    • Author(s)
      河上裕
    • Organizer
      第36回日本臨床免疫学会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2008-10-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] Immunotherapy by intratumoral administration of BCG-CWS treated DC following cryoablative tumor pretreatment.2008

    • Author(s)
      Kawakami Y
    • Organizer
      10thInternational Symposium on Dendritic Cells
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2008-10-03
    • Related Report
      2009 Final Research Report
  • [Presentation] "Session 4-1 & 4-2 腫瘍における樹状細胞と細胞間相互作用(I & II)"Immunotherapy by intratumoral administradon of BCG-CWS treated DC following cryoablative tumor pretreatment2008

    • Author(s)
      Kawakami Y
    • Organizer
      第10回国際樹状細胞シンポジウム
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2008-10-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 国際シンポジウム生体の「事態」をめぐって。「生命の維持、破綻と再生...免疫・移植癌・感染・幹細胞」TUMor Immunotherapv2008

    • Author(s)
      河上裕
    • Organizer
      東京理科大学生命科学研究所設立20周年記念シンポジウム
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-09-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Wnt/β-cateninシグナル亢進による悪性黒色腫の免疫逃避機構の解明2008

    • Author(s)
      谷口智憲、木藤健治、塚本信夫、桜井敏晴、持丸博史、丸山正太郎、里見良輔、井田陽介、住本秀敏、河上裕
    • Organizer
      第12回基盤的癌免疫研究会総会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2008-07-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] siRNAライブラリーを用いた癌免疫回避シグナルの同定2008

    • Author(s)
      川村直、住本秀敏、河上裕
    • Organizer
      第12回基盤的癌免疫研究会総会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2008-07-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cancer metastasis is accelerated through immunosuppression during epithelial-mesenchymal transition of cancer cells2008

    • Author(s)
      工藤千恵、竹内直志、河上裕
    • Organizer
      第12回基盤的癌免疫研究会総会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2008-07-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 癌幹細胞様性質を示すヒト癌細胞株side pqpulation分画の免疫抵抗性機序2008

    • Author(s)
      塚本信夫、永濱康晴、長谷川豪、大浪陽子、河上裕
    • Organizer
      第12回基盤的癌免疫研究会総会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2008-07-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 悪性黒色腫に対するBCG-CWS感作樹状細胞の腫瘍内投与による臨床試験2008

    • Author(s)
      藤田知信、斉藤昌孝、石田明、桜井敏晴、谷川瑛子、半田誠、天谷雅行、河上裕
    • Organizer
      第12回基盤的癌免疫研究会総会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2008-07-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] より有効な細胞障害性T細胞誘導を目指して2008

    • Author(s)
      河上裕
    • Organizer
      第32回日本リンパ学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Progress and perspectives in melanoma immunotherapy2008

    • Author(s)
      Kawakami Y
    • Organizer
      International investigative dermatology 2008
    • Place of Presentation
      Kyoto International Conference Center(Japan)
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] A new melanoma antigen FABP7 is a potential target for diagnosis, immunotherapy, and molecular target therapy2008

    • Author(s)
      Goto Y, Matsuzaki Y, Murata H, Takata M, Aburatani H, Hoon D, Saida T, Kawakami Y
    • Organizer
      International investigative dermatology 2008
    • Place of Presentation
      Kyoto International. Conference Center(Japan)
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecular mechanismis for immuno-suppression induced by melanoma cells2008

    • Author(s)
      Kawakami Y, Sumimoto H, Kudo C, Tsukamoto N, Yaguchi T
    • Organizer
      20th International Pigment Cell Conference & 5th International Melanoma Research Congress
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2008-05-12
    • Related Report
      2009 Final Research Report
  • [Presentation] Molecular mechanismis for immuno-suppression induced by melanoma cells2008

    • Author(s)
      Kawakami Y, Sumimoto H, Kudo C, Tsukamoto N. Yaguchi T
    • Organizer
      20th International Pigment Cell Conference & 5th International Melanoma Research Congress
    • Place of Presentation
      Royton Sapporo(Japan)
    • Year and Date
      2008-05-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Immunosuppression induced by melanoma during epithelial-mesenchymal transition2008

    • Author(s)
      Kudo-Saito C, Takeuchi T, Shirako H, Kawakami Y
    • Organizer
      20th International Pigment Cell Conference & 5th International Melanoma Research Congress
    • Place of Presentation
      Royton Sapporo(Japan)
    • Year and Date
      2008-05-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Identification of a novel cancer-testis antigen calreticulin2(CRT2) frequently expressed in melanoma2008

    • Author(s)
      Yaguchi T, Hayashi E, Hasegawa Fujita T, Kageshita T, Sano M, Matsuzaki Y, Kawakami Y
    • Organizer
      20th International Pigment Cell Conference & 5th International Melanoma Research Congress
    • Place of Presentation
      Royton Sapporo(Japan)
    • Year and Date
      2008-05-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Phase I/II clinical trial of immunotherapy by intratumoral administration of dendritic cells for patients with melanoma2008

    • Author(s)
      Saito M, Fujita T, Tanikawa A, Ishida A, Sakurai T, Handa M, Amagai M, Kawakami Y
    • Organizer
      20th International Pigment Cell Conference & 5th International Melanoma Research Congress
    • Place of Presentation
      Royton Sapporo(Japan)
    • Year and Date
      2008-05-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Immunosuppressive mechanisms induced by tumor cells during epithelial-mesenchymal transition leading to tumor metastasis2008

    • Author(s)
      Kudo-Saito C, Shirako H, Kawakami Y
    • Organizer
      AACR Annual Meeting 2008
    • Place of Presentation
      San Diego(USA)
    • Year and Date
      2008-04-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Use of RNA interference for analysis of anti-cancer immune responses anddevelopment of immunotherapy.2008

    • Author(s)
      Kawakami Y.
    • Organizer
      The Avison Biomedical Symposium 2008
    • Place of Presentation
      The Yonsei Univ. (Seoul)
    • Year and Date
      2008-01-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] Molecular mechanisms for generation of immunosuppressivemicroenvironment by cancer ceels.2007

    • Author(s)
      Kawakami y, et. a1.
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Induction of high ILIO producing DC by melanoma cells with alteredWnt A)eta- catenin signaling.2007

    • Author(s)
      Yaguchi T, et. al.
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Possiblemechanismofmetastasisenhancementoftumors du:ringepithelial-mesenchymal transition by mediating via immvuiosuppressionepithelial-mesenchymal transition by mediating via immvuiosuppression2007

    • Author(s)
      Takeuchi T, et. a1.
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Possible immunosuppression by ligands for immunoglobiilm-like transcript7(ILT7)・2007

    • Author(s)
      Tsukamoto N, et. al.
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Immunotherapy by Intra-tumoral Administration of Dendritic Cells Following Cryoablative Tumor Treatment.2007

    • Author(s)
      Kawakami Y.
    • Organizer
      14th World Congress of cryosurgery International society of cryosurgery
    • Place of Presentation
      グランドプリンスホテル新高輪Presidential Plaza(BeijingChina)
    • Year and Date
      2007-11-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] MITF Protein Levels Determine the Proliferation Status of Melanoma Cells2007

    • Author(s)
      Sumimoto H, et. a1.
    • Organizer
      2007 International Melanoma Congress
    • Place of Presentation
      New York Marriott Financial Center
    • Year and Date
      2007-11-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] The Proliferation of melanoma cells depends on the protein levels of MITF2007

    • Author(s)
      Sumimoto H, et. al.
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフイコ横浜
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] DNER is involved in melanoma cell proliferation and a potential therapeutic target2007

    • Author(s)
      Nagahama Y, et. al.
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフイコ横浜
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] がんに対する免疫応答と免疫療法2007

    • Author(s)
      河上 裕
    • Organizer
      第28回日本炎症・再生医学会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2007-08-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Immunoglobiilin-like transcript 7(ILT7)リガンドの癌細胞株における発現2007

    • Author(s)
      塚本 信夫 その他
    • Organizer
      第11回基盤的癌免疫研究会
    • Place of Presentation
      東京大学・鉄門講堂
    • Year and Date
      2007-07-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Kole of WntADeta-catenin Signaling Pathway in Production of an Immunosuppressive Cytokine, ILIO, by Melanoma Cells: Possible Mechanisms for Cancer Immunoescape2007

    • Author(s)
      谷口 智憲 その他
    • Organizer
      第11回基盤的癌免疫研究会
    • Place of Presentation
      東京大学・鉄門講堂
    • Year and Date
      2007-07-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Dendritic cells transduced with novel autoantigenn FCRLA induce cjrtotoxic lymphocjrtes and vaccinate against murine B cell lymphoma.2007

    • Author(s)
      柴垣 直孝 その他
    • Organizer
      第11回基盤的癌免疫研究会
    • Place of Presentation
      東京大学・鉄門講堂
    • Year and Date
      2007-07-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Inhibition of Proliferation and Invasion of Melanoma cells by Inactivation ofMITF with Lentiviral shRNA.2007

    • Author(s)
      Kido K, et. al.
    • Organizer
      第13回日本遺伝子治療学会
    • Place of Presentation
      愛知がんセンター
    • Year and Date
      2007-06-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] Immunotherapy and gene therapy using viral vectors.2007

    • Author(s)
      Kawakami Y, et. a1.
    • Organizer
      第13回日本遺伝子治療学会
    • Place of Presentation
      愛知がんセンター
    • Year and Date
      2007-06-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] レンチウイルスshENAを用いたMITF発現抑制による悪性黒色腫細胞の増殖・浸潤の抑制2007

    • Author(s)
      木藤健治 その他
    • Organizer
      日本研究皮膚科学会・第32回年次学術大会・総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-04-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] テーラーメイド医療と免疫治療2007

    • Author(s)
      河上 裕
    • Organizer
      第27回日本医学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2007-04-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] 細胞療法の可能性と限界」癌免疫療法:固形癌に対するT細胞・樹状細胞療法2007

    • Author(s)
      河上 裕
    • Organizer
      第104回日本内科学会総会・講演会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2007-04-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of invidualized immunotherapy by intratumoral injection of dendritc cells based on the immunological analysis of the malanoma antigens identified by various methods2005

    • Author(s)
      Kawakami Y, Fujita T, Matsuzaki Y, Sakurai T, Tsukamoto M, Sumimoto H, Hasegawa G, Udagawa M
    • Organizer
      19th International Pigment cell Conference
    • Place of Presentation
      Reston VA, USA
    • Year and Date
      2005-09-21
    • Related Report
      2009 Final Research Report
  • [Presentation] BRAF and Skp2 are targets for development of new treatment for melanoma2005

    • Author(s)
      Kawakami Y, Sumimoto H, Fujita T, Matsuzaki Y
    • Organizer
      6th World Congress on melanoma
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2005-09-08
    • Related Report
      2009 Final Research Report
  • [Book] Innate and adaptive immune regulation and Cancer immunotherapy(Wang RF ed)2010

    • Author(s)
      Ueda R, Kawakami Y
    • Publisher
      Springer Science/Business Media(in press)
    • Related Report
      2009 Final Research Report
  • [Book] Wang RF ed, Springer Science/Business Media, New York USA2010

    • Author(s)
      Ueda R, Kawakami Y.
    • Publisher
      Human tumor antigens recognized by T cells and their implications for cancer immunotherapy in "Innate and adaptive immuneregulation and Cancer immunotherapy"(in press)
    • Related Report
      2009 Annual Research Report
  • [Book] Lentivirus Gene Engineering Protocols Second edition2009

    • Author(s)
      Sumimoto H, Kawakami Y
    • Publisher
      Humana Press
    • Related Report
      2009 Final Research Report
  • [Book] Gene Therapy(Development of individualized immunotherapy based on the analysis on anti-tumor immune responses to the human tumor antigens identified using immunological and genetic methods)2009

    • Author(s)
      Kawakami Y, Fujita T, Kudo C, Sakurai T, Udagawa M, Hasegawa G, Ishida A, Kitagawa Y, Tanabe M, Saito M, Izumi Y, Kawamura M, Yaguchi T, Ueda Y, Hayashi E, Wang Q, Tsukamoto N, Matsuzaki Y, Sumimoto H,Takeuchi H, Tanikawa A, Handa M, Amagai M, Kobayashi K, Ikeda Y, Azuma I, Kitajima M
    • Related Report
      2009 Final Research Report
  • [Book] Humana Press2009

    • Author(s)
      Sumimoto H, Kawakami Y.
    • Publisher
      The RNA silencing technology applied by lentiviral vectors in oncology, in "Lentivirus Gene Engineering Protocols second edition"
    • Related Report
      2009 Annual Research Report
  • [Book] Chapter 13. The RNA silencing technology applied by lentiviral vectors in oncology. Lentivirus Gene Engineering Protocols. the 2^<nd> edition2009

    • Author(s)
      Sumimoto H, and Kawakami Y
    • Publisher
      Human Press(in press)
    • Related Report
      2008 Annual Research Report
  • [Book] Gene Therapy.2007

    • Author(s)
      Kawakami Y, et al.
    • Total Pages
      9
    • Publisher
      Development of individualized immunotherapy based on the analysis on anti-tumor immune responses to the human tumor antigens identified using immunological and genetic methods.
    • Related Report
      2006 Annual Research Report
  • [Remarks]

    • URL

      http://web.sc.itc.keio.ac.jp/admedres/index-jp.html

    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 腫瘍細胞による免疫抑制の解除剤とそれを用いた抗腫瘍剤2008

    • Inventor(s)
      工藤千恵・河上裕
    • Industrial Property Rights Holder
      慶應義塾
    • Filing Date
      2008-08-22
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 腫瘍細胞による免疫抑制の解除剤とそれを用いた抗腫瘍剤2008

    • Inventor(s)
      工藤千恵
    • Industrial Property Rights Holder
      慶應義塾
    • Filing Date
      2008-08-22
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] がんの診断方法と治療方法2008

    • Inventor(s)
      工藤恵
    • Industrial Property Rights Holder
      慶應義塾
    • Industrial Property Number
      2008-239943
    • Filing Date
      2008-09-18
    • Related Report
      2008 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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