| Project/Area Number |
17016070
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Keio University |
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Principal Investigator |
KAWAKAMI Yutaka Keio University, 医学部, 教授 (50161287)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Tomonobu 慶應義塾大学, 医学部, 助教 (20199334)
SAKURAI Toshiharu 慶應義塾大学, 医学部, 助教 (20101933)
KUDO Chie 慶應義塾大学, 医学部, 講師 (90424126)
TSUKAMOTO Nobuo 慶應義塾大学, 医学部, 助教 (20407117)
UEDA Ryo 慶應義塾大学, 医学部, 助教 (30317143)
MATSUZAKI Yuriko 慶應義塾大学, 医学部, 助教 (40255435)
TSUKAMOTO Makoto 慶應義塾大学, 医学部, 助教 (50365441)
住本 秀敏 慶應義塾大学, 医学部, 助教 (00306838)
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| Project Period (FY) |
2005 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥54,200,000 (Direct Cost: ¥54,200,000)
Fiscal Year 2009: ¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 2008: ¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 2007: ¥8,600,000 (Direct Cost: ¥8,600,000)
Fiscal Year 2006: ¥8,600,000 (Direct Cost: ¥8,600,000)
Fiscal Year 2005: ¥9,000,000 (Direct Cost: ¥9,000,000)
|
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| Keywords | 免疫療法 / 腫瘍抗原 / がん幹細胞 / 上皮間葉転換 / 悪性黒色腫 / 免疫抵抗性 / 免疫抑制 / 樹状細胞 / 制御性T細胞 / 転移 / 網羅的遺伝子解析 / RNA干渉 / HLA遺伝子導入マウス / 免疫回避 / DNAチップ |
|---|
| Research Abstract |
Cancer immunotherapy has not been established as a standard cancer therapy. To improve current immunotherapy, in this project we have identified new human tumor antigens, revealed cancer immune responses particularly cancer induced immunosuppression, and evaluated immunological characteristics of cancer stem cells and epithelial-mesenchymal transitioned cancer cells. Newly identified tumor antigens and immune modulation methods may lead to development of new diagnostic and therapeutic methods for cancer.
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