| Project/Area Number |
17016073
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
MITSUHASHI Norio Tokyo Women's Medical University, 医学部, 教授 (20008585)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
AKIMOTO Tetsuo 東京女子医科大学, 医学部, 准教授 (10261851)
MAEBAYASHI Katsuya 東京女子医科大学, 医学部, 講師 (60332350)
IZUMI Sachiko 東京女子医科大学, 医学部, 助教 (50292602)
ISHIKAWA Hitoshi 群馬大学, 医学部, 講師 (70344918)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
ISHIKAWA Hitoshi 群馬大学, 医学部, 講師 (70344918)
|
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| Project Period (FY) |
2005 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥43,800,000 (Direct Cost: ¥43,800,000)
Fiscal Year 2009: ¥8,400,000 (Direct Cost: ¥8,400,000)
Fiscal Year 2008: ¥8,400,000 (Direct Cost: ¥8,400,000)
Fiscal Year 2007: ¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 2006: ¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 2005: ¥9,000,000 (Direct Cost: ¥9,000,000)
|
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| Keywords | 放射線感受性 / 分子標的 / シグナル伝達 / 放射線増感 / 上皮細胞増殖因子受容体 / 細胞接着因子 / 子宮頸癌 / 放射線治療 / HER family / 遺伝子解析 / 生存シグナル / 遺伝子 / クラスター解析 / マイクロアレイ解析 / p73蛋白 |
|---|
| Research Abstract |
Identification of the candidate gene and molecule constituting radiosensitivity and investigation of radiosensitization strategies which targeted them were performed. Consequently, it became evident that it can become a candidate moleculefor radiosensitization since molecules, such as HER family, Hsp90, H2AX, and CoX-2, are closely connected with radiosensitivity, and that characteristic changes in gene expression characteristic were observed according to the treatment modalities for cervical cancer patients.
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