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Drug discovery research based on the molecular mechanisms of tumor growth and metastasis

Research Project

Project/Area Number 17016079
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

OSADA Hiroyuki  The Institute of Physical and Chemical Research, ケミカルバイオロジー研究基盤施設, 施設長 (80160836)

Co-Investigator(Kenkyū-buntansha) KANOH Naoki  独立行政法人理化学研究所, 長田抗生物質研究室, 先任研究員 (40317293)
須藤 龍彦  独立行政法人理化学研究所, 長田抗生物質研究室, 先任研究員 (30260227)
室井 誠  独立行政法人理化学研究所, 長田抗生物質研究室, 先任研究員 (30261168)
植木 雅志  独立行政法人理化学研究所, 長田抗生物質研究室, 先任研究員 (90312264)
清水 史郎  独立行政法人理化学研究所, 長田抗生物質研究室, 専任研究員 (30312268)
Co-Investigator(Renkei-kenkyūsha) SUDO Tatsuhiko  独立行政法人理化学研究所, 化合物ライブラリー評価研究チーム, 先任研究員 (30260227)
MUROI Makoto  独立行政法人理化学研究所, 化合物ライブラリー評価研究チーム, 先任研究員 (30261168)
UEKI Masashi  独立行政法人理化学研究所, 化学情報・化合物創製チーム, 先任研究員 (90312264)
SIMIZU Siro  独立行政法人理化学研究所, 化合物ライブラリー評価研究チーム, 専任研究員 (30312268)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥82,000,000 (Direct Cost: ¥82,000,000)
Fiscal Year 2009: ¥16,400,000 (Direct Cost: ¥16,400,000)
Fiscal Year 2008: ¥16,400,000 (Direct Cost: ¥16,400,000)
Fiscal Year 2007: ¥16,400,000 (Direct Cost: ¥16,400,000)
Fiscal Year 2006: ¥16,400,000 (Direct Cost: ¥16,400,000)
Fiscal Year 2005: ¥16,400,000 (Direct Cost: ¥16,400,000)
Keywordsケミカルバイオロジー / 癌転移 / 血管新生 / 天然化合物 / プロテオーム / フミトレモルジン / プロテオミクス / 生合成遺伝子 / p38 / リベロマイシン / 2D-DIGE / メチルゲルフィリン / GLO1 / 放線菌 / Epoxyquinol B / 血管内皮細胞 / VEGF / ビオチン / リベロマイシンA / 骨転移 / イエジマライド / V-ATPase / がん細胞 / 破骨細胞 / アポトーシス / 金属依存性マトリックス分解酵素
Research Abstract

The purpose of this study is to clarify the molecular mechanisms of tumor growth and metastasis, and to develop new anticancer agents using microbial metabolites and chemical library. We exhibited some new molecular targets through the analysis of metastasis-related proteins such as RECK and heparanase, and developed proteomic profiling system for classification of compounds according to the mechanism of action. In addition, we developed various anticancer lead compounds including reveromycin A (bone metastasis inhibitor9), epoxyquinol B (antiangiogenic agent), methyl-gerfelin (osteoclastogenesis inhibitor), and purpurogallin (inhibitor of PBD dependent binding).

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (323 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (127 results) (of which Peer Reviewed: 81 results) Presentation (184 results) Book (12 results)

  • [Journal Article] Cleavable linker for photo-cross-linked small-molecule affinity matrix.2010

    • Author(s)
      Kanoh, N. (8名中1番目), Simizu, S. (8名中6番目), Osada, H. (8名中7番目)
    • Journal Title

      Bioconjugate Chem. 21

      Pages: 182-186

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vitro reconstruction of tetronate RK-682 biosynthesis.2010

    • Author(s)
      Osada, H. (7名中6番目)
    • Journal Title

      Nature Chem. Biol. 6

      Pages: 99-101

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cleavable linker for photo-cross-linked small-molecule affinity matrix2010

    • Author(s)
      Kanoh, N., et al.
    • Journal Title

      Bioconjugate Chem. 21

      Pages: 182-186

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro reconstruction of tetronate RK-682 biosynthesis2010

    • Author(s)
      Sun, Y., et al.
    • Journal Title

      Nature Chem.Biol. 6

      Pages: 99-101

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoclast-targeting small molecules for the treatment of neoplastic bone metastases.2009

    • Author(s)
      Osada, H. (2名中2番目)
    • Journal Title

      Cancer Sci. 100

      Pages: 1999-2005

    • NAID

      10027196327

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells.2009

    • Author(s)
      Simizu, S. (8名中1番目), Osada, H. (8名中8番目)
    • Journal Title

      Biochem. Biophys. Res. Commun. 383

      Pages: 406-410

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.2009

    • Author(s)
      Osada, H. (10名中10番目)
    • Journal Title

      Chembiochem 10

      Pages: 920-928

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure-affinity relationship study of bleomycins and Shble protein by use of a chemical array.2009

    • Author(s)
      Simizu, S. (8名中3番目), Kanoh, N. (8名中5番目), Osada, H. (8名中8番目)
    • Journal Title

      Chembiochem 10

      Pages: 845-852

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] On-chip fragment-based approach for discovery of high-affinity bivalent inhibitors.2009

    • Author(s)
      Simizu, S. (4名中2番目), Osada, H. (4名中4番目)
    • Journal Title

      Chembiochem 10

      Pages: 838-843

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] RECK negatively regulates matrix metalloproteinase-9 transcription.2009

    • Author(s)
      Simizu, S. (3名中2番目), Osada, H. (3名中3番目)
    • Journal Title

      Cancer Res. 69

      Pages: 1502-1508

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency in chromosome congression by the inhibition of Plk1 polo box domain-dependent recognition.2009

    • Author(s)
      Osada, H. (7名中7番目)
    • Journal Title

      J. Biol. Chem. 284

      Pages: 2344-2353

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis.2009

    • Author(s)
      Simizu, S. (7名中2番目), Muroi, M. (7名中3番目), Osada, H. (7名中7番目)
    • Journal Title

      Oncogene 28

      Pages: 107-116

    • NAID

      120006385868

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A p38 mitogen-activated protein kinase inhibitor screening method using growth recovery of Escberichia coil as an index2009

    • Author(s)
      Kawai, K., et al.
    • Journal Title

      Anal.Biochem. 388

      Pages: 128-133

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] On-chip fragment-based approach for discovery of high-affinity bivalent inhibitors2009

    • Author(s)
      Miyazaki, I., et al.
    • Journal Title

      Chembiochem 10

      Pages: 838-843

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-affinity relationship study of bleomycins and Shble protein by use of a chemical array2009

    • Author(s)
      Miyazaki, I., et al.
    • Journal Title

      Chembiochem 10

      Pages: 845-852

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus2009

    • Author(s)
      Kato, N., et al.
    • Journal Title

      Chembiochem 10

      Pages: 920-928

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells2009

    • Author(s)
      Simizu, S., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 383

      Pages: 406-410

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ATM blocks tunicamycin-induced endoplasmic reticulum stress2009

    • Author(s)
      He, L., Kim, et al.
    • Journal Title

      FEBS Lett. 583

      Pages: 903-908

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity2009

    • Author(s)
      Ju, J., Li, W., et al.
    • Journal Title

      Org.Lett. 11

      Pages: 1639-1642

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kerriamycin B inhibits protein SUMOylation2009

    • Author(s)
      Fukuda, I., et al.
    • Journal Title

      J.Antibiot. 62

      Pages: 221-224

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide maps of mono- and di-nucleosomes of Aspergillus fumigatus2009

    • Author(s)
      Nishida, H., et al.
    • Journal Title

      Bioinformatics 25

      Pages: 2295-2297

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoclast-targeting small molecules for the treatment of neoplastic bone metastases2009

    • Author(s)
      川谷誠, et al.
    • Journal Title

      Cancer Sci. 100

      Pages: 1999-2005

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of protein tyrosine phosphatase 1B by lupeol and lupenone isolated from Sorbus commixta2009

    • Author(s)
      Na, M., et al.
    • Journal Title

      J Enzyme Inhib.Med.Chem. 24

      Pages: 1056-1059

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the tautomycetin biosynthetic gene cluster from streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis2009

    • Author(s)
      Li, W., et al.
    • Journal Title

      J Nat.Prod. 72

      Pages: 450-459

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional analyses of P450 genes responsible for the early steps of brassicicene C biosynthesis2009

    • Author(s)
      Hashimoto, M., et al.
    • Journal Title

      Bioorg.Med.Chem.Lett. 19

      Pages: 5640-5643

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nocardamin production by Streptomyces avermitilis2009

    • Author(s)
      Ueki, M., et al.
    • Journal Title

      Actinomycetologica 23

      Pages: 34-39

    • NAID

      10025872918

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of cyclophilin D in mitochondrial permeability transition induction in intact cells2009

    • Author(s)
      Tazawa, H., et al.
    • Journal Title

      Arch.Biochem.Biophys. 481

      Pages: 59-64

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exploring the chemical space of microbial natural products2009

    • Author(s)
      長田裕之, et al.
    • Journal Title

      Curr.Opn.Chem.Biol. 13

      Pages: 133-134

    • Related Report
      2009 Annual Research Report
  • [Journal Article] グリオキサラーゼI2009

    • Author(s)
      川谷誠
    • Journal Title

      Medical Tribune 42

      Pages: 50-50

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 砕骨細胞を標的とする天然低分子化合物のケミカルジェネティクス2009

    • Author(s)
      川谷誠, 他
    • Journal Title

      細胞工学 28

      Pages: 338-344

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 農薬開発とケミカルバイオロジー2009

    • Author(s)
      長田裕之
    • Journal Title

      日本農薬学会誌 34

      Pages: 215-220

    • NAID

      110007340709

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 化合物スクリーニングデータベース2009

    • Author(s)
      斎藤臣雄, 他
    • Journal Title

      THE LUNG perspectives 17

      Pages: 61-66

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 天然化合物ライブラリーの構築と利用2009

    • Author(s)
      斎藤臣雄, 他
    • Journal Title

      蛋白質 核酸 酵素 154

      Pages: 1551-1556

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 化合物ライブラリーの効率的構築と利用2009

    • Author(s)
      上杉志成, 他
    • Journal Title

      ファルマシア 45

      Pages: 965-970

    • Related Report
      2009 Annual Research Report
  • [Journal Article] レドックス制御に干渉する小分子のケミカルバイオロジー2009

    • Author(s)
      川谷誠, 他
    • Journal Title

      実験医学(増刊) 27

      Pages: 218-224

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Involvement of cyclophilin D in mitochondrial permeability transition induction in intact cells.2009

    • Author(s)
      Tazawa H., et al.
    • Journal Title

      Arch. Biochem. Biophys. 481

      Pages: 59-64

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis.2009

    • Author(s)
      Tamura Y., et al.
    • Journal Title

      Oncogene 28

      Pages: 107-116

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency in chromosome congression by the inhibition of Plkl polo box domain-dependent recognition.2009

    • Author(s)
      Watanabe N., et al.
    • Journal Title

      J. Biol. Chem. 284

      Pages: 2344-2353

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RECK negatively regulates matrix metalloproteinase-9 transcription.2009

    • Author(s)
      Takagi S., et al.
    • Journal Title

      Cancer Res. 69

      Pages: 1502-1508

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A cell-based screening to detect inhibitors of BRAF signaling pathway.2009

    • Author(s)
      Asami Y., et al.
    • Journal Title

      J. Antibiot. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 癌細胞の細胞周期異常2009

    • Author(s)
      渡辺 信元, 他
    • Journal Title

      日本臨牀 67

      Pages: 71-76

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 分子細胞学的解析2009

    • Author(s)
      晴水 史郎, 他
    • Journal Title

      日本臨牀 67

      Pages: 143-147

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 砕骨細胞の分化を阻害する小分子化合物2009

    • Author(s)
      川谷 誠, 他
    • Journal Title

      バイオサイエンスとインダストリー 67

      Pages: 24-28

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Distribution of photo-cross-linked products from 3-aryl-3-trifluoromethyldiazirines and alcohols.2008

    • Author(s)
      Kanoh, N. (6名中1番目), Osada, H. (6名中6番目)
    • Journal Title

      Tetrahedron 64

      Pages: 5692-5698

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone.2008

    • Author(s)
      Osada, H. (7名中6番目)
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 105

      Pages: 15541-15546

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I.2008

    • Author(s)
      Kanoh, N. (7名中4番目), Muroi, M. (7名中5番目), Osada, H. (11名中11番目)
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 105

      Pages: 11691-11696

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase.2008

    • Author(s)
      Simizu, S. (5名中2番目), Osada, H. (5名中5番目)
    • Journal Title

      Exp. Cell Res 314

      Pages: 2834-2845

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation.2008

    • Author(s)
      Osada, H. (8名中8番目)
    • Journal Title

      Cancer Sci. 99

      Pages: 1853-1858

    • NAID

      10024011306

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAK1.2008

    • Author(s)
      Osada, H. (7名中7番目)
    • Journal Title

      Biosci. Biotechnol. Biochem. 72

      Pages: 1894-1900

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and biological activities of reveromycin A and spirofungin A derivatives.2008

    • Author(s)
      Kanoh, N. (10名中7番目), Osada, H. (10名中9番目)
    • Journal Title

      Bioorg. Med. Chem. Lett. 18

      Pages: 3756-3760

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Specific regulation of cytokine dependent p38 MAP kinase activation by p62/SQSTM1.2008

    • Author(s)
      Sudo, T. (4名中3番目), Osada, H. (4名中4番目)
    • Journal Title

      J. Biochem. 143

      Pages: 765-772

    • NAID

      10024910311

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation.2008

    • Author(s)
      Osada, H. (8名中8番目)
    • Journal Title

      J. Antibiot. 61

      Pages: 94-97

    • NAID

      80019478123

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epoxyquinol B shows antiangiogenic effects in vitro and in vivo by inhibiting not only VEGFR2 but also EGFR, FGFR, and PDGFR.2008

    • Author(s)
      Osada, H. (7名中7番目)
    • Journal Title

      Oncol. Res. 17

      Pages: 11-21

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein.2008

    • Author(s)
      Jain HD., et al.
    • Journal Title

      Bioorg. Med. Chem. 16

      Pages: 4626-4651

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and biological activities of reveromycin A and spirofungin A derivatives.2008

    • Author(s)
      Shimizu T., et al.
    • Journal Title

      Bioorg. Med. Chem. Lett. 18

      Pages: 3576-3760

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAKl.2008

    • Author(s)
      Kamiyama H., et al.
    • Journal Title

      Biosci. Biotechnol. Biochem. 72

      Pages: 1894-1900

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation.2008

    • Author(s)
      Asami Y., et al.
    • Journal Title

      Cancer Sci. 99

      Pages: 1853-1858

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of photoaffinity SPR imaging platform and determination of the binding site of p62/SQSTM1 to p38 MAP kinase.2008

    • Author(s)
      Saito A., et al.
    • Journal Title

      Chem. Asian J. 3

      Pages: 1607-1612

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The asymmetric total synthesis of (+)-cytotrienin a, an ansamycin-type anticancer drug.2008

    • Author(s)
      Hayashi Y., et al.
    • Journal Title

      Angew. Chem. Int. Ed. Engl. 47

      Pages: 6657-6660

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase.2008

    • Author(s)
      Lai N. S., et al.
    • Journal Title

      Exp. Cell Res. 314

      Pages: 2834-2845

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I.2008

    • Author(s)
      Kawatani M., et al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 105

      Pages: 11691-11696

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis.2008

    • Author(s)
      Li W., et al.
    • Journal Title

      J. Biol. Chem. 283

      Pages: 28607-28617

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages.2008

    • Author(s)
      Hiraoka K., et al.
    • Journal Title

      Cancer Sci. 99

      Pages: 1595-1602

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Robust and systematic drug screening method using chemical arrays and the protein library: identification of novel inhibitors of carbonic anhydrase II.2008

    • Author(s)
      Miyazaki I., et al.
    • Journal Title

      Biosci. Biotechnol. Biochem. 72

      Pages: 2739-2749

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and anti-angiogenic activity of cortistatin analogs.2008

    • Author(s)
      Sato Y., et al.
    • Journal Title

      Biosci. Biotechnol. Biochem. 72

      Pages: 2992-2997

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone.2008

    • Author(s)
      Yano A., et al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 105

      Pages: 15541-15546

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution of photo-cross-linked products from 3 -aryl-3-trifluoromethyldiazirines and alcohols.2008

    • Author(s)
      Kanoh N., et al.
    • Journal Title

      Tetrahedron 64

      Pages: 5692-5698

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hot springs and cool natural products.2008

    • Author(s)
      Kwon H. J., et al.
    • Journal Title

      Nat.Chem. Biol. 4

      Pages: 444-446

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 癌の分子生物と分子標的2008

    • Author(s)
      長田 裕之
    • Journal Title

      Frontiers in Gastroentelogy 13

      Pages: 66-73

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Epoxyquinol B shows antiangiogenic effects in vitro and in vivo by inhibiting not only VEGFR2 but also EGFR, FGFR, and PDGFR.2008

    • Author(s)
      Kamiyama H., et. al.
    • Journal Title

      Oncol. Res. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation.2008

    • Author(s)
      Kamiyama H., et. al.
    • Journal Title

      J. Antibiot. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specific regulation of cytokine dependent p38 MAP kinase activation by p62/SQSTM1.2008

    • Author(s)
      Kawai K., et. al.
    • Journal Title

      J. Biochem. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of disulfide bond formation in the activation of heparanase.2007

    • Author(s)
      Simizu, S. (7名中1番目), Muroi, M. (7名中3番目), Osada, H. (7名中7番目)
    • Journal Title

      Cancer Res. 67

      Pages: 7841-7849

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antiproliferating activity of the mitotic inhibitor pironetin against vindesine-and paclitaxel-rcsistant human small cell lung cancer H69 cells.2007

    • Author(s)
      Yoshida M., et. al.
    • Journal Title

      Anticancer Res. 27

      Pages: 729-736

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glaziovianin A, a new isoflavone, from the leaves of Ateleia glazioviana and its cytotoxic activity against human cancer cells.2007

    • Author(s)
      Yokosuka A., et. al.
    • Journal Title

      Bioorg Med Chem Lett. 17

      Pages: 3091-3094

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of disulfide bond formation in the activation of heparanase.2007

    • Author(s)
      Simizu S., et. al.
    • Journal Title

      Cancer Res. 67

      Pages: 7841-7849

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical genetic screening identifies a novel inhibitor of parallel alignment of cortical microtubules and cellulose microfibrils.2007

    • Author(s)
      Yoneda A., et. al.
    • Journal Title

      Plant Cell Physiol. 48

      Pages: 1393-1403

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of(+)-vinblastine and its analogues.2007

    • Author(s)
      Miyazaki T., et. al.
    • Journal Title

      Org. Lett. 9

      Pages: 4737-4740

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts.2006

    • Author(s)
      Kanoh, N. (12名中6番目), Osada, H. (12名中12番目)
    • Journal Title

      Proc. Natl. Acad. Sci., USA. 103

      Pages: 4729-4734

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells.2006

    • Author(s)
      Osada, H. (3名中3番目)
    • Journal Title

      J. Biol. Chem. 281

      Pages: 14314-14320

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Iejimalides, the antitumor 24-membered macrolides, are novel V-ATPases inhibitors., Biosci.2006

    • Author(s)
      Muroi, M. (7名中2番目), Osada, H. (7名中7番目)
    • Journal Title

      Biotechnol. Biochem. 70

      Pages: 1364-1370

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] SPR imaging measurement of photo-cross-linked small molecule microarrays on gold.2006

    • Author(s)
      Kanoh, N. (7名中1番目), Osada, H. (7名中7番目)
    • Journal Title

      Anal. Chem. 78

      Pages: 2226-2230

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] RK-95113, a new angiogenesis inhibitor produced by Aspergillus fumigatus.2006

    • Author(s)
      Osada, H. (5名中5番目)
    • Journal Title

      J. Antibiot. 59

      Pages: 724-728

    • NAID

      10019271192

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enzymatic generation of the antimetabolite gamma, gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete.2006

    • Author(s)
      Ueki, M. (9名中1番目), Osada, H. (9名中8番目)
    • Journal Title

      Chem. Biol. 13

      Pages: 1183-1191

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brasilicardin A, a natural immunosuppressant, targets amino acid transport system L.2006

    • Author(s)
      Osada, H. (7名中7番目)
    • Journal Title

      Chem. Biol. 13

      Pages: 1153-1160

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts.2006

    • Author(s)
      J.-T.Woo et al.
    • Journal Title

      Proc. Natl. Acad. Sci., USA. 103

      Pages: 4729-4734

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Computational study on the reaction mechanism of the key thermal [4+4] cycloaddition reaction in the biosynthesis of epoxytwinol A.2006

    • Author(s)
      I.Shiina et al.
    • Journal Title

      Organic Lett. 8

      Pages: 1041-1044

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis.2006

    • Author(s)
      V.Temkin et al.
    • Journal Title

      Mol. Cell Biol. 26

      Pages: 2215-2225

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Suppression of apoptosis by cyclophilin d via stabilization of hexokinase ii mitochondrial binding in cancer cells.2006

    • Author(s)
      K.Machida et al.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 14314-14320

    • Related Report
      2006 Annual Research Report
  • [Journal Article] SPR imaging measurement of photo-cross-linked small molecule microarrays on gold.2006

    • Author(s)
      N.Kanoh et al.
    • Journal Title

      Annal. Chem. 78

      Pages: 2226-2230

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Iejimalides show anti-osteoclast activity via V-ATPase inhibition.2006

    • Author(s)
      S.Kazami et al.
    • Journal Title

      Biosci. Biotechnol. Biochem. 70

      Pages: 1364-1370

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Enantio- and diastereoselective total synthesis of (+)-panepophenanthrin, an ubiquitin-activating enzyme inhibitor, and biological properties of its new derivatives.2006

    • Author(s)
      M.Matsuzawa et al.
    • Journal Title

      Chemistry Asian J. 1

      Pages: 845-851

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Photo-cross-linked small-molecule microarrays as chemical genomic tools for dissecting protein-ligand interactions.2006

    • Author(s)
      N.Kanoh et al.
    • Journal Title

      Chemistry Asian J. 1

      Pages: 789-797

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Synthesis and biological properties of new phosmidosine analogs having an N-acylsulfamate linkage.2006

    • Author(s)
      H.Taguchi et al.
    • Journal Title

      Nucleosides Nucleotides Nucleic Acids. 25

      Pages: 647-654

    • Related Report
      2006 Annual Research Report
  • [Journal Article] N-Linked oligosaccharide processing enzymes as molecular targets for drug discovery.2006

    • Author(s)
      W.Hakamata et al.
    • Journal Title

      J. Appl. Glycosci. 53

      Pages: 149-154

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of Saccharomyces cerevisiae ribosomal protein L3 as a target of Curvularol, a G(1)-specific inhibitor of mammalian cells.2006

    • Author(s)
      Y.Kobayashi et al.
    • Journal Title

      Biosci. Biotechnol. Biochem. 70

      Pages: 2451-2459

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of a strong binding site for kinesin on the microtubule using mutant analysis of tubulin.2006

    • Author(s)
      S.Uchimura et al.
    • Journal Title

      EMBO J. 25

      Pages: 5932-5941

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Phenothiazine and carbazole-related compounds inhibit mitotic kinesin Eg5 and trigger apoptosis in transformed culture cells.2006

    • Author(s)
      H.Okumura et al.
    • Journal Title

      Toxicol. Lett. 166

      Pages: 44-52

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity.2006

    • Author(s)
      N.Watanabe et al.
    • Journal Title

      FEBS Lett. 580

      Pages: 2598-2602

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus.2006

    • Author(s)
      W.Li et al.
    • Journal Title

      J. Bacteriol. 188

      Pages: 4148-4152

    • Related Report
      2006 Annual Research Report
  • [Journal Article] RK-95113, a new angiogenesis inhibitor produced by Aspergillus fumigatus.2006

    • Author(s)
      Y.Asami et al.
    • Journal Title

      J. Antibiot. 59

      Pages: 724-728

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Enzymatic generation of the antimetabolite γ,γ-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete.2006

    • Author(s)
      M.Ueki et al.
    • Journal Title

      Chem. Biol. 13

      Pages: 1183-1191

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Brasilicardin A, an natural immunosuppressant, targets amino acid transport system L.2006

    • Author(s)
      T.Usui et al.
    • Journal Title

      Chem. Biol. 13

      Pages: 1153-1160

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Computational study on the reaction mechanism of the key thermal [4+4] cycloaddition reaction in the biosynthesis of epoxytwinol A.2006

    • Author(s)
      I.Shiina et al.
    • Journal Title

      Org.Lett. (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Concise enantio- and diastereoselective total syntheses of Fumagillol, RK-805, FR65814,Ovalicin, and 5-demethylovalicin.2006

    • Author(s)
      J.Yamaguchi et al.
    • Journal Title

      Angew.Chem.Int.Ed. 45

      Pages: 789-793

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells, SBC-5, through an anti-osteoclastic activity.2005

    • Author(s)
      Osada, H. (7名中6番目)
    • Journal Title

      Clin. Cancer Res. 11

      Pages: 8822-8828

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] p38 mitogen-activated protein kinase plays a key role in regulating MAPKAPK2 expression.2005

    • Author(s)
      Sudo, T. (4名中1番目), Osada, H. (4名中4番目)
    • Journal Title

      Biochem. Biophys. Res. Commun. 337

      Pages: 415-421

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines.2005

    • Author(s)
      Simizu, S. (4名中1番目), Osada, H. (4名中4番目)
    • Journal Title

      Cancer Res. 65

      Pages: 7455-7461

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways.2005

    • Author(s)
      Osada, H. (7名中7番目)
    • Journal Title

      Proc. Natl. Acad. Sci., USA. 102

      Pages: 11663-11668

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photo-crosslinked small molecule affinity matrix for facilitating forward and reverse chemical genetics.2005

    • Author(s)
      Kanoh, N. (5名中1番目), Simizu, S. (5名中3番目), Muroi, M. (5名中4番目), Osada, H. (5名中5番目)
    • Journal Title

      Angew. Chem. Int. Ed. 44

      Pages: 3559-3562

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells.2005

    • Author(s)
      Simizu, S. (4名中2番目), Kanoh, N. (4名中3番目), Osada, H. (4名中4番目)
    • Journal Title

      FEBS Lett. 579

      Pages: 2463-2468

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus.2005

    • Author(s)
      Osada, H. (4名中4番目)
    • Journal Title

      Chem. Commun. 20

      Pages: 2575-2577

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells, SBC-5, through an anti-osteoclastic activity.2005

    • Author(s)
      H.Muguruma et al.
    • Journal Title

      Clin.Cancer Res. 11

      Pages: 8822-8828

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Enantio- and diastereo-selective total synthesis of EI-1941-1,-2 and -3,inhibitors of interleukin-1 alpha converting enzyme and biological properties of their derivatives.2005

    • Author(s)
      M.Shoji et al.
    • Journal Title

      J.Org.Chem 70

      Pages: 9905-9915

    • Related Report
      2005 Annual Research Report
  • [Journal Article] RKTS-33,an epoxycyclohexenone derivative that specifically inhibits Fas liganddependent apoptosis in CTL-mediated cytotoxicity.2005

    • Author(s)
      T.Mitsui et al.
    • Journal Title

      Biosci.Biotechnol.Biochem. 69

      Pages: 1923-1928

    • Related Report
      2005 Annual Research Report
  • [Journal Article] p38 mitogen-activated protein kinase plays a key role in regulating MAPKAPK2 expression.2005

    • Author(s)
      T.Sudo et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 337

      Pages: 415-421

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mutational analysis of growth arrest and cellular localization of human immunodeficiency virus type 1 Vpr in the budding yeast, Saccharomyces cerevisiae.2005

    • Author(s)
      J.Nakazawa et al.
    • Journal Title

      J.Gen.Appl.Microbiol. 51

      Pages: 245-256

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ZHD-0501, a novel naturally occurring staurosporine analog from Actinomadura sp.0072005

    • Author(s)
      XX.Han et al.
    • Journal Title

      Tetrahedron Lett. 46

      Pages: 6137-6140

    • Related Report
      2005 Annual Research Report
  • [Journal Article] RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines.2005

    • Author(s)
      S.Simizu et al.
    • Journal Title

      Cancer Res. 65

      Pages: 7455-7461

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Weel via multiple pathways.2005

    • Author(s)
      N.Watanabe et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 102

      Pages: 11663-11668

    • Related Report
      2005 Annual Research Report
  • [Journal Article] First asymmetric total synthesis of synerazol, an antifungal antibiotic, and determination of its absolute stereochemistry.2005

    • Author(s)
      Y.Hayashi et al.
    • Journal Title

      J.Org.Chem. 70

      Pages: 5643-5654

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Determination by asymmetric total synthesis of the absolute configuration of Lucilactaene, a cell-cycle inhibitor in p53-transfected cancer cells.2005

    • Author(s)
      J.Yamaguchi et al.
    • Journal Title

      Angew.Chem.Int.Ed. 44

      Pages: 3110-3115

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Photo-cross-linked small molecule affinity matrix for facilitating forward and reverse chemical genetics.2005

    • Author(s)
      N.Kanoh et al.
    • Journal Title

      Angew.Chem.Int.Ed. 44

      Pages: 3559-3562

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells.2005

    • Author(s)
      T.Teruya et al.
    • Journal Title

      FEBS Lett. 579

      Pages: 2463-2468

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Epoxytwinol A, a novel unique angiogenesis inhibitor with C_2 symmetry, produced by a fungus.2005

    • Author(s)
      H.Kakeya et al.
    • Journal Title

      Chem.Commun. 2005

      Pages: 2575-2577

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The application of the chemical array for biological study

    • Author(s)
      Miyazaki, I., et al.
    • Journal Title

      Methods Mol.Biol. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glyoxalase-I is a novel target against Bcr-Abl^+ leukemic cells acquiring stem-like characteristics in hypoxic environment

    • Author(s)
      Takeuchi, M., et al.
    • Journal Title

      Cell Death Diff. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 生合成酵素を用いた非天然型サイトトリエニンの創製に関する研究2010

    • Author(s)
      植木雅志
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学駒場キャンパス(東京)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 分子内 peroxide 架橋形成を触媒する verruculogen 合成酵素FtmFの機能解析2010

    • Author(s)
      加藤直樹
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学駒場キャンパス(東京)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 糸状菌 Chaunopycnis alba が生産するM期キネシンEg5阻害剤の生合成遺伝子クラスター2010

    • Author(s)
      本山高幸
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学駒場キャンパス(東京)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] ケミカルバイオロジー研究に向けた微生物代謝産物フラクションライブラリーの構築2010

    • Author(s)
      野川俊彦
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学駒場キャンパス(東京)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] リベロマイシンAスピロケタール生成に関わる新規デヒドロゲナーゼの機能解析2010

    • Author(s)
      高橋俊二
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学駒場キャンパス(東京)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] リベロマイシン構造多様化に関わる2-アルキルマロニルCoA生合成機構の解析2010

    • Author(s)
      高木海
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学駒場キャンパス(東京)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] プロテオミクスを用いたリン酸化修飾に基づく薬剤作用標的解析システム2010

    • Author(s)
      野田和恵
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学駒場キャンパス(東京)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] GO-Y086のプロテオミクス解析を用いた作用標的の推測2010

    • Author(s)
      室井誠
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学駒場キャンパス(東京)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] リンカーの改変による化合物アレイの高感度化2010

    • Author(s)
      近藤恭光
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学駒場キャンパス(東京)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] p38MAPキナーゼ阻害剤としてのベンジルクマリン類縁体の構造-活性相関研究2010

    • Author(s)
      齊藤安貴子
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学駒場キャンパス(東京)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞空胞化を誘導するNPD1801の作用機構解析2010

    • Author(s)
      南谷武志
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学駒場キャンパス(東京)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Chemical control of bone metastasis through the suppression of osteoclasts.2010

    • Author(s)
      Osada, H.
    • Organizer
      8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
    • Place of Presentation
      Waikoloa, Hawaii, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Chemical array-based screening of inhibitors for cyanobacterial HtpG(aneukaryotic Hsp90 homologue)2010

    • Author(s)
      近藤恭光
    • Organizer
      The 5th Japan-Korea Chemical Biology Symposium
    • Place of Presentation
      Busan, Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pathway Engineering of a Polyketide Compound, Reveromycin A.2010

    • Author(s)
      高橋俊二
    • Organizer
      The 5th Japan-Korea Chemical Biology Symposium
    • Place of Presentation
      Busan, Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] Chemical control of bone metastasis through the suppression of osteoclasts2010

    • Author(s)
      川谷誠
    • Organizer
      8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
    • Place of Presentation
      Waikoloa, Hawaii, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] A small molecule inhibitor of phosphorylation-dependent protein-protein interaction2010

    • Author(s)
      渡邉信元
    • Organizer
      8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
    • Place of Presentation
      Waikoloa, Hawaii, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] 創薬資源としての微生物代謝産物2009

    • Author(s)
      長田裕之
    • Organizer
      第26回白金シンポジウム
    • Place of Presentation
      北里大学薬学部コンベンションホール(東京)
    • Year and Date
      2009-12-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Sequence requirement for degradation of Cdc25B by SCF^<βTrCP> in response to cellular stress2009

    • Author(s)
      内田早苗
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role of peptidyl prolyl isomerization during M-phase progression2009

    • Author(s)
      渡邉信元
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of benzyl coumarin derivatives as the p38 MAP kinase inhibitors.2009

    • Author(s)
      須藤龍彦
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-12-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Identification of benzyl coumarin derivatives as the p38 MAP kinase inhibitors2009

    • Author(s)
      須藤龍彦
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-12-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞空胞化を誘導するNPD1801の作用機構解析2009

    • Author(s)
      南谷武志
    • Organizer
      化学生物学研究会
    • Place of Presentation
      北里大学白金校舎(東京)
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] いもち病菌 Magnaporthe oryzae の形態変化を指標とした新規生理活性物質の探索2009

    • Author(s)
      長谷川慎哉
    • Organizer
      化学生物学研究会
    • Place of Presentation
      北里大学白金校舎(東京)
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] 破骨細胞の機能を制御する小分子のケミカルバイオロジー2009

    • Author(s)
      川谷誠
    • Organizer
      昭和大学歯学部セミナー
    • Place of Presentation
      昭和大学(東京)
    • Year and Date
      2009-10-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 麹菌 Aspergillus oryzae における cyclopiazonic acid 生合成と安全性2009

    • Author(s)
      加藤直樹
    • Organizer
      第51回天然有機化合物討論会
    • Place of Presentation
      名古屋市公会堂(名古屋)
    • Year and Date
      2009-10-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 理研天然化合物バンクにおけるケミカルバイオロジー2009

    • Author(s)
      長田裕之
    • Organizer
      第26回和漢医薬学会学術大会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2009-08-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 微生物二次代謝産物のケミカルバイオロジー2009

    • Author(s)
      長田裕之
    • Organizer
      2009年度日本農芸化学会東北支部シンポジウム
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2009-07-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 化合物アレイを用いた抗がん剤スクリーニング法の開発2009

    • Author(s)
      清水史郎
    • Organizer
      第13回日本がん分子標的治療学会学術集会
    • Place of Presentation
      ホテルクレメント徳島(徳島)
    • Year and Date
      2009-06-26
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 新規抗癌剤スクリーニング法の開発:化合物アレイを用いたフラグメントベースデザイン2009

    • Author(s)
      宮崎功
    • Organizer
      第13回日本がん分子標的治療学会学術集会
    • Place of Presentation
      ホテルクレメント徳島(徳島)
    • Year and Date
      2009-06-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 分化誘導活性物質NPD723の作用機構解析2009

    • Author(s)
      川谷誠
    • Organizer
      第13回日本がん分子標的治療学会学術集会
    • Place of Presentation
      ホテルクレメント徳島(徳島)
    • Year and Date
      2009-06-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 最先端創薬システム:分子標的治療薬開発のためのケミカルバイオロジー2009

    • Author(s)
      清水史郎
    • Organizer
      第13回日本がん分子標的治療学会学術集会
    • Place of Presentation
      ホテルクレメント徳島(徳島)
    • Year and Date
      2009-06-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低酸素環境に適応した慢性骨髄性白血病細胞(CML)に対する glyoxalase-1(Glo-)阻害剤の有効性2009

    • Author(s)
      武内美紀
    • Organizer
      第13回日本がん分子標的治療学会学術集会
    • Place of Presentation
      ホテルクレメント徳島(徳島)
    • Year and Date
      2009-06-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characterization and target identification of cobtorin, a novel inhibitor against cortical microtubule-cellulose microfibril parallel alignment by chemical genetics2009

    • Author(s)
      米田新
    • Organizer
      Sweden-Japan joint colloquium "Green Chemistry"
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2009-05-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Screening of small molecule inhibitors of osteoclast function2009

    • Author(s)
      長田裕之
    • Organizer
      RIKEN-NTU-NUS Joint Seminar-Frontier of Chemical and Material Sciences
    • Place of Presentation
      NTU, Singapore
    • Year and Date
      2009-05-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 天然化合物バンク NPDepo における抗がん剤の分子標的研究2009

    • Author(s)
      長田 裕之
    • Organizer
      公開シンポジウム「抗がん剤創薬の新たな展開」新しい分子標的、探索法、ライブラリー、情報学など
    • Place of Presentation
      岩手医科大学 (盛岡)
    • Year and Date
      2009-01-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] A small molecule inhibitor of Pirin that suppresses tumor cell migration.2009

    • Author(s)
      Simizu, S.
    • Organizer
      2009 AACR-NCI-EORTC International Conference
    • Place of Presentation
      Boston, U.S. A
    • Related Report
      2009 Final Research Report
  • [Presentation] Chemical biology of microbial metabolites.2009

    • Author(s)
      Osada, H.
    • Organizer
      Australia-Japan workshop on biodiversity
    • Place of Presentation
      Canberra, Australia
    • Related Report
      2009 Final Research Report
  • [Presentation] 化合物アレイを使用した抗がん剤のスクリーニング法2009

    • Author(s)
      清水史郎
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Systematic isolation and target identification of microbial metabolites.2009

    • Author(s)
      Osada, H.
    • Organizer
      The 25th Naito Conference on Chemical Biology [II]
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] Nocardamin production by Streptomyces Avermitilis K139.2009

    • Author(s)
      Ueki, M.
    • Organizer
      15th International Symposium on the Biology of Actinomycetes
    • Place of Presentation
      Shanghai, China
    • Related Report
      2009 Final Research Report
  • [Presentation] Reveromycin A: Polyketide biosynthesis and anti-osteoclasts activity.2009

    • Author(s)
      Osada, H.
    • Organizer
      15th International Symposium on the Biology of Actinomycetes
    • Place of Presentation
      Shanghai, China
    • Related Report
      2009 Final Research Report
  • [Presentation] 薬剤処理HeLa細胞のプロテオームプロファイリングシステムの拡張2009

    • Author(s)
      室井誠
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2009 Final Research Report
  • [Presentation] Establishment of novel antitumor drugs screening method by using chemical array.2009

    • Author(s)
      Simizu, S.
    • Organizer
      AACR-ACS Joint Conference on Chemistry in Cancer Research
    • Place of Presentation
      New Orleans, USA.
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Nucleoprotein をターゲットにした新規抗インフルエンザ薬の開発2009

    • Author(s)
      萩原恭二
    • Organizer
      第147回日本獣医学会学術集会
    • Place of Presentation
      栃木県総合文化センター栃木県自治会館(宇都宮)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 抗生物質研究からケミカルバイオロジー研究へ2009

    • Author(s)
      長田裕之
    • Organizer
      天然有機化合物討論会50周年記念講演会
    • Place of Presentation
      仙台国際センター(仙台)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Screening of small molecule inhibitors of osteoclast function2009

    • Author(s)
      長田裕之
    • Organizer
      A* STAR-RIKEN Symposium
    • Place of Presentation
      Agency for Science, Technology and Research, Singapore
    • Related Report
      2009 Annual Research Report
  • [Presentation] 表層微小管-セルロース微繊維相互作用に対する新規阻害剤コブトリンの標的因子の探索2009

    • Author(s)
      米田新
    • Organizer
      日本ケミカルバイオロジー学会第4回年会
    • Place of Presentation
      神戸市産業振興センター(神戸)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Prenyltransferase from Streptomyces reveromyceticus2009

    • Author(s)
      高橋俊二
    • Organizer
      TERPNET2009
    • Place of Presentation
      東京大学(東京)
    • Related Report
      2009 Annual Research Report
  • [Presentation] NRPS Adenylation protein CytC1の基質特異性改変に関する研究2009

    • Author(s)
      植木雅志
    • Organizer
      日本放線菌学会2009年度大会
    • Place of Presentation
      秋田ビューホテル(秋田)
    • Related Report
      2009 Annual Research Report
  • [Presentation] リベロマイシンAのスピロケタール生合成機構の解析2009

    • Author(s)
      高橋俊二
    • Organizer
      日本放線菌学会2009年度大会
    • Place of Presentation
      秋田ビューホテル(秋田)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Reveromycin A : Polyketide biosynthesis and anti-osteoclasts activity2009

    • Author(s)
      長田裕之
    • Organizer
      15th International Symposium on the Biology of Actinomycetes
    • Place of Presentation
      Shanghai, China
    • Related Report
      2009 Annual Research Report
  • [Presentation] Nocardamin production by Streptomyces Avermitilis K1392009

    • Author(s)
      Ueki, M.
    • Organizer
      15th International Symposium on the Biology of Actinomycetes
    • Place of Presentation
      Shanghai, China
    • Related Report
      2009 Annual Research Report
  • [Presentation] Biochemical and crystal structure analyses of reveromycin E hydroxylase(P450RME)in reveromycin A biosynthetic gene cluster2009

    • Author(s)
      高橋俊二
    • Organizer
      15th International Symposium on the Biology of Actinomycetes
    • Place of Presentation
      Shanghai, China
    • Related Report
      2009 Annual Research Report
  • [Presentation] 化合物アレイを用いた創薬候補化合物のスクリーニング2009

    • Author(s)
      長田裕之
    • Organizer
      日本化学会第3回関東支部大会
    • Place of Presentation
      早稲田大学理工キャンパス(東京)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fragment-based approach for new tool of inhibitor design2009

    • Author(s)
      宮崎功
    • Organizer
      The 25th Naito Conference on Chemical Biology[II]
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Discovery of bioactive compounds through morphology-based chemical-genetic screens2009

    • Author(s)
      Futamura, Y.
    • Organizer
      The 25th Naito Conference on Chemical Biology[II]
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Systematic isolation and target identification of microbial metabolites2009

    • Author(s)
      長田裕之
    • Organizer
      The 25th Naito Conference on Chemical Biology[II]
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] ポロボックス領域依存結合を阻害する小分子化合物の探索2009

    • Author(s)
      渡邉信元
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 化合物アレイを用いた新規インフルエンザ阻害剤のスクリーニング2009

    • Author(s)
      萩原恭二
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      都市センターホテル(東京)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Chemical biology of microbial metabolites2009

    • Author(s)
      長田裕之
    • Organizer
      Australia-Japan workshop on biodiversity
    • Place of Presentation
      Canberra, Australia
    • Related Report
      2009 Annual Research Report
  • [Presentation] Methyl gerfelin, a small molecule inhibitor of osteoclastogenesis that acts via inhibition of glyoxalase I.2009

    • Author(s)
      川谷誠
    • Organizer
      The 26th Naito Conference on Osteobiology
    • Place of Presentation
      Awaji, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] A small molecule inhibitor of Pirin that suppresses tumor cell migration2009

    • Author(s)
      清水史郎
    • Organizer
      2009 AACR-NCI-EORTC International Conference
    • Place of Presentation
      Boston, U.S.A
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of a novel DNA topoisomerase II inhibitor by proteomic profiling2009

    • Author(s)
      川谷誠
    • Organizer
      2009 AACR-NCI-EORTC International Conference
    • Place of Presentation
      Boston, U.S.A
    • Related Report
      2009 Annual Research Report
  • [Presentation] 糸状菌 Chaunopycnis albs が生産するM期キネシンEg5阻害剤の生合成クラスター2009

    • Author(s)
      本山高幸
    • Organizer
      第9回糸状菌分子生物学コンファレンス
    • Place of Presentation
      東京大学農学部弥生講堂(東京)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Aspergillus fumigatus における pseurotin 生合成遺伝子クラスターの解析2009

    • Author(s)
      加藤直樹
    • Organizer
      第9回糸状菌分子生物学コンファレンス
    • Place of Presentation
      東京大学農学部弥生講堂(東京)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 麹菌における cyclopiazonic acid 生合成遺伝クラスターの解析2009

    • Author(s)
      篠原靖智
    • Organizer
      第9回糸状菌分子生物学コンファレンス
    • Place of Presentation
      東京大学農学部弥生講堂(東京)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 表層微小管・セルロース微繊維平行性を乱す新規阻害剤コブトリンの標的因子の解析2009

    • Author(s)
      米田新
    • Organizer
      第51回日本植物生理学会年会
    • Place of Presentation
      熊本大学(熊本)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Discovery of small-molecule inhibitors by chemical array.2009

    • Author(s)
      清水 史郎, 他
    • Organizer
      RIKEN 2009 Joint retreat
    • Place of Presentation
      熱海ニューフジヤホテル (熱海)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Screening of bioactive small molecules in RIKEN NPDepo.2009

    • Author(s)
      Osada H.
    • Organizer
      MPG RIKEN Conference on Interdisciplinary cooperation
    • Place of Presentation
      Munich, Germany
    • Related Report
      2008 Annual Research Report
  • [Presentation] 砕骨細胞阻害剤のケミカルバイオロジー2009

    • Author(s)
      長田 裕之
    • Organizer
      有機合成のニュートレンド2009
    • Place of Presentation
      大阪科学技術センター (大阪)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 創薬支援基盤としての NPDepo の活動状況2009

    • Author(s)
      長田 裕之
    • Organizer
      第13回理事長ファンドワークショップ「創薬研究基盤システムの構築の展開」-ライフサイエンス研究から創薬研究への展開とその研究システムの確立-
    • Place of Presentation
      ヤマハリゾー卜つま恋 (掛川)
    • Related Report
      2008 Annual Research Report
  • [Presentation] On-chip fragment-based approach for new tool of antitumor drug design.2009

    • Author(s)
      Miyazaki I., et al.
    • Organizer
      AACR-ACS Joint Conference on Chemistry in Cancer Research
    • Place of Presentation
      New Orleans, USA.
    • Related Report
      2008 Annual Research Report
  • [Presentation] Hsp90 (HtpG)の機能及び構造に影響を与える化合物の網羅的探索2009

    • Author(s)
      皆川 俊, 他
    • Organizer
      第50回日本植物生理学会年会
    • Place of Presentation
      名古屋大学 (名古屋)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 糸状菌 Albophoma yamanashiensis のM期キネシン Eg5 阻害二次代謝産物生合成遺伝子クラスターの解析2009

    • Author(s)
      本山 高幸, 他
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡国際会議場 (福岡)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 病原性糸状菌 Aspergillus fumigatus におけるフミトレモルジン生合成経路の改変2009

    • Author(s)
      加藤 直樹, 他
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡国際会議場 (福岡)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 化合物アレイを用いたシアノバクテリア HtpG (Hsp90) の阻害剤探索2009

    • Author(s)
      近藤 恭光, 他
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡国際会議場 (福岡)
    • Related Report
      2008 Annual Research Report
  • [Presentation] NRPS アデニレーションタンパク質 CytC1 の基質特異性の改変に関する研究2009

    • Author(s)
      植木 雅志, 他
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡国際会議場 (福岡)
    • Related Report
      2008 Annual Research Report
  • [Presentation] リベロマイシン構造多様化に関わる CoA ligase 機能の解析2009

    • Author(s)
      河田 章寛, 他
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡国際会議場 (福岡)
    • Related Report
      2008 Annual Research Report
  • [Presentation] リベロマイシンA 生合成遺伝子 P450RME の機能解析2009

    • Author(s)
      高橋 俊二, 他
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡国際会議場 (福岡)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 薬剤処理 HeLa 細胞のプロテオームプロファイリングシステムの拡張2009

    • Author(s)
      室井 誠, 他
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡国際会議場 (福岡)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 化合物アレイと SPR イメージング法を用いたタウタンパク質凝集阻害活性物質の探索2009

    • Author(s)
      齊藤 安貴子, 他
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡国際会議場 (福岡)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 微生物代謝産物からの PBD 依存結合阻害剤の探索研究2009

    • Author(s)
      荻田 紀子, 他
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡国際会議場 (福岡)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Activation and function of heparanase: roles of post-translational modifications.2008

    • Author(s)
      Simizu, S.
    • Organizer
      International Symposium on System Glycobiology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-12-05
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Chemical biological approach to elucidate heparanase function.2008

    • Author(s)
      Osada, H.
    • Organizer
      International Symposium on System Glycobiology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-12-05
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Natural products depository (NPDepo)-Its role in drug discovery.2008

    • Author(s)
      Osada, H.
    • Organizer
      2008 International Symposium of Oral Cancer Research Institute: Oral Cancer and Cancer Prevention
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-10-23
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Natural products depository (NPDepo)-Its role in drug discovery.2008

    • Author(s)
      Osada H.
    • Organizer
      Frontiers in Chemical Biology: A joint symposium of RIKEN and Academia Sinica
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2008-07-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Complete analysis of the fumitremorgin biosynthetic gene cluster.2008

    • Author(s)
      Kato N., et al.
    • Organizer
      The 4th Korea-Japan Chemical Biology Symposium
    • Place of Presentation
      Kinugawa, Tochigi, Japan
    • Year and Date
      2008-05-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] The identification of a novel inhibitor of osteoclastogenesis that acts via inhibition of glyoxalase I.2008

    • Author(s)
      Kawatani M., et al.
    • Organizer
      The 4th Korea-Japan Chemical Biology Symposium
    • Place of Presentation
      Kinugawa, Tochigi, Japan
    • Year and Date
      2008-05-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development of a screening system for HIV-1 Vpr Inhibitors and the study of its mechanism of action.2008

    • Author(s)
      Eugene O., et al.
    • Organizer
      The 4th Korea-Japan Chemical Biology Symposium
    • Place of Presentation
      Kinugawa, Tochigi, Japan
    • Year and Date
      2008-05-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] ER-stress induction by a compound isolated from Magnolia obovata.2008

    • Author(s)
      Kim S. O., et al.
    • Organizer
      The 4th Korea-Japan Chemical Biology Symposium
    • Place of Presentation
      Kinugawa, Tochigi, Japan
    • Year and Date
      2008-05-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Chemical biology on osteoclast inhibitors isolated from microorganisms.2008

    • Author(s)
      Osada, H.
    • Organizer
      Seminar at Inernational Leibniz Research School for Microbial and Biomolecular Interactions
    • Place of Presentation
      Jena, Germany
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Chemistry and biology of bioprobes for elucidating the osteoclast function.2008

    • Author(s)
      Osada, H.
    • Organizer
      3rd Medicinal Chemistry Symposium: Trends in Medicinal Chemistry and Chemical Biology
    • Place of Presentation
      Singapore, Singapore
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 細胞分裂期進行における Plkl ポロボックスドメイン依存性結合の役割の化学生物学的解析2008

    • Author(s)
      渡邉 信元, 他
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      学術総合センター (東京)
    • Related Report
      2008 Annual Research Report
  • [Presentation] GeneライブラリーGLORIAの構築2008

    • Author(s)
      一宮 治美, 他
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      学術総合センター (東京)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 化合物アレイスクリーニング系の構築と新規 CA II リガンドの検出2008

    • Author(s)
      宮崎 功他
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      学術総合センター (東京)
    • Related Report
      2008 Annual Research Report
  • [Presentation] タウ蛋白質に結合して凝集を阻害するバイオプローブのスクリーニング研究2008

    • Author(s)
      川崎 安貴子, 他
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      学術総合センター (東京)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗腫瘍活性物質BNS-22 はDNA topoisomerase II 活性を阻害する2008

    • Author(s)
      川谷 誠, 他
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      学術総合センター (東京)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Aspergillus fumigatus の生産するフミトレモルジンの生合成機構解明とその応用2008

    • Author(s)
      加藤 直樹, 他
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      学術総合センター (東京)
    • Related Report
      2008 Annual Research Report
  • [Presentation] ケミカルジェネティクスよる表層微小管-細胞壁相互作用に対する新規阻害剤の同定と作用機序の解析2008

    • Author(s)
      米田 新, 他
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      学術総合センター (東京)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 酸化酵素 cytochrome P450 の基質と阻害剤を検出する化合物アレイ型プラットフォームの開発2008

    • Author(s)
      叶 直樹, 他
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      学術総合センター (東京)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Glaziovianin A の微小管機能阻害作用2008

    • Author(s)
      臼井 健郎, 他
    • Organizer
      第12回がん分子標的治療研究会
    • Place of Presentation
      学術総合センター (東京)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗腫瘍活性物質 GUT-70 の作用機構解析2008

    • Author(s)
      川谷 誠, 他
    • Organizer
      第12回がん分子標的治療研究会
    • Place of Presentation
      学術総合センター (東京)
    • Related Report
      2008 Annual Research Report
  • [Presentation] GUT-70、並びに、誘導体 BNS-22 のプロテオミクスを用いた作用標的解析2008

    • Author(s)
      室井 誠, 他
    • Organizer
      第12回がん分子標的治療研究会
    • Place of Presentation
      学術総合センター (東京)
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヘパラナーゼ結合タンパク質の探索と活性化機構の解析2008

    • Author(s)
      清水 史郎, 他
    • Organizer
      第12回がん分子標的治療研究会
    • Place of Presentation
      学術総合センター (東京)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 慢性骨髄性白血病細胞の低酸素環境適応におけるGlyoxalase-1の重要性2008

    • Author(s)
      武内 美紀, 他
    • Organizer
      第12回がん分子標的治療研究会
    • Place of Presentation
      学術総合センター (東京)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 放線菌Streptomyces reverormyceticus代謝物の系統的解析2008

    • Author(s)
      高木 海, 他
    • Organizer
      2008年日本放線菌学会大会
    • Place of Presentation
      フルーツパーク富士屋ホテル (山梨)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Streptomyces griseusにおけるDNA制限修飾系の解析2008

    • Author(s)
      鈴木 宏和, 他
    • Organizer
      2008年日本放線菌学会大会
    • Place of Presentation
      フルーツパーク富士屋ホテル (山梨)
    • Related Report
      2008 Annual Research Report
  • [Presentation] リベロマイシン多様化に関わるCoA ligase機能の解析2008

    • Author(s)
      河田 章寛, 他
    • Organizer
      2008年日本放線菌学会大会
    • Place of Presentation
      フルーツパーク富士屋ホテル (山梨)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Streptomyces reveromyceticus 由来インドールプレニルトランスフェラーゼの機能解析2008

    • Author(s)
      高橋 俊二, 他
    • Organizer
      2008年日本放線菌学会大会
    • Place of Presentation
      フルーツパーク富士屋ホテル (山梨)
    • Related Report
      2008 Annual Research Report
  • [Presentation] NRPS Adenylation protein CytC1 の基質特異性に関する研究2008

    • Author(s)
      植木 雅志, 他
    • Organizer
      2008年日本放線菌学会大会
    • Place of Presentation
      フルーツパーク富士屋ホテル (山梨)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 化合物 NPD4284のヒト白血病細胞HL-60細胞に対する分化誘導活性2008

    • Author(s)
      青野 晴美, 他
    • Organizer
      第67回目本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場 (名古屋)
    • Related Report
      2008 Annual Research Report
  • [Presentation] RECK は Fra-1 の MMP-9 プロモーター領域への結合低下を介して MMP-9 の転写を抑制している2008

    • Author(s)
      高木 聡, 他
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場 (名古屋)
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト線維肉腫細胞株におけるヘパラナーゼ結合タンパク質の探索と同定2008

    • Author(s)
      清水 史郎, 他
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場 (名古屋)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 小分子阻害剤による Plk1 ポロボックス依存性結合の細胞分裂進行における役割の解析2008

    • Author(s)
      渡邉 信元, 他
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場 (名古屋)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 化合物ライブラリーを利用した抗がん剤探索2008

    • Author(s)
      長田 裕之
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場 (名古屋)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Challenge and opportunity of the drug-discovery from microbial metabolites.2008

    • Author(s)
      Osada H.
    • Organizer
      2008 RIKEN Conference on Chemical Biology
    • Place of Presentation
      Narita, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] イネいもち病菌 Magnaporthe oryzae の二成分情報伝達系は二次代謝を制御する2008

    • Author(s)
      本山 高幸, 他
    • Organizer
      第8回糸状菌分子生物学コンファレンス
    • Place of Presentation
      石川県文教会館 (金沢)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生合成経路改変によるスピロトリプロスタチンBの生産2008

    • Author(s)
      加藤 直樹, 他
    • Organizer
      第8回糸状菌分子生物学コンファレンス
    • Place of Presentation
      石川県文教会館 (金沢)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生理活性天然物を活用したケミカルバイオロジー : 創薬への展開を目指して2008

    • Author(s)
      長田 裕之
    • Organizer
      第27回メディシナルケミストリーシンポジウム
    • Place of Presentation
      メルパルク大阪 (大阪)
    • Related Report
      2008 Annual Research Report
  • [Presentation] グリオキサラーゼIの阻害剤複合体の結晶構造2008

    • Author(s)
      奥村 英夫, 他
    • Organizer
      2008年度第46回生物物理学会年会
    • Place of Presentation
      福岡国際会議場 (福岡)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 小分子阻害剤を用いた細胞分裂における PBD 依存性結合の役割の解析2008

    • Author(s)
      渡邉 信元, 他
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 (BMB2008)
    • Place of Presentation
      神戸ポートアイランド (神戸)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 大腸菌を用いた新たな p38 MAP Kinase 調節薬剤の探索2008

    • Author(s)
      河合 香代子, 他
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 (BMB2008)
    • Place of Presentation
      神戸ポートアイランド (神戸)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規磁気ビーズを用いた ADLib システムによる抗体の作製2008

    • Author(s)
      中村 晃歩, 他
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 (BMB2008)
    • Place of Presentation
      神戸ポートアイランド (神戸)
    • Related Report
      2008 Annual Research Report
  • [Presentation] SCF^<β-TrCP> による Cdc25B の制御2008

    • Author(s)
      内田 早苗, 他
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 (BMB2008)
    • Place of Presentation
      神戸ポートアイランド (神戸)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 放線菌由来NRPSアデニレーションドメインのX線結晶構造解析2007

    • Author(s)
      奥村 英夫 他
    • Organizer
      日本生物物理学会 第45回年会講演
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] p62/SQSTM1はp38の炎症性サイトカイン刺激特異的制御因子である2007

    • Author(s)
      河合 香代子 他
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会 BMB2007
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] モノクローナル抗体を用いたp38αスプライシング分子Exipの発現解析2007

    • Author(s)
      須藤 龍彦 他
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会 BMB2007
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Plk1のポロボックス依存結合は分裂中期染色体の速やかな整列に必要である2007

    • Author(s)
      渡辺 信元 他
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会 BMB2007
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] メチルゲルフェリンはGLO1阻害を介して破骨細胞の分化を阻害する2007

    • Author(s)
      長田 裕之 他
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会 BMB2007
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Specific regulation of cytokine dependent p38 MAP kinase activation by p62/SQSTMI2007

    • Author(s)
      Kawai K., et. al.
    • Organizer
      The 4th Takeda Science Foundation Symposium on PharmaSciences, On the Frontiers of Chemical Biology
    • Place of Presentation
      Sheraton Miyako Hotel Tokyo
    • Year and Date
      2007-12-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Establishment of chemical array platform and discovery of novel carbonic anhydrase II ligands2007

    • Author(s)
      Miyazaki I., et. al.
    • Organizer
      The 4th Takeda Science Foundation Symposium on PharmaSciences, On the Frontiers of Chemical Biology
    • Place of Presentation
      Sheraton Miyako Hotel Tokyo
    • Year and Date
      2007-12-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Analysis of reveromycin A biosynthetic gene cluster in Streptomyces reveromyceticus2007

    • Author(s)
      Takahashi S., et. al.
    • Organizer
      The 4th Takeda Science Foundation Symposium on PharmaSciences, On the Frontiers of Chemical Biology
    • Place of Presentation
      Sheraton Miyako Hotel Tokyo
    • Year and Date
      2007-12-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] A small molecule which inhibits the polo box domain dependent recognition of Plkl2007

    • Author(s)
      Watanabe N., et. al.
    • Organizer
      The 4th Takeda Science Foundation Symposium on PharmaSciences, On the Frontiers of Chemical Biology
    • Place of Presentation
      Sheraton Miyako Hotel Tokyo
    • Year and Date
      2007-12-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Biosynthesis of cytotrienin in Streptomyces sp. RK95-742007

    • Author(s)
      Ueki M., et. al.
    • Organizer
      The 4th Takeda Science Foundation Symposium on PharmaSciences, On the Frontiers of Chemical Biology
    • Place of Presentation
      Sheraton Miyako Hotel Tokyo
    • Year and Date
      2007-12-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Substrate recognition mechanism of NRPS A domain from Streptomyces2007

    • Author(s)
      Okumura H., et. al.
    • Organizer
      The 4th Takeda Science Foundation Symposium on PharmaSciences, On the Frontiers of Chemical Biology
    • Place of Presentation
      Sheraton Miyako Hotel Tokyo
    • Year and Date
      2007-12-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Application of 2D-DIGE for target identification and binding site determination of bioprobes2007

    • Author(s)
      Kazami S., et. al.
    • Organizer
      The 4th Takeda Science Foundation Symposium on PharmaSciences, On the Frontiers of Chemical Biology
    • Place of Presentation
      Sheraton Miyako Hotel Tokyo
    • Year and Date
      2007-12-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Glaziovianin A, a novel isoflavonoid, induces mitotic arrest by interfering with microtubule dynamics2007

    • Author(s)
      Usui T., et. al.
    • Organizer
      The 4th Takeda Science Foundation Symposium on PharmaSciences, On the Frontiers of Chemical Biology
    • Place of Presentation
      Sheraton Miyako Hotel Tokyo
    • Year and Date
      2007-12-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Aspergillus fumigatusの産生するトリプロスタチン類の生合成遺伝子クラスターの同定2007

    • Author(s)
      加藤 直樹 他
    • Organizer
      第7回糸状菌分子生物学コンファレンス
    • Place of Presentation
      東京大学
    • Year and Date
      2007-11-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] The identification of a novel inhibitor of osteoclastogenesis that acts via inhibition of glyoxalase I2007

    • Author(s)
      Kawatani., et. al.
    • Organizer
      AACR-NCI-EORTC International Conference "Molecular Tarets and Cancer Therapeutics" Discovery, Biology, and Clinical Applications
    • Place of Presentation
      Moscone West Convention Center, San Francisco, USA
    • Year and Date
      2007-10-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] Phosphorylation of Bcl-xL by polo-like kinase 1 results in the inactivation of the anti-apoptotic activity during tubulin binder-induced apoptosis.2007

    • Author(s)
      Simizu, S.
    • Organizer
      AACR-NCI-EORTC International Conference "Molecular Targets and Cancer Therapeutics"Discovery, Biology, and Clinical Applications
    • Place of Presentation
      Moscone West Convention, Center, San Francisco, USA
    • Year and Date
      2007-10-23
    • Related Report
      2009 Final Research Report
  • [Presentation] Phosphorylation of Bcl-xL by polo-1ike kinase I results inactivation of the anti-apoptotic activity during tubulin binder-induced apoptosis2007

    • Author(s)
      Simizu S., et. al.
    • Organizer
      AACR-NCI-EORTC International Conference "MolecularTargets and Cancer Therapeutics" Discovery, Biology, and Clinical Applications
    • Place of Presentation
      Moscone West Convention Center, San Francisco, USA
    • Year and Date
      2007-10-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] Small molecule inhibitors for polo box domain dependent recognition2007

    • Author(s)
      Watanabe N., et. al.
    • Organizer
      AACR-NCI-EORTC International Conference "Molecular Targets and Cancer Therapeutics" Discovery, Biology, and Clinical Applications
    • Place of Presentation
      Moscone West Convention Center, San Francisco, USA
    • Year and Date
      2007-10-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] Chemical biology of osteoclast-targeting small molecules2007

    • Author(s)
      Osada, H.
    • Organizer
      2007 Chemical Genetics Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2007-10-11
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] Systematic exporation of the interaction between bioactive compounds and their target proteins.2007

    • Author(s)
      Osada, H.
    • Organizer
      HUPO 6TH ANNUAL WORLD CONGRESS
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2007-10-08
    • Related Report
      2009 Final Research Report
  • [Presentation] Systematic exporation of the interaction between bioactive compounds and their target proteins2007

    • Author(s)
      Osada H.
    • Organizer
      HUPO 6TH ANNUAL WORLD CONGRESS
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2007-10-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] ポロボックスドメイン依存結合阻害剤の探索2007

    • Author(s)
      渡辺 信元 他
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] A novel chemical microarray platform for searching anticancer drugs2007

    • Author(s)
      清水 史郎 他
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Epoxyquinol BのTAK1活性化抑制効果によるNF-κBシグナル伝達阻害2007

    • Author(s)
      神山 洋 他
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒトがん細胞におけるRECKの発現はMMP-9 mRNA量を減少させる2007

    • Author(s)
      高木 聡 他
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of a photo-cross-linked natural product microayyay platform for screeninglysate of human cells2007

    • Author(s)
      Miyazaki I., et. al.
    • Organizer
      The 2nd International Workshop on Approaches to Single-Cell Analysis
    • Place of Presentation
      早稲田大学
    • Year and Date
      2007-09-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] Metabolomic and genomic analyses of Streptomyses reveromyceticus, a producer of antiosteoclasts compound2007

    • Author(s)
      Osada, H.
    • Organizer
      INDUSTRIAL MICROBIOGY & BIOTECHNOLOGY, Society for Industrial Microbiology Annual Meeting
    • Place of Presentation
      Denver, USA
    • Year and Date
      2007-07-31
    • Related Report
      2009 Final Research Report
  • [Presentation] Metabolomic and genomic analyses of Streptomyses reveromyceticus, a producer of antiosteoclasts compound2007

    • Author(s)
      Osada H.
    • Organizer
      INDUSTRIAL MICROBIOGY & BIOTECHNOLOGY Society for Industrial Microbiology Annual Meeting
    • Place of Presentation
      Denver, USA
    • Year and Date
      2007-07-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of small molecule inhibitors of polo box domain dependent recognition2007

    • Author(s)
      Watanabe N., et. al.
    • Organizer
      The 5th Salk Institute CELL CYCLE MEETING
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-07-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] メチルゲルフェリンによる破骨細胞分化阻害機構の解析2007

    • Author(s)
      川谷 誠 他
    • Organizer
      第11回がん分子標的治療研究会総会
    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2007-07-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] GlaziovianinAの微小管阻害機構解析2007

    • Author(s)
      風見 紗弥香 他
    • Organizer
      第11回がん分子標的治療研究会総会
    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2007-07-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヘパラナーゼに存在するシステイン残基の修飾とその役割解析2007

    • Author(s)
      清水 史郎, 他
    • Organizer
      第11回がん分子標的治療研究会総会
    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2007-07-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Epoxyquinol BはVEGFR2と結合し血管新生抑制効果を示す2007

    • Author(s)
      神山 洋, 他
    • Organizer
      第11回がん分子標的治療研究会総会
    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2007-07-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] RECKによるMMP-9mRNA減少機構の解明2007

    • Author(s)
      高木 聡 他
    • Organizer
      第11回がん分子標的治療研究会総会
    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2007-07-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] 細胞周期阻害剤のケミカルバイオロジー2007

    • Author(s)
      長田 裕之
    • Organizer
      第18回万有仙台シンポジウム
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2007-06-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] Post protein research future possibilities of chemical genome/chemical biology: Chemical library for pursuing "Chemical biology"2007

    • Author(s)
      Osada H.
    • Organizer
      6th International BIO FORUM & BIO EXPO JAPAN
    • Place of Presentation
      東京ビッグサイト
    • Year and Date
      2007-06-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] リベロマイシンA生合成遺伝子クラスターの解析2007

    • Author(s)
      高橋 俊二, 他
    • Organizer
      2007年度日本放線菌学会大会
    • Place of Presentation
      しまなみ交流館(尾道)
    • Year and Date
      2007-06-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] サイトトリエニンの生合成遺伝子群の機能解析2007

    • Author(s)
      植木 雅志, 他
    • Organizer
      2007年度日本放線菌学会大会
    • Place of Presentation
      しまなみ交流館(尾道)
    • Year and Date
      2007-05-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] プロテインホスファターゼ阻害剤のケミカルバイオロジー2007

    • Author(s)
      長田 裕之, 他
    • Organizer
      第7回日本蛋白質科学会年会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2007-05-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Plk1ポロボックスドメイン依存結合阻害剤の探索2007

    • Author(s)
      渡邉 信元, 他
    • Organizer
      日本ケミカルバイオロジー研究会 第2回年会
    • Place of Presentation
      京都大学
    • Year and Date
      2007-05-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Aspergillus fumigatusの生産する細胞周期阻害剤トリプロスタチンの生合成遺伝子クラスターの同定2007

    • Author(s)
      加藤 直樹, 他
    • Organizer
      日本ケミカルバイオロジー研究会 第2回年会
    • Place of Presentation
      京都大学
    • Year and Date
      2007-05-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 官能基非依存型低分子マイクロアレイとヒト培養細胞抽出物を用いた、タンパク質-低分子リガンド・スクリーニング系の構築2007

    • Author(s)
      宮崎 功, 他
    • Organizer
      日本ケミカルバイオロジー研究会 第2回年会
    • Place of Presentation
      京都大学
    • Year and Date
      2007-05-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 低分子リガンドの網羅的スクリーニングを目指したSPRイメージング法の高感度化2007

    • Author(s)
      高山 浩, 他
    • Organizer
      日本ケミカルバイオロジー研究会 第2回年会
    • Place of Presentation
      京都大学
    • Year and Date
      2007-05-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] Biosynthesis of cytotrienin A by NRPS in Streptomyces, KRIBB-RIKEN Joint Symposium2007

    • Author(s)
      Ueki, M.
    • Organizer
      Global Partnership Program of KRIBB-RIKEN Bioactive Metabolite Research Center
    • Place of Presentation
      Daejon, Korea
    • Year and Date
      2007-04-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Chemical biology bridges chemists and biologists and also Japan and Korea, KRIBB-RIKEN Joint Symposium2007

    • Author(s)
      Osada, H.
    • Organizer
      Global Partnership Program of KRIBB-RIKEN Bioactive Metabolite Research Center
    • Place of Presentation
      Daejon, Korea
    • Year and Date
      2007-04-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Chemical biology bridges chemists and biologists and also Japan and Korea2007

    • Author(s)
      Osada H., et. al.
    • Organizer
      KRIBB-RIKEN Joint Symposium Global Partnership Program of KRIBB-RIKEN Bioactive Metabolite Research Center
    • Place of Presentation
      Daejon, Korea
    • Year and Date
      2007-04-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cell cycle regulation by phospho-dependent ubiquitination of WeelA2007

    • Author(s)
      Watanabe N., et. al.
    • Organizer
      KRIBB-RIKEN Joint Symposium Global Partnership Program of KRIBB-RIKEN Bioactive Metabolite Research Center
    • Place of Presentation
      Daejon, Korea
    • Year and Date
      2007-04-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] Biosynthesis of cytotrienin A by NRPS in Streptomyces2007

    • Author(s)
      Ueki M., et. al.
    • Organizer
      KRIBB-RIKEN Joint Symposium Global Partnership Program of KRIBB-RIKEN Bioactive Metabolite Research Center
    • Place of Presentation
      Daejon, Korea
    • Year and Date
      2007-04-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] 微生物化学の復権2007

    • Author(s)
      長田 裕之
    • Organizer
      日本化学会第87春季年会
    • Place of Presentation
      関西大学
    • Year and Date
      2007-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] リベロマイシン生産菌S. reveromyceticusの網羅的代謝産物の解析とリベロマイシン生合成系の研究2007

    • Author(s)
      長田 裕之 他
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京農業大学
    • Year and Date
      2007-03-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] リベロマイシA生合成遺伝子クラスターの解析2007

    • Author(s)
      高橋 俊二 他
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京農業大学
    • Year and Date
      2007-03-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 放線菌のアミノシクロプロパンカルボン酸の生合成に関する研究2007

    • Author(s)
      植木 雅志 他
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京農業大学
    • Year and Date
      2007-03-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 放線菌由来NRPSのアデニレーションドメインのX線結晶構造解析2007

    • Author(s)
      奥村 英夫 他
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京農業大学
    • Year and Date
      2007-03-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] Aspergillus fumigatusトリプロスタチン生産株(BM939)とゲノム解読株(Af293)の二次代謝産物の比較検討2007

    • Author(s)
      高木 海 他
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京農業大学
    • Year and Date
      2007-03-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] Aspergillus fumigatusトリプロスタチン生合成遺伝子クラスターの解析2007

    • Author(s)
      加藤 直樹 他
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京農業大学
    • Year and Date
      2007-03-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] PP2A特異的阻害剤ホストラクトマイシン類が有するHL60細胞の分化誘導活性2007

    • Author(s)
      照屋 貴之 他
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京農業大学
    • Year and Date
      2007-03-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 放線菌が生産する新規細胞周期阻害剤RK-2215Aに関する研究2007

    • Author(s)
      森 美穂子 他
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京農業大学
    • Year and Date
      2007-03-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 光親和型低分子マイクロアレイ基板上での官能基変換及び脱保護2007

    • Author(s)
      齊藤 安貴子 他
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京農業大学
    • Year and Date
      2007-03-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 植物由来の新規化合物GlaziovianinAの作用解析2007

    • Author(s)
      風見 紗弥香, 他
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京農業大学
    • Year and Date
      2007-03-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 免疫抑制物質brasilicardin Aの標的分子同定2007

    • Author(s)
      臼井 健郎, 他
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京農業大学
    • Year and Date
      2007-03-25
    • Related Report
      2007 Annual Research Report
  • [Book] 化合物アレイを用いた抗がん剤探索系がん分子標的治療研究実践マニュアル2009

    • Author(s)
      清水史郎、宮崎功、本田香織、近藤恭光、長田裕之、金芳堂
    • Publisher
      日本がん分子標的治療学会
    • Related Report
      2009 Final Research Report
  • [Book] がん化学療法の標的細胞周期「がん化学療法・分子標的治療update(西條&西尾編)」2009

    • Author(s)
      渡辺信元、長田裕之
    • Publisher
      中外医学社
    • Related Report
      2009 Final Research Report
  • [Book] Protein Targeting with Small Molecules2009

    • Author(s)
      Osada, H.Ed.
    • Total Pages
      289
    • Publisher
      A John Wiley & Sons, Inc.
    • Related Report
      2009 Annual Research Report
  • [Book] 化合物アレイを用いた抗がん剤探索系「がん分子標的治療研究 実践マニュアル(日本がん分子標的治療学会編)」2009

    • Author(s)
      清水史郎, 他
    • Total Pages
      340
    • Publisher
      金芳堂
    • Related Report
      2009 Annual Research Report
  • [Book] コンピューターモデリングによる最適化「がん分子標的治療研究 実践マニュアル(日本がん分子標的治療学会編)」2009

    • Author(s)
      奥村英夫, 他
    • Total Pages
      340
    • Publisher
      金芳堂
    • Related Report
      2009 Annual Research Report
  • [Book] がん化学療法の標的 細胞周期「がん化学療法・分子標的治療 update(西條&西尾編)」2009

    • Author(s)
      渡邉信元, 他
    • Total Pages
      736
    • Publisher
      中外医学社
    • Related Report
      2009 Annual Research Report
  • [Book] ケミカルゲノミクス「がんの分子標的治療(鶴尾隆編)」2008

    • Author(s)
      長田裕之
    • Publisher
      南山堂
    • Related Report
      2009 Final Research Report
  • [Book] 浸潤と転移-1タンパク質分解酵素と糖分解酵素「がんの分子標的治療(鶴尾隆編)」2008

    • Author(s)
      清水史郎、長田裕之
    • Publisher
      南山堂
    • Related Report
      2009 Final Research Report
  • [Book] 入門ケミカルバイオロジー2008

    • Author(s)
      長田裕之
    • Total Pages
      189
    • Publisher
      オーム社
    • Related Report
      2009 Final Research Report
  • [Book] がんの分子標的治療 第II部 13 「ケミカルゲノミクス」2008

    • Author(s)
      長田 裕之
    • Total Pages
      441
    • Publisher
      南山堂
    • Related Report
      2008 Annual Research Report
  • [Book] がんの分子標的治療 第III部 25 「浸潤と転移-1 タンパク質分解酵素と糖分解酵素」2008

    • Author(s)
      清水 史郎, 他
    • Total Pages
      441
    • Publisher
      南山堂
    • Related Report
      2008 Annual Research Report
  • [Book] 入門ケミカルバイオロジー2008

    • Author(s)
      長田 裕之, 他
    • Total Pages
      189
    • Publisher
      オーム社
    • Related Report
      2008 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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