| Budget Amount *help |
¥49,600,000 (Direct Cost: ¥49,600,000)
Fiscal Year 2009: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2008: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2007: ¥10,400,000 (Direct Cost: ¥10,400,000)
Fiscal Year 2006: ¥10,400,000 (Direct Cost: ¥10,400,000)
Fiscal Year 2005: ¥10,000,000 (Direct Cost: ¥10,000,000)
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| Research Abstract |
We searched for compounds that induce apoptosis in cancer cells only when cells are nonanchored (anoikis sensitizer). We found that MEK-inhibitors such as hypothemycin induce anoikis sensitivity in human cancer cells that rely heavily on the MEK-ERK pathway, and elucidated the molecular mechanism. We also discovered anicequol, HSP90 inhibitors, and sesquiterpene lactones as inhibitors of oncogenic signaling, and analyzed their mechanisms of action.
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