| Project/Area Number |
17016089
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
AKATSUKA Yoshiki (2006-2009) Aichi Cancer Center Research Institute, 医学部, 准教授 (70333391)
高橋 利忠 (2005) 愛知県がんセンター(研究所), 総長 (00124529)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJIMURA Kunio 浜松医科大学, 感染症学講座・生体防御部門, 准教授 (10227407)
KUZUSHIMA Kiyotaka 愛知県がんセンター, 研究所・腫瘍免疫学部, 部長 (30311442)
赤塚 美樹 愛知県がんセンター(研究所), 腫瘍免疫部, 室長 (70333391)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥54,400,000 (Direct Cost: ¥54,400,000)
Fiscal Year 2009: ¥10,800,000 (Direct Cost: ¥10,800,000)
Fiscal Year 2008: ¥10,800,000 (Direct Cost: ¥10,800,000)
Fiscal Year 2007: ¥10,800,000 (Direct Cost: ¥10,800,000)
Fiscal Year 2006: ¥10,800,000 (Direct Cost: ¥10,800,000)
Fiscal Year 2005: ¥11,200,000 (Direct Cost: ¥11,200,000)
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| Keywords | 造血器腫瘍 / 同種移植 / マイナー組織適合抗原 / 腫瘍免疫 / 一塩基多型 / 抗腫瘍効果 / 移植片対白血病効果 / 移植片対宿主病 / 同種造血細胞移植 / 細胞傷害性T細胞 / 全ゲノム解析 / 国際HapMap計画 / SNPアレイ / 発現クローニング法 / 造血幹細胞移植 / 抗白血病効果 / マイナー移植抗原 / 細胞障害性T細胞 / カテプシンH / 連鎖解析法 |
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| Research Abstract |
We have identified novel minor histocompatibility antigen (mHAg) epitopes that could serve as good targets for immunotherapy against recurrent malignancies following allogeneic blood and marrow transplantation. Using CTL clones isolated from recipient peripheral blood post-transplant, eight novel mHAgs encoded by CTSH, HMSD, HMHA1, BCL2A1, SLC1A5, UGT2B17, P2RX7, DPT1 have been determined. We have shown for the first time that both a whole genome analysis against the DNA pools and also an association study using the International HapMap genomic database are powerful methods that can quickly identify mHAgs of interest.
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