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The mechanism of molecular oscillation in animal development

Research Project

Project/Area Number 17017027
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNara Institute of Science and Technology

Principal Investigator

BESSHO Yasumasa  Nara Institute of Science and Technology, バイオサイエンス研究科, 教授 (70261253)

Co-Investigator(Kenkyū-buntansha) MATSUI Takaaki  奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (60403333)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥79,300,000 (Direct Cost: ¥79,300,000)
Fiscal Year 2009: ¥12,400,000 (Direct Cost: ¥12,400,000)
Fiscal Year 2008: ¥12,400,000 (Direct Cost: ¥12,400,000)
Fiscal Year 2007: ¥18,100,000 (Direct Cost: ¥18,100,000)
Fiscal Year 2006: ¥12,400,000 (Direct Cost: ¥12,400,000)
Fiscal Year 2005: ¥24,000,000 (Direct Cost: ¥24,000,000)
Keywords振動 / 波 / 体節 / 生物時計 / 形態形成 / シミュレーション / 転写因子 / パターン形成 / Notchシグナル / 発生 / FGFシグナル / 濃度勾配 / 遺伝子発現 / 体節形成 / 等間隔パターン / 分子時計 / 分節化 / マウス / 発生生物学
Research Abstract

In this project, we charged mechanism of oscillatory gene expression in somite formation in vertebrate development. According to accumulated data of our molecular biological and biochemical experiments, we established a molecular model for the oscillatory gene expression. We analyzed this model by mathematical simulation in silico, and inspected it by molecular experiments. Our interdisciplinary approach revealed the mechanism of the oscillatory gene expression.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (29 results)

All 2011 2009 2008 2007 2006 2005

All Journal Article (11 results) (of which Peer Reviewed: 3 results) Presentation (16 results) Book (2 results)

  • [Journal Article] Canopy1, a positive feedback regulator of FGF signaling, controls progenitor cell clustering during Kupffer's vesicle organogenesis.2011

    • Author(s)
      Matsui T, Thitamadee S, Murata T, Kakinuma H, Nabetani T, Hirabayashi Y, Hirate Y, Okamoto H, 別所康全
    • Journal Title

      Proc.Natl.Acad.Sci.USA in press

    • NAID

      120005716658

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse.2009

    • Author(s)
      Hayashi S, Shimoda T, Nakajima M, Tsukada Y, Sakumura Y, Dale JK, Maroto M, Kohno K, Matsui T, Bessho Y.
    • Journal Title

      PSM, PLoS ONE 4

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites.2009

    • Author(s)
      Ferjentsik Z, Hayashi S, Dale JK, Bessho Y, Herreman A, De Strooper B, del Monte G, de la Pompa, JL, Maroto M.
    • Journal Title

      PLoS Genet. 5

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝子発現の振動が制御する生物の形づくり2007

    • Author(s)
      別所康全
    • Journal Title

      システム/制御/情報 51巻

      Pages: 493-498

    • NAID

      110006452913

    • Related Report
      2009 Final Research Report
  • [Journal Article] 形づくりを制御する生物時計としての分子振動2007

    • Author(s)
      別所康全
    • Journal Title

      細胞工学 26巻

      Pages: 755-758

    • Related Report
      2009 Final Research Report
  • [Journal Article] 形づくりを制御する生物時計としての分子振動2007

    • Author(s)
      別所 康全
    • Journal Title

      細胞工学 7

      Pages: 755-758

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 遺伝子発現の振動が制御する生物の形づくり2007

    • Author(s)
      別所 康全
    • Journal Title

      システム/制御/情報 51

      Pages: 493-498

    • NAID

      110006452913

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 体節の分節メカニズム2005

    • Author(s)
      別所康全
    • Journal Title

      蛋白質核酸酵素 50巻

      Pages: 650-654

    • Related Report
      2009 Final Research Report
  • [Journal Article] 体節形成を支配する生物時計のメカニズム2005

    • Author(s)
      別所康全, 影山龍一郎
    • Journal Title

      細胞工学 24巻

      Pages: 499-503

    • Related Report
      2009 Final Research Report
  • [Journal Article] 体節形成を支配する生物時計のメカニズム2005

    • Author(s)
      別所 康全
    • Journal Title

      細胞工学 24巻・5号

      Pages: 499-503

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 体節の分節メカニズム2005

    • Author(s)
      別所 康全
    • Journal Title

      蛋白質核酸酵素 50巻・6号

      Pages: 650-654

    • Related Report
      2005 Annual Research Report
  • [Presentation] The mechanism of the biological clock that controls animal development2011

    • Author(s)
      Bessho Y.
    • Organizer
      HUS-UET-NAIST Symposium in Hanoi
    • Place of Presentation
      Hanoi
    • Year and Date
      2011-03-02
    • Related Report
      2009 Final Research Report
  • [Presentation] The mechanism of the biological clock that controls animal development2011

    • Author(s)
      Bessho, Y
    • Organizer
      HUS-UET-NAIST Symposium
    • Place of Presentation
      Hanoi, Vietnam
    • Year and Date
      2011-03-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 体節分節化のロバスト性を担うフィードバックループ2009

    • Author(s)
      別所康全
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-24
    • Related Report
      2009 Final Research Report
  • [Presentation] 体節形成周期の制御機構2009

    • Author(s)
      別所康全
    • Organizer
      第114回日本解剖学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 体節形成周期の制御機構2009

    • Author(s)
      別所康全
    • Organizer
      第114回日本解剖学会総会・全国学術集会
    • Place of Presentation
      岡山
    • Related Report
      2008 Annual Research Report
  • [Presentation] The mechanism of the biological clock that controls animal development2008

    • Author(s)
      Bessho Y.
    • Organizer
      International Joint Symposium Frontier In Biomedical Sciences : From Genes to Applications
    • Place of Presentation
      Yogyakarta
    • Year and Date
      2008-11-25
    • Related Report
      2009 Final Research Report
  • [Presentation] 時間制御を利用した形態形成2008

    • Author(s)
      別所康全
    • Organizer
      第113回日本解剖学会総会
    • Place of Presentation
      大分
    • Year and Date
      2008-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 生物の形づくりを制御する分子振動2008

    • Author(s)
      別所康全
    • Organizer
      第2回SICE生物制御システム調査研究会
    • Place of Presentation
      京都
    • Year and Date
      2008-01-31
    • Related Report
      2009 Final Research Report
  • [Presentation] The mechanism of the biological clock that controls animal development2008

    • Author(s)
      Bessho Y.
    • Organizer
      NAIST Global COE International Symposium Developmental Biology
    • Place of Presentation
      Nara
    • Year and Date
      2008-01-15
    • Related Report
      2009 Final Research Report
  • [Presentation] The Mechanism of The Biological Clock That Controls Animal Development.2008

    • Author(s)
      Bessho Y.
    • Organizer
      International Joint Symposium Frontier In Biomedical Sciences : From Genes to Applications
    • Place of Presentation
      Yogyakarta, Indonesia
    • Related Report
      2008 Annual Research Report
  • [Presentation] The mechanism the biological clock that controls animal development2007

    • Author(s)
      Bessho Y.
    • Organizer
      NAIST The 21st century COE Program International Symposiun
    • Place of Presentation
      Nara
    • Year and Date
      2007-01-16
    • Related Report
      2009 Final Research Report
  • [Presentation] The biological clock generates repetitive patterns in mouse development2006

    • Author(s)
      Shimoda T, Matsui T, Bessho Y.
    • Organizer
      8th KRIBB-KU-NAIST Symposium
    • Place of Presentation
      Seoul
    • Year and Date
      2006-11-10
    • Related Report
      2009 Final Research Report
  • [Presentation] 2時間を刻む生物時計~時間制御を利用した形づくり~2006

    • Author(s)
      別所康全
    • Organizer
      関西眼科先進医療研究会
    • Place of Presentation
      大阪
    • Year and Date
      2006-10-18
    • Related Report
      2009 Final Research Report
  • [Presentation] 2時間を刻む生物時計2006

    • Author(s)
      別所康全
    • Organizer
      第25回分子病理学会2006年東京シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2006-08-04
    • Related Report
      2009 Final Research Report
  • [Presentation] The segmantation clock generates metameric patterns in mouse development2005

    • Author(s)
      Bessho Y.
    • Organizer
      7th Northeastern Asia Symposium on Biotechnology
    • Place of Presentation
      Nara
    • Year and Date
      2005-12-04
    • Related Report
      2009 Final Research Report
  • [Presentation] The segmantation clock generates metameric patterns in mouse development2005

    • Author(s)
      Bessho Y.
    • Organizer
      NAIST-CDB International Symposium Frontiers in Developmental Biology
    • Place of Presentation
      Gyeongju
    • Year and Date
      2005-11-07
    • Related Report
      2009 Final Research Report
  • [Book] Advances in experimental medicine and biology(vol.638)(ed. Maroto, M. and Whittock, N.V.)2008

    • Author(s)
      Nariti M, Iimura T, Dale JK, Bessho Y.
    • Publisher
      bHLH proteins and their role in somitogenesis Somitogenesis
    • Related Report
      2009 Final Research Report
  • [Book] Advances in Experimental Medicine and Bioloby, vol.638, Somitogenesis(bHLH Proteins and their Role in Somitogenesis)2008

    • Author(s)
      Maroto, M., Iimura, T., Dale, J. K. and Bessho, Y. (ed. Maroto, M. and Whittock, N.V.
    • Total Pages
      194
    • Publisher
      Landes Bioscience and Spronger Science+Business Media, LLC (New York)
    • Related Report
      2008 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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