The mechanism of molecular oscillation in animal development
| Project/Area Number |
17017027
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
BESSHO Yasumasa Nara Institute of Science and Technology, バイオサイエンス研究科, 教授 (70261253)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUI Takaaki 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (60403333)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥79,300,000 (Direct Cost: ¥79,300,000)
Fiscal Year 2009: ¥12,400,000 (Direct Cost: ¥12,400,000)
Fiscal Year 2008: ¥12,400,000 (Direct Cost: ¥12,400,000)
Fiscal Year 2007: ¥18,100,000 (Direct Cost: ¥18,100,000)
Fiscal Year 2006: ¥12,400,000 (Direct Cost: ¥12,400,000)
Fiscal Year 2005: ¥24,000,000 (Direct Cost: ¥24,000,000)
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| Keywords | 振動 / 波 / 体節 / 生物時計 / 形態形成 / シミュレーション / 転写因子 / パターン形成 / Notchシグナル / 発生 / FGFシグナル / 濃度勾配 / 遺伝子発現 / 体節形成 / 等間隔パターン / 分子時計 / 分節化 / マウス / 発生生物学 |
|---|
| Research Abstract |
In this project, we charged mechanism of oscillatory gene expression in somite formation in vertebrate development. According to accumulated data of our molecular biological and biochemical experiments, we established a molecular model for the oscillatory gene expression. We analyzed this model by mathematical simulation in silico, and inspected it by molecular experiments. Our interdisciplinary approach revealed the mechanism of the oscillatory gene expression.
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Report
(6 results)
Research Products
(29 results)
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[Journal Article] Canopy1, a positive feedback regulator of FGF signaling, controls progenitor cell clustering during Kupffer's vesicle organogenesis.2011
Author(s)
Matsui T, Thitamadee S, Murata T, Kakinuma H, Nabetani T, Hirabayashi Y, Hirate Y, Okamoto H, 別所康全
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Journal Title
Proc.Natl.Acad.Sci.USA in press
NAID
Related Report
Peer Reviewed
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[Journal Article] Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse.2009
Author(s)
Hayashi S, Shimoda T, Nakajima M, Tsukada Y, Sakumura Y, Dale JK, Maroto M, Kohno K, Matsui T, Bessho Y.
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Journal Title
Related Report
Peer Reviewed
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[Book] Advances in Experimental Medicine and Bioloby, vol.638, Somitogenesis(bHLH Proteins and their Role in Somitogenesis)2008
Author(s)
Maroto, M., Iimura, T., Dale, J. K. and Bessho, Y. (ed. Maroto, M. and Whittock, N.V.
Total Pages
194
Publisher
Landes Bioscience and Spronger Science+Business Media, LLC (New York)
Related Report
