Quantitation analysis of pathway network analysis
Project/Area Number |
17017042
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | National Institute of Advanced Industrial Science and Technology |
Principal Investigator |
NATSUME Tohru National Institute of Advanced Industrial Science and Technology, バイオメディシナル情報研究センター, 研究チーム長 (00357683)
|
Co-Investigator(Kenkyū-buntansha) |
IEMURA Shun-ichiro 独立行政法人産業技術総合研究所, バイオメディシナル情報研究センター, 主任研究員 (90356410)
NAKAYAMA hiroshi 独立行政法人理化学研究所, 中央研究所, 研究員 (80321793)
SHIBUYA Kohji 東京医科歯科大学, 難治疾患研究所, 教授 (30261324)
|
Project Period (FY) |
2005 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥74,000,000 (Direct Cost: ¥74,000,000)
Fiscal Year 2009: ¥15,200,000 (Direct Cost: ¥15,200,000)
Fiscal Year 2008: ¥14,600,000 (Direct Cost: ¥14,600,000)
Fiscal Year 2007: ¥14,100,000 (Direct Cost: ¥14,100,000)
Fiscal Year 2006: ¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2005: ¥15,800,000 (Direct Cost: ¥15,800,000)
|
Keywords | タンパク質間相互作 / タンパク質ネットワーク解析 / プロテオミクス / 質量分析 / 動態解析 / マップキナーゼカスケー / シグナル伝達 / Erk / プロテミクス / タンパク質問相互作用 / マップキナーゼカスケード / ダイレクトナノLC / 古典的MAPキナーゼカスケ / Erkイフェクター / 安定同位体ラベル |
Research Abstract |
Cellular signaling comprises numerous numbers of proteins, which interact each other, Forming protein interaction network. To understand networks systematic andcomprehensively, we developed proteomic analytical platform to quantify proteininteractions. By the system, we found several novel signaling pathways.
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Report
(6 results)
Research Products
(54 results)
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[Journal Article] The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap12010
Author(s)
Komatsu, M., H. Kurokawa, S. Waguri, K. Taguchi, A. Kobayashi, Y. Ichimura, Y.S. Sou, I. Ueno, A. Sakamoto, K.I. Tong, M. Kim, Y. Nishito, S.I. Iemura, T. Natsume, T. Ueno, E. Kominami, H. Motohashi, K. Tanaka, M. Yamamoto
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Journal Title
Nat cell biology 12(3)
Pages: 213-223
Related Report
Peer Reviewed
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[Journal Article] The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.2010
Author(s)
Komatsu, M., H.Kurokawa, S.Waguri, K.Taguchi, A.Kobayashi, Y.Ichimura, Y.S.Sou, I.Ueno, A.Sakamoto, K.I.Tong, M.Kim, Y.Nishito, S.I.Iemura, T.Natsume, T.Ueno, E.Kominami, H.Motohashi, K.Tanaka, M.Yamamoto
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Journal Title
Nat cell biology. 12
Pages: 213-223
Related Report
Peer Reviewed
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[Journal Article] CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis2009
Author(s)
Nishiyama, M., K. Oshikawa, Y. Tsukada, T. Nakagawa, S. Iemura, T. Natsume, Y. Fan, A. Kikuchi, A.I. Skoultchi, K.I. Nakayama
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Journal Title
Nat cell biology 11(2)
Pages: 863-876
Related Report
Peer Reviewed
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[Journal Article] Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.2009
Author(s)
Hosokawa, N., T.Hara, T.Kaizuka, C.Kishi, A.Takamura, Y.Miura, S.lemura, T.Natsume, K.Takehana, N.Yamada, J.L.Guan, N.Oshiro, N.Mizushima
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Journal Title
Molecular biology of the cell 20
Pages: 1981-1991
Related Report
Peer Reviewed
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[Journal Article] Novel In Vitro Protein Fragment Complementation Assay Applicable to High-Throughput Screening in a 1536-Well Format.2009
Author(s)
Hashimoto, J., T.Watanabe, T.Seki, S.Karasawa, M.lzumikawa, T.Seki, S.I.lemura, T.Natsume, N.Nomura, N.Goshima, A.Miyawaki, M.Takagi, K.Shin-Ya
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Journal Title
J Biomol Screen. 14
Pages: 970-979
Related Report
Peer Reviewed
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[Journal Article] A novel Grb2 associating protein (Gasp) is critical for positiveselection of thym ocytes,.2009
Author(s)
Michael, P., Oda, H., Hayakawa, K., Sato, Y., Eshima, K., Kirikae, T., lemura, S., Shirai, M., Abe, T., Natsume, T., Sasazuki, T., Suzuki, H.
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Journal Title
Proc Natl Acad Sci USA. MS2009-08593
Related Report
Peer Reviewed
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[Journal Article] Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes.2009
Author(s)
Patrick, M.S., H.Oda, K.Hayakawa, Y.Sato, K.Eshima, T.Kirikae, S.Iemura, M.Shirai, T.Abe, T.Natsume, T.Sasazuki, H.Suzuki
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Journal Title
Proc Natl Acad Sci USA 106
Pages: 16345-16350
Related Report
Peer Reviewed
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[Journal Article] NLK, an essential effector of anterior formation, functions downstream of p38 MAP kinase.2009
Author(s)
Ohnishi, E., T.Goto, A.Sato, M.S.Kim, S.I.Iemura, T.Ishitani, T.Natsume, J.Ohnishi, H.Shibuyaup
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Journal Title
Mol cell Biol. 30
Pages: 675-683
Related Report
Peer Reviewed
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[Journal Article] A novel type of E3-ligase for the Ufm1-conjugation system.2009
Author(s)
Tatsumi, K., Y.S.Sou, N.Tada, E.Nakamura, S.I.Iemura, T.Natsume, S.H.Kang, C.H.Chung, M.Kasahara, E.Kominami, M.Yamamoto, K.Tanaka, M.Komatsu
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Journal Title
J Biol Chem. 285
Pages: 5417-5427
Related Report
Peer Reviewed
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[Journal Article] Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice2007
Author(s)
Komatsu, M., S. Waguri, M. Koike, Y.S. Sou, T. Ueno, T. Hara, N. Mizushima, J. Iwata, J. Ezaki, S. Murata, J. Hamazaki, Y. Nishito, S. Iemura, T. Natsume, T. Yanagawa, J. Uwayama, E. Warabi, H. Yoshida, T. Ishii, A. Kobayashi, M. Yamamoto, Z. Yue, Y. Uchiyama, E. Kominami, K. Tanaka
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Journal Title
Cell 131(6)
Pages: 1149-1163
Related Report
Peer Reviewed
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[Journal Article] A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes2006
Author(s)
Hamazaki, J., Iemura, S., Natsume, T., Yashiroda, H., Tanaka, K., Murata, S.
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Journal Title
The EMBO journal 25(19)
Pages: 4524-36
Related Report
Peer Reviewed
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[Journal Article] XGAP, an ArfGAP, is required for polarized localization of PAR proteins and cell polarity in Xenopus gastrulation2006
Author(s)
Hyodo-Miura, J., Yamamoto, T.S., Hyodo, A.C., Iemura, S., Kusakabe, M., Nishida, E., Natsume, T., Ueno, N.
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Journal Title
Dev Cell 11(1)
Pages: 69-79
Related Report
Peer Reviewed
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[Journal Article] Shugoshin collaborates with protein phosphatase 2A to protect cohesin2006
Author(s)
Kitajima, T.S., Sakuno, T., Ishiguro, K., Iemura, S., Natsume, T., Kawashima, S.A., Watanabe, Y.
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Journal Title
Nature 441(7089)
Pages: 46-52
Related Report
Peer Reviewed
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[Journal Article] A novel ubiquitin-binding protein ZNF216 functioning in muscle atrophy2006
Author(s)
Hishiya, A., Iemura, S., Natsume, T., Takayama, S., Ikeda, K., Watanabe, K.
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Journal Title
Embo J 25(3)
Pages: 554-64
Related Report
Peer Reviewed
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