Comparative Transcriptome Study of Brain

• Project/Area Number: 17018015
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Niigata University
• Principal Investigator: NAWA Hiroyuki Niigata University, 脳研究所, 教授 (50183083)
• Co-Investigator(Kenkyū-buntansha): KAKITA Akiyoshi 新潟大学, 脳研究所, 准教授 (80281012)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥44,800,000 (Direct Cost: ¥44,800,000); Fiscal Year 2009: ¥10,000,000 (Direct Cost: ¥10,000,000); Fiscal Year 2008: ¥10,000,000 (Direct Cost: ¥10,000,000); Fiscal Year 2007: ¥11,200,000 (Direct Cost: ¥11,200,000); Fiscal Year 2006: ¥10,500,000 (Direct Cost: ¥10,500,000); Fiscal Year 2005: ¥3,100,000 (Direct Cost: ¥3,100,000)
• Keywords: 霊長類 / 進化 / ジンクフィンガー / 脳 / DNAマイクロアレイ / ゲノム配列 / 脳進化 / トランスクリプトーム / 脳神経 / 遺伝子 / DNAアレイ

Research Abstract

Using the DNA microarray technique, we performed comparative expression profiling of brain transcriptomes among primates. The profiling revealed the marked strain variation in mRNA signal intensity or homology of the zinc finger genes located at human chromosome 19q13.43. DNA sequence analysis suggests that this genomic region has evolved rapidly in primates.

Research Products

• [Journal Article] Molecular characterization and genedisruption of a novel zinc-finger protein,HIT-4, expressed in rodent brain. (2010)
  • Author(s): Tanabe, Y., Hirano, A., Iwasato, T., Itohara S., Araki, A., Yamaguchi, T., Ichikawa, T., Kumanishi T., Aizawa, Y., Takahashi, H., Kakita, A., Nawa, H.
  • Journal Title: J. Neurochemistry 112 Pages: 1035-1044
  • Peer Reviewed
• [Journal Article] Molecular characterization and gene disruption of a novel zinc-finger protein, HIT-4, expressed in rodent brain. (2010)
  • Author(s): Tanebe Y., 他11名
  • Journal Title: Journal of Neurochemistry 112 Pages: 1035-1044
  • Peer Reviewed
• [Journal Article] ヒトの脳機能進化;ゲノム科学と発達脳科学の視点から (2007)
  • Author(s): 那波宏之
  • Journal Title: 人工知能学会誌 Vol22 Pages: 49-53
  • Peer Reviewed
• [Journal Article] ヒトの脳機能進化;ゲノム科学と発達脳科学の視点から (2007)
  • Author(s): 那波宏之
  • Journal Title: 人工知能学会誌 22 Pages: 49-53
• [Presentation] Molecular and behavioral analyses of a non-human primate model for schizophrenia (2008)
  • Author(s): Nawa, H.
  • Organizer: 第31回日本分子生物学会+第81回日本生化学会合同年会
  • Place of Presentation: 神戸