Genome medical research supporting committee

• Project/Area Number: 17019004
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Chiba University
• Principal Investigator: HATA Akira Chiba University, 大学院・医学研究院, 教授 (00244541)
• Co-Investigator(Kenkyū-buntansha): TSUJI Shioji 東京大学, 医学部附属病院, 教授 (70150612) ; KASUGA Masato 国立国際医療センター, 所長 (50161047) ; OKAZAKI Yuji (財)東京都医学研究機構, 東京都精神医学研究所, 研究員 (40010318) ; INOUE Ituro 東海大学, 医学部, 教授 (00192500) ; TAKEDA Masatoshi 大阪大学, 大学院・医学系研究科, 教授 (00179649) ; TOKUNAGA Katsushi 東京大学, 大学院・医学系研究科, 教授 (40163977) ; KUWANO Ryozo 新潟大学, 脳研究所, 教授 (20111734)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥407,500,000 (Direct Cost: ¥407,500,000); Fiscal Year 2009: ¥102,100,000 (Direct Cost: ¥102,100,000); Fiscal Year 2008: ¥102,100,000 (Direct Cost: ¥102,100,000); Fiscal Year 2007: ¥67,400,000 (Direct Cost: ¥67,400,000); Fiscal Year 2006: ¥68,100,000 (Direct Cost: ¥68,100,000); Fiscal Year 2005: ¥67,800,000 (Direct Cost: ¥67,800,000)
• Keywords: 遺伝子タイピング / ゲノム医学研究 / インフォームド・コンセント / 履行補助者 / 匿名化 / ヒト試料 / 多施設共同研究

Research Abstract

The aim of this study is to support human genome sample collectionand genome typing. Target diseases are common diseases including type 2 diabetes mellitus (DM), panic disorder, intracranial aneurysm, Alzheimer disease, and rarediseases such as multiple system atrophy. Main support of later half was a financial support for genotyping of genome-wide association study (GWAS). Through this support,genetic background of DM, Parkinson disease, intracranial aneurysm and other diseaseswas clarified.

Research Products

• [Journal Article] International web-based survey of informed consent procedures in genetic epidemiological studies: towards the establishment of a research coordinator accrefitation system. (2009)
  • Author(s): Yamamoto M, Funamizu M, Muto K, Hata A.
  • Journal Title: J Hum Genet. 54 Pages: 713-720
• [Journal Article] CD14 and IL4R gene polymorphisms modify the effect of day care attendance on serum IgE levels. (2009)
  • Author(s): Suzuki Y, Hattori S, Mashimo Y, Funamizu M, Kohno Y, Okamoto Y, Hata A, Shimojo N.
  • Journal Title: J Allergy Clin Immunol. 123 Pages: 1408-1411
• [Journal Article] International web-based survey of informed consent procedures in genetic epidemiological studies : towards the establishment of a research coordinator accreditation system (2009)
  • Author(s): Yamamoto M, et al.
  • Journal Title: J Hum Genet 54 Pages: 713-720
  • Peer Reviewed
• [Journal Article] CD14 and IL4R gene polymorphisms modify the effect of day care attendance on serum IgE levels (2009)
  • Author(s): Suzuki Y, et al.
  • Journal Title: J Allergy Clin Immunol 123 Pages: 1408-1411
  • Peer Reviewed
• [Journal Article] Association analysis of genes involved in the maintenance of the integrity of the extracellular matrix with intracranial aneurysms in a Japanese cohort (2009)
  • Author(s): Ruigrok YM, et al.
  • Journal Title: Cerebrovasc Dis. 28 Pages: 131-134
  • Peer Reviewed
• [Journal Article] Susceptibility loci for intracranial aneurysm in European and Japanese populations. (2008)
  • Author(s): Bilguvar K, Yasuno K, Niemela M,Ruigrok YM, von Und Zu Fraunberg M, vanDuijn CM, van den Berg LH, Mane S,Mason CE, Choi M, Gaal E, Bayri Y, KolbL, Arlier Z, Ravuri S, Ronkainen A,Tajima A, Laakso A, Hata A, Kasuya H,Koivisto T, Rinne J, Ohman J, BretelerMM, Wijmenga C, State MW, Rinkel GJ,Hernesniemi J, Jaaskelainen JE,Palotie A, Inoue I, Lifton RP, GunelM.
  • Journal Title: Nature Genet 40 Pages: 1472-1477
• [Journal Article] Heterozygous Deletion at 14q22. 1-q22. 3 including the BMP4 gene in a Patient with Psychomotor Retardation, Congenital Corneal Opacity and Feet Polysyndactyly. (2008)
  • Author(s): Hayashi S, Okamoto N, Yoshio Makita Y, Hata A, Imoto I, Inazawa J.
  • Journal Title: Am J Med Genet. 146A Pages: 2905-2910
• [Journal Article] The CASK gene harbored in a deletion detected by array-CGH as a potential candidate for a gene causative of X-linked dominant mental retardation. (2008)
  • Author(s): Hayashi S, Mizuno S, Migita O, Okuyama T, Makita Y, Hata A, Imoto I, Inazawa J.
  • Journal Title: Am J Med Genet. 146A Pages: 2145-2151
• [Journal Article] A functional polymorphism in ITPKC is associated with Kawasaki disea se susceptibility and formation of coronary artery aneurysms (2008)
  • Author(s): Onouchi, et.al.
  • Journal Title: Nature Genet 40 Pages: 35-42
  • Peer Reviewed
• [Journal Article] The CASK gene harbored in a deletion detected by array-CGH as a pot ential candidate for a gene causative of X-linked dominant mental retar dation (2008)
  • Author(s): Hayashi, et.al.
  • Journal Title: Am J Med Genet 146A Pages: 2145-2151
  • Peer Reviewed
• [Journal Article] Susceptibility loci for intracranial aneurysm in European and Japanese populations (2008)
  • Author(s): Bilguvar K, Yasuno K, et.al.
  • Journal Title: Nature Genet 40 Pages: 1472-1477
  • Peer Reviewed
• [Presentation] GMRC制度の未来へ向けて-スキルと制度設計 (2009)
  • Author(s): 羽田明, 山本緑, 小林いずみ
  • Organizer: 第54回日本人類遺伝学会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-26
• [Presentation] 海外ゲノム疫学研究におけるインフォームドコンセントの実態調査 (2008)
  • Author(s): 山本緑, 船水真紀子, 羽田明
  • Organizer: 第53回日本人類遺伝学会
  • Place of Presentation: 横浜
• [Presentation] インフォームド・コンセント履行補助者の有用性に関する検討 (2007)
  • Author(s): 船水真紀子, ら
  • Organizer: 第14回日本遺伝子診療学会
  • Place of Presentation: 松山
• [Book] アレイCGH診断活用ガイドブック (2008)
  • Author(s): 稲澤譲治, 蒔田芳男, 羽田明
  • Total Pages: 239
  • Publisher: 医薬ジャーナル社
• [Book] アレイCGH診断活用ガイドブック (2007)
  • Author(s): 稲澤譲治, 蒔田芳男, 羽田 明編
  • Total Pages: 239
  • Publisher: 医薬ジャーナル社
• [Remarks]
  • URL: http://www.genome-sci.jp/kumomaku/
• [Remarks]
  • URL: http://jshg.jp/qualifications/gmrc.html