| Budget Amount *help |
¥104,000,000 (Direct Cost: ¥104,000,000)
Fiscal Year 2009: ¥20,500,000 (Direct Cost: ¥20,500,000)
Fiscal Year 2008: ¥20,500,000 (Direct Cost: ¥20,500,000)
Fiscal Year 2007: ¥20,900,000 (Direct Cost: ¥20,900,000)
Fiscal Year 2006: ¥21,100,000 (Direct Cost: ¥21,100,000)
Fiscal Year 2005: ¥21,000,000 (Direct Cost: ¥21,000,000)
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| Research Abstract |
In Clostridium perfringens and Streptococcus pyogenes, both of which causes severe soft-tissue infection (flesh-eating bacteria), we proceed comprehensive analyses by genome sequencing and DNA microarray experiments. We found that these bacteria share common mechanism using small non-coding RNA for the control of virulence expression and that both have different unique mechanism for genome maintenance and total regulatory system for virulence control. These research would be important for finding molecular targets for prevention and/or therapy, which will lead to the innovation of new bacterial infection control.
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